ATE236981T1 - Von menschlichen t-zellen immunodominante epiropen des virus der c-hepatitis - Google Patents
Von menschlichen t-zellen immunodominante epiropen des virus der c-hepatitisInfo
- Publication number
- ATE236981T1 ATE236981T1 AT94931000T AT94931000T ATE236981T1 AT E236981 T1 ATE236981 T1 AT E236981T1 AT 94931000 T AT94931000 T AT 94931000T AT 94931000 T AT94931000 T AT 94931000T AT E236981 T1 ATE236981 T1 AT E236981T1
- Authority
- AT
- Austria
- Prior art keywords
- epiropes
- human
- hepatitis virus
- cell immunodominant
- amino acids
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 108010076039 Polyproteins Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93402718 | 1993-11-04 | ||
| PCT/EP1994/003555 WO1995012677A2 (en) | 1993-11-04 | 1994-10-28 | Immunodominant human t-cell epitopes of hepatitis c virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE236981T1 true ATE236981T1 (de) | 2003-04-15 |
Family
ID=8214764
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99116672T ATE274578T1 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen t-zellen immunodominante epitopen des virus der c-hepatitis |
| AT99116671T ATE290592T1 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen t-zellen immunodominante epitopen des virus der c-hepatitis |
| AT94931000T ATE236981T1 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen t-zellen immunodominante epiropen des virus der c-hepatitis |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99116672T ATE274578T1 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen t-zellen immunodominante epitopen des virus der c-hepatitis |
| AT99116671T ATE290592T1 (de) | 1993-11-04 | 1994-10-28 | Von menschlichen t-zellen immunodominante epitopen des virus der c-hepatitis |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US6555114B1 (de) |
| EP (4) | EP0992580B1 (de) |
| JP (2) | JPH09504534A (de) |
| AT (3) | ATE274578T1 (de) |
| AU (1) | AU698878B2 (de) |
| CA (1) | CA2175692A1 (de) |
| DE (3) | DE69434295T2 (de) |
| DK (2) | DK0992580T3 (de) |
| ES (2) | ES2239819T3 (de) |
| PT (2) | PT725824E (de) |
| WO (1) | WO1995012677A2 (de) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE249838T1 (de) | 1993-05-12 | 2003-10-15 | Chiron Corp | Konserviertes motiv der hepatitis c virus e2/ns1 region |
| US7070790B1 (en) * | 1993-06-29 | 2006-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
| EP0992580B1 (de) * | 1993-11-04 | 2005-03-09 | Innogenetics N.V. | Von menschlichen T-Zellen immunodominante Epitopen des Virus der C-Hepatitis |
| US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
| DE69517521T2 (de) * | 1994-04-08 | 2001-03-08 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Rockville | Peptid aus dem inneren des hepatitis-c-virus brauchbar für die stimulation cytotoxischer t-lymphocyten und die diagnose des hcv-kontaktes |
| AU752131C (en) | 1997-11-06 | 2003-12-04 | Innogenetics N.V. | Multi-mer peptides derived from hepatitis C virus envelope proteins for diagnostic use and vaccination purposes |
| TR200202213T2 (tr) | 1998-04-17 | 2002-11-21 | Innogenetics N.V. | İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller |
| WO1999058561A1 (fr) * | 1998-05-14 | 1999-11-18 | Pasteur Merieux Serums & Vaccins | Mimotopes du virus de l'hepatite c |
| NZ508812A (en) * | 1998-06-12 | 2002-11-26 | Aventis Pasteur | Peptides for the prevention or treatment of HIV |
| NZ528952A (en) * | 1998-06-24 | 2004-09-24 | Innogenetics N | Particles of HCV envelope proteins: use for vaccination |
| US7108855B2 (en) | 1998-06-24 | 2006-09-19 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
| US6685944B1 (en) | 1998-08-21 | 2004-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Modified HCV peptide vaccines |
| DE19908423A1 (de) * | 1999-02-26 | 2000-08-31 | Deutsches Krebsforsch | An der Entwicklung des ZNS beteiligtes Protein (TP) |
| AT408721B (de) * | 1999-10-01 | 2002-02-25 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung enthaltend ein antigen |
| EP1535628B1 (de) * | 1999-11-24 | 2013-07-31 | Novartis Vaccines and Diagnostics, Inc. | Hbv/hcv virus-ähnliche teilchen |
| US6858590B2 (en) * | 2000-08-17 | 2005-02-22 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| US6680059B2 (en) | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| US7022830B2 (en) * | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
| JP2004522415A (ja) * | 2000-09-01 | 2004-07-29 | エピミューン インコーポレーティッド | Hla結合ペプチドおよびその使用方法 |
| GB0026094D0 (en) * | 2000-10-25 | 2000-12-13 | Imp College Innovations Ltd | Methods |
| US7402567B2 (en) * | 2000-10-27 | 2008-07-22 | The Regents Of The University Of California | Treatment of disease by inducing cell apoptosis |
| US8129349B2 (en) * | 2000-10-27 | 2012-03-06 | The Regents Of The University Of California | Treatment of disease by inducing cell apoptosis |
| US7101561B2 (en) | 2000-12-01 | 2006-09-05 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
| AU2002252856A1 (en) | 2001-04-24 | 2002-11-05 | Innogenetics N.V. | Expression of core-glycosylated hcv envelope proteins in yeast |
| FR2825093B1 (fr) * | 2001-05-28 | 2003-07-18 | Bio Merieux | Polypeptide reagissant avecles anticorps de patients infectes par vhc et utilisations |
| FR2825363A1 (fr) * | 2001-05-31 | 2002-12-06 | Bio Merieux | Polypeptides reagissant avec les anticorps de patients infectes par vhc et utilisations |
| US7736677B2 (en) * | 2001-06-20 | 2010-06-15 | Metaproteomics, Llc | Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment |
| JP2003064096A (ja) * | 2001-08-29 | 2003-03-05 | Mitsubishi Kagaku Bio-Clinical Laboratories Inc | C型肝炎ウイルス特異的細胞障害性t細胞認識エピトープ |
| GB0126782D0 (en) * | 2001-11-07 | 2002-01-02 | Medical Res Council | Assay |
| US20040126395A1 (en) * | 2001-12-18 | 2004-07-01 | Geert Maertens | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
| WO2003051912A2 (en) * | 2001-12-18 | 2003-06-26 | Innogenetics N.V. | Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use |
| US7201904B2 (en) | 2002-05-16 | 2007-04-10 | The General Hospital Corporation | Epitopes of hepatitis C virus |
| US8029803B2 (en) * | 2002-06-20 | 2011-10-04 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
| US8025873B2 (en) * | 2002-06-20 | 2011-09-27 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
| EP1539809A4 (de) * | 2002-07-02 | 2006-03-08 | Chiron Corp | Hcv-fusionsproteine mit modifizierten ns3-domänen |
| CA2504711A1 (en) * | 2002-11-08 | 2004-05-21 | Innogenetics N.V. | Hcv vaccine compositions comprising e1 and ns3 peptides |
| US20060269562A1 (en) * | 2003-01-07 | 2006-11-30 | Christine Bain | Polypeptides f' of the hepatitis c virus, t epitopeo, and the diagnostic and therapeutic applications thereof |
| US8007805B2 (en) * | 2003-08-08 | 2011-08-30 | Paladin Labs, Inc. | Chimeric antigens for breaking host tolerance to foreign antigens |
| US7785875B2 (en) | 2004-07-03 | 2010-08-31 | Mogam Biotechnology Research Institute | Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same |
| JP2008505636A (ja) * | 2004-07-03 | 2008-02-28 | モガム バイオテクノロジー リサーチ インスティチュート | Hcvに有効なctl反応を誘導するスーパータイプのエピトープ、これをコードするオリゴヌクレオチド並びにそれらの用途 |
| CU23470A1 (es) * | 2004-08-11 | 2009-12-17 | Ct Ingenieria Genetica Biotech | Vectores vivos recombinantes y su uso en composiciones farmacéuticas contra el virus de la hepatitis c |
| EP1797112B1 (de) * | 2004-09-29 | 2010-07-21 | The Administrators of the Tulane Educational Fund | Inhibitoren des hepatitis-c-virus |
| WO2006044923A2 (en) * | 2004-10-18 | 2006-04-27 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis c infection |
| CA2618429A1 (en) * | 2005-05-25 | 2007-03-22 | Tripep Ab | A hepatitis c virus non-structural ns3/4a fusion gene |
| BRPI0617330A2 (pt) * | 2005-10-13 | 2011-07-19 | Virexx Medical Corp | antìgeno quimérico contendo polipeptìdeo do vìrus da hepatite c e fragmento fc para despertar uma resposta imunológica |
| WO2007149503A2 (en) * | 2006-06-20 | 2007-12-27 | Metaproteomics, Llc. | Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment |
| EP2040745B1 (de) * | 2006-06-28 | 2012-12-05 | Statens Serum Institut | Expansion des t-zell-repertoirs, um subdominante epitope durch impfung mit antigenen, die als proteinfragmente oder peptidcocktails abgegeben werden, aufzunehmen |
| WO2009022236A2 (en) | 2007-08-16 | 2009-02-19 | Tripep Ab | Immunogen platform |
| ES2303496B1 (es) * | 2008-02-21 | 2009-07-07 | Fundacion Para El Estudio De Las Hepatitis Virales | Metodo analitico perfeccionado para la deteccion de hepatitis c oculta, aplicaciones del mismo y su correspondiente kit de diagnostico. |
| WO2009130588A2 (en) * | 2008-04-22 | 2009-10-29 | Tripep Ab | Immunogen platform |
| WO2010033841A1 (en) | 2008-09-19 | 2010-03-25 | Globeimmune, Inc. | Immunotherapy for chronic hepatitis c virus infection |
| AU2010229675B2 (en) * | 2009-03-27 | 2016-02-25 | Academia Sinica | Methods and compositions for immunization against virus |
| WO2010112733A1 (fr) * | 2009-03-30 | 2010-10-07 | bioMérieux | Support solide de détection du vhc |
| WO2012033142A1 (ja) | 2010-09-08 | 2012-03-15 | 学校法人 埼玉医科大学 | C型肝炎ウイルスリポソームワクチン |
| TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
| AU2011335551B2 (en) | 2010-12-02 | 2016-10-06 | Bionor Immuno As | Peptide scaffold design |
| BR112013017488A2 (pt) | 2011-01-06 | 2017-08-01 | Bionor Immuno As | peptídeos imunogênicos multiméricos e monoméricos |
| WO2013182661A1 (en) | 2012-06-06 | 2013-12-12 | Bionor Immuno As | Peptides derived from viral proteins for use as immunogens and dosage reactants |
| CN105073989A (zh) * | 2013-02-19 | 2015-11-18 | 国立大学法人神户大学 | 免疫原性多肽表层表达双歧杆菌 |
| US9790478B2 (en) | 2013-03-14 | 2017-10-17 | Abbott Laboratories | HCV NS3 recombinant antigens and mutants thereof for improved antibody detection |
| CN113549148B (zh) * | 2013-03-14 | 2025-11-21 | 雅培制药有限公司 | Hcv核心脂质结合结构域单克隆抗体 |
| JP6505076B2 (ja) | 2013-03-14 | 2019-04-24 | アボット・ラボラトリーズAbbott Laboratories | Hcv抗原−抗体組み合わせアッセイおよびこれに使用するための方法および組成物 |
| WO2015006337A2 (en) * | 2013-07-08 | 2015-01-15 | Nanjingjinsirui Science & Technology Biology Corporation | Compositions and methods for increasing protein half-life in a serum |
| CA3037813A1 (en) | 2016-09-21 | 2018-03-29 | The Governors Of The University Of Alberta | Hepatitis c virus immunogenic compositions and methods of use thereof |
| CA3093314A1 (en) * | 2018-03-16 | 2019-09-19 | The Governors Of The University Of Alberta | Hepatitis c virus peptide compositions and methods of use thereof |
| CN109160942B (zh) * | 2018-09-26 | 2021-06-29 | 广州市第八人民医院 | Hcv包膜蛋白高度保守区域的肽段502-518及其用途 |
| JP2022518488A (ja) * | 2019-01-25 | 2022-03-15 | センティ バイオサイエンシズ インコーポレイテッド | タンパク質機能を制御するための融合構築物 |
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|---|---|---|---|---|
| US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| US6027729A (en) | 1989-04-20 | 2000-02-22 | Chiron Corporation | NANBV Diagnostics and vaccines |
| US5747239A (en) * | 1990-02-16 | 1998-05-05 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines |
| US5639594A (en) * | 1990-02-16 | 1997-06-17 | United Biomedical, Inc. | Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis |
| IE911130A1 (en) * | 1990-04-04 | 1991-10-09 | Protos | Hepatitis c protease inhibitors |
| US5747339A (en) | 1990-06-25 | 1998-05-05 | Research Foundation For Microbial Diseases Of Osaka | Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide |
| EP0468657A3 (en) * | 1990-07-09 | 1992-02-05 | Tonen Corporation | Non-a non b hepatitis-specific antigen and its use in hepatitus diagnosis |
| CA2047792C (en) * | 1990-07-26 | 2002-07-02 | Chang Y. Wang | Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines |
| CA2049679C (en) * | 1990-08-24 | 2005-06-21 | Sushil G. Devare | Hepatitis c assay utilizing recombinant antigens |
| EP0485209A1 (de) * | 1990-11-08 | 1992-05-13 | Immuno Japan Inc. | Mit Non-A Non-B Hepatitis Virus verwandtes Antigen, Aufspürsysteme für Antikörper, Polynukleotide und Polypeptide |
| AU648912B2 (en) | 1991-06-13 | 1994-05-05 | Dade International Inc. | Immunoassay for non-A non-B hepatitis |
| EP0591431B1 (de) * | 1991-06-24 | 2002-12-11 | Chiron Corporation | Polypeptide des hepatitis c-virus (hiv) |
| DE4209215A1 (de) * | 1991-07-04 | 1993-01-07 | Boehringer Mannheim Gmbh | Hcv peptidantigene und verfahren zur bestimmung von hcv |
| US5428145A (en) | 1991-08-09 | 1995-06-27 | Immuno Japan, Inc. | Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems |
| AU2513592A (en) * | 1991-08-21 | 1993-03-16 | Abbott Laboratories | Hepatitis c assay utilizing recombinant antigens to ns1 |
| ES2182822T3 (es) * | 1991-09-13 | 2003-03-16 | Chiron Corp | Composiciones de polipeptidos inmunorreactivos del virus de la hepatitis c. |
| ES2145746T5 (es) * | 1991-09-16 | 2005-04-16 | Abbott Laboratories | Analisis de deteccion de la hepatitis c. |
| CA2128896A1 (en) * | 1992-02-04 | 1993-08-05 | Douglas J. Jolly | Hepatitis therapeutics |
| ATE364621T1 (de) | 1992-03-06 | 2007-07-15 | Innogenetics Nv | Hiv-peptide |
| EP0728764A4 (de) * | 1993-10-19 | 1999-01-20 | Ajinomoto Kk | Peptide das eine immunantwort gegen hiv unduziert und arzneimittel die esenthaelt zur vorbeugung oder behandlung von aids |
| EP0992580B1 (de) * | 1993-11-04 | 2005-03-09 | Innogenetics N.V. | Von menschlichen T-Zellen immunodominante Epitopen des Virus der C-Hepatitis |
| US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
| US5543657A (en) * | 1994-10-07 | 1996-08-06 | International Business Machines Corporation | Single layer leadframe design with groundplane capability |
-
1994
- 1994-10-28 EP EP99116671A patent/EP0992580B1/de not_active Revoked
- 1994-10-28 DK DK99116671T patent/DK0992580T3/da active
- 1994-10-28 EP EP99116672A patent/EP0992581B2/de not_active Expired - Lifetime
- 1994-10-28 WO PCT/EP1994/003555 patent/WO1995012677A2/en not_active Ceased
- 1994-10-28 PT PT94931000T patent/PT725824E/pt unknown
- 1994-10-28 DE DE69434295T patent/DE69434295T2/de not_active Revoked
- 1994-10-28 ES ES99116671T patent/ES2239819T3/es not_active Expired - Lifetime
- 1994-10-28 EP EP94931000A patent/EP0725824B1/de not_active Revoked
- 1994-10-28 CA CA002175692A patent/CA2175692A1/en not_active Abandoned
- 1994-10-28 DK DK94931000T patent/DK0725824T3/da active
- 1994-10-28 AT AT99116672T patent/ATE274578T1/de not_active IP Right Cessation
- 1994-10-28 DE DE69432475T patent/DE69432475T2/de not_active Revoked
- 1994-10-28 ES ES94931000T patent/ES2197170T3/es not_active Expired - Lifetime
- 1994-10-28 AT AT99116671T patent/ATE290592T1/de not_active IP Right Cessation
- 1994-10-28 US US08/635,886 patent/US6555114B1/en not_active Expired - Fee Related
- 1994-10-28 JP JP7513004A patent/JPH09504534A/ja active Pending
- 1994-10-28 PT PT99116671T patent/PT992580E/pt unknown
- 1994-10-28 EP EP99116673A patent/EP0979867A3/de not_active Withdrawn
- 1994-10-28 AT AT94931000T patent/ATE236981T1/de not_active IP Right Cessation
- 1994-10-28 DE DE69433971T patent/DE69433971T2/de not_active Expired - Fee Related
- 1994-10-28 AU AU79932/94A patent/AU698878B2/en not_active Ceased
-
1997
- 1997-11-19 US US08/974,685 patent/US6689368B1/en not_active Expired - Fee Related
- 1997-11-19 US US08/974,690 patent/US6613333B1/en not_active Expired - Fee Related
-
2003
- 2003-08-29 US US10/651,165 patent/US20040047877A1/en not_active Abandoned
-
2004
- 2004-02-12 JP JP2004034983A patent/JP2004194668A/ja active Pending
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