DE69619661D1 - 1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-on-derivate mit pde iv-und cytokin-inhibisender aktivität - Google Patents

1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-on-derivate mit pde iv-und cytokin-inhibisender aktivität

Info

Publication number: DE69619661D1
Authority: DE; Germany
Prior art keywords: cytokin; pde; phenylalkyl; imidazol; dihydro
Prior art date: 1995-04-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69619661T

Other languages

English (en)

Other versions

DE69619661T2 (de

Inventor

Jean Freyne

Stanislas Diels

Gil Jose Ignacio Andres

Gadea Francisco Javi Fernandez

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee

Janssen Pharmaceutica NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-06

Filing date

1996-03-28

Publication date

2002-04-11

1996-03-28 Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV

2002-04-11 Publication of DE69619661D1 publication Critical patent/DE69619661D1/de

2002-10-31 Application granted granted Critical

2002-10-31 Publication of DE69619661T2 publication Critical patent/DE69619661T2/de

2016-03-29 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DE69619661T 1995-04-06 1996-03-28 1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-on-derivate mit pde iv-und cytokin-inhibisender aktivität Expired - Lifetime DE69619661T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP95200868		1995-04-06
EP95202898		1995-10-26
PCT/EP1996/001394 WO1996031485A1 (en)	1995-04-06	1996-03-28	1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-one derivatives having pdeiv and cytokine activity

Publications (2)

Publication Number	Publication Date
DE69619661D1 true DE69619661D1 (de)	2002-04-11
DE69619661T2 DE69619661T2 (de)	2002-10-31

Family

ID=26139205

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69619661T Expired - Lifetime DE69619661T2 (de)	1995-04-06	1996-03-28	1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-on-derivate mit pde iv-und cytokin-inhibisender aktivität

Country Status (27)

Country	Link
US (2)	US5994376A (de)
EP (1)	EP0819122B1 (de)
JP (1)	JP4562101B2 (de)
KR (1)	KR100406628B1 (de)
CN (1)	CN1068591C (de)
AR (1)	AR002732A1 (de)
AT (1)	ATE214052T1 (de)
AU (1)	AU702947B2 (de)
CA (1)	CA2216653C (de)
CY (1)	CY2328B1 (de)
CZ (1)	CZ293127B6 (de)
DE (1)	DE69619661T2 (de)
DK (1)	DK0819122T3 (de)
ES (1)	ES2174064T3 (de)
HK (1)	HK1007880A1 (de)
HR (1)	HRP960155A2 (de)
HU (1)	HU223324B1 (de)
IL (1)	IL117807A (de)
MX (1)	MX9707652A (de)
MY (1)	MY119254A (de)
NO (1)	NO314339B1 (de)
NZ (1)	NZ304877A (de)
PL (1)	PL187375B1 (de)
PT (1)	PT819122E (de)
SI (1)	SI0819122T1 (de)
TW (1)	TW332201B (de)
WO (1)	WO1996031485A1 (de)

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US5703098A (en) *	1994-12-30	1997-12-30	Celgene Corporation	Immunotherapeutic imides/amides
TW332201B (en)	1995-04-06	1998-05-21	Janssen Pharmaceutica Nv	1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives
PL194673B1 (pl) *	1996-10-02	2007-06-29	Janssen Pharmaceutica Nv	Pochodna 2-cyjanoiminoimidazolu, sposób jej wytwarzania i zastosowanie oraz kompozycja farmaceutyczna
CN1261881A (zh) *	1997-07-10	2000-08-02	詹森药业有限公司	作为il－5－抑制剂的6－氮杂尿嘧啶衍生物
US6017926A (en) *	1997-12-17	2000-01-25	Merck & Co., Inc.	Integrin receptor antagonists
TR200002801T2 (tr) *	1998-04-01	2000-12-21	Janssen Pharmaceutica N.V.	PDE IV engelleyici piridin türevleri
US6172118B1 (en) *	1998-04-14	2001-01-09	Smithkline Beecham Corporation	Compounds
CA2328250A1 (en) *	1998-04-14	1999-10-21	Cornelia Jutta Forster	Phosphodiesterase isoenzyme denominated 4 (pde 4) inhibiting compounds
WO2000031053A1 (en) *	1998-11-23	2000-06-02	Janssen Pharmaceutica N.V.	Il-5 inhibiting 6-azauracil derivatives
TR200101729T2 (tr)	1998-12-18	2001-10-22	Janssen Pharmaceutica N.V.	IL-5 engelleyici 6-azaurasil türevleri
EP1322310A4 (de) *	2000-09-13	2004-09-15	Merck & Co Inc	Alpha-v-integrin-rezeptorantagonisten
KR20040007596A (ko)	2001-05-23	2004-01-24	다나베 세이야꾸 가부시키가이샤	골절 치료 촉진용 조성물
KR20040007583A (ko) *	2001-05-23	2004-01-24	다나베 세이야꾸 가부시키가이샤	연골 질환의 재생치료용 조성물
US6706739B2 (en) *	2001-08-21	2004-03-16	National Health Research Institute	Imidazolidinone compounds
SE0200667D0 (sv) *	2002-03-05	2002-03-05	A & Science Invest Ab	Novel use of cytokine inhibitors
GB0326407D0 (en) *	2003-11-12	2003-12-17	Glaxo Group Ltd	Chemical compounds
GB0412865D0 (en) *	2004-06-09	2004-07-14	Glaxo Group Ltd	Chemical compounds
WO2006004370A1 (en) *	2004-07-05	2006-01-12	Dong Wha Pharmaceutical. Ind. Co., Ltd.	Composition for the prevention and treatment of allergic inflammatory disease
AR057455A1 (es) *	2005-07-22	2007-12-05	Merck & Co Inc	Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
WO2007085357A1 (en) *	2006-01-30	2007-08-02	Euro-Celtique S.A.	Cyclourea compounds as calcium channel blockers
EP1834953A1 (de)	2006-03-14	2007-09-19	Ranbaxy Laboratories Limited	Tetrahydropyran-Derivate als 5-Lipoxygenase-Hemmer
US7390772B2 (en) *	2006-05-18	2008-06-24	International Flavor & Fragrances Inc.	1-phenyl-spiro[2.5]octane-1-carbonitrile analogues their use in fragrance formulations
WO2008157425A2 (en) *	2007-06-14	2008-12-24	The Regents Of The University Of California	Compounds for inhibiting protein aggregation, and methods for making and using them
KR101713452B1 (ko)	2010-03-12	2017-03-07	오메로스 코포레이션	Pde10 억제제 및 관련 조성물 및 방법
NZ630810A (en)	2014-04-28	2016-03-31	Omeros Corp	Processes and intermediates for the preparation of a pde10 inhibitor
NZ630803A (en)	2014-04-28	2016-03-31	Omeros Corp	Optically active pde10 inhibitor
RU2017134509A (ru)	2015-04-24	2019-04-04	Омерос Корпорейшн	Ингибиторы pde10 и соответствующие композиции и способы
JP2018535969A (ja)	2015-11-04	2018-12-06	オメロスコーポレーション	Ｐｄｅ１０阻害剤の固体状態形態

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Publication number	Priority date	Publication date	Assignee	Title
NL285394A (de) *	1961-11-17
US3184060A (en)	1963-02-13	1965-05-18	Owens Illinois Glass Co	Packaging tacky latex emulsion paints in containers manufactured from polyolefinic maerials
IE913855A1 (en) *	1990-11-06	1992-05-22	Smithkline Beecham Corp	Imidazolidinone compounds
KR950704228A (ko) *	1992-12-02	1995-11-17	알렌 제이. 스피겔	선택적 포스포디에스테르가수분해효소 iv형(pde_iv) 저해제로서의 카테콜 디에테르(catecol diethers as selective pde_iv inhibitors)
TW263495B (de) *	1992-12-23	1995-11-21	Celltech Ltd
GB9304920D0 (en) *	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
TW332201B (en)	1995-04-06	1998-05-21	Janssen Pharmaceutica Nv	1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives

1996
- 1996-03-22 TW TW085103447A patent/TW332201B/zh not_active IP Right Cessation
- 1996-03-28 PL PL96322654A patent/PL187375B1/pl unknown
- 1996-03-28 DK DK96909150T patent/DK0819122T3/da active
- 1996-03-28 MX MX9707652A patent/MX9707652A/es unknown
- 1996-03-28 ES ES96909150T patent/ES2174064T3/es not_active Expired - Lifetime
- 1996-03-28 CN CN96193101A patent/CN1068591C/zh not_active Expired - Lifetime
- 1996-03-28 JP JP52995996A patent/JP4562101B2/ja not_active Expired - Lifetime
- 1996-03-28 CA CA002216653A patent/CA2216653C/en not_active Expired - Lifetime
- 1996-03-28 US US08/930,296 patent/US5994376A/en not_active Expired - Lifetime
- 1996-03-28 CZ CZ19973149A patent/CZ293127B6/cs not_active IP Right Cessation
- 1996-03-28 HU HU9801575A patent/HU223324B1/hu active IP Right Grant
- 1996-03-28 DE DE69619661T patent/DE69619661T2/de not_active Expired - Lifetime
- 1996-03-28 WO PCT/EP1996/001394 patent/WO1996031485A1/en active IP Right Grant
- 1996-03-28 EP EP96909150A patent/EP0819122B1/de not_active Expired - Lifetime
- 1996-03-28 AT AT96909150T patent/ATE214052T1/de active
- 1996-03-28 KR KR1019970706853A patent/KR100406628B1/ko not_active IP Right Cessation
- 1996-03-28 SI SI9630434T patent/SI0819122T1/xx unknown
- 1996-03-28 NZ NZ304877A patent/NZ304877A/en not_active IP Right Cessation
- 1996-03-28 PT PT96909150T patent/PT819122E/pt unknown
- 1996-03-28 AU AU52755/96A patent/AU702947B2/en not_active Expired
- 1996-04-02 HR HR95202898.3A patent/HRP960155A2/hr not_active Application Discontinuation
- 1996-04-03 IL IL11780796A patent/IL117807A/en not_active IP Right Cessation
- 1996-04-03 AR ARP960102076A patent/AR002732A1/es active IP Right Grant
- 1996-04-05 MY MYPI96001300A patent/MY119254A/en unknown
1997
- 1997-10-06 NO NO19974602A patent/NO314339B1/no not_active IP Right Cessation
1998
- 1998-07-07 HK HK98108913A patent/HK1007880A1/xx not_active IP Right Cessation
1999
- 1999-07-27 US US09/362,007 patent/US6403805B1/en not_active Expired - Lifetime
2002
- 2002-07-15 CY CY0200043A patent/CY2328B1/xx unknown

Also Published As

Publication number	Publication date
AU5275596A (en)	1996-10-23
NO314339B1 (no)	2003-03-10
EP0819122B1 (de)	2002-03-06
PT819122E (pt)	2002-08-30
AR002732A1 (es)	1998-04-29
IL117807A (en)	2001-06-14
NO974602L (no)	1997-10-06
NZ304877A (en)	1999-06-29
ATE214052T1 (de)	2002-03-15
HRP960155A2 (en)	1997-10-31
CN1181072A (zh)	1998-05-06
HUP9801575A2 (hu)	1999-01-28
MY119254A (en)	2005-04-30
PL187375B1 (pl)	2004-06-30
US6403805B1 (en)	2002-06-11
PL322654A1 (en)	1998-02-16
ES2174064T3 (es)	2002-11-01
CN1068591C (zh)	2001-07-18
CY2328B1 (en)	2004-02-06
KR19980703449A (ko)	1998-11-05
US5994376A (en)	1999-11-30
HUP9801575A3 (en)	1999-03-01
DE69619661T2 (de)	2002-10-31
JPH11503136A (ja)	1999-03-23
CA2216653A1 (en)	1996-10-10
NO974602D0 (no)	1997-10-06
JP4562101B2 (ja)	2010-10-13
CA2216653C (en)	2009-05-26
HK1007880A1 (en)	1999-04-30
CZ293127B6 (cs)	2004-02-18
WO1996031485A1 (en)	1996-10-10
KR100406628B1 (ko)	2004-05-31
US20020068830A1 (en)	2002-06-06
DK0819122T3 (da)	2002-07-01
SI0819122T1 (en)	2002-06-30
AU702947B2 (en)	1999-03-11
TW332201B (en)	1998-05-21
EP0819122A1 (de)	1998-01-21
HU223324B1 (hu)	2004-06-28
IL117807A0 (en)	1996-08-04
MX9707652A (es)	1997-11-29
CZ314997A3 (cs)	1998-12-16

Publication	Publication Date	Title
DE69619661D1 (de)	2002-04-11	1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-on-derivate mit pde iv-und cytokin-inhibisender aktivität
NL350016I1 (nl)	2004-02-02	3-Aryl-4-hydroxy-delta#3-dihydrofuranon-en 3-aryl-4-hydroxy-delta#3-dihydrothiofenon-derivaten.
NO932176D0 (no)	1993-06-14	Kinolin-, naftyridin- og pyridobenzoksazinderivater
PT900210E (pt)	2005-06-30	Derivados azahexano heterociclicos com actividade antviral
DE68929361D1 (de)	2002-01-31	Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel
DK0877734T3 (da)	2000-11-20	Quinolin- og quinazolinforbindelser, der er egnede i terapi
FI970502A0 (fi)	1997-02-06	Makrofagiperäinen kemokiini ja kemokiinijohdannaisia
HK1003436A1 (en)	1998-10-30	Novel benzimidazole derivatives having cgmp-phosphodisterase inhibiting activity
NO932146D0 (no)	1993-06-11	Benzimidazolderivater
PT551048E (pt)	2002-12-31	Derivados de 2-imidazolina-5-ona e 2-imidazolina-5-tionas fungicidas
DK0562583T3 (da)	1997-09-29	Hidtil ukendte alkylendiammoniumdiclavulanatderivater, fremgangsmåde til fremstilling deraf samt anvendelse deraf
DE69424051D1 (de)	2000-05-25	Rapamycin-derivat mit antimikrobe, antikrebs und immunomodulatorischer aktivität
NO905485D0 (no)	1990-12-19	Benzazepin- og benzotiazepin-derivater.
DE69637363D1 (de)	2008-01-24	1,3-dihydro-1-(phenylalkenyl)-2h-imidazol-2 on-derivate mit pde iv und cytokin-inhibirendes aktivität
MA22916A1 (fr)	1993-12-31	Derives de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides.
DE69635224D1 (de)	2006-02-09	1,3-dihydro-2h-imidazol-2-on-derivate mit pdeiv und cytokin inhibierender aktivität
FI955679A0 (fi)	1995-11-24	Piperidiinijohdannaisia, niiden valmistus ja käyttö
FI934665L (fi)	1994-04-23	Aryliden-1-azacykloalkaner och arylalkyl-1-azacyckloalkaner, deras salter, dessa foereningar innehaollande laekemedel och deras anvaendning och framstaellning
ITMI922071A0 (it)	1992-09-07	Derivati xantonici, loro preparazione ed attivita'
KR970019252U (ko)	1997-05-26	보안기능을 갖는 모니터
FI19992134L (fi)	1999-10-04	Piperidiinijohdannaisia, joilla on rauhoittava vaikutus
NO970498D0 (no)	1997-02-04	Benzimidazolderivater med dopaminergisk aktivitet
ATE104289T1 (de)	1994-04-15	Aminoethylthiazole und aminoethyloxazol-derivate.
NO920307L (no)	1993-07-26	Nye dihydro-isokinolinderivater med farmasoeytisk virkning
NO940122D0 (no)	1994-01-13	Nye adenosinderivater

Legal Events

Date	Code	Title	Description
2003-04-03	8364	No opposition during term of opposition