[go: up one dir, main page]

DE69429159D1 - Verfahren für einen spezifischen Bindungstest mit magnetischen Teilchen - Google Patents

Verfahren für einen spezifischen Bindungstest mit magnetischen Teilchen

Info

Publication number
DE69429159D1
DE69429159D1 DE69429159T DE69429159T DE69429159D1 DE 69429159 D1 DE69429159 D1 DE 69429159D1 DE 69429159 T DE69429159 T DE 69429159T DE 69429159 T DE69429159 T DE 69429159T DE 69429159 D1 DE69429159 D1 DE 69429159D1
Authority
DE
Germany
Prior art keywords
magnetic particle
specific magnetic
binding test
particle binding
test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69429159T
Other languages
English (en)
Other versions
DE69429159T2 (de
Inventor
Jukka Tuunanen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermo Fisher Scientific Oy
Original Assignee
Thermo Labsystems Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FI930440A external-priority patent/FI930440A0/fi
Priority claimed from FI932866A external-priority patent/FI932866A0/fi
Application filed by Thermo Labsystems Oy filed Critical Thermo Labsystems Oy
Application granted granted Critical
Publication of DE69429159D1 publication Critical patent/DE69429159D1/de
Publication of DE69429159T2 publication Critical patent/DE69429159T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/286—Magnetic plugs and dipsticks disposed at the inner circumference of a recipient, e.g. magnetic drain bolt
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0657—Pipetting powder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1055—General features of the devices using the transfer device for another function for immobilising reagents, e.g. dried reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Sampling And Sample Adjustment (AREA)
DE69429159T 1993-02-01 1994-02-01 Verfahren für einen spezifischen Bindungstest mit magnetischen Teilchen Expired - Lifetime DE69429159T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI930440A FI930440A0 (fi) 1993-02-01 1993-02-01 Bestaemningsfoerfarande
FI932866A FI932866A0 (fi) 1993-06-21 1993-06-21 Separeringsfoerfarande
PCT/FI1994/000048 WO1994018565A1 (en) 1993-02-01 1994-02-01 Method and means for magnetic particle specific binding assay

Publications (2)

Publication Number Publication Date
DE69429159D1 true DE69429159D1 (de) 2002-01-03
DE69429159T2 DE69429159T2 (de) 2002-08-14

Family

ID=26159425

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69434867T Expired - Lifetime DE69434867T2 (de) 1993-02-01 1994-02-01 Gerät zur Bestimmung eines Analyten in einer Probe
DE1130397T Pending DE1130397T1 (de) 1993-02-01 1994-02-01 Ausrüstung zur Bestimmung eines Analyten in einer Probe
DE69429159T Expired - Lifetime DE69429159T2 (de) 1993-02-01 1994-02-01 Verfahren für einen spezifischen Bindungstest mit magnetischen Teilchen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69434867T Expired - Lifetime DE69434867T2 (de) 1993-02-01 1994-02-01 Gerät zur Bestimmung eines Analyten in einer Probe
DE1130397T Pending DE1130397T1 (de) 1993-02-01 1994-02-01 Ausrüstung zur Bestimmung eines Analyten in einer Probe

Country Status (7)

Country Link
US (2) US6040192A (de)
EP (2) EP1130397B1 (de)
JP (1) JP3142873B2 (de)
DE (3) DE69434867T2 (de)
FI (1) FI953669L (de)
NO (1) NO318762B1 (de)
WO (1) WO1994018565A1 (de)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI930440A0 (fi) 1993-02-01 1993-02-01 Labsystems Oy Bestaemningsfoerfarande
EP1130397B1 (de) * 1993-02-01 2006-10-11 Thermo Electron Oy Gerät zur Bestimmung eines Analyten in einer Probe
US5837144A (en) * 1994-06-16 1998-11-17 Boehringer Mannheim Gmbh Method of magnetically separating liquid components
FI944937A0 (fi) 1994-10-20 1994-10-20 Labsystems Oy Separeringsanordning
FI944939A0 (fi) * 1994-10-20 1994-10-20 Labsystems Oy Foerfarande foer separering av partiklar
FI944940A0 (fi) * 1994-10-20 1994-10-20 Labsystems Oy Tvaofasigt separeringsfoerfarande
FI944938A0 (fi) * 1994-10-20 1994-10-20 Labsystems Oy Foerflyttningsanordning
US6509193B1 (en) * 1996-05-20 2003-01-21 Precision System Science Co., Ltd. Method and apparatus for controlling magnetic particles by pipetting machine
WO1998034114A1 (de) * 1997-01-30 1998-08-06 Merck Patent Gmbh Verfahren zur immunologischen bestimmung eines analyten
DE19730497C2 (de) 1997-07-16 2000-02-10 Heermann Klaus Hinrich Verfahren zum Waschen, zur Separierung und Konzentrierung von Biomolekülen unter Verwendung eines Magnetstifts
US6248542B1 (en) 1997-12-09 2001-06-19 Massachusetts Institute Of Technology Optoelectronic sensor
FI990082A0 (fi) * 1999-01-18 1999-01-18 Labsystems Oy Puhdistusprosessi magneettipartikkeleita käyttäen
EP1198566A2 (de) * 1999-07-05 2002-04-24 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Methode mit einer hohen durchsatzrate zur selektion von interagierenden molekülen
EP1202808B1 (de) * 1999-07-19 2008-10-15 bioMerieux B.V. Verfahren zum mengen von magnetteilchen mit einer flüssigkeit
FI20000583A0 (fi) * 2000-03-14 2000-03-14 Labsystems Oy Astia ja sauva
US7410807B2 (en) * 2000-07-24 2008-08-12 D Aurora Vito J Pregnancy and sex identification test based on saliva or other bodily fluids
DE10057396C1 (de) * 2000-11-18 2002-04-04 Karlsruhe Forschzent Verfahren zum Abtrennen eines dispergierten oder gelösten Stoffes und Magnetseparator
US6649419B1 (en) 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation
US20050047976A1 (en) * 2001-01-25 2005-03-03 Klaus Gubernator Method and apparatus for solid or solution phase reaction under ambient or inert conditions
JP4295511B2 (ja) 2001-02-07 2009-07-15 マサチューセッツ・インスティテュート・オブ・テクノロジー 光電子による検出システム
US7422860B2 (en) 2001-02-07 2008-09-09 Massachusetts Institute Of Technology Optoelectronic detection system
US8216797B2 (en) 2001-02-07 2012-07-10 Massachusetts Institute Of Technology Pathogen detection biosensor
US6962674B2 (en) * 2001-02-28 2005-11-08 Varian, Inc. Dissolution test apparatus
GB0110476D0 (en) * 2001-04-30 2001-06-20 Secr Defence Reagent delivery system
US6790413B2 (en) 2001-05-03 2004-09-14 Beckman Coulter, Inc. Sample presentation unit
US20030040129A1 (en) * 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
US20060188875A1 (en) * 2001-09-18 2006-08-24 Perlegen Sciences, Inc. Human genomic polymorphisms
CA2481545A1 (en) * 2002-04-12 2003-10-23 Instrumentation Laboratory Company Immunoassay probe
FI120863B (fi) * 2002-10-18 2010-04-15 Biocontrol Systems Inc Magneettinen siirtomenetelmä ja mikropartikkelien siirtolaite
CN100538362C (zh) 2002-11-07 2009-09-09 株式会社三菱化学药得论 用于收集磁性颗粒的磁性材料及其应用
KR100483684B1 (ko) * 2003-01-29 2005-04-18 (주)바이오넥스 핵산 또는 다양한 생물학적 물질을 분리 및 정제하기 위한키트와, 이러한 키트를 이용하여 생물학적 물질의 분리또는 정제 작업을 자동화하기 위한 시스템
US7601491B2 (en) * 2003-02-06 2009-10-13 Becton, Dickinson And Company Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
US20040157219A1 (en) * 2003-02-06 2004-08-12 Jianrong Lou Chemical treatment of biological samples for nucleic acid extraction and kits therefor
GB0319671D0 (en) * 2003-08-21 2003-09-24 Secr Defence Apparatus for processing a fluid sample
FI20040159A0 (fi) 2003-10-20 2004-02-02 Bio Mobile Oy Magneettinen siirtomenetelmä, mikropartikkelien siirtolaite, ja reaktioyksikkö
FI20031635A0 (fi) 2003-11-11 2003-11-11 Thermo Electron Oy Partikkelien erotusväline
US20050239091A1 (en) * 2004-04-23 2005-10-27 Collis Matthew P Extraction of nucleic acids using small diameter magnetically-responsive particles
US8211386B2 (en) * 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
US20060024776A1 (en) * 2004-08-02 2006-02-02 Mcmillian Ray Magnetic particle capture of whole intact organisms from clinical samples
JP5053089B2 (ja) * 2004-08-03 2012-10-17 ベクトン・ディキンソン・アンド・カンパニー 化合物の直接単離および多成分サンプルの分別のための磁性材料の使用
JP2008511816A (ja) * 2004-08-03 2008-04-17 ベクトン・ディキンソン・アンド・カンパニー サンプルを分別するための磁性材料の使用
GB2420850A (en) 2004-12-03 2006-06-07 Orion Diagnostica Oy Particle based binding assay
GB0503986D0 (en) * 2005-02-26 2005-04-06 Secr Defence Reaction apparatus
US7534081B2 (en) 2005-05-24 2009-05-19 Festo Corporation Apparatus and method for transferring samples from a source to a target
US7597520B2 (en) 2005-05-24 2009-10-06 Festo Corporation Apparatus and method for transferring samples from a source to a target
CA2631615A1 (en) * 2005-11-30 2007-04-24 Massachusetts Institute Of Technology Pathogen detection biosensor
EP2069041A4 (de) * 2006-10-06 2013-04-24 Promega Corp Verfahren und vorrichtung zur ausscheidung magnetischer partikel aus einer lösung
EP2097751A4 (de) * 2006-10-30 2013-05-08 Stc Unm Magnetisch empfängliche partikel und mischgeräte dafür
US7799281B2 (en) 2007-01-16 2010-09-21 Festo Corporation Flux concentrator for biomagnetic particle transfer device
CA2692186C (en) * 2007-06-29 2019-03-12 Becton, Dickinson And Company Methods for extraction and purification of components of biological samples
ATE471761T1 (de) * 2007-08-14 2010-07-15 Qiagen Gmbh Verfahren zum suspendieren oder resuspendieren von partikeln in einer lösung sowie daran angepasste vorrichtung
US20090181359A1 (en) * 2007-10-25 2009-07-16 Lou Sheng C Method of performing ultra-sensitive immunoassays
US8222048B2 (en) 2007-11-05 2012-07-17 Abbott Laboratories Automated analyzer for clinical laboratory
US8691149B2 (en) * 2007-11-06 2014-04-08 Abbott Laboratories System for automatically loading immunoassay analyzer
US8685322B2 (en) 2007-11-13 2014-04-01 Stratec Biomedical Ag Apparatus and method for the purification of biomolecules
US8071395B2 (en) * 2007-12-12 2011-12-06 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatus for magnetic separation of cells
KR101384142B1 (ko) * 2007-12-28 2014-04-14 삼성디스플레이 주식회사 표시기판, 이의 제조방법 및 이를 갖는 표시장치
CA2712430A1 (en) * 2008-01-25 2009-07-30 Luminex Corporation Assay preparation plates, fluid assay preparation and analysis systems, and methods for preparing and analyzing assays
CN101990639B (zh) * 2008-04-09 2014-08-13 株式会社百奥尼 自动提纯设备、多井板试样盒以及用于从生物试样提取核酸的方法
US20110263044A1 (en) * 2008-07-31 2011-10-27 Eads Deutschland Gmbh Device and method for the automatic detection of biological particles
DK2331954T3 (da) 2008-08-27 2020-04-06 Life Technologies Corp Apparat og fremgangsmåde til processering af biologiske prøver
US11235323B2 (en) 2008-08-27 2022-02-01 Life Technologies Corporation Apparatus for and method of processing biological samples
EP2394175B1 (de) 2009-02-09 2016-02-03 caprotec bioanalytics GmbH Vorrichtungen, systeme und verfahren zur trennung magnetischer partikel
DE102009001864A1 (de) * 2009-03-25 2010-09-30 Qiagen Gmbh Überschichtung zur Partikelabtrennung
GB2473868A (en) 2009-09-28 2011-03-30 Invitrogen Dynal As Apparatus and method of automated processing of biological samples
CN113145298B (zh) * 2009-05-15 2023-09-22 简·探针公司 用于在执行磁性分离工序的仪器中实现磁体的自动移动的方法和设备
US20100297778A1 (en) * 2009-05-20 2010-11-25 Abbott Laboratories Conjugate Having Cleavable Linking Agent
JP2011013042A (ja) * 2009-06-30 2011-01-20 Beckman Coulter Inc 自動分析装置および測定方法
FR2951961B1 (fr) * 2009-10-30 2011-11-04 Snecma Dispositif et procede de recuperation de particules magnetiques piegees sur un bouchon magnetique
ES2863454T3 (es) 2010-04-30 2021-10-11 Bioneer Corp Dispositivo de purificación automática de muestras biológicas con unidad de aplicación de campo magnético, método para extraer una sustancia diana de una muestra biológica, y método de purificación y expresión de proteínas
US8784734B2 (en) 2010-05-20 2014-07-22 Abbott Laboratories Reusable sheaths for separating magnetic particles
KR101279577B1 (ko) * 2010-11-25 2013-06-27 삼성테크윈 주식회사 자성입자 분리장치
US9804179B2 (en) 2011-01-08 2017-10-31 Access Medical Systems, Ltd. Systems for immunoassay tests
FI20115175A0 (fi) 2011-02-23 2011-02-23 Helsinki Thermo Fisher Scient Oy Partikkelien prosessointi
JP5650056B2 (ja) * 2011-05-30 2015-01-07 株式会社日立ハイテクノロジーズ 試料処理装置、および試料処理方法
US8920751B2 (en) * 2011-07-08 2014-12-30 Life Technologies Corporation Automated enrichment for nucleic acid sequencing
RU2528885C2 (ru) * 2011-10-04 2014-09-20 Общество с ограниченной ответственностью "Инноград Пущино" Способ детекции аналита из раствора на частицах и устройство для его реализации
US9315853B2 (en) 2012-01-30 2016-04-19 Exact Sciences Corporation Modification of DNA on magnetic beads
CN103657548A (zh) * 2012-08-31 2014-03-26 艾博生物医药(杭州)有限公司 一种自动添加液体试剂的方法及设备
CN103805498B (zh) * 2013-08-23 2015-11-25 常州金麦格生物技术有限公司 抓取装置以及具有该抓取装置的提取生物活性物质的仪器
CN105219641B (zh) * 2014-05-27 2017-12-12 北京自由度科学机器有限公司 用于磁珠法的装置和方法
KR102323205B1 (ko) * 2014-08-22 2021-11-08 삼성전자주식회사 표적물질 분리장치 및 표적물질 분리방법
US9656267B2 (en) * 2015-09-17 2017-05-23 Nvigen, Inc. Magnetic rack
CN105527150B (zh) * 2015-12-10 2018-10-23 南京医科大学 一种高通量磁性萃取富集装置及富集方法
JP6258567B1 (ja) * 2016-05-26 2018-01-10 株式会社Ｉｆｇ 培養液中の細胞の非接触電気刺激装置と非接触電気刺激方法
LU93333B1 (en) * 2016-12-06 2018-06-08 Stratec Biomedical Ag Transfer Tool for use in automated analyser systems
DE202017001238U1 (de) * 2017-03-09 2017-05-05 Ritter Gmbh Kunststoff-Magnetseparationsplatte zur Durchführung automatischer Magnetseparationsprozesse
EP3605107A4 (de) * 2017-04-28 2020-12-30 Ezdia Tech Inc. Automatisierte immunoassay-vorrichtung und verfahren unter verwendung eines grossen magnetischen partikelkomplexes
KR102256776B1 (ko) 2018-07-26 2021-05-27 (주)바이오니아 자석봉 블록의 교체가 가능한 표적물질 추출장치
EP3938114B1 (de) 2019-03-15 2024-01-10 Siemens Healthcare Diagnostics Inc. Verfahren und vorrichtung zur manipulation magnetischer beads
JP2023505195A (ja) 2019-12-03 2023-02-08 アラマー バイオサイエンシーズ， インク． 核酸結合免疫サンドイッチアッセイ（ｎｕｌｉｓａ）
CN118591548A (zh) * 2022-01-17 2024-09-03 南京金斯瑞生物科技有限公司 纯化方法
GB2633685A (en) * 2023-07-20 2025-03-19 Plexbio Co Ltd Devices and systems for automated assays and uses thereof
WO2025042729A1 (en) 2023-08-18 2025-02-27 Life Technologies Corporation Cell preparation composition, system and method for single cell transcriptomics
WO2025126479A1 (ja) * 2023-12-15 2025-06-19 株式会社日立ハイテク 磁性粒子分離装置

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2471764A (en) * 1946-01-31 1949-05-31 Carl H Miller Magnetic hand pickup tool
US2683618A (en) 1950-12-11 1954-07-13 Louis Slovis Automatic pickup device
US2970002A (en) 1959-01-20 1961-01-31 Laviano Samuel Magnetic pickup
US3826619A (en) * 1971-12-21 1974-07-30 Abbott Lab Test apparatus for direct radioimmuno-assay for antigens and their antibodies
BE791340A (fr) * 1972-01-06 1973-03-01 Becton Dickinson Co Nouveaux procede et appareil de prelevement de culture et d'identification de micro-organismes des humeurs
US3985649A (en) * 1974-11-25 1976-10-12 Eddelman Roy T Ferromagnetic separation process and material
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4018886A (en) * 1975-07-01 1977-04-19 General Electric Company Diagnostic method and device employing protein-coated magnetic particles
US4272510A (en) * 1976-04-26 1981-06-09 Smith Kendall O Magnetic attraction transfer process for use in solid phase radioimmunoassays and in other assay methods
US4200613A (en) * 1977-06-03 1980-04-29 Ramco Laboratories Inc. Radioimmunoassay apparatus
US4197287A (en) 1977-06-10 1980-04-08 Ventrex Laboratories Inc. Method and apparatus for performing in nitro clinical diagnostic tests using a solid phase assay system having special utility for use with automatic pipetting equipment
GB1584129A (en) * 1977-06-10 1981-02-04 Nayak P Method and apparatus for performing in vitro clinical diagnostic tests using a solid phase assay system
US4225575A (en) 1978-05-15 1980-09-30 Ventrex Laboratories, Inc. Method and apparatus for performing in vitro clinical diagnostic tests using a solid phase assay system
US4115535A (en) * 1977-06-22 1978-09-19 General Electric Company Diagnostic method employing a mixture of normally separable protein-coated particles
US4378344A (en) * 1979-09-28 1983-03-29 Ventrex Laboratories, Inc. Method and apparatus for performing multiple, simultaneous in vitro diagnostic tests using a solid phase system
EP0030086B2 (de) * 1979-11-13 1990-03-14 TECHNICON INSTRUMENTS CORPORATION (a New York corporation) Vereinigung von Reaktionsbehältern, Teile für ihre Herstellung und manuelles Immunoassayverfahren
US4261815A (en) 1979-12-31 1981-04-14 Massachusetts Institute Of Technology Magnetic separator and method
WO1982000058A1 (en) * 1980-06-20 1982-01-07 Porter P Processes and apparatus for carrying out specific binding assays
JPS585656A (ja) * 1981-07-01 1983-01-13 Olympus Optical Co Ltd 粒子凝集判定装置
JPS585657A (ja) * 1981-07-01 1983-01-13 Toyo Jozo Co Ltd 免疫測定用エレメントおよびそれを用いた測定法
JPS585658A (ja) * 1981-07-02 1983-01-13 Japan Synthetic Rubber Co Ltd 免疫血清学的検査試薬用担体
GB2147698B (en) * 1981-11-17 1986-05-08 Unilever Plc Test apparatus for immunoassay
IL73187A0 (en) * 1983-10-11 1985-01-31 Lilly Co Eli Purification of esters of alkanoic acids
FR2554016B1 (fr) * 1983-10-27 1986-08-08 Pasteur Institut Perfectionnements apportes aux moyens magnetiques destines a retirer des billes de gel magnetique d'un fluide de dosage
FI842992A0 (fi) * 1984-07-26 1984-07-26 Labsystems Oy Immunologiskt definitionsfoerfarande.
US4681742A (en) * 1984-10-01 1987-07-21 Cetus Corporation Assay tray
FR2572178B1 (fr) * 1984-10-23 1988-10-28 Pasteur Institut Nouveau dispositif magnetique destine a retirer des billes de gel magnetique d'un milieu a analyser et a les transferer sur un milieu de dosage immunoenzymatique
US4839276A (en) * 1984-12-05 1989-06-13 Technicon Instruments Corporation Interference - resistant liposome specific binding assay
FI851702A0 (fi) * 1985-04-29 1985-04-29 Labsystems Oy Foerfarande och anordning foer utfoering immunobestaemningar.
SE8601143L (sv) * 1986-03-12 1987-09-13 Carbematrix Ab Sett och anordning for samling och spridning av ferromagnetiska partiklar i ett fluidformigt medium
JPS635263A (ja) * 1986-06-24 1988-01-11 Yasunobu Tsukioka 血液等の検査方法
JPS635266A (ja) * 1986-06-25 1988-01-11 Toshiba Corp 分析装置
JPS635265A (ja) * 1986-06-25 1988-01-11 Toshiba Corp 免疫分析方法
US4891321A (en) * 1987-10-21 1990-01-02 Hubscher Thomas T Apparatus for performing determinations of immune reactants in biological fluids
AU621316B2 (en) * 1987-11-16 1992-03-12 Gene-Trak Systems Magnetic separation device and methods for use in heterogeneous assays
US4895650A (en) * 1988-02-25 1990-01-23 Gen-Probe Incorporated Magnetic separation rack for diagnostic assays
DE68916843T2 (de) * 1988-04-26 1995-02-02 Nippon Telegraph & Telephone Mikropartikel, Verfahren und Gerät zur Sammlung von Proben zur Verwendung bei der Markierung von Immunreaktionen und Verfahren und Gerät zur Bereitung von Proben.
DE68919565T2 (de) * 1988-07-20 1995-06-29 Olympus Optical Co Immuntestverfahren unter Verwendung magnetischer Markerteilchen.
US5147529A (en) * 1988-08-10 1992-09-15 E. I. Du Pont De Nemours And Company Method for automatically processing magnetic solid phase reagents
US5167926A (en) * 1989-09-13 1992-12-01 Kabushiki Kaisha Tiyoda Seisakusho Apparatus for pretreating cells for flow cytometry
US5066390A (en) 1990-06-04 1991-11-19 Rhodes Keith J Magnetic separator with reciprocating grate
JPH0477225A (ja) 1990-07-18 1992-03-11 Nissei Plastics Ind Co 射出成形機
US5200084A (en) * 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
EP0479448A3 (en) * 1990-10-02 1992-12-23 Beckman Instruments, Inc. Magnetic separation device
US5466574A (en) * 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means
JPH0792459B2 (ja) * 1991-06-18 1995-10-09 オリンパス光学工業株式会社 免疫学的試験方法
FR2679660B1 (fr) * 1991-07-22 1993-11-12 Pasteur Diagnostics Procede et dispositif magnetique d'analyse immunologique sur phase solide.
FI922687A0 (fi) * 1992-06-10 1992-06-10 Labsystems Oy Avlaegsningsanordning.
FI932866A0 (fi) * 1993-06-21 1993-06-21 Labsystems Oy Separeringsfoerfarande
FI930440A0 (fi) * 1993-02-01 1993-02-01 Labsystems Oy Bestaemningsfoerfarande
EP1130397B1 (de) 1993-02-01 2006-10-11 Thermo Electron Oy Gerät zur Bestimmung eines Analyten in einer Probe
US5316151A (en) 1993-03-09 1994-05-31 The Boeing Company Magnetic particle separator
FI944939A0 (fi) * 1994-10-20 1994-10-20 Labsystems Oy Foerfarande foer separering av partiklar
FI944938A0 (fi) * 1994-10-20 1994-10-20 Labsystems Oy Foerflyttningsanordning
FI944937A0 (fi) * 1994-10-20 1994-10-20 Labsystems Oy Separeringsanordning
FI944940A0 (fi) * 1994-10-20 1994-10-20 Labsystems Oy Tvaofasigt separeringsfoerfarande

Also Published As

Publication number Publication date
EP1130397A2 (de) 2001-09-05
US6447729B1 (en) 2002-09-10
EP1130397A3 (de) 2004-01-14
NO953014L (no) 1995-10-02
NO318762B1 (no) 2005-05-02
DE69429159T2 (de) 2002-08-14
WO1994018565A1 (en) 1994-08-18
DE69434867T2 (de) 2007-05-16
EP1130397B1 (de) 2006-10-11
FI953669A7 (fi) 1995-08-01
JPH08506661A (ja) 1996-07-16
JP3142873B2 (ja) 2001-03-07
FI953669A0 (fi) 1995-08-01
DE1130397T1 (de) 2002-04-04
DE69434867D1 (de) 2006-11-23
EP0681700A1 (de) 1995-11-15
NO953014D0 (no) 1995-07-31
EP0681700B1 (de) 2001-11-21
US6040192A (en) 2000-03-21
FI953669L (fi) 1995-08-01

Similar Documents

Publication Publication Date Title
DE69429159D1 (de) Verfahren für einen spezifischen Bindungstest mit magnetischen Teilchen
DE69424856D1 (de) Steuerschaltung und verfahren für einen schwingspulenmotor
DE59509918D1 (de) Verfahren zum Empfangen von in einem Fernsehsignal übertragenen Daten
DE69517526D1 (de) Verfahren zum zusammenfügen von elastischen teilen
DE69121369D1 (de) Steuervorrichtung für einen sich selbständig bewegenden Körper und Verfahren zur Auswertung der Daten davon
DE69739969D1 (de) Verfahren zum verstecken von daten
DE69232876D1 (de) Ein verfahren zur identifikation von liganden und ligandantagonisten
DE69118244D1 (de) Spuradressenmuster für ein Magnetplattengerät
DE69019579D1 (de) Spulensystem für einen Kernspinresonazapparat zur Abbildung.
DE59410364D1 (de) Verfahren zur prüfung von elektronischen steuergeräten
DE59309320D1 (de) Verfahren und Schaltungsanordnung zum Prüfen einer Wertkarte
DE69407772D1 (de) Gerät und verfahren für ein verschiebbares dateiformat
DE69625894D1 (de) Verfahren zum verbinden von hohlplatten aus kunststoffharz
DE69425497D1 (de) Verfahren zum anreichern von löslichen ballaststoffen
DE68923372D1 (de) Verfahren zum zusammensetzen eines festen magnetplattengerätes.
DE59205115D1 (de) Verfahren zum aufzeichnen von informationen
DE69326072D1 (de) Verfahren zur Prüfung eines sequentiellen endlichen Automaten
DE59108996D1 (de) Verfahren zum auswerten binärer informationen einer magnetspeicherkarte
DE69430519D1 (de) Verfahren und Gerät für einen Dekoder mit reduzierter Iteration
DE69840021D1 (de) Verfahren zur erkennung von durch einen sternsensor aufgefundenen sternen in einem vorerzeugten verzeichnis
DE69032602D1 (de) Servoschaltungsanordnung für einen magnetischen Plattenspieler
DE69429562D1 (de) Ein Detektionssystem in einem Durchlauf für Bildbereiche, die von einer Markierung umschlossen sind und Verfahren für einen Photokopierer
DE69726824D1 (de) Verfahren zum Laden für einen Transponder
DE69117477D1 (de) Verfahren zur Servoregelung bei einem Magnetplattengerät
DE59507697D1 (de) Verfahren zur ermittlung von einstelldaten für einen schleuderdüngerstreuer

Legal Events

Date Code Title Description
8364 No opposition during term of opposition