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DE69621166D1 - Elektrostatisch bindender makromolekulärer Mizellen-Typ Wirkstoffträger mit daran gebundenem Wirkstoff - Google Patents

Elektrostatisch bindender makromolekulärer Mizellen-Typ Wirkstoffträger mit daran gebundenem Wirkstoff

Info

Publication number
DE69621166D1
DE69621166D1 DE69621166T DE69621166T DE69621166D1 DE 69621166 D1 DE69621166 D1 DE 69621166D1 DE 69621166 T DE69621166 T DE 69621166T DE 69621166 T DE69621166 T DE 69621166T DE 69621166 D1 DE69621166 D1 DE 69621166D1
Authority
DE
Germany
Prior art keywords
drug
attached
electrostatically binding
type
macromolecular micelle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69621166T
Other languages
English (en)
Other versions
DE69621166T2 (de
Inventor
Yasuhisa Sakurai
Teruo Okano
Kazunori Kataoka
Masayuki Yokoyama
Satoshi Katayose
Satoru Suwa
Atsushi Harada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toudai Tlo Ltd Tokyo Jp
Original Assignee
Research Development Corp of Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Development Corp of Japan filed Critical Research Development Corp of Japan
Publication of DE69621166D1 publication Critical patent/DE69621166D1/de
Application granted granted Critical
Publication of DE69621166T2 publication Critical patent/DE69621166T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyesters Or Polycarbonates (AREA)
DE69621166T 1995-01-10 1996-01-10 Elektrostatisch bindender makromolekulärer Mizellen-Typ Wirkstoffträger mit daran gebundenem Wirkstoff Expired - Lifetime DE69621166T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7002210A JP2690276B2 (ja) 1995-01-10 1995-01-10 静電結合型高分子ミセル薬物担体とその薬剤

Publications (2)

Publication Number Publication Date
DE69621166D1 true DE69621166D1 (de) 2002-06-20
DE69621166T2 DE69621166T2 (de) 2002-11-14

Family

ID=11522995

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69621166T Expired - Lifetime DE69621166T2 (de) 1995-01-10 1996-01-10 Elektrostatisch bindender makromolekulärer Mizellen-Typ Wirkstoffträger mit daran gebundenem Wirkstoff

Country Status (8)

Country Link
US (3) US20010000510A1 (de)
EP (1) EP0721776B1 (de)
JP (1) JP2690276B2 (de)
KR (2) KR100664527B1 (de)
AU (1) AU4090096A (de)
CA (1) CA2166931C (de)
DE (1) DE69621166T2 (de)
ES (1) ES2174024T3 (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4039466B2 (ja) * 1995-09-29 2008-01-30 靖久 桜井 新規アンスラサイクリン系化合物誘導体及びそれを含む医薬製剤
WO1999003448A1 (en) * 1997-07-14 1999-01-28 The Board Of Trustees Of The University Of Illinois Materials and methods for making improved micelle compositions
GB9811059D0 (en) * 1998-05-23 1998-07-22 Univ Strathclyde Polyamino acid vesicles
KR100596641B1 (ko) * 1998-12-11 2006-10-04 이승진 진단용 공중합성 미셀 및 그의 제조방법
US20080281041A1 (en) 1999-06-07 2008-11-13 Rozema David B Reversibly Masked Polymers
FR2801226B1 (fr) 1999-11-23 2002-01-25 Flamel Tech Sa Suspension colloidale de particules submicroniques de vectorisation de principes actifs et son mode de preparation
FR2814952B1 (fr) * 2000-10-06 2004-01-02 Flamel Tech Sa Suspension colloidale de particules submicromiques de vectorisation de principes actifs et leur mode de preparation
FR2814951B1 (fr) * 2000-10-06 2003-01-17 Flamel Tech Sa Suspension colloidale de particules submicroniques de vectorisation de principes actifs hydrophiles (insuline) et leur mode de preparation
FR2822834B1 (fr) 2001-04-02 2005-02-25 Flamel Tech Sa Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation
KR100566911B1 (ko) 2001-06-25 2006-04-03 주식회사 삼양사 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체
AU2002319922B2 (en) 2001-07-14 2004-12-16 Samyang Biopharmaceuticals Corporation Positively charged amphiphilic block copolymer as drug carrier and complex thereof with negatively charged drug
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
US8008355B2 (en) * 2002-03-11 2011-08-30 Roche Madison Inc. Endosomolytic poly(vinyl ether) polymers
US8138383B2 (en) * 2002-03-11 2012-03-20 Arrowhead Madison Inc. Membrane active heteropolymers
US7906145B2 (en) 2002-04-09 2011-03-15 Flamel Technologies Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s)
CN100577164C (zh) 2002-04-09 2010-01-06 弗拉梅技术公司 可改进释放阿莫西林的微囊含水混悬液形式的口服药物制剂
JP2004067703A (ja) * 2002-04-24 2004-03-04 Japan Science & Technology Corp 架橋ポリマー、微粒子および製造方法
FR2840614B1 (fr) 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2843117B1 (fr) 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
ATE432095T1 (de) * 2003-09-25 2009-06-15 Wageningen Universiteit Agrote Mizellen mit einem komplexkoazervatkern als fäulnishemmende mittel
FR2860516B1 (fr) 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2862536B1 (fr) 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
WO2005073370A1 (ja) * 2004-01-31 2005-08-11 Transparent Inc. 酵素複合体
WO2005078084A1 (ja) * 2004-02-13 2005-08-25 Toudai Tlo, Ltd. ２本鎖オリゴ核酸を担持したポリイオンコンプレックスおよびその製造法とそれを含む医薬組成物
JP5061349B2 (ja) * 2005-02-10 2012-10-31 国立大学法人 東京大学 ポリカチオン荷電性ポリマー及び核酸のキャリヤーとしての使用
WO2006090924A1 (ja) * 2005-02-28 2006-08-31 The University Of Tokyo ペプチドリガンドを有するブロック共重合体
KR100732013B1 (ko) 2005-03-18 2007-06-25 성균관대학교산학협력단 ｐＨ 민감성 블록 공중합체 및 이를 이용한 고분자 마이셀
WO2006118260A1 (ja) * 2005-05-02 2006-11-09 The University Of Tokyo 静電結合型高分子ベシクル
KR101126016B1 (ko) * 2005-10-04 2012-03-19 주식회사 엘지화학 잔류 단량체 함량이 낮은 그라프트 고무 라텍스의 제조방법
BRPI0616877A2 (pt) 2005-10-05 2011-07-05 Tokyo Cro Inc copolìmero em bloco biocompatìvel, micela, particulado, compósito, composição farmacêutica, método para fabricar uma micela, particulado ou compósito, e, uso de um copolìmero em bloco biocompatìvel
KR100857389B1 (ko) 2006-06-30 2008-09-11 (주)아모레퍼시픽 Ａｐ-ｇｒｒ 펩티드 또는 ａｐ-ｇｒｒ 펩티드를 포함하는펩티드사슬 및 이를 포함하는 약물전달담체
US8147868B2 (en) 2006-07-18 2012-04-03 Nanocarrier Co., Ltd. Physiologically active polypeptide- or protein-encapsulating polymer micelles, and method for production of the same
CA2660842C (en) * 2006-08-18 2012-03-13 F. Hoffmann-La Roche Ag Polyconjugates for in vivo delivery of polynucleotides
US8017109B2 (en) * 2006-08-18 2011-09-13 Roche Madison Inc. Endosomolytic poly(acrylate) polymers
JP2008214324A (ja) * 2007-02-28 2008-09-18 Hokkaido Univ ミセル封入リポソーム
EP2272897B1 (de) * 2008-03-10 2016-12-28 The University of Tokyo Copolymer mit einem ungeladenen hydrophilen block und kationischer polyaminosäureblock mit einer seitenkette mit partiell eingefügten hydrophoben radikalen sowie verwendung des copolymers
US20110060123A1 (en) * 2008-04-30 2011-03-10 Kazunori Kataoka Charge conversional ternary polyplex
KR101688666B1 (ko) * 2008-08-29 2016-12-21 젠자임 코포레이션 제어 방출성 펩티드 제형
WO2010083154A2 (en) * 2009-01-13 2010-07-22 The Uab Research Foundation Heterofunctional segment-poly(ethylene glycol) polymers as delivery vehicles
WO2010098265A1 (ja) * 2009-02-27 2010-09-02 国立大学法人 東京大学 プロテアソームインヒビター内包高分子ミセル
JP5472288B2 (ja) * 2009-03-17 2014-04-16 国立大学法人 東京大学 タンパク質の電荷調節剤、及びタンパク質内包高分子ミセル複合体
JP5622254B2 (ja) 2009-03-31 2014-11-12 国立大学法人東京大学 二本鎖リボ核酸ポリイオンコンプレックス
WO2010137167A1 (ja) 2009-05-29 2010-12-02 トヨタ自動車株式会社 半導体装置
JP5463531B2 (ja) * 2009-07-22 2014-04-09 国立大学法人 東京大学 Ｐｈｄ２発現抑制物質搭載ポリイオンコンプレックス
CA2788600C (en) 2010-02-24 2019-12-03 Arrowhead Research Corporation Compositions for targeted delivery of sirna
EP2572780B1 (de) * 2010-05-21 2018-07-11 Japan Science And Technology Agency Vesikel mit einer eingekapselten substanz und herstellungsverfahren dafür
CA2804815C (en) 2010-07-09 2016-06-07 The University Of Tokyo Nucleic acid delivery composition and carrier composition, pharmaceutical composition using the same, and method for nucleic acid delivery
US9051437B2 (en) 2010-07-28 2015-06-09 The University Of Tokyo Electrostatically bonded vesicle
US9320814B2 (en) * 2011-11-01 2016-04-26 Board Of Regents Of The University Of Nebraska Polyplexes of hydrophobically-modified siRNA for delivery of siRNA
ITRM20120169A1 (it) 2012-04-19 2013-10-20 Consiglio Nazionale Ricerche Dispositivo di rilascio di specie chimiche a controllo ottico
WO2014133172A1 (ja) 2013-03-01 2014-09-04 独立行政法人科学技術振興機構 物質内包ベシクル及びその製造方法
JP2015046867A (ja) 2013-07-31 2015-03-12 株式会社リコー 撮像装置
JP6108369B2 (ja) 2013-08-06 2017-04-05 国立研究開発法人科学技術振興機構 核酸内包高分子ミセル複合体及びその製造方法
JP5971264B2 (ja) 2014-01-10 2016-08-17 Ｊｆｅスチール株式会社 極厚肉油井管用ねじ継手
JP6106104B2 (ja) 2014-01-16 2017-03-29 信越化学工業株式会社 末端にアミノ基を有する狭分散ポリアルキレングリコール誘導体の製造方法
JP6106103B2 (ja) 2014-01-16 2017-03-29 信越化学工業株式会社 末端にアミノ基を有する狭分散ポリアルキレングリコール誘導体の製造方法、並びにこれに用いる新規なアセタール基含有アルコール化合物及びそのアルカリ金属塩
CN105524272B (zh) * 2014-10-24 2018-08-21 江苏师范大学 硫辛酸修饰的聚乙二醇-聚氨基酸嵌段共聚物的制备和应用
CN105524271B (zh) * 2014-10-24 2018-07-03 江苏师范大学 胆酸修饰的聚氨基酸嵌段共聚物的合成及应用
US10377775B2 (en) 2014-12-04 2019-08-13 Shin-Etsu Chemical Co., Ltd. Method for producing polyalkylene glycol derivative having amino group at end
US9708350B2 (en) 2014-12-04 2017-07-18 Shin-Etsu Chemical Co., Ltd. Method for producing polyalkylene glycol derivative having amino group at end, polymerization initiator for use in the same, and alcohol compound as raw material for the polymerization initiator
JP6460937B2 (ja) 2014-12-04 2019-01-30 信越化学工業株式会社 末端にアミノ基を有するポリアルキレングリコール誘導体の製造方法
JP6463229B2 (ja) 2014-12-04 2019-01-30 信越化学工業株式会社 末端にアミノ基を有するポリアルキレングリコール誘導体の製造方法、並びにこれに用いる重合開始剤及びその原料となるアルコール化合物
KR102094200B1 (ko) * 2017-02-28 2020-03-27 중앙대학교 산학협력단 인돌-3-아세트산을 포함하는 광역학 진단 또는 치료용 조성물
JP6848743B2 (ja) 2017-07-24 2021-03-24 信越化学工業株式会社 ポリアルキレングリコール誘導体の製造方法及び精製方法
JP6644326B2 (ja) 2017-08-31 2020-02-12 国立大学法人 東京大学 核酸搭載ユニット型ポリイオンコンプレックス
CN114080412B (zh) * 2019-06-28 2023-08-25 国立大学法人东京大学 蛋白质内包高分子胶束
WO2021006318A1 (ja) * 2019-07-11 2021-01-14 国立大学法人東京大学 医療器具
JP2023102362A (ja) * 2022-01-12 2023-07-25 国立大学法人 東京大学 サイトカイン内包高分子ミセル

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE66830B1 (en) * 1987-08-12 1996-02-07 Hem Res Inc Topically active compositions of double-stranded RNAs
JP2517760B2 (ja) * 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
US5198360A (en) * 1990-01-19 1993-03-30 Eli Lilly And Company Dna sequence conferring a plaque inhibition phenotype
CA2033714A1 (en) * 1990-01-25 1991-07-26 Alberto Ferro Pharmaceutical preparations
DE4015108A1 (de) * 1990-05-11 1991-11-14 Leopold Pharma Gmbh Stabile emulsion zur applikation pharmakologisch aktiver wirkstoffe
CA2087125A1 (en) * 1992-01-23 1993-07-24 Mridula Nair Chemically fixed micelles
KR940003548U (ko) * 1992-08-14 1994-02-21 김형술 세탁물 건조기
JP3270592B2 (ja) * 1992-10-26 2002-04-02 日本化薬株式会社 ブロック共重合体−抗癌剤複合体医薬製剤
JPH06206830A (ja) * 1992-10-27 1994-07-26 Nippon Kayaku Co Ltd ブロック共重合体−薬剤複合体及び高分子ブロック共重合体
JP3268913B2 (ja) * 1992-10-27 2002-03-25 日本化薬株式会社 高分子担体
US5567410A (en) * 1994-06-24 1996-10-22 The General Hospital Corporation Composotions and methods for radiographic imaging
US5656611A (en) * 1994-11-18 1997-08-12 Supratek Pharma Inc. Polynucleotide compositions

Also Published As

Publication number Publication date
KR20060106972A (ko) 2006-10-13
EP0721776B1 (de) 2002-05-15
AU4090096A (en) 1996-07-18
US20010000510A1 (en) 2001-04-26
JPH08188541A (ja) 1996-07-23
JP2690276B2 (ja) 1997-12-10
KR960028904A (ko) 1996-08-17
ES2174024T3 (es) 2002-11-01
CA2166931A1 (en) 1996-07-11
EP0721776A1 (de) 1996-07-17
US20020082198A1 (en) 2002-06-27
KR100839900B1 (ko) 2008-06-20
DE69621166T2 (de) 2002-11-14
KR100664527B1 (ko) 2008-11-12
US20060025330A1 (en) 2006-02-02
CA2166931C (en) 2008-05-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: JAPAN SCIENCE AND TECHNOLOGY CORP., KAWAGUCHI,, JP

8327 Change in the person/name/address of the patent owner

Owner name: JAPAN SCIENCE AND TECHNOLOGY AGENCY, KAWAGUCHI, JP

8327 Change in the person/name/address of the patent owner

Owner name: KATAOKA, KAZUNORI, KASHIWA, CHIBA, JP

8327 Change in the person/name/address of the patent owner

Owner name: TOUDAI TLO, LTD., TOKYO, JP

8328 Change in the person/name/address of the agent

Representative=s name: KUDLEK & GRUNERT PATENTANWAELTE PARTNERSCHAFT, 803