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DE69429774D1 - Magnesium-omeprazol - Google Patents

Magnesium-omeprazol

Info

Publication number
DE69429774D1
DE69429774D1 DE69429774T DE69429774T DE69429774D1 DE 69429774 D1 DE69429774 D1 DE 69429774D1 DE 69429774 T DE69429774 T DE 69429774T DE 69429774 T DE69429774 T DE 69429774T DE 69429774 D1 DE69429774 D1 DE 69429774D1
Authority
DE
Germany
Prior art keywords
magnesium
omeprazol
crystallinity
manufacture
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69429774T
Other languages
English (en)
Other versions
DE69429774T2 (de
Inventor
Ake Kaellstroem
Annelie Nygren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20390588&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69429774(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE69429774D1 publication Critical patent/DE69429774D1/de
Application granted granted Critical
Publication of DE69429774T2 publication Critical patent/DE69429774T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Contacts (AREA)
  • Conductive Materials (AREA)
  • Electroplating Methods And Accessories (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Medicinal Preparation (AREA)
  • Glass Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Powder Metallurgy (AREA)
DE69429774T 1993-07-09 1994-07-08 Magnesium-omeprazol Expired - Lifetime DE69429774T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE19939302396A SE9302396D0 (sv) 1993-07-09 1993-07-09 A novel compound form
PCT/SE1994/000680 WO1995001977A1 (en) 1993-07-09 1994-07-08 Magnesium omeprazole

Publications (2)

Publication Number Publication Date
DE69429774D1 true DE69429774D1 (de) 2002-03-14
DE69429774T2 DE69429774T2 (de) 2002-11-14

Family

ID=20390588

Family Applications (2)

Application Number Title Priority Date Filing Date
DE0707580T Pending DE707580T1 (de) 1993-07-09 1994-07-08 Magnesium-omeprazol
DE69429774T Expired - Lifetime DE69429774T2 (de) 1993-07-09 1994-07-08 Magnesium-omeprazol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE0707580T Pending DE707580T1 (de) 1993-07-09 1994-07-08 Magnesium-omeprazol

Country Status (42)

Country Link
US (1) US5900424A (de)
EP (2) EP1164132A3 (de)
JP (2) JP3635432B2 (de)
KR (1) KR100353783B1 (de)
CN (1) CN1064680C (de)
AT (1) ATE212628T1 (de)
AU (1) AU679766B2 (de)
BR (1) BR9406940A (de)
CA (1) CA2166794C (de)
CZ (1) CZ288933B6 (de)
DE (2) DE707580T1 (de)
DK (1) DK0707580T3 (de)
DZ (1) DZ1792A1 (de)
EE (1) EE03127B1 (de)
EG (1) EG21437A (de)
ES (1) ES2100136T3 (de)
FI (1) FI114154B (de)
GR (1) GR970300015T1 (de)
HK (1) HK1008329A1 (de)
HR (1) HRP940385B1 (de)
HU (1) HU226861B1 (de)
IL (1) IL110190A (de)
IS (1) IS2075B (de)
MA (1) MA23257A1 (de)
MX (1) MX9405217A (de)
MY (1) MY113274A (de)
NO (1) NO308702B1 (de)
NZ (1) NZ268693A (de)
PL (1) PL175999B1 (de)
PT (1) PT707580E (de)
RU (1) RU2139868C1 (de)
SA (1) SA94150058B1 (de)
SE (1) SE9302396D0 (de)
SG (1) SG52464A1 (de)
SI (1) SI0707580T1 (de)
SK (1) SK281230B6 (de)
TN (1) TNSN94079A1 (de)
TW (1) TW504509B (de)
UA (1) UA43343C2 (de)
WO (1) WO1995001977A1 (de)
YU (1) YU49193B (de)
ZA (1) ZA944933B (de)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
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US6875872B1 (en) 1993-05-28 2005-04-05 Astrazeneca Compounds
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
SE9302396D0 (sv) * 1993-07-09 1993-07-09 Ab Astra A novel compound form
SE9302395D0 (sv) * 1993-07-09 1993-07-09 Ab Astra New pharmaceutical formulation
BR9508261A (pt) * 1994-07-08 1997-12-23 Astra Ab Formulação oral entericamente revestida uso da mesma processo para preparer a formulação inibir a secreção de ácido gástrico em mamíferos e no ser humano e tratar doenças relacionadas ao ácido gástrico em maníferos e no ser humano e pacote de empola de pressão transversal
MX9600857A (es) 1994-07-08 1997-06-28 Astra Ab Forma de dosificacion i en tabletas, con unidades multiples.
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
SE508669C2 (sv) * 1996-04-26 1998-10-26 Astra Ab Nytt förfarande
US6623759B2 (en) 1996-06-28 2003-09-23 Astrazeneca Ab Stable drug form for oral administration with benzimidazole derivatives as active ingredient and process for the preparation thereof
TW385306B (en) * 1996-11-14 2000-03-21 Takeda Chemical Industries Ltd Method for producing crystals of benzimidazole derivatives
SE510666C2 (sv) * 1996-12-20 1999-06-14 Astra Ab Nya Kristallmodifikationer
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SE510650C2 (sv) 1997-05-30 1999-06-14 Astra Ab Ny förening
US6747155B2 (en) 1997-05-30 2004-06-08 Astrazeneca Ab Process
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US6096340A (en) 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
SE9704870D0 (sv) 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulation I
FR2774288B1 (fr) * 1998-01-30 2001-09-07 Ethypharm Sa Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques
US6048981A (en) * 1998-04-22 2000-04-11 Torcan Chemical Ltd. Magnesium omeprazole and process for its preparation
DE19843413C1 (de) 1998-08-18 2000-03-30 Byk Gulden Lomberg Chem Fab Neue Salzform von Pantoprazol
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
SE9803772D0 (sv) 1998-11-05 1998-11-05 Astra Ab Pharmaceutical formulation
IL142703A (en) * 1998-11-10 2006-04-10 Astrazeneca Ab Crystalline form of omeprazole
UA72748C2 (en) * 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole
AU770633B2 (en) 1998-11-18 2004-02-26 Astrazeneca Ab Improved chemical process and pharmaceutical formulation
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
US6316020B1 (en) * 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
CA2290893C (en) * 1999-11-16 2007-05-01 Bernard Charles Sherman Magnesium omeprazole
SE0000774D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
AU5248601A (en) * 2000-05-15 2001-11-26 Ranbaxy Laboratories Limited Novel amorphous form of omeprazole salts
JP5412023B2 (ja) 2000-08-04 2014-02-12 武田薬品工業株式会社 ベンズイミダゾール化合物の塩およびその用途
CA2386716C (en) * 2002-05-17 2012-07-24 Bernard Charles Sherman Magnesium salt of s-omeprazole
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
US20020064555A1 (en) * 2000-09-29 2002-05-30 Dan Cullen Proton pump inhibitor formulation
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
US20040006111A1 (en) * 2002-01-25 2004-01-08 Kenneth Widder Transmucosal delivery of proton pump inhibitors
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US20030228363A1 (en) * 2002-06-07 2003-12-11 Patel Mahendra R. Stabilized pharmaceutical compositons containing benzimidazole compounds
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US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
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EP1708684A2 (de) 2003-09-26 2006-10-11 Alza Corporation Arzneimittelbeschichtung mit hoher arzneimittelbeladung und verfahren dafür
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US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
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US20060024362A1 (en) * 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
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US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
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US7553857B2 (en) 2005-12-23 2009-06-30 Lek Pharmaceuticals D.D. S-omeprazole magnesium
EP2026768B1 (de) * 2006-06-01 2018-02-28 Dexcel Pharma Technologies Ltd. Pharmazeutische formulierung auf mehreren einheiten
RU2467747C2 (ru) 2006-07-25 2012-11-27 Векта Лтд. Композиции и способы для ингибирования секреции желудочной кислоты с использованием производных малых дикарбоновых кислот в сочетании с ppi
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AU2007317561A1 (en) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same
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US8911787B2 (en) 2008-02-26 2014-12-16 Ranbaxy Laboratories Limited Stable oral benzimidazole compositions and process of preparation thereof
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EP2345408A3 (de) 2010-01-08 2012-02-29 Dr. Reddy's Laboratories Ltd. Säurelabile Arzneimittelformulierungen
EP2601947A1 (de) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Kombinationspräparat mit fester Dosierung zur Behandlung von Erkrankungen einhergehend mit Helicobacter pylori
EP2797600A4 (de) 2011-12-28 2015-09-16 Pozen Inc Verbesserte zusammensetzungen und verfahren zur abgabe von omeprazol und acetylsalicylsäure
CN102993184A (zh) * 2013-01-08 2013-03-27 湖南方盛制药股份有限公司 一种埃索美拉唑及其镁盐三水合物的制备方法
US20170042806A1 (en) 2015-04-29 2017-02-16 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
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WO2024075017A1 (en) 2022-10-04 2024-04-11 Zabirnyk Arsenii Inhibition of aortic valve calcification

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
DE4035455A1 (de) * 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab Enantiomerentrennung
SE9302396D0 (sv) * 1993-07-09 1993-07-09 Ab Astra A novel compound form

Also Published As

Publication number Publication date
HU9503873D0 (en) 1996-02-28
HK1008329A1 (en) 1999-05-07
WO1995001977A1 (en) 1995-01-19
IL110190A0 (en) 1994-10-21
AU7198194A (en) 1995-02-06
CZ288933B6 (cs) 2001-09-12
GR970300015T1 (en) 1997-05-31
IL110190A (en) 2000-07-26
HRP940385B1 (en) 2003-06-30
MA23257A1 (fr) 1995-04-01
HU226861B1 (en) 2009-12-28
NO960068L (no) 1996-01-05
PL175999B1 (pl) 1999-03-31
FI960101A0 (fi) 1996-01-09
ES2100136T3 (es) 2002-09-01
EP1164132A3 (de) 2002-01-02
NO308702B1 (no) 2000-10-16
PL312440A1 (en) 1996-04-29
YU49193B (sh) 2004-09-03
DE707580T1 (de) 1997-09-04
NO960068D0 (no) 1996-01-05
RU2139868C1 (ru) 1999-10-20
CN1064680C (zh) 2001-04-18
DE69429774T2 (de) 2002-11-14
SI0707580T1 (en) 2002-06-30
JP2002105072A (ja) 2002-04-10
KR100353783B1 (ko) 2004-04-03
US5900424A (en) 1999-05-04
CA2166794C (en) 1997-03-04
SE9302396D0 (sv) 1993-07-09
EG21437A (en) 2001-10-31
CZ6996A3 (en) 1996-05-15
EP1164132A2 (de) 2001-12-19
MX9405217A (es) 1995-01-31
SG52464A1 (en) 1998-09-28
ZA944933B (en) 1995-02-20
TW504509B (en) 2002-10-01
IS2075B (is) 2005-12-15
ATE212628T1 (de) 2002-02-15
CN1126993A (zh) 1996-07-17
YU43694A (sh) 1997-07-31
JP3878826B2 (ja) 2007-02-07
DK0707580T3 (da) 2002-04-15
EP0707580B1 (de) 2002-01-30
AU679766B2 (en) 1997-07-10
DZ1792A1 (fr) 2002-02-17
HRP940385A2 (en) 1997-02-28
NZ268693A (en) 1997-05-26
HUT75314A (en) 1997-05-28
JPH08512315A (ja) 1996-12-24
ES2100136T1 (es) 1997-06-16
SK2296A3 (en) 1996-10-02
SK281230B6 (sk) 2001-01-18
FI114154B (fi) 2004-08-31
IS4186A (is) 1995-01-10
TNSN94079A1 (fr) 1995-04-25
BR9406940A (pt) 1996-09-10
JP3635432B2 (ja) 2005-04-06
EP0707580A1 (de) 1996-04-24
FI960101L (fi) 1996-01-09
PT707580E (pt) 2002-06-28
SA94150058B1 (ar) 2006-06-20
MY113274A (en) 2002-01-31
UA43343C2 (uk) 2001-12-17
EE03127B1 (et) 1998-10-15

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