DE69434295D1 - Von menschlichen T-Zellen immunodominante Epitopen des Virus der C-Hepatitis - Google Patents
Von menschlichen T-Zellen immunodominante Epitopen des Virus der C-HepatitisInfo
- Publication number
- DE69434295D1 DE69434295D1 DE69434295T DE69434295T DE69434295D1 DE 69434295 D1 DE69434295 D1 DE 69434295D1 DE 69434295 T DE69434295 T DE 69434295T DE 69434295 T DE69434295 T DE 69434295T DE 69434295 D1 DE69434295 D1 DE 69434295D1
- Authority
- DE
- Germany
- Prior art keywords
- hepatitis
- virus
- cells
- human
- immunodominant epitopes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 108010076039 Polyproteins Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93402718 | 1993-11-04 | ||
EP93402718 | 1993-11-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69434295D1 true DE69434295D1 (de) | 2005-04-14 |
DE69434295T2 DE69434295T2 (de) | 2006-02-16 |
Family
ID=8214764
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69433971T Expired - Fee Related DE69433971T2 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen T-Zellen immunodominante Epitopen des Virus der C-Hepatitis |
DE69432475T Revoked DE69432475T2 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen t-zellen immunodominante epiropen des virus der c-hepatitis |
DE69434295T Revoked DE69434295T2 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen T-Zellen immunodominante Epitopen des Virus der C-Hepatitis |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69433971T Expired - Fee Related DE69433971T2 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen T-Zellen immunodominante Epitopen des Virus der C-Hepatitis |
DE69432475T Revoked DE69432475T2 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen t-zellen immunodominante epiropen des virus der c-hepatitis |
Country Status (11)
Country | Link |
---|---|
US (4) | US6555114B1 (de) |
EP (4) | EP0992581B2 (de) |
JP (2) | JPH09504534A (de) |
AT (3) | ATE290592T1 (de) |
AU (1) | AU698878B2 (de) |
CA (1) | CA2175692A1 (de) |
DE (3) | DE69433971T2 (de) |
DK (2) | DK0992580T3 (de) |
ES (2) | ES2239819T3 (de) |
PT (2) | PT725824E (de) |
WO (1) | WO1995012677A2 (de) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE249838T1 (de) | 1993-05-12 | 2003-10-15 | Chiron Corp | Konserviertes motiv der hepatitis c virus e2/ns1 region |
US7070790B1 (en) * | 1993-06-29 | 2006-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
ES2239819T3 (es) * | 1993-11-04 | 2005-10-01 | Innogenetics N.V. | Epitopos inmunodominantes de celulas t humanas del virus de la hepatitis c. |
US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
CA2187299A1 (en) * | 1994-04-08 | 1995-10-19 | Jay A. Berzofsky | Hepatitis c virus core peptide for stimulation of cytotoxic t lymphocytes and diagnosis of hcv exposure |
CA2305847A1 (en) | 1997-11-06 | 1999-05-20 | Innogenetics N.V. | Multi-mer peptides derived from hepatitis c virus envelope proteins for diagnostic use and vaccination purposes |
DE69939132D1 (de) | 1998-04-17 | 2008-08-28 | Innogenetics Nv | Verfahren zur Verbesserung der Proteinkonformation mit Hilfe von Reduktionsmitteln |
AU3714499A (en) * | 1998-05-14 | 1999-11-29 | Pasteur Merieux Serums Et Vaccins | Hepatitis c virus mimotopes |
AU748700B2 (en) * | 1998-06-12 | 2002-06-13 | Aventis Pasteur | HIV virus mimotopes |
RU2247729C2 (ru) * | 1998-06-24 | 2005-03-10 | Иннодженетикс Н.В. | Олигомерная частица, индуцирующая иммунитет против вируса гепатита с, способ получения олигомерной частицы, композиция, специфическое антитело, набор (варианты), иммунологический анализ и вакцина против вируса гепатита с |
US7108855B2 (en) | 1998-06-24 | 2006-09-19 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
EP1105496B1 (de) | 1998-08-21 | 2007-03-21 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Modifizierte hcv peptid-impfstoffe |
DE19908423A1 (de) * | 1999-02-26 | 2000-08-31 | Deutsches Krebsforsch | An der Entwicklung des ZNS beteiligtes Protein (TP) |
AT408721B (de) | 1999-10-01 | 2002-02-25 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung enthaltend ein antigen |
EP1535628B1 (de) * | 1999-11-24 | 2013-07-31 | Novartis Vaccines and Diagnostics, Inc. | Hbv/hcv virus-ähnliche teilchen |
US7022830B2 (en) * | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
US6680059B2 (en) * | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
US6858590B2 (en) | 2000-08-17 | 2005-02-22 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
DE60045776D1 (de) * | 2000-09-01 | 2011-05-05 | Epimmune Inc | Hla-bindungspeptide und ihre anwendungszwecke |
GB0026094D0 (en) * | 2000-10-25 | 2000-12-13 | Imp College Innovations Ltd | Methods |
US7402567B2 (en) * | 2000-10-27 | 2008-07-22 | The Regents Of The University Of California | Treatment of disease by inducing cell apoptosis |
US8129349B2 (en) * | 2000-10-27 | 2012-03-06 | The Regents Of The University Of California | Treatment of disease by inducing cell apoptosis |
US7101561B2 (en) | 2000-12-01 | 2006-09-05 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
WO2002086101A2 (en) | 2001-04-24 | 2002-10-31 | Innogenetics N.V. | Core-glycosylated hcv envelope proteins |
FR2825093B1 (fr) * | 2001-05-28 | 2003-07-18 | Bio Merieux | Polypeptide reagissant avecles anticorps de patients infectes par vhc et utilisations |
FR2825363A1 (fr) * | 2001-05-31 | 2002-12-06 | Bio Merieux | Polypeptides reagissant avec les anticorps de patients infectes par vhc et utilisations |
US7736677B2 (en) * | 2001-06-20 | 2010-06-15 | Metaproteomics, Llc | Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment |
JP2003064096A (ja) * | 2001-08-29 | 2003-03-05 | Mitsubishi Kagaku Bio-Clinical Laboratories Inc | C型肝炎ウイルス特異的細胞障害性t細胞認識エピトープ |
GB0126782D0 (en) * | 2001-11-07 | 2002-01-02 | Medical Res Council | Assay |
IL162236A0 (en) * | 2001-12-18 | 2005-11-20 | Innogenetics Nv | Purified hepatitis c virus envelopeproteins for dagnostic and therapeutic use |
US20040126395A1 (en) * | 2001-12-18 | 2004-07-01 | Geert Maertens | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
US7201904B2 (en) | 2002-05-16 | 2007-04-10 | The General Hospital Corporation | Epitopes of hepatitis C virus |
US8029803B2 (en) * | 2002-06-20 | 2011-10-04 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
US8025873B2 (en) | 2002-06-20 | 2011-09-27 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
CA2491508A1 (en) * | 2002-07-02 | 2004-01-15 | Chiron Corporation | Hcv fusion proteins with modified ns3 domains |
AU2003283365A1 (en) * | 2002-11-08 | 2004-06-07 | Innogenetics N.V. | HCV vaccine compositions comprising E1 and NS3 peptides |
WO2004069864A1 (fr) * | 2003-01-07 | 2004-08-19 | Biomerieux | Polypeptides f’ du virus de l’hepatite c, epitopes et leurs applications diagnostiques et therapeutiques |
US8007805B2 (en) * | 2003-08-08 | 2011-08-30 | Paladin Labs, Inc. | Chimeric antigens for breaking host tolerance to foreign antigens |
US7785875B2 (en) | 2004-07-03 | 2010-08-31 | Mogam Biotechnology Research Institute | Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same |
KR100790646B1 (ko) * | 2004-07-03 | 2008-01-02 | 재단법인 목암생명공학연구소 | 세포매개 면역반응을 효과적으로 유도하는 hcv수퍼타입 에피토프, 그를 코딩하는 올리고뉴클레오타이드및 그의 용도 |
CU23470A1 (es) * | 2004-08-11 | 2009-12-17 | Ct Ingenieria Genetica Biotech | Vectores vivos recombinantes y su uso en composiciones farmacéuticas contra el virus de la hepatitis c |
US7381705B2 (en) * | 2004-09-29 | 2008-06-03 | The Administrators Of The Tulane Educational Fund | Inhibitors of hepatitis C virus |
MX2007004662A (es) * | 2004-10-18 | 2007-11-23 | Globeimmune Inc | Terapia basada en levaduras para infeccion cronica por hepatitis c. |
CA2618429A1 (en) * | 2005-05-25 | 2007-03-22 | Tripep Ab | A hepatitis c virus non-structural ns3/4a fusion gene |
US20090238822A1 (en) * | 2005-10-13 | 2009-09-24 | Virexx Medical Corp. | Chimeric Hepatitis C Virus Antigens For Eliciting an Immune Response |
US20080031893A1 (en) * | 2006-06-20 | 2008-02-07 | Metaproteomics, Llc | Acacia based protein kinase modulation cancer treatment |
EP2402023A1 (de) * | 2006-06-28 | 2012-01-04 | Statens Serum Institut | Ausweitung des T-Zell-Repertoires zum Einbeziehen subdominanter Epitope durch Impfung mit als Proteinfragmente oder Peptid-Cocktails abgegebenen Antigenen |
US20090214593A1 (en) * | 2007-08-16 | 2009-08-27 | Tripep Ab | Immunogen platform |
WO2009022236A2 (en) | 2007-08-16 | 2009-02-19 | Tripep Ab | Immunogen platform |
ES2303496B1 (es) * | 2008-02-21 | 2009-07-07 | Fundacion Para El Estudio De Las Hepatitis Virales | Metodo analitico perfeccionado para la deteccion de hepatitis c oculta, aplicaciones del mismo y su correspondiente kit de diagnostico. |
US8728489B2 (en) | 2008-09-19 | 2014-05-20 | Globeimmune, Inc. | Immunotherapy for chronic hepatitis C virus infection |
CN107375919B (zh) | 2009-03-27 | 2022-07-29 | 台湾地区“中央研究院” | 抗病毒免疫的方法和组合物 |
US20120046188A1 (en) * | 2009-03-30 | 2012-02-23 | bioMerieux, SA | Solid Support for HCV Detection |
US20130183376A1 (en) | 2010-09-08 | 2013-07-18 | Saitama Medical University | Hepatitis c virus liposome vaccine |
TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
US9550811B2 (en) | 2010-12-02 | 2017-01-24 | Bionor Immuno As | Peptide scaffold design |
US9493514B2 (en) | 2011-01-06 | 2016-11-15 | Bionor Immuno As | Dimeric scaffold proteins comprising HIV-1 GP120 and GP41 epitopes |
CA2874923C (en) | 2012-06-06 | 2021-08-31 | Bionor Immuno As | Peptides derived from viral proteins for use as immunogens and dosage reactants |
CN105073989A (zh) * | 2013-02-19 | 2015-11-18 | 国立大学法人神户大学 | 免疫原性多肽表层表达双歧杆菌 |
BR112015023355A8 (pt) | 2013-03-14 | 2018-01-30 | Abbott Lab | antígenos recombinantes ns3 de hcv e mutantes dos mesmos para detecção de anticorpos aprimorada. |
EP2968526A4 (de) | 2013-03-14 | 2016-11-09 | Abbott Lab | Hcv-antigen-antikörper-kombinationstest sowie verfahren und zusammensetzungen zur verwendung darin |
EP2971046A4 (de) * | 2013-03-14 | 2016-11-02 | Abbott Lab | Monoklonale antikörper gegen hcv-core lipid-bindender domäne |
CN105555310B (zh) * | 2013-07-08 | 2019-07-23 | 南京传奇生物科技有限公司 | 一种提高蛋白血清半衰期的组合物和方法 |
AU2017332854B2 (en) | 2016-09-21 | 2024-11-14 | The Governors Of The University Of Alberta | Hepatitis C virus immunogenic compositions and methods of use thereof |
CA3093314A1 (en) | 2018-03-16 | 2019-09-19 | The Governors Of The University Of Alberta | Hepatitis c virus peptide compositions and methods of use thereof |
CN109160942B (zh) * | 2018-09-26 | 2021-06-29 | 广州市第八人民医院 | Hcv包膜蛋白高度保守区域的肽段502-518及其用途 |
JP2022518488A (ja) * | 2019-01-25 | 2022-03-15 | センティ バイオサイエンシズ インコーポレイテッド | タンパク質機能を制御するための融合構築物 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
US6027729A (en) | 1989-04-20 | 2000-02-22 | Chiron Corporation | NANBV Diagnostics and vaccines |
US5639594A (en) * | 1990-02-16 | 1997-06-17 | United Biomedical, Inc. | Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis |
US5747239A (en) * | 1990-02-16 | 1998-05-05 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines |
AU7679491A (en) * | 1990-04-04 | 1991-10-30 | Protos, Inc. | Hepatitis c virus protease inhibitors |
US5747339A (en) * | 1990-06-25 | 1998-05-05 | Research Foundation For Microbial Diseases Of Osaka | Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide |
KR0181517B1 (ko) * | 1990-07-09 | 1999-04-01 | 나까하라 노부유끼 | 비-에이 비-비형 간염-특이 항원 및 간염 진단에서 그의 용도 |
CA2047792C (en) | 1990-07-26 | 2002-07-02 | Chang Y. Wang | Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines |
CA2049679C (en) * | 1990-08-24 | 2005-06-21 | Sushil G. Devare | Hepatitis c assay utilizing recombinant antigens |
CA2055149A1 (en) * | 1990-11-08 | 1992-05-09 | Hiroaki Okamoto | Non-a, non-b hepatitis virus related antigen, antibody, detection systems, polynucleotides and polypeptides |
CA2087974A1 (en) | 1991-06-13 | 1992-12-14 | David C. Leahy | Immunoassay for non-a non-b hepatitis |
WO1993000365A2 (en) * | 1991-06-24 | 1993-01-07 | Chiron Corporation | Hepatitis c virus (hcv) polypeptides |
DE4209215A1 (de) * | 1991-07-04 | 1993-01-07 | Boehringer Mannheim Gmbh | Hcv peptidantigene und verfahren zur bestimmung von hcv |
US5428145A (en) | 1991-08-09 | 1995-06-27 | Immuno Japan, Inc. | Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems |
JPH06510191A (ja) * | 1991-08-21 | 1994-11-17 | アボツト・ラボラトリーズ | Ns1に対する組換え抗原を利用したc型肝炎アッセイ |
AU679429B2 (en) * | 1991-09-13 | 1997-07-03 | Novartis Vaccines And Diagnostics, Inc. | Immunoreactive hepatitis C virus polypeptide compositions |
AU2679492A (en) * | 1991-09-16 | 1993-04-27 | Abbott Laboratories | Hepatitis c assay |
CA2128896A1 (en) * | 1992-02-04 | 1993-08-05 | Douglas J. Jolly | Hepatitis therapeutics |
ES2133392T5 (es) | 1992-03-06 | 2004-12-16 | N.V. Innogenetics S.A. | Procedimiento para la determinacion de peptidos que correspondan a epitopos hcv importantes desde el punto de vista inmunologico. |
EP0728764A4 (de) * | 1993-10-19 | 1999-01-20 | Ajinomoto Kk | Peptide das eine immunantwort gegen hiv unduziert und arzneimittel die esenthaelt zur vorbeugung oder behandlung von aids |
ES2239819T3 (es) * | 1993-11-04 | 2005-10-01 | Innogenetics N.V. | Epitopos inmunodominantes de celulas t humanas del virus de la hepatitis c. |
US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
US5543657A (en) * | 1994-10-07 | 1996-08-06 | International Business Machines Corporation | Single layer leadframe design with groundplane capability |
-
1994
- 1994-10-28 ES ES99116671T patent/ES2239819T3/es not_active Expired - Lifetime
- 1994-10-28 DE DE69433971T patent/DE69433971T2/de not_active Expired - Fee Related
- 1994-10-28 AU AU79932/94A patent/AU698878B2/en not_active Ceased
- 1994-10-28 DK DK99116671T patent/DK0992580T3/da active
- 1994-10-28 CA CA002175692A patent/CA2175692A1/en not_active Abandoned
- 1994-10-28 JP JP7513004A patent/JPH09504534A/ja active Pending
- 1994-10-28 DK DK94931000T patent/DK0725824T3/da active
- 1994-10-28 AT AT99116671T patent/ATE290592T1/de not_active IP Right Cessation
- 1994-10-28 EP EP99116672A patent/EP0992581B2/de not_active Expired - Lifetime
- 1994-10-28 EP EP99116673A patent/EP0979867A3/de not_active Withdrawn
- 1994-10-28 AT AT94931000T patent/ATE236981T1/de not_active IP Right Cessation
- 1994-10-28 ES ES94931000T patent/ES2197170T3/es not_active Expired - Lifetime
- 1994-10-28 DE DE69432475T patent/DE69432475T2/de not_active Revoked
- 1994-10-28 DE DE69434295T patent/DE69434295T2/de not_active Revoked
- 1994-10-28 EP EP99116671A patent/EP0992580B1/de not_active Revoked
- 1994-10-28 WO PCT/EP1994/003555 patent/WO1995012677A2/en not_active Application Discontinuation
- 1994-10-28 EP EP94931000A patent/EP0725824B1/de not_active Revoked
- 1994-10-28 PT PT94931000T patent/PT725824E/pt unknown
- 1994-10-28 US US08/635,886 patent/US6555114B1/en not_active Expired - Fee Related
- 1994-10-28 AT AT99116672T patent/ATE274578T1/de not_active IP Right Cessation
- 1994-10-28 PT PT99116671T patent/PT992580E/pt unknown
-
1997
- 1997-11-19 US US08/974,685 patent/US6689368B1/en not_active Expired - Fee Related
- 1997-11-19 US US08/974,690 patent/US6613333B1/en not_active Expired - Fee Related
-
2003
- 2003-08-29 US US10/651,165 patent/US20040047877A1/en not_active Abandoned
-
2004
- 2004-02-12 JP JP2004034983A patent/JP2004194668A/ja active Pending
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8331 | Complete revocation |