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DE69528591D1 - Herstellung des inhibitors fuer die komplexbildung des gewebefaktors - Google Patents

Herstellung des inhibitors fuer die komplexbildung des gewebefaktors

Info

Publication number
DE69528591D1
DE69528591D1 DE69528591T DE69528591T DE69528591D1 DE 69528591 D1 DE69528591 D1 DE 69528591D1 DE 69528591 T DE69528591 T DE 69528591T DE 69528591 T DE69528591 T DE 69528591T DE 69528591 D1 DE69528591 D1 DE 69528591D1
Authority
DE
Germany
Prior art keywords
tissue factor
production
inhibitor
complex formation
tfpi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69528591T
Other languages
English (en)
Other versions
DE69528591T2 (de
Inventor
A Innis
A Creasey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of DE69528591D1 publication Critical patent/DE69528591D1/de
Application granted granted Critical
Publication of DE69528591T2 publication Critical patent/DE69528591T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69528591T 1994-08-05 1995-07-25 Herstellung des inhibitors fuer die komplexbildung des gewebefaktors Expired - Fee Related DE69528591T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28653094A 1994-08-05 1994-08-05
PCT/US1995/009377 WO1996004377A1 (en) 1994-08-05 1995-07-25 Production of tissue factor pathway inhibitor

Publications (2)

Publication Number Publication Date
DE69528591D1 true DE69528591D1 (de) 2002-12-05
DE69528591T2 DE69528591T2 (de) 2003-02-20

Family

ID=23099037

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528591T Expired - Fee Related DE69528591T2 (de) 1994-08-05 1995-07-25 Herstellung des inhibitors fuer die komplexbildung des gewebefaktors

Country Status (8)

Country Link
US (2) US6103500A (de)
EP (1) EP0774001B1 (de)
JP (2) JP3779728B2 (de)
AT (1) ATE226249T1 (de)
AU (1) AU707762B2 (de)
CA (1) CA2196296C (de)
DE (1) DE69528591T2 (de)
WO (1) WO1996004377A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
DE69528591T2 (de) * 1994-08-05 2003-02-20 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Herstellung des inhibitors fuer die komplexbildung des gewebefaktors
US5863894A (en) * 1995-06-05 1999-01-26 Corvas International, Inc. Nematode-extracted anticoagulant protein
CA2202351A1 (en) * 1994-10-18 1996-04-25 George Phillip Vlasuk Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5872098A (en) * 1995-06-05 1999-02-16 Corvas International, Inc. Nematode-extracted anticoagulant protein
ES2276396T3 (es) 1994-10-18 2007-06-16 Dendreon Corporation Proteinas anticoagulantes e inhibidores de la serina proteasa extraidos de nematodos.
US5866543A (en) * 1995-06-05 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5945275A (en) * 1994-10-18 1999-08-31 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5866542A (en) * 1994-10-18 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
WO1996040784A2 (en) * 1995-06-07 1996-12-19 Chiron Corporation Method of solubilizing, purifying, and refolding protein
DE69618560T2 (de) * 1995-08-09 2002-08-14 Toray Industries, Inc. Medikament gegen ophthalmische erkrankungen
JP4243355B2 (ja) 1997-03-26 2009-03-25 インペリアル カレッジ イノベイションズ リミテッド 細胞膜に固定された抗凝固性融合タンパク質
DE60333758D1 (de) * 2002-06-07 2010-09-23 Dyax Corp Prevention und Verringerung von Ischemia
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
PT1599222E (pt) * 2003-01-08 2009-06-12 Novartis Vaccines & Diagnostic Composições aquosas estabilizadas que contêm um inibidor da via do factor tecidular (tfpi) ou uma variante do inibidor da via do factor tecidular
US7419801B2 (en) * 2003-08-08 2008-09-02 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
CA2535562A1 (en) * 2003-08-13 2005-03-03 Chiron Corporation Improved method of purifying tfpi and tfpi analogs
EP1684719B1 (de) * 2003-11-14 2011-10-26 Baxter International Inc. Alpha1-antitrypsin-zusammensetzungen und behandlungsverfahren unter verwendung dieser zusammensetzungen
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
JP2008515908A (ja) * 2004-10-06 2008-05-15 ユニバーシティー オブ ロチェスター 組織因子経路を阻害する薬剤を使用する、肺高血圧症の治療
WO2007070372A2 (en) * 2005-12-09 2007-06-21 Entremed, Inc. Compositions and methods for inhibiting cellular proliferation
EP1981519B1 (de) 2005-12-29 2017-12-27 Dyax Corp. Proteasehemmung
CN100451116C (zh) * 2006-09-14 2009-01-14 中国医学科学院生物医学工程研究所 人类组织因子途径抑制因子突变基因mTFPI、包括该基因的重组载体及其宿主细胞
AU2008289005A1 (en) * 2007-08-21 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
CN102307594A (zh) * 2009-01-06 2012-01-04 戴埃克斯有限公司 用激肽释放酶抑制剂治疗粘膜炎
US8088599B2 (en) * 2009-02-06 2012-01-03 Fudan University Nucleic acids encoding genetically modified tissue factor pathway inhibitor (TFPI) and method of making the same
SMT201800552T1 (it) 2010-01-06 2018-11-09 Dyax Corp Proteine che legano la callicreina plasmatica
KR102320178B1 (ko) 2011-01-06 2021-11-02 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
CA2942713A1 (en) 2014-03-27 2015-10-01 Dyax Corp. Compositions and methods for treatment of diabetic macular edema
EA201891388A1 (ru) 2015-12-11 2018-11-30 Дайэкс Корп. Ингибиторы калликреина плазмы и их применение для лечения обострения наследственного ангионевротического отека

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751180A (en) * 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4966852A (en) * 1987-07-23 1990-10-30 Monsanto Company DNA clone of human tissue factor inhibitor
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner
DK0473564T3 (da) * 1990-08-27 1996-04-15 Monsanto Co Antikoagulant kombination af LACI og sulfatiserede polysaccharider
IL104324A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
IL104326A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
IL104325A (en) * 1992-01-07 2000-10-31 Novo Nordisk As Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above
US5212091A (en) * 1992-03-02 1993-05-18 Monsanto Company Method of producing tissue factor pathway inhibitor
DE69528591T2 (de) * 1994-08-05 2003-02-20 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Herstellung des inhibitors fuer die komplexbildung des gewebefaktors

Also Published As

Publication number Publication date
US6103500A (en) 2000-08-15
CA2196296A1 (en) 1996-02-15
US20050064556A1 (en) 2005-03-24
EP0774001B1 (de) 2002-10-16
JPH10507071A (ja) 1998-07-14
DE69528591T2 (de) 2003-02-20
WO1996004377A1 (en) 1996-02-15
AU3104495A (en) 1996-03-04
EP0774001A1 (de) 1997-05-21
AU707762B2 (en) 1999-07-22
JP3779728B2 (ja) 2006-05-31
CA2196296C (en) 2004-04-06
ATE226249T1 (de) 2002-11-15
JP2005348744A (ja) 2005-12-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US

8339 Ceased/non-payment of the annual fee