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DE69520384D1 - Small balls of coumarin and / or derivatives and process for their preparation - Google Patents

Small balls of coumarin and / or derivatives and process for their preparation

Info

Publication number
DE69520384D1
DE69520384D1 DE69520384T DE69520384T DE69520384D1 DE 69520384 D1 DE69520384 D1 DE 69520384D1 DE 69520384 T DE69520384 T DE 69520384T DE 69520384 T DE69520384 T DE 69520384T DE 69520384 D1 DE69520384 D1 DE 69520384D1
Authority
DE
Germany
Prior art keywords
coumarin
derivatives
spherules
esp
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69520384T
Other languages
German (de)
Other versions
DE69520384T2 (en
Inventor
Eric Cervos
Pierre Labourt-Ibarre
Eraclis Statiotis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhodia Chimie SAS
Original Assignee
Rhodia Chimie SAS
Rhone Poulenc Chimie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhodia Chimie SAS, Rhone Poulenc Chimie SA filed Critical Rhodia Chimie SAS
Publication of DE69520384D1 publication Critical patent/DE69520384D1/en
Application granted granted Critical
Publication of DE69520384T2 publication Critical patent/DE69520384T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Spherules of coumarin and its derivatives, esp. those of formula (I), are new. R1, R2 = H, 1-4C alkyl or alkoxy. The spherules are prepd by melting coumarin, then forming the molten mass into droplets which are solidified as spherules and recovered. Solidification is usually effected by dropping against a counter-current of cold gas (esp. one low in oxygen). The droplets are formed by passing the molten coumarin through perforations 100-1000 mu m, esp. 200-600 mu m in dia., the vessel pref. being vibrated at a frequency of 500-10000 Hertz.
DE69520384T 1994-03-16 1995-03-10 Small balls of coumarin and / or derivatives and process for their preparation Expired - Fee Related DE69520384T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9403094A FR2717476B1 (en) 1994-03-16 1994-03-16 Coumarin spherules and / or derivatives and process for obtaining them.

Publications (2)

Publication Number Publication Date
DE69520384D1 true DE69520384D1 (en) 2001-04-26
DE69520384T2 DE69520384T2 (en) 2001-08-09

Family

ID=9461117

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69520384T Expired - Fee Related DE69520384T2 (en) 1994-03-16 1995-03-10 Small balls of coumarin and / or derivatives and process for their preparation

Country Status (8)

Country Link
US (1) US5693342A (en)
EP (1) EP0672664B1 (en)
JP (1) JPH07278132A (en)
CN (1) CN1064963C (en)
AT (1) ATE199903T1 (en)
DE (1) DE69520384T2 (en)
ES (1) ES2154716T3 (en)
FR (1) FR2717476B1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7237679B1 (en) 2001-09-04 2007-07-03 Aveka, Inc. Process for sizing particles and producing particles separated into size distributions
US7413690B1 (en) 2003-10-29 2008-08-19 The University Of Mississippi Process and apparatus for producing spherical pellets using molten solid matrices
CN105899195B (en) 2013-05-27 2018-10-19 驶帝生命科学印度私人有限公司 Hot melt is crushed extruder and method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3556789A (en) * 1988-04-22 1989-11-24 Massachusetts Institute Of Technology Process for forming and using microdroplets
JPH01164430A (en) * 1988-06-17 1989-06-28 Ise Kagaku Kogyo Kk Production of sphere of sublimable substance
EP0360749B1 (en) * 1988-09-22 1992-06-03 Ciba-Geigy Ag Apparatus for preparing spherical granules
EP0418596A3 (en) * 1989-09-21 1991-10-23 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
US5260072A (en) * 1990-08-30 1993-11-09 Mcneil-Ppc, Inc. Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets

Also Published As

Publication number Publication date
EP0672664A1 (en) 1995-09-20
JPH07278132A (en) 1995-10-24
EP0672664B1 (en) 2001-03-21
ES2154716T3 (en) 2001-04-16
US5693342A (en) 1997-12-02
FR2717476A1 (en) 1995-09-22
CN1115758A (en) 1996-01-31
FR2717476B1 (en) 1996-04-19
ATE199903T1 (en) 2001-04-15
DE69520384T2 (en) 2001-08-09
CN1064963C (en) 2001-04-25

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Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Representative=s name: PATENTANWAELTE GESTHUYSEN, VON ROHR & EGGERT, 45128

8339 Ceased/non-payment of the annual fee