[go: up one dir, main page]

DE69434820D1 - Nukleinsäurevektor, einen solchen vektor enthaltene verbindung und impfstoff zur immunisierung gegen hepatitis - Google Patents

Nukleinsäurevektor, einen solchen vektor enthaltene verbindung und impfstoff zur immunisierung gegen hepatitis

Info

Publication number
DE69434820D1
DE69434820D1 DE69434820T DE69434820T DE69434820D1 DE 69434820 D1 DE69434820 D1 DE 69434820D1 DE 69434820 T DE69434820 T DE 69434820T DE 69434820 T DE69434820 T DE 69434820T DE 69434820 D1 DE69434820 D1 DE 69434820D1
Authority
DE
Germany
Prior art keywords
vector
gene
vaccine
nucleic acid
compound containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69434820T
Other languages
English (en)
Other versions
DE69434820T2 (de
DE69434820T3 (de
Inventor
Heather Lynn Davis
Robert Gerald Whalen
Marie-Louise Michel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Ottawa
Institut National de la Sante et de la Recherche Medicale INSERM
Institut Pasteur
Original Assignee
University of Ottawa
Institut National de la Sante et de la Recherche Medicale INSERM
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9452149&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69434820(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Ottawa, Institut National de la Sante et de la Recherche Medicale INSERM, Institut Pasteur filed Critical University of Ottawa
Publication of DE69434820D1 publication Critical patent/DE69434820D1/de
Publication of DE69434820T2 publication Critical patent/DE69434820T2/de
Application granted granted Critical
Publication of DE69434820T3 publication Critical patent/DE69434820T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69434820T 1993-10-22 1994-04-27 Nukleinsäurevektor, einen solchen Vektor enthaltene Verbindung und Impfstoff zur Immunisierung gegen Hepatitis Expired - Lifetime DE69434820T3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9312659 1993-10-22
FR9312659A FR2711670B1 (fr) 1993-10-22 1993-10-22 Vecteur nucléotidique, composition le contenant et vaccin pour l'immunisation à l'encontre d'une hépatite.
PCT/FR1994/000483 WO1995011307A1 (fr) 1993-10-22 1994-04-27 Vecteur nucleotidique, composition le contenant et vaccin pour l'immunisation a l'encontre d'une hepatite

Publications (3)

Publication Number Publication Date
DE69434820D1 true DE69434820D1 (de) 2006-09-21
DE69434820T2 DE69434820T2 (de) 2007-03-29
DE69434820T3 DE69434820T3 (de) 2011-02-24

Family

ID=9452149

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69434820T Expired - Lifetime DE69434820T3 (de) 1993-10-22 1994-04-27 Nukleinsäurevektor, einen solchen Vektor enthaltene Verbindung und Impfstoff zur Immunisierung gegen Hepatitis

Country Status (11)

Country Link
US (2) US6635624B1 (de)
EP (1) EP0724642B2 (de)
AT (1) ATE335831T1 (de)
AU (1) AU6681794A (de)
CA (1) CA2174652C (de)
DE (1) DE69434820T3 (de)
DK (1) DK0724642T4 (de)
ES (1) ES2270416T5 (de)
FR (1) FR2711670B1 (de)
PT (1) PT724642E (de)
WO (1) WO1995011307A1 (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2711670B1 (fr) * 1993-10-22 1996-01-12 Pasteur Institut Vecteur nucléotidique, composition le contenant et vaccin pour l'immunisation à l'encontre d'une hépatite.
US7935675B1 (en) * 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030026782A1 (en) 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US5837534A (en) * 1995-11-14 1998-11-17 The Board Of Regents Of The University Of Texas System Smooth muscle 22α promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells
US5981274A (en) * 1996-09-18 1999-11-09 Tyrrell; D. Lorne J. Recombinant hepatitis virus vectors
EP0855184A1 (de) * 1997-01-23 1998-07-29 Grayson B. Dr. Lipford Pharmazeutisches Präparat das ein Polynukleotid und ein Antigen enthält, insbesondere zur Impfung
CN1044092C (zh) 1997-02-26 1999-07-14 上海医科大学 抗原－抗体－重组dna复合型疫苗
FR2767337B1 (fr) 1997-08-14 2002-07-05 Pasteur Institut Sequences nucleiques de polypeptides exportes de mycobacteri es, vecteurs les comprenant et applications au diagnostic et a la prevention de la tuberculose
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
CN1280619A (zh) 1997-11-28 2001-01-17 根瑟特公司 沙眼衣原体的基因组序列和多肽,其片段以及其用途,特别是用于诊断、预防和治疗感染
US20040062775A1 (en) 1997-12-05 2004-04-01 Agence Francaise De Securite Sanitaire Des Aliments Circovirus sequences associated with piglet weight loss disease (PWD)
FR2772047B1 (fr) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
US6759193B2 (en) * 1999-07-28 2004-07-06 The Government Of The Republic Of Singapore Detection of human hepatitis B virus surface antigen mutants by specific amplification and its application on gene chip
WO2001095935A1 (en) * 2000-01-20 2001-12-20 Ottawa Health Research Institute Immunostimulatory nucleic acids for inducing a th2 immune response
US7585847B2 (en) * 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
US7001760B2 (en) * 2000-04-20 2006-02-21 Wang-Schick Ryu Hepatitis B virus vectors for gene therapy
US6867189B2 (en) 2001-07-26 2005-03-15 Genset S.A. Use of adipsin/complement factor D in the treatment of metabolic related disorders
BR0315810A (pt) * 2002-10-29 2005-09-13 Coley Pharmaceutical Group Ltd Uso de oligonucleotìdeos cpg no tratamento de infecção por vìrus da hepatite c
AU2004226605A1 (en) * 2003-04-02 2004-10-14 Coley Pharmaceutical Group, Ltd. Immunostimulatory nucleic acid oil-in-water formulations for topical application
CA2528774A1 (en) * 2003-06-20 2005-01-27 Coley Pharmaceutical Gmbh Small molecule toll-like receptor (tlr) antagonists
CN1704475A (zh) * 2004-05-31 2005-12-07 成都生物制品研究所 羧端含前s2免疫决定簇的乙肝表面抗原融合基因及蛋白质
CA2595795A1 (en) 2005-01-24 2006-07-27 Laboratoires Serono S.A. Use of soluble cd164 variants in inflammatory and/or autoimmune disorders
AU2007239095B2 (en) 2006-01-09 2012-05-03 The Regents Of The University Of California Immunostimulatory combinations for vaccine adjuvants
US8202967B2 (en) 2006-10-27 2012-06-19 Boehringer Ingelheim Vetmedica, Inc. H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use
WO2010027818A2 (en) 2008-08-25 2010-03-11 Dana-Farber Cancer Institute, Inc. Conserved hemagglutinin epitope, antibodies to the epitope, and methods of use
AR078253A1 (es) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
AR083533A1 (es) 2010-10-22 2013-03-06 Boehringer Ingelheim Vetmed Proteinas de hemaglutinina 5 (h5) para el tratamiento y prevencion de las infecciones de gripe
AR088028A1 (es) 2011-08-15 2014-05-07 Boehringer Ingelheim Vetmed Proteinas h5, de h5n1 para un uso medicinal
WO2013033092A2 (en) 2011-09-03 2013-03-07 Boehringer Ingelheim Vetmedica Gmbh Streptococcus suis pilus antigens
WO2014127825A1 (en) 2013-02-21 2014-08-28 Boehringer Ingelheim Vetmedica Gmbh H5 proteins of h5n1 influenza virus for use as a medicament
JP6821429B2 (ja) 2013-09-25 2021-01-27 ゾエティス・サービシーズ・エルエルシー Ｐｃｖ２ｂ分岐ワクチン組成物及び使用方法
CN107073101B (zh) 2014-04-03 2020-10-27 勃林格殷格翰动物保健美国有限公司 猪流行性腹泻病毒疫苗
CN108135993B (zh) 2015-08-31 2022-03-22 贝林格尔·英格海姆维特梅迪卡有限公司 用于先天性震颤的瘟病毒疫苗
AU2016323106A1 (en) 2015-09-16 2018-03-29 Boehringer Ingelheim Animal Health USA Inc. Salmonella Choleraesuis-Salmonella Typhimurium vaccines
BR112019005418A2 (pt) 2016-09-20 2019-10-01 Boehringer Ingelheim Vetmedica Gmbh novos promotores
MY199929A (en) 2016-09-20 2023-11-29 Boehringer Ingelheim Vetmedica Gmbh Canine adenovirus vectors
CN110072546B (zh) 2016-09-20 2023-10-31 勃林格殷格翰动物保健有限公司 新的猪流感疫苗
UY37406A (es) 2016-09-20 2018-03-23 Boehringer Ingelheim Vetmedica Gmbh Nuevo sitio de inserción orf70 de ehv
WO2018083156A1 (en) 2016-11-03 2018-05-11 Boehringer Ingelheim Vetmedica Gmbh Vaccine against porcine parvovirus and porcine reproductive and respiratory syndrome virus and methods of production thereof
CA3042573A1 (en) 2016-11-03 2018-05-11 Boehringer Ingelheim Vetmedica Gmbh Vaccine against porcine parvovirus
CA3046684A1 (en) 2017-01-30 2018-08-02 Boehringer Ingelheim Animal Health USA Inc. Porcine coronavirus vaccines
WO2019014144A1 (en) 2017-07-12 2019-01-17 Boehringer Ingelheim Vetmedica, Inc. IMMUNOGENIC COMPOSITIONS BASED ON SENECAVIRUS TYPE A AND CORRESPONDING METHODS
CA3072553A1 (en) 2017-09-23 2019-03-28 Boehringer Ingelheim Vetmedica Gmbh Paramyxoviridae expression system
WO2019092027A1 (en) 2017-11-09 2019-05-16 Boehringer Ingelheim Vetmedica Gmbh Sapelovirus immunogenic compositions and uses thereof
EA202091958A1 (ru) 2018-02-23 2021-02-04 Бёрингер Ингельхайм Ветмедика Гмбх Рекомбинантные вирусные векторные системы, экпрессирующие экзогенные гены кошачьего парамиксовируса, и вакцины, приготовленные из них
KR20200132958A (ko) 2018-03-19 2020-11-25 베링거잉겔하임베트메디카게엠베하 불활성화된 ul18 및/또는 ul8을 갖는 신규한 ehv
EA202092165A1 (ru) 2018-03-19 2021-02-25 Бёрингер Ингельхайм Ветмедика Гмбх Новый ehv сайт инсерции ul43
EA202092216A1 (ru) 2018-03-26 2021-06-11 Бёрингер Ингельхайм Энимал Хелс Ю-Эс-Эй Инк. Способ получения иммуногенной композиции
EP3852800A1 (de) 2018-09-20 2021-07-28 Boehringer Ingelheim Vetmedica GmbH Intranasaler vektorimpfstoff gegen epidemische virusdiarrhoe
US11464852B2 (en) 2018-09-20 2022-10-11 Boehringer Ingelheim Vetmedica Gmbh Modified PEDV spike protein
JP2023513135A (ja) 2020-02-06 2023-03-30 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 抗ラブドウイルス抗体を検出するのに有用なポリペプチド
CN116438195A (zh) 2020-10-05 2023-07-14 勃林格殷格翰动物保健有限公司 用于针对轮状病毒疫苗接种的融合蛋白质
EP4225361A1 (de) 2020-10-05 2023-08-16 Boehringer Ingelheim Animal Health USA Inc. Fusionsprotein mit circoviridae-kapsidprotein und chimäre virusähnliche partikel daraus
EP4504251A1 (de) 2022-04-05 2025-02-12 Boehringer Ingelheim Vetmedica GmbH Immunogene zusammensetzung zur impfung gegen rotavirus

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US565203A (en) 1896-08-04 espersen
IN151589B (de) * 1978-12-22 1983-05-28 Biogen Nv
DE2942780A1 (de) 1979-10-23 1981-05-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Eukaryotische zellen, eukaryotische protoplasten und vielzellige eukaryotische lebende organismen mit einem gehalt an durch lipidvesikel eingebrachter dna, verfahren zu ihrer herstellung von gen-produkten, zur immunisierung und zur behebung genetisch bedingter defekte
US4803164A (en) * 1981-08-31 1989-02-07 Genentech, Inc. Preparation of hepatitis b surface antigen in yeast
US4547367A (en) * 1983-12-20 1985-10-15 The United States Of America As Represented By The Department Of Health And Human Services Hepatitis B core antigen vaccine
FR2560890B1 (fr) 1984-03-07 1987-10-16 Grp Genie Genetique Composition utile pour la fabrication de vaccins contenant des particules portant l'antigene de surface du virus de l'hepatite b et le recepteur de l'albumine serique humaine polymerisee, cellules animales capables de produire de telles particules et procede pour leur obtention
JPS6137738A (ja) * 1984-07-31 1986-02-22 Tetsuo Nakamura Ｂ型肝炎ワクチン
BR8404286A (pt) * 1984-08-28 1986-04-08 Sergio Landau Seringa hipodermica a pressao
FR2573436B1 (fr) 1984-11-20 1989-02-17 Pasteur Institut Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins
CA1268437A (en) * 1984-12-21 1990-05-01 Haruo Fujita Method for purification of hbc antigen and method for measurement of hbc antibody by using said purified hbc antigen
US4957869A (en) * 1985-07-12 1990-09-18 New York University Immunogenic peptide corresponding to P. vivax CS protein
EP0301083A4 (en) * 1987-02-11 1990-09-26 Scripps Clinic And Research Foundation Retroviral expression vectors and methods for producing hbv antigens
US5256767A (en) 1987-06-10 1993-10-26 The Immune Response Corporation Retroviral antigens
US5256553A (en) 1987-10-09 1993-10-26 Immunex Corporation Multiple promoter transforming retroviral vectors
ATE277193T1 (de) 1989-03-21 2004-10-15 Vical Inc Expression von exogenen polynukleotidsequenzen in wirbeltieren
US5786189A (en) * 1989-11-29 1998-07-28 Smithkline Beecham Biologicals (S.A.) Vaccine
EP0502179A1 (de) * 1990-09-28 1992-09-09 Smithkline Beecham Corporation Erhöhte expression von viralen proteinen in drosophila zellen
DK0538437T3 (da) 1991-05-08 2000-02-07 Schweiz Serum & Impfinst Immunstimulerende og immunforstærkende, rekonstituerede influenzavirosomer og vacciner indeholdende dem
WO1993000103A1 (en) 1991-06-21 1993-01-07 The Wistar Institute Of Anatomy And Biology Chimeric envelope proteins for viral targeting
US5298422A (en) * 1991-11-06 1994-03-29 Baylor College Of Medicine Myogenic vector systems
HU209110B (en) 1991-12-02 1994-03-28 Foeldtani Kutato Es Furo Kft Process for the local treatment of soil, particularly for the examination and cleaning of contaminated soil
ES2174845T3 (es) 1992-02-04 2002-11-16 Chiron Corp Terapeutica de la hepatitis.
GB9204274D0 (en) * 1992-02-28 1992-04-08 Wellcome Found Novel peptides
US5643578A (en) 1992-03-23 1997-07-01 University Of Massachusetts Medical Center Immunization by inoculation of DNA transcription unit
US5620896A (en) 1992-03-23 1997-04-15 University Of Massachusetts Medical Center DNA vaccines against rotavirus infections
US5593972A (en) * 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US5679647A (en) 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
US5830877A (en) 1993-08-26 1998-11-03 The Regents Of The University Of California Method, compositions and devices for administration of naked polynucleotides which encode antigens and immunostimulatory
US5985847A (en) 1993-08-26 1999-11-16 The Regents Of The University Of California Devices for administration of naked polynucleotides which encode biologically active peptides
US5804566A (en) 1993-08-26 1998-09-08 The Regents Of The University Of California Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides
AU705889B2 (en) 1993-08-26 1999-06-03 Regents Of The University Of California, The Method, compositions and devices for administration of naked polynucleotides which encode antigens and immunostimulatory peptides
FR2711670B1 (fr) * 1993-10-22 1996-01-12 Pasteur Institut Vecteur nucléotidique, composition le contenant et vaccin pour l'immunisation à l'encontre d'une hépatite.
US5814617A (en) 1994-10-07 1998-09-29 The United States Of America As Represented By The Secretary Of The Navy Protective 17 KDA malaria hepatic and erythrocytic stage immunogen and gene
US5736524A (en) 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
GB9503863D0 (en) 1995-02-25 1995-04-19 Smithkline Beecham Biolog Vaccine compositions
US5780448A (en) 1995-11-07 1998-07-14 Ottawa Civic Hospital Loeb Research DNA-based vaccination of fish
US5565023A (en) * 1995-11-15 1996-10-15 Fusion All-Sport Grip, Inc. Moisture absorbing and frictional grip enhancing composition and method of forming same
CA2244946C (en) 1996-01-30 2010-04-13 The Regents Of The University Of California Gene expression vectors which generate an antigen specific immune response and methods of using the same
US5856462A (en) 1996-09-10 1999-01-05 Hybridon Incorporated Oligonucleotides having modified CpG dinucleosides
US5981274A (en) 1996-09-18 1999-11-09 Tyrrell; D. Lorne J. Recombinant hepatitis virus vectors
FR2790955B1 (fr) * 1999-03-19 2003-01-17 Assist Publ Hopitaux De Paris Utilisation d'oligonucleotides stabilises comme principe actif antitumoral
US20020142978A1 (en) * 2000-04-07 2002-10-03 Eyal Raz Synergistic improvements to polynucleotide vaccines
EP2275131A3 (de) 2003-07-11 2012-01-25 Intercell AG HCV-Impfstoff
ATE381942T1 (de) 2003-10-24 2008-01-15 Mologen Ag Mittel zur behandlung von infektionen mit leishmanien

Also Published As

Publication number Publication date
EP0724642A1 (de) 1996-08-07
EP0724642B1 (de) 2006-08-09
DK0724642T4 (da) 2010-10-25
CA2174652C (fr) 2010-03-30
DK0724642T3 (da) 2006-12-18
ES2270416T5 (es) 2010-11-30
US7825097B2 (en) 2010-11-02
ATE335831T1 (de) 2006-09-15
EP0724642B2 (de) 2010-07-21
WO1995011307A1 (fr) 1995-04-27
ES2270416T3 (es) 2007-04-01
FR2711670A1 (fr) 1995-05-05
DE69434820T2 (de) 2007-03-29
AU6681794A (en) 1995-05-08
US20050042203A1 (en) 2005-02-24
CA2174652A1 (fr) 1995-04-27
DE69434820T3 (de) 2011-02-24
FR2711670B1 (fr) 1996-01-12
PT724642E (pt) 2006-12-29
US6635624B1 (en) 2003-10-21

Similar Documents

Publication Publication Date Title
DE69434820D1 (de) Nukleinsäurevektor, einen solchen vektor enthaltene verbindung und impfstoff zur immunisierung gegen hepatitis
CA2210353A1 (en) Stabilized external guide sequences
BR0010725A (pt) Expressão e exportação de proteìnas de interferon-alfa como proteìnas de fusão de fc
BR0007414A (pt) Expressão e exportação de proteìnas antiobesidade como proteìnas de fusão fc
EP0331939A3 (de) Verfahren und Zusammensetzungen zum Widerstand gegen Retroviralinfektionen
DE69636032D1 (de) Plasmid zur verabreichung von nukleine säuren und verwendungsverfahren
SI0935660T1 (sl) Infekcijski kloni RNA virusov ter cepiva in diagnostični testi, izvedeni iz le-teh
IT1206311B (it) Agente terapeutico a base di oligonucleotide e metodi per laproduzione dello stesso.
AU1634092A (en) Vaccines and methods for their production
DE69828193D1 (de) Hyaluronan synthase gen und seine verwendung
AUPN477695A0 (en) Gene therapy
KR930701610A (ko) 미생물의 세포, 조직 또는 숙주 지향성을 변화시키는 방법, 이 방법으로 수득된 재조합 미생물, 및 의학 및 수의학분야에서 이들을 사용하는 방법
DE69635472D1 (de) Impfstoff gegen Geflügelkokzidose
EP0256677A3 (de) Pseudorabiesvirus-Rekombinanten und ihre Verwendung zur Herstellung von Proteinen
AU686000B2 (en) Infectious peritonitis vaccine
AU7514087A (en) Vaccine containing the protein f of the aids virus
ATE209683T1 (de) Planze resistent gegen mindestens zwei viren und dessen preparation
IL146191A0 (en) Viral expression vectors
AU6111294A (en) Composition for use in the treatment of tumours and the immunization of humans and animals
DE69939212D1 (de) Polypeptid mit aktivität gegen das humane immundefizienz virus, dafür kodierende gene und verfahren zur herstellung des polypeptids
AU3964189A (en) Complete nucleotidic sequence of the complementary dna of the genomic rna of the potyvirus, genes coding for the potyvirus capside protein and application of said genes to the creation of potyvirus-resistant transgenic plants
EP0789563B8 (de) Impfstoffe gegen den hepatitis b und c virus
Bowers DNA and other technologies for HIV vaccines
TH1348A (th) การประดิษฐ์ไวรัสที่มีโปรตีนพื้นผิวเป็นรีคอมบิแนนท์โปรตีน

Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings