DE69422064D1 - Verfahren zur Herstellung von optischaktiven 4-Halo-3-hydroxybuttersäure-Estern - Google Patents

Verfahren zur Herstellung von optischaktiven 4-Halo-3-hydroxybuttersäure-Estern

Info

Publication number: DE69422064D1
Authority: DE; Germany
Prior art keywords: halo; preparation; acid esters; optically active; hydroxybutyric acid
Prior art date: 1993-01-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69422064T

Other languages

English (en)

Other versions

DE69422064T2 (de

Inventor

Akinobu Matsuyama

Akira Tomita

Yoshinori Kobayashi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Daicel Corp

Original Assignee

Daicel Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-01-12

Filing date

1994-01-12

Publication date

2000-01-20

1994-01-12 Application filed by Daicel Chemical Industries Ltd filed Critical Daicel Chemical Industries Ltd

2000-01-20 Publication of DE69422064D1 publication Critical patent/DE69422064D1/de

2000-05-25 Application granted granted Critical

2000-05-25 Publication of DE69422064T2 publication Critical patent/DE69422064T2/de

2014-01-13 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DE69422064T 1993-01-12 1994-01-12 Verfahren zur Herstellung von optischaktiven 4-Halo-3-hydroxybuttersäure-Estern Expired - Fee Related DE69422064T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP00342293A JP3155107B2 (ja)	1993-01-12	1993-01-12	光学活性４−ハロ−３−ヒドロキシ酪酸エステルの製造方法

Publications (2)

Publication Number	Publication Date
DE69422064D1 true DE69422064D1 (de)	2000-01-20
DE69422064T2 DE69422064T2 (de)	2000-05-25

Family

ID=11556946

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69422064T Expired - Fee Related DE69422064T2 (de)	1993-01-12	1994-01-12	Verfahren zur Herstellung von optischaktiven 4-Halo-3-hydroxybuttersäure-Estern

Country Status (5)

Country	Link
US (1)	US5559030A (de)
EP (1)	EP0606899B1 (de)
JP (1)	JP3155107B2 (de)
CA (1)	CA2113240A1 (de)
DE (1)	DE69422064T2 (de)

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US5776766A (en) *	1995-05-29	1998-07-07	Daiso Co., Ltd.	Optical resolution of chlorohydrin with microorganism
US5891685A (en) *	1996-06-03	1999-04-06	Mitsubishi Chemical Corporation	Method for producing ester of (S)-γ-halogenated-β-hydroxybutyric acid
KR100506134B1 (ko)	1997-02-07	2005-08-08	카네카 코포레이션	신규한 카르보닐 환원효소 및 이것을 코딩하는 유전자 및 이러한 환원효소 및 유전자 이용방법
JPH11187869A (ja) *	1997-12-25	1999-07-13	Daicel Chem Ind Ltd	新規な４−ハロアセト酢酸エステル還元酵素、該酵素の製造方法、及び該酵素を利用したアルコールの製造方法
JP4012299B2 (ja) *	1998-02-25	2007-11-21	ダイセル化学工業株式会社	ハロゲン置換を含む光学活性アルコールの製造方法
JP2000189170A (ja) *	1998-05-08	2000-07-11	Daicel Chem Ind Ltd	光学活性４―ハロ―３―ヒドロキシ酪酸エステルの製造方法
KR100461561B1 (ko) *	1998-07-24	2005-04-06	삼성정밀화학 주식회사	(s)-3-카르복시-4-브로모부티르산의 제조방법
GB0011120D0 (en)	2000-05-09	2000-06-28	Avecia Ltd	Process
US6884607B2 (en) *	2000-12-07	2005-04-26	Sumitomo Chemical Company, Limited	Process for producing optically active 4-halo-3-hydroxybutanoate
US6910717B1 (en)	2001-11-28	2005-06-28	William Frederick Moyer	Outside-hinged cover for protecting articles stored therein and method for fabricating same
JP4578240B2 (ja) *	2002-08-09	2010-11-10	コデクシス，インコーポレイテッド	４−置換３−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス
EP1660669A4 (de) *	2003-08-11	2008-10-01	Codexis Inc	Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate und von mit vicinalem cyano, hydroxy substituierten carbonsäureestern
US7879585B2 (en) *	2006-10-02	2011-02-01	Codexis, Inc.	Ketoreductase enzymes and uses thereof
US20080314835A1 (en) *	2007-01-16	2008-12-25	Regina Valluzzi	Chiral separating agents with active support
CN101627116B (zh) *	2007-02-08	2013-07-10	科德克希思公司	酮还原酶及其用途
CN101784669B (zh)	2007-08-24	2015-02-18	科德克希思公司	用于(r)-3-羟基四氢噻吩的立体选择性制备的改善的酮还原酶多肽
WO2009036404A2 (en)	2007-09-13	2009-03-19	Codexis, Inc.	Ketoreductase polypeptides for the reduction of acetophenones
KR20100061571A (ko) *	2007-09-28	2010-06-07	코덱시스, 인코포레이티드	케토리덕타제 폴리펩티드 및 이의 용도
SI2205727T1 (sl)	2007-10-01	2015-09-30	Codexis, Inc.	Polipeptidi ketoreduktaze za izdelavo azetidinona
ES2560459T3 (es)	2008-08-27	2016-02-19	Codexis, Inc.	Polipéptidos cetorreductasa para la producción de una 3-aril-3-hidroxipropanamina a partir de una 3-aril-3-cetopropanamina
US8288131B2 (en)	2008-08-27	2012-10-16	Codexis, Inc.	Ketoreductase polypeptides and uses thereof
WO2010025287A2 (en)	2008-08-27	2010-03-04	Codexis, Inc.	Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8273554B2 (en)	2008-08-29	2012-09-25	Codexis, Inc.	Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
HUE055413T2 (hu)	2009-06-22	2021-11-29	Codexis Inc	Ketoreduktáz-közvetített sztereoszelektív útvonal alfa-klóralkoholokhoz
WO2011022548A2 (en)	2009-08-19	2011-02-24	Codexis, Inc.	Ketoreductase polypeptides for the preparation of phenylephrine
US9080192B2 (en)	2010-02-10	2015-07-14	Codexis, Inc.	Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
WO2011140219A1 (en)	2010-05-04	2011-11-10	Codexis, Inc.	Biocatalysts for ezetimibe synthesis
HUE046089T2 (hu)	2011-11-18	2020-01-28	Codexis Inc	Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításához
DE102012017026A1 (de)	2012-08-28	2014-03-06	Forschungszentrum Jülich GmbH	Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen
JP6330028B2 (ja)	2013-04-17	2018-05-23	カウンシルオブサイエンティフィックアンドインダストリアルリサーチ	ケトンのエナンチオ選択性還元のためのデザイナー細胞及びエナンチオ濃縮アルコールの効率的製造におけるその使用
US9133488B2 (en)	2013-12-30	2015-09-15	University Of Alaska Fairbanks	Synthetic methods and compounds related thereto
US10696953B2 (en)	2015-02-10	2020-06-30	Codexis, Inc.	Ketoreductase polypeptides for the synthesis of chiral compounds
JP6064011B1 (ja) *	2015-09-07	2017-01-18	志拓有限公司	衝撃防止機能を有する自在スパナ
CN117511890A (zh)	2017-04-27	2024-02-06	科德克希思公司	酮还原酶多肽及多核苷酸
WO2019087085A1 (en) *	2017-10-31	2019-05-09	Dr. Reddy's Laboratories Limited	Process for enantioselective enzymatic reduction of keto compounds
ES2975412T3 (es)	2018-06-21	2024-07-05	Fis Fabbrica Italiana Sintetici Spa	Proceso enzimático para la preparación de droxidopa
IL307250A (en)	2021-04-02	2023-11-01	Hoffmann La Roche	Processes for preparing bicyclic ketone compounds
WO2024150146A1 (en)	2023-01-12	2024-07-18	Novartis Ag	Engineered ketoreductase polypeptides

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US4642290A (en) *	1982-12-06	1987-02-10	Sih Charles J	Process for preparing a compound for use in the production of L-carnitine
IE56322B1 (en) *	1982-12-06	1991-06-19	Sigma Tau Ind Farmaceuti	Process for preparing l-carnitine and chemical intermediates employed therein
US4710468A (en) *	1983-10-24	1987-12-01	Sigma-Tau Industrie Pharmaceutiche Riunite S.P.A.	Process for preparing L-carnitine and chemical intermediates employed therein
JPS60251890A (ja) *	1984-05-30	1985-12-12	Nippon Synthetic Chem Ind Co Ltd:The	γ−ハロ−β−ヒドロキシ酪酸エステルの製造法
JPS61146191A (ja) *	1984-12-20	1986-07-03	Kanegafuchi Chem Ind Co Ltd	（Ｓ）−γ−ハロ−β−ヒドロキシ酪酸エステルの製造法
IT1184284B (it) *	1985-06-28	1987-10-22	Sigma Tau Ind Farmaceuti	Procedimento per la preparazione di r(-)-norcarnitina terz-butil estere
JPS62126997A (ja) *	1985-11-28	1987-06-09	Nippon Synthetic Chem Ind Co Ltd:The	光学活性のγ−ハロ−βヒドロキシ酪酸エステルの製造法
JPS63123387A (ja) *	1986-11-13	1988-05-27	Denki Kagaku Kogyo Kk	γ−ハロ−β−ヒドロキシ酪酸エステルの製造法
JP2566962B2 (ja) *	1987-06-11	1996-12-25	電気化学工業株式会社	γ−置換−β−ハイドロキシ酪酸エステルの製造法
JPH01277494A (ja) *	1988-04-28	1989-11-07	Agency Of Ind Science & Technol	光学活性アルコールの製造方法
US5413921A (en) *	1992-05-28	1995-05-09	Ajinomoto Co., Ltd.	Method of the production of (s)-gamma-halogenated-γ-hydroxybutyric acid esters
JP3163338B2 (ja) *	1992-05-28	2001-05-08	味の素株式会社	（Ｓ）−γ−ハロゲン化−β−ハイドロキシ酪酸エステルの製造方法

1993
- 1993-01-12 JP JP00342293A patent/JP3155107B2/ja not_active Expired - Fee Related
1994
- 1994-01-11 CA CA002113240A patent/CA2113240A1/en not_active Abandoned
- 1994-01-12 DE DE69422064T patent/DE69422064T2/de not_active Expired - Fee Related
- 1994-01-12 US US08/180,420 patent/US5559030A/en not_active Expired - Fee Related
- 1994-01-12 EP EP94100369A patent/EP0606899B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0606899A3 (de)	1995-07-05
EP0606899B1 (de)	1999-12-15
US5559030A (en)	1996-09-24
JP3155107B2 (ja)	2001-04-09
DE69422064T2 (de)	2000-05-25
EP0606899A2 (de)	1994-07-20
CA2113240A1 (en)	1994-07-13
JPH06209782A (ja)	1994-08-02

Publication	Publication Date	Title
DE69422064D1 (de)	2000-01-20	Verfahren zur Herstellung von optischaktiven 4-Halo-3-hydroxybuttersäure-Estern
DE69614174D1 (de)	2001-09-06	Verfahren zur Herstellung von optisch-aktiven Gamma-substituierte-Hydroxy-Buttersäure-Ester
DE59306546D1 (de)	1997-07-03	Verfahren zur Herstellung von omega-Formylalkancarbonsäureestern
DE69502300D1 (de)	1998-06-10	Verfahren zur Herstellung von 5-Formylvaleriansäureester
DE69426017D1 (de)	2000-11-02	Verfahren zur Herstellung von Arylestern
DE69528008D1 (de)	2002-10-10	Verfahren zur Herstellung von optisch-aktiven 4-Hydroxy-2-Ketoglutarsäuren
DE69500868D1 (de)	1997-11-20	Verfahren zur Herstellung von Carbonsäureestern
DE58907182D1 (de)	1994-04-14	Verfahren zur Herstellung von 6-Aminocapronsäureestern.
DE69121778D1 (de)	1996-10-10	Verfahren zur Herstellung von optisch aktiven alpha-Hydroxyestern
DE69428502D1 (de)	2001-11-08	Verfahren zur Herstellung von Saccharosefettsäureestern
DE69920568D1 (de)	2004-11-04	Verfahren zur Herstellung von optisch aktivem 4-Halo-3-hydroxybuttersäureester
DE59400025D1 (de)	1995-11-09	Verfahren zur Herstellung von 2-Alkyl-4-fluormethyl-thiazolcarbonsäure-alkylestern.
DE59404310D1 (de)	1997-11-20	Verfahren zur Herstellung von Alkoxy-carbonsäureestern
DE69321304D1 (de)	1998-11-05	Verfahren zur Herstellung von optisch aktivem 4-Methyl-2-oxetanon
DE59300921D1 (de)	1995-12-21	Verfahren zur Herstellung von beta-Hydroxycarbonsäureestern.
DE69512329D1 (de)	1999-10-28	Verfahren zur Herstellung von optisch aktiver Gamma-hydroxy-L-Glutaminsäure
DE59401489D1 (de)	1997-02-20	Verfahren zur Herstellung von 5-Cyanvaleriansäureestern
DE69715955D1 (de)	2002-11-07	Verfahren zur Herstellung von optisch-aktiven Aminopolycarbonsäuren
DE69410312D1 (de)	1998-06-25	Verfahren zur Herstellung von Poly-3-hydroxybuttersäure
DE59602149D1 (de)	1999-07-15	Verfahren zur Herstellung von 2-Fluor-isobuttersäure-alkylestern
DE69318666D1 (de)	1998-06-25	Verfahren zur Herstellung von optisch aktiven gamma-Hydroxyketonen
DE69410856D1 (de)	1998-07-16	Verfahren zur Herstellung von optisch aktiven Beta-hydroxy-ketonen
DE69409733D1 (de)	1998-05-28	Verfahren zur Herstellung optisch aktiven 2-Norbornanons
DE69304634D1 (de)	1996-10-17	Verfahren zur Herstellung von N,O-Dialkylhydroxycarbaminsäureestern
DE59705359D1 (de)	2001-12-20	Verfahren zur Herstellung von 2-Cyanoethyl-phosphinsäureestern

Legal Events

Date	Code	Title	Description
2001-01-04	8364	No opposition during term of opposition
2007-11-15	8339	Ceased/non-payment of the annual fee