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DE69434696D1 - Verfahren zur Herstellung von Verbindungen geeignet als Zwischenprodukte - Google Patents

Verfahren zur Herstellung von Verbindungen geeignet als Zwischenprodukte

Info

Publication number
DE69434696D1
DE69434696D1 DE69434696T DE69434696T DE69434696D1 DE 69434696 D1 DE69434696 D1 DE 69434696D1 DE 69434696 T DE69434696 T DE 69434696T DE 69434696 T DE69434696 T DE 69434696T DE 69434696 D1 DE69434696 D1 DE 69434696D1
Authority
DE
Germany
Prior art keywords
intermediates
preparation
compounds suitable
compounds
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69434696T
Other languages
English (en)
Other versions
DE69434696T2 (de
Inventor
Ambra Thomas E D
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curia Global Inc
Original Assignee
Albany Molecular Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22176189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69434696(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Albany Molecular Research Inc filed Critical Albany Molecular Research Inc
Publication of DE69434696D1 publication Critical patent/DE69434696D1/de
Application granted granted Critical
Publication of DE69434696T2 publication Critical patent/DE69434696T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69434696T 1993-06-24 1994-06-21 Verfahren zur Herstellung von Verbindungen geeignet als Zwischenprodukte Expired - Lifetime DE69434696T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8310293A 1993-06-24 1993-06-24
US83102 1993-06-24

Publications (2)

Publication Number Publication Date
DE69434696D1 true DE69434696D1 (de) 2006-05-18
DE69434696T2 DE69434696T2 (de) 2006-11-16

Family

ID=22176189

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69434696T Expired - Lifetime DE69434696T2 (de) 1993-06-24 1994-06-21 Verfahren zur Herstellung von Verbindungen geeignet als Zwischenprodukte
DE69415319T Expired - Lifetime DE69415319T2 (de) 1993-06-24 1994-06-21 Verfahren zur herstellung von piperidinderivaten
DE69433346T Expired - Lifetime DE69433346T2 (de) 1993-06-24 1994-06-21 Herstellung von Verbindungen, die in der Produktion von Piperidin-Derivaten nützlich sind

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69415319T Expired - Lifetime DE69415319T2 (de) 1993-06-24 1994-06-21 Verfahren zur herstellung von piperidinderivaten
DE69433346T Expired - Lifetime DE69433346T2 (de) 1993-06-24 1994-06-21 Herstellung von Verbindungen, die in der Produktion von Piperidin-Derivaten nützlich sind

Country Status (16)

Country Link
US (9) US5750703A (de)
EP (4) EP1369409B1 (de)
JP (4) JP3034047B2 (de)
KR (2) KR100387347B1 (de)
AT (3) ATE322473T1 (de)
AU (1) AU670004B2 (de)
CA (1) CA2147126C (de)
DE (3) DE69434696T2 (de)
DK (3) DK0703902T3 (de)
ES (3) ES2261871T3 (de)
FI (1) FI109691B (de)
HU (1) HU226559B1 (de)
NO (2) NO308599B1 (de)
NZ (1) NZ268513A (de)
PT (2) PT1026147E (de)
WO (1) WO1995000482A1 (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69316660T3 (de) * 1992-08-03 2001-04-05 Sepracor Inc., Marlborough Terfanadin Metaboliten und deren optisch reine Isomere zur Behandlung von allergischen Krankheiten
PT1026147E (pt) 1993-06-24 2004-04-30 Albany Molecular Res Inc Compostos uteis como intermediarios na producao de derivados de piperidina
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
CN1275916C (zh) 1993-06-25 2006-09-20 阿温蒂斯公司 用于制备抗组胺哌啶衍生物的新中间体
ES2176329T3 (es) * 1994-05-18 2002-12-01 Aventis Pharma Inc Procedimientos para preparar formas anhidras e hidratadas de derivados antihistaminicos de piperidina, sus polimeros y pseudomorfos.
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
DK0812195T3 (da) * 1995-02-28 2003-03-03 Aventis Pharma Inc Farmaceutisk sammensætning til piperidinoalkanolforbindelser
US6153754A (en) 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
ZA985939B (en) 1997-07-08 2000-01-10 Aristocrat Leisure Ind Pty Ltd Slot machine game and system with improved jackpot feature.
SI0998272T1 (en) * 1997-08-26 2003-12-31 Aventis Pharmaceuticals Inc. Pharmaceutical composition for combination of piperidinoalkanol-decongestant
US6194431B1 (en) 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
BR9911794A (pt) * 1998-07-02 2001-03-27 Aventis Pharma Inc Derivados anti-histamìnicos de piperidina e intermediários para a preparação dos mesmos
US6683094B2 (en) 1998-07-02 2004-01-27 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
AU2007200674C1 (en) * 1998-07-02 2011-02-24 Aventisub Llc Novel antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6689898B2 (en) 1998-07-02 2004-02-10 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6362375B1 (en) 1999-12-03 2002-03-26 College Of The Holy Cross Process for the preparation of aryl ketones generating reduced amounts of toxic byproducts
US6613906B1 (en) 2000-06-06 2003-09-02 Geneva Pharmaceuticals, Inc. Crystal modification
GB0018691D0 (en) * 2000-07-28 2000-09-20 Rolabo Sl Process
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
KR20040012747A (ko) * 2001-04-09 2004-02-11 테바 파마슈티컬 인더스트리즈 리미티드 펙소페나딘 염산염의 다형체
US6743941B2 (en) 2001-06-15 2004-06-01 Aventis Pharma Deutschland Gmbh Process for the production of piperidine derivatives
WO2003000658A1 (en) * 2001-06-25 2003-01-03 Aurobindo Pharma Limited PROCESS FOR THE PREPARATION OF A HIGHLY PURE PHARMACEUTICAL INTERMEDIATE, 4-(CYCLOPROPYLCARBONYL)-α,α-DIMETHYLPHENYLACETIC ACID
US6593499B2 (en) * 2001-08-29 2003-07-15 Council Of Scientific & Industrial Research Process for the preparation of phenyl ketones
EP1453509A2 (de) * 2001-11-08 2004-09-08 Teva Pharmaceutical Industries Ltd. Polymorphen einer fexofenadin-basis
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
WO2003104197A1 (en) * 2002-06-10 2003-12-18 Teva Pharmaceutical Industries Ltd. Polymorphic form xvi of fexofenadine hydrochloride
US20050065183A1 (en) * 2003-07-31 2005-03-24 Indranil Nandi Fexofenadine composition and process for preparing
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
GB0319935D0 (en) 2003-08-26 2003-09-24 Cipla Ltd Polymorphs
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
KR20070007196A (ko) * 2004-04-26 2007-01-12 테바 파마슈티컬 인더스트리즈 리미티드 펙소페나딘 히드로클로라이드의 결정형 및 이의 제조 방법
ITMI20041568A1 (it) * 2004-07-30 2004-10-30 Dipharma Spa "polimorfi di fexofenadina base"
US7498345B2 (en) 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US7498443B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
EP1685106A2 (de) * 2004-09-28 2006-08-02 Teva Pharmaceutical Industries, Inc. Fexofendadin-kristallform und verfahren zu deren herstellung
US7568973B2 (en) 2005-09-09 2009-08-04 Igt Server based gaming system having multiple progressive awards
US7841939B2 (en) 2005-09-09 2010-11-30 Igt Server based gaming system having multiple progressive awards
US8067433B2 (en) 2005-11-09 2011-11-29 Zalicus Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
US7780520B2 (en) 2006-03-15 2010-08-24 Igt Gaming device having multiple different types of progressive awards
WO2007135693A2 (en) * 2006-05-18 2007-11-29 Ind-Swift Laboratories Limited Intermediates useful for the preparation of antihistaminic piperidine derivative
ITMI20061492A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
US8070597B2 (en) 2006-08-03 2011-12-06 Igt Gaming device and method having multiple progressive award levels and a secondary game for advancing through the progressive award levels
US9047733B2 (en) 2006-11-08 2015-06-02 Igt Gaming system and method for providing multiple level progressive awards with increased odds of winning higher level progressive awards
EP2105134A1 (de) 2008-03-24 2009-09-30 Ranbaxy Laboratories Limited Stabiles und amorphes Fexofenadin-Hydrochlorid
WO2009136412A2 (en) * 2008-04-25 2009-11-12 Matrix Laboratories Limited PROCESS FOR PREPARATION OF 4-[4-(4-(HYDROXYDIPHENYLMETHYL)- 1-PIPERIDINYL]-1-OXOBUTYL]-α,α-DIMETHYLBENZENE ACETIC ACID METHYL ESTER AND USE THEREOF
EP3067352A3 (de) * 2008-05-07 2016-10-19 Cardioxyl Pharmaceuticals Inc. Neuartige nitrosoverbindungen als nitroxyldonatoren und verfahren zur verwendung davon
EP2288355A1 (de) * 2008-05-30 2011-03-02 Fairfield Clinical Trials LLC Verfahren und zusammensetzungen für hautentzündungen und -verfärbungen
WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
EP2289867A3 (de) 2009-08-19 2012-04-25 Jubilant Organosys Limited Verfahren zur Herstellung von 4-(4-Halogen-1-oxybutyl)-alpha,alpha-dimethylbenzolessigsäure oder Alkylestern davon
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
CN102070512B (zh) * 2009-11-21 2014-11-19 浙江华海药业股份有限公司 一种高纯度非索非那定及其中间体的合成路线与制备方法
US20110160200A1 (en) * 2009-11-23 2011-06-30 Cardioxyl Pharmaceuticals, Inc. Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension
CN102962288A (zh) * 2012-11-21 2013-03-13 苏州江南航天机电工业有限公司 圆弧状大板与直板拼接工艺
ITMI20131652A1 (it) * 2013-10-07 2015-04-08 Dipharma Francis Srl Procedimento per la purificazione di derivati dell'acido 2-fenil-2-metil-propanoico
US10696633B2 (en) 2015-10-22 2020-06-30 Sanofi-Aventis Deutschland Gmbh Process for the preparation of fexofenadine and of intermediates used therein
CN116178222B (zh) * 2021-11-29 2025-04-25 上海晓明检测技术服务有限公司 环磺酮代谢物m9的制备方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028404A (en) * 1967-07-31 1977-06-07 Allen & Hanburys Limited Acetic acid derivatives
GB1242169A (en) * 1969-04-09 1971-08-11 Ucb Sa Piperidine derivatives
US3839431A (en) * 1970-07-13 1974-10-01 Squibb & Sons Inc Cyclopropylmethylphenylacetic acids and derivatives
US3898271A (en) * 1971-06-08 1975-08-05 Squibb & Sons Inc Cyclopropylmethylphenylacetic acids and derivatives
BE794598A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation
US3965257A (en) * 1972-01-28 1976-06-22 Richardson-Merrell Inc. Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
BE794596A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Piperidinoalcanone-oximes substituees et leur procede de preparation
US3931197A (en) * 1974-02-08 1976-01-06 Richardson-Merrell Inc. Substituted piperidine derivatives
US3941795A (en) * 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
US3946022A (en) * 1974-03-04 1976-03-23 Richardson-Merrell Inc. Piperidine derivatives
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
DD141422A5 (de) * 1978-01-27 1980-04-30 Schering Ag Verfahren zur herstellung von phenylessigsaeure-derivaten
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4285958A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof
US4285957A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
US4254130A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
GB8321157D0 (en) * 1983-08-05 1983-09-07 Fordonal Sa Piperidine derivatives
IT1200123B (it) 1985-09-27 1989-01-05 Ind Chimica Srl Procedimento per la preparazione di alfa-(p-terbutilfenil)-4-(idrossidifenilmetil)-1-piperidinobutanolo
US4742175A (en) * 1986-05-07 1988-05-03 Merrell Dow Pharmaceuticals Inc. Preparation of polymorphically pure terfenadine
PT635004E (pt) * 1992-04-10 2002-12-31 Merrell Pharma Inc Derivados da 4-difenilmetil piperidina e processo para a sua preparacao
DE69316660T3 (de) * 1992-08-03 2001-04-05 Sepracor Inc., Marlborough Terfanadin Metaboliten und deren optisch reine Isomere zur Behandlung von allergischen Krankheiten
PT1026147E (pt) * 1993-06-24 2004-04-30 Albany Molecular Res Inc Compostos uteis como intermediarios na producao de derivados de piperidina
US20020007068A1 (en) * 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
US6147216A (en) 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
CN1275916C (zh) * 1993-06-25 2006-09-20 阿温蒂斯公司 用于制备抗组胺哌啶衍生物的新中间体
WO2002028814A2 (en) * 2000-10-06 2002-04-11 Regents Of The University Of California Nmda receptor channel blocker with neuroprotective activity

Also Published As

Publication number Publication date
KR100387347B1 (ko) 2003-11-28
US5663412A (en) 1997-09-02
JP2001031650A (ja) 2001-02-06
ES2129130T3 (es) 1999-06-01
JP3658291B2 (ja) 2005-06-08
NO994582L (no) 1995-12-12
KR960703398A (ko) 1996-08-17
CA2147126C (en) 1999-08-24
JP2002212166A (ja) 2002-07-31
US20060052610A1 (en) 2006-03-09
DK1369409T3 (da) 2006-08-14
ATE254594T1 (de) 2003-12-15
KR100387348B1 (ko) 2003-06-12
DK0703902T3 (da) 1999-08-23
DE69433346D1 (de) 2003-12-24
EP0703902A1 (de) 1996-04-03
ATE322473T1 (de) 2006-04-15
US5994549A (en) 1999-11-30
US5578610A (en) 1996-11-26
NO955023D0 (no) 1995-12-12
EP1369409B1 (de) 2006-04-05
JP3034047B2 (ja) 2000-04-17
FI956270L (fi) 1995-12-27
US20080227983A1 (en) 2008-09-18
ES2261871T3 (es) 2006-11-16
NO308599B1 (no) 2000-10-02
JPH11236373A (ja) 1999-08-31
HUT73235A (en) 1996-07-29
US20060241303A1 (en) 2006-10-26
FI109691B (fi) 2002-09-30
AU7174894A (en) 1995-01-17
DE69415319T2 (de) 1999-06-10
US7238834B2 (en) 2007-07-03
WO1995000482A1 (en) 1995-01-05
JP3195297B2 (ja) 2001-08-06
EP0703902B1 (de) 1998-12-16
DE69433346T2 (de) 2004-09-09
US5589487A (en) 1996-12-31
JPH08511806A (ja) 1996-12-10
DK1026147T3 (da) 2004-03-22
US5750703A (en) 1998-05-12
NZ268513A (en) 1996-09-25
HU9503719D0 (en) 1996-02-28
CA2147126A1 (en) 1995-01-05
US7390906B2 (en) 2008-06-24
NO994582D0 (no) 1999-09-21
US5581011A (en) 1996-12-03
EP0723958A1 (de) 1996-07-31
PT1369409E (pt) 2006-08-31
DE69434696T2 (de) 2006-11-16
EP0703902A4 (de) 1996-04-10
EP1026147B1 (de) 2003-11-19
EP1369409A1 (de) 2003-12-10
PT1026147E (pt) 2004-04-30
ATE174589T1 (de) 1999-01-15
FI956270A0 (fi) 1995-12-27
HU226559B1 (en) 2009-03-30
NO955023L (no) 1995-12-12
EP1026147A1 (de) 2000-08-09
JP4124998B2 (ja) 2008-07-23
DE69415319D1 (de) 1999-01-28
AU670004B2 (en) 1996-06-27
ES2211444T3 (es) 2004-07-16

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