DE69523961D1 - Beta-Carbolin Thromboxansynthase Inhibitoren - Google Patents
Beta-Carbolin Thromboxansynthase InhibitorenInfo
- Publication number
- DE69523961D1 DE69523961D1 DE69523961T DE69523961T DE69523961D1 DE 69523961 D1 DE69523961 D1 DE 69523961D1 DE 69523961 T DE69523961 T DE 69523961T DE 69523961 T DE69523961 T DE 69523961T DE 69523961 D1 DE69523961 D1 DE 69523961D1
- Authority
- DE
- Germany
- Prior art keywords
- carboline
- beta
- synthase inhibitors
- thromboxane synthase
- thromboxane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical compound N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 title 2
- 239000003768 thromboxane synthase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18563494A | 1994-01-24 | 1994-01-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69523961D1 true DE69523961D1 (de) | 2002-01-03 |
| DE69523961T2 DE69523961T2 (de) | 2002-07-04 |
Family
ID=22681809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69523961T Expired - Fee Related DE69523961T2 (de) | 1994-01-24 | 1995-01-23 | Beta-Carbolin Thromboxansynthase Inhibitoren |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5604236A (de) |
| EP (1) | EP0667347B1 (de) |
| JP (1) | JPH07206862A (de) |
| CA (1) | CA2140722A1 (de) |
| DE (1) | DE69523961T2 (de) |
| ES (1) | ES2165407T3 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1498124T3 (da) * | 1997-10-17 | 2007-11-05 | Ark Therapeutics Ltd | Anvendelse af inhibitorer i renin-angiotensinsystemet |
| EP1209158A1 (de) * | 2000-11-18 | 2002-05-29 | Aventis Pharma Deutschland GmbH | Substitutierte beta-Carboline |
| EP1134221A1 (de) * | 2000-03-15 | 2001-09-19 | Aventis Pharma Deutschland GmbH | Substituierte beta-Carboline als lkB-Kinasehemmer |
| EE200200523A (et) | 2000-03-15 | 2004-04-15 | Aventis Pharma Deutschland Gmbh | Asendatud beeta-karboliinide klassi kuuluv ühend,selle valmistamine ja kasutamine laiaspektrilise ravimi valmistamiseks ning seda sisaldav ravim |
| WO2006053249A2 (en) * | 2004-11-13 | 2006-05-18 | Metaproteomics, Llc | Compositions exhibiting inhibition of cyclooxygenase-2 |
| DE102007009264A1 (de) * | 2007-02-26 | 2008-08-28 | Ellneuroxx Ltd. | 9-Alkyl-ß-Carboline zur Behandlung von neurodegenerativen Erkrankungen |
| CN102844029A (zh) | 2009-12-28 | 2012-12-26 | 奥迪欧医药设备有限公司 | 用于治疗听力损伤和眩晕的β-咔啉 |
| AR096721A1 (es) | 2013-06-25 | 2016-01-27 | Bristol Myers Squibb Co | Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos |
| AU2014302550A1 (en) | 2013-06-25 | 2016-02-11 | Bristol-Myers Squibb Company | Carbazole carboxamide compounds useful as kinase inhibitors |
| CN107108555B (zh) | 2014-10-24 | 2020-12-01 | 百时美施贵宝公司 | 三环阻转异构体化合物 |
| BR112017007545A2 (pt) | 2014-10-24 | 2017-12-19 | Bristol Myers Squibb Co | derivados de carbazol |
| ES2809974T3 (es) | 2014-10-24 | 2021-03-08 | Bristol Myers Squibb Co | Compuestos de indol carboxamida útiles como inhibidores de cinasas |
| EP3318563A1 (de) | 2016-11-07 | 2018-05-09 | Sanofi | Substituierte pyrido[3,4-b]indole zur behandlung von knorpelerkrankungen |
| US10947253B2 (en) | 2019-08-05 | 2021-03-16 | Ankh Life Sciences Limited | Fused polycyclic dimers |
| US12129265B2 (en) | 2020-07-21 | 2024-10-29 | Ankh Life Sciences Limited | Therapeutic agents and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2850501A (en) * | 1956-07-30 | 1958-09-02 | Searle & Co | Basic esters of 9-pyrid (3, 4-b) indole alkanoic acid |
| US3015660A (en) * | 1959-11-12 | 1962-01-02 | Searle & Co | 9-carboxyalkyl-9-pyrid[3, 4-b] indole piperazides |
| GB2111050B (en) * | 1981-11-19 | 1985-09-11 | Ciba Geigy Ag | N-substituted-2-pyridylindoles |
| JPS6045580A (ja) * | 1983-08-22 | 1985-03-12 | Kaken Pharmaceut Co Ltd | β−カルボリン誘導体 |
| JPS6058990A (ja) * | 1983-09-12 | 1985-04-05 | Kaken Pharmaceut Co Ltd | β−カルボリン誘導体 |
| JPS60112791A (ja) * | 1983-11-25 | 1985-06-19 | Kaken Pharmaceut Co Ltd | カンチン誘導体 |
| JPS60132984A (ja) * | 1983-12-22 | 1985-07-16 | Kaken Pharmaceut Co Ltd | β−カルボリン誘導体 |
| DE3535928A1 (de) * | 1985-10-04 | 1987-04-09 | Schering Ag | Tetrahydro-(beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| EP0380155A1 (de) * | 1989-01-19 | 1990-08-01 | Duphar International Research B.V | 8,9-Annelierte-1,2,3,4-tetrahydro-beta-carboline-Derivate |
| DE4308788A1 (de) * | 1993-03-18 | 1994-09-22 | Bayer Ag | Hetero-tricyclisch-substituierte Phenyl-cyclohexan-carbonsäurederivate |
-
1995
- 1995-01-20 CA CA002140722A patent/CA2140722A1/en not_active Abandoned
- 1995-01-23 DE DE69523961T patent/DE69523961T2/de not_active Expired - Fee Related
- 1995-01-23 EP EP95300396A patent/EP0667347B1/de not_active Expired - Lifetime
- 1995-01-23 JP JP7008054A patent/JPH07206862A/ja active Pending
- 1995-01-23 ES ES95300396T patent/ES2165407T3/es not_active Expired - Lifetime
- 1995-05-05 US US08/436,052 patent/US5604236A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07206862A (ja) | 1995-08-08 |
| DE69523961T2 (de) | 2002-07-04 |
| EP0667347A1 (de) | 1995-08-16 |
| EP0667347B1 (de) | 2001-11-21 |
| US5604236A (en) | 1997-02-18 |
| ES2165407T3 (es) | 2002-03-16 |
| CA2140722A1 (en) | 1995-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |