DE69521209D1 - Triazolopyridazine, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel - Google Patents
Triazolopyridazine, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittelInfo
- Publication number
- DE69521209D1 DE69521209D1 DE69521209T DE69521209T DE69521209D1 DE 69521209 D1 DE69521209 D1 DE 69521209D1 DE 69521209 T DE69521209 T DE 69521209T DE 69521209 T DE69521209 T DE 69521209T DE 69521209 D1 DE69521209 D1 DE 69521209D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- products
- triazolopyridazine
- production
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- CBHTTYDJRXOHHL-UHFFFAOYSA-N 2h-triazolo[4,5-c]pyridazine Chemical compound N1=NC=CC2=C1N=NN2 CBHTTYDJRXOHHL-UHFFFAOYSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- -1 Triazolopyridazine compound Chemical class 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 230000013764 eosinophil chemotaxis Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/306,423 US5482939A (en) | 1992-03-18 | 1994-09-16 | Triazolopyridazine compounds, their production and use |
| JP22748194 | 1994-09-22 | ||
| PCT/JP1995/001797 WO1996008496A1 (en) | 1994-09-16 | 1995-09-11 | Triazolopyridazines process and intermediates for their preparation and their use as medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69521209D1 true DE69521209D1 (de) | 2001-07-12 |
| DE69521209T2 DE69521209T2 (de) | 2002-03-07 |
Family
ID=26527697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69521209T Expired - Fee Related DE69521209T2 (de) | 1994-09-16 | 1995-09-11 | Triazolopyridazine, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0781283B1 (de) |
| KR (1) | KR970706287A (de) |
| CN (1) | CN1046517C (de) |
| AT (1) | ATE201875T1 (de) |
| AU (1) | AU695377B2 (de) |
| CA (1) | CA2198019A1 (de) |
| DE (1) | DE69521209T2 (de) |
| FI (1) | FI971081L (de) |
| HU (1) | HUT77130A (de) |
| NO (1) | NO308003B1 (de) |
| NZ (1) | NZ292271A (de) |
| RU (1) | RU2156252C2 (de) |
| WO (1) | WO1996008496A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7079998A (en) | 1997-04-25 | 1998-11-24 | Takeda Chemical Industries Ltd. | Condensed pyridazine derivatives, their production and use |
| EP1059924A1 (de) * | 1998-03-04 | 2000-12-20 | Takeda Chemical Industries, Ltd. | Triazolo-pyridazine derivate zur behandlung von chronisch-obstruktiven atemwegserkrankungen |
| WO1999049865A1 (en) * | 1998-03-31 | 1999-10-07 | Mayo Foundation For Medical Education And Research | Use of platelet activating factor (paf) inhibitors to inhibit il-5 induced eosinophil activation or degranulation |
| WO2000020417A1 (fr) | 1998-10-06 | 2000-04-13 | Takeda Chemical Industries, Ltd. | Composes de pyridazine condenses, leur procede de preparation et leur utilisation |
| KR20010087738A (ko) | 1998-10-21 | 2001-09-21 | 다케다 야쿠힌 고교 가부시키가이샤 | 축합 피리다진 유도체, 이의 제조 방법 및 용도 |
| AU7315900A (en) * | 1999-09-20 | 2001-04-24 | Takeda Chemical Industries Ltd. | Chemokine/cytokine expression inhibitors |
| CN101133057B (zh) * | 2004-09-02 | 2011-03-09 | 尼科梅德有限责任公司 | 三唑并酞嗪化合物 |
| NZ587142A (en) * | 2008-02-05 | 2012-04-27 | Sanofi Aventis | Triazolium salts as par1 inhibitors, production thereof, and use as medicaments |
| JP5526040B2 (ja) * | 2008-02-05 | 2014-06-18 | サノフイ | Ｐａｒ１阻害剤としてのトリアゾロピリダジン類、その製造法および薬剤としての使用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW211013B (de) * | 1991-12-27 | 1993-08-11 | Takeda Pharm Industry Co Ltd | |
| LT3200B (en) * | 1992-03-18 | 1995-03-27 | Takeda Chemical Industries Ltd | Triazolopyridazine methodfor production thereof and use |
| TW304878B (de) * | 1993-09-21 | 1997-05-11 | Takeda Pharm Industry Co Ltd |
-
1995
- 1995-09-11 KR KR1019970701706A patent/KR970706287A/ko not_active Abandoned
- 1995-09-11 AU AU33999/95A patent/AU695377B2/en not_active Ceased
- 1995-09-11 CN CN95195101A patent/CN1046517C/zh not_active Expired - Fee Related
- 1995-09-11 WO PCT/JP1995/001797 patent/WO1996008496A1/en active IP Right Grant
- 1995-09-11 EP EP95930729A patent/EP0781283B1/de not_active Expired - Lifetime
- 1995-09-11 NZ NZ292271A patent/NZ292271A/en unknown
- 1995-09-11 RU RU97106020/04A patent/RU2156252C2/ru active
- 1995-09-11 CA CA002198019A patent/CA2198019A1/en not_active Abandoned
- 1995-09-11 HU HU9701974A patent/HUT77130A/hu unknown
- 1995-09-11 DE DE69521209T patent/DE69521209T2/de not_active Expired - Fee Related
- 1995-09-11 AT AT95930729T patent/ATE201875T1/de active
-
1997
- 1997-03-11 NO NO971117A patent/NO308003B1/no not_active IP Right Cessation
- 1997-03-14 FI FI971081A patent/FI971081L/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0781283B1 (de) | 2001-06-06 |
| KR970706287A (ko) | 1997-11-03 |
| NZ292271A (en) | 1998-04-27 |
| AU3399995A (en) | 1996-03-29 |
| CN1046517C (zh) | 1999-11-17 |
| FI971081L (fi) | 1997-05-06 |
| ATE201875T1 (de) | 2001-06-15 |
| EP0781283A1 (de) | 1997-07-02 |
| WO1996008496A1 (en) | 1996-03-21 |
| NO308003B1 (no) | 2000-07-03 |
| CA2198019A1 (en) | 1996-03-21 |
| AU695377B2 (en) | 1998-08-13 |
| RU2156252C2 (ru) | 2000-09-20 |
| NO971117L (no) | 1997-03-11 |
| NO971117D0 (no) | 1997-03-11 |
| CN1158130A (zh) | 1997-08-27 |
| DE69521209T2 (de) | 2002-03-07 |
| FI971081A0 (fi) | 1997-03-14 |
| HUT77130A (hu) | 1998-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |