DE69410419D1 - Quinolin-Carboxylsäurester von 21-Hydroxypregnan Derivaten und antibakterielle und entzüdungshemmende Präparate davon - Google Patents
Quinolin-Carboxylsäurester von 21-Hydroxypregnan Derivaten und antibakterielle und entzüdungshemmende Präparate davonInfo
- Publication number
- DE69410419D1 DE69410419D1 DE69410419T DE69410419T DE69410419D1 DE 69410419 D1 DE69410419 D1 DE 69410419D1 DE 69410419 T DE69410419 T DE 69410419T DE 69410419 T DE69410419 T DE 69410419T DE 69410419 D1 DE69410419 D1 DE 69410419D1
- Authority
- DE
- Germany
- Prior art keywords
- hydroxypregnan
- antibacterial
- derivatives
- carboxylic acid
- acid ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- DBMUNIJZUYVPCQ-XFNFOBRPSA-N pregnan-21-ol Chemical class C1CCC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)CCO)[C@@H]4[C@@H]3CCC21 DBMUNIJZUYVPCQ-XFNFOBRPSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical compound C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- XOQQVKDBGLYPGH-UHFFFAOYSA-N 2-oxo-1h-quinoline-3-carboxylic acid Chemical compound C1=CC=C2NC(=O)C(C(=O)O)=CC2=C1 XOQQVKDBGLYPGH-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- -1 steroid compound Chemical class 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32440593 | 1993-12-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69410419D1 true DE69410419D1 (de) | 1998-06-25 |
| DE69410419T2 DE69410419T2 (de) | 1998-09-17 |
Family
ID=18165437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69410419T Expired - Fee Related DE69410419T2 (de) | 1993-12-22 | 1994-12-20 | Quinolin-Carboxylsäurester von 21-Hydroxypregnan Derivaten und antibakterielle und entzüdungshemmende Präparate davon |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5599807A (de) |
| EP (1) | EP0659763B1 (de) |
| KR (1) | KR950018036A (de) |
| AT (1) | ATE166358T1 (de) |
| CA (1) | CA2136803A1 (de) |
| DE (1) | DE69410419T2 (de) |
| ES (1) | ES2115854T3 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2206891T3 (es) * | 1997-02-11 | 2004-05-16 | The Victoria University Of Manchester | Conjugados bioreductivos para el direccionamiento de medicamentos. |
| WO1999061055A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
| US6696592B2 (en) | 2001-05-22 | 2004-02-24 | Nicox-S.A. | Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof |
| GB0114672D0 (en) | 2001-06-15 | 2001-08-08 | Orthogenics As | Pharmaceutical formulations and methods of medical treatment |
| AU2003265576A1 (en) * | 2002-08-23 | 2004-03-11 | The Mclean Hospital Corporation | Corticosteroid conjugates and uses thereof |
| EP2671507A3 (de) | 2005-04-28 | 2014-02-19 | Proteus Digital Health, Inc. | Pharma-Informatiksystem |
| US9062126B2 (en) | 2005-09-16 | 2015-06-23 | Raptor Pharmaceuticals Inc. | Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof |
| PL3395372T3 (pl) | 2009-02-20 | 2022-07-25 | EnhanX Biopharm Inc. | Układ do dostarczania leków na bazie glutationu |
| MX2011011833A (es) | 2009-05-06 | 2012-01-27 | Lab Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de partículas de fosfato de calcio-agente activo y métodos para utilizar las mismas. |
| CU20110244A7 (es) | 2011-12-27 | 2013-08-29 | Ct De Investigación Y Desarrollo De Medicamentos Cidem | Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios |
| WO2014138350A1 (en) | 2013-03-08 | 2014-09-12 | Allergan, Inc. | Antibiotic conjugates directly linked with steroid drugs |
| WO2014138437A1 (en) | 2013-03-08 | 2014-09-12 | Allergan, Inc. | Steroid conjugates |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH421957A (de) * | 1962-03-23 | 1966-10-15 | Thomae Gmbh Dr K | Verfahren zur Herstellung von Steroidestern |
| JPS4925279A (de) * | 1972-06-29 | 1974-03-06 | ||
| IT1036870B (it) * | 1975-02-13 | 1979-10-30 | Acraf | Derivati steroidei dell acido bendazolico |
| GB1565680A (en) * | 1976-12-31 | 1980-04-23 | Leo Ab | Method for the preparation of carboxylic acid esters |
| US5382661A (en) * | 1985-09-12 | 1995-01-17 | The Upjohn Company | Pyrazinylpiperazinyl steroids |
| WO1990001933A1 (en) * | 1988-08-26 | 1990-03-08 | Alcon Laboratories, Inc. | Combination of quinolone antibiotics and steroids for topical ophthalmic use |
-
1994
- 1994-11-28 CA CA002136803A patent/CA2136803A1/en not_active Abandoned
- 1994-12-16 US US08/356,962 patent/US5599807A/en not_active Expired - Fee Related
- 1994-12-20 ES ES94120195T patent/ES2115854T3/es not_active Expired - Lifetime
- 1994-12-20 AT AT94120195T patent/ATE166358T1/de not_active IP Right Cessation
- 1994-12-20 EP EP94120195A patent/EP0659763B1/de not_active Expired - Lifetime
- 1994-12-20 DE DE69410419T patent/DE69410419T2/de not_active Expired - Fee Related
- 1994-12-21 KR KR1019940035684A patent/KR950018036A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES2115854T3 (es) | 1998-07-01 |
| US5599807A (en) | 1997-02-04 |
| DE69410419T2 (de) | 1998-09-17 |
| EP0659763A3 (de) | 1995-12-20 |
| ATE166358T1 (de) | 1998-06-15 |
| KR950018036A (ko) | 1995-07-22 |
| CA2136803A1 (en) | 1995-06-23 |
| EP0659763B1 (de) | 1998-05-20 |
| EP0659763A2 (de) | 1995-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |