DE69330949D1 - Gaba und l-glutaminsaüre analoga zur behandlung der epilepsie - Google Patents

Gaba und l-glutaminsaüre analoga zur behandlung der epilepsie

Info

Publication number: DE69330949D1
Authority: DE; Germany
Prior art keywords: treatment; gaba; epilepsy; compound; glutaminic acid
Prior art date: 1992-05-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69330949T

Other languages

English (en)

Other versions

DE69330949T2 (de

DE122004000039I1 (de

DE122004000039I2 (de

Inventor

Richard B Silverman

Ryszard Andruszkiewicz

Po-Wai Yuen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Northwestern University

Original Assignee

Northwestern University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-05-20

Filing date

1993-05-18

Publication date

2001-11-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25388336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69330949(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-05-18 Application filed by Northwestern University filed Critical Northwestern University

2001-11-22 Publication of DE69330949D1 publication Critical patent/DE69330949D1/de

2002-04-04 Application granted granted Critical

2002-04-04 Publication of DE69330949T2 publication Critical patent/DE69330949T2/de

2013-05-19 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Anesthesiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Steroid Compounds (AREA)

DE69330949T 1992-05-20 1993-05-18 Gaba und l-glutaminsaüre analoga zur behandlung der epilepsie Expired - Lifetime DE69330949T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US88608092A	1992-05-20	1992-05-20
PCT/US1993/004680 WO1993023383A1 (en)	1992-05-20	1993-05-18	Gaba and l-glutamic acid analogs for antiseizure treatment

Publications (2)

Publication Number	Publication Date
DE69330949D1 true DE69330949D1 (de)	2001-11-22
DE69330949T2 DE69330949T2 (de)	2002-04-04

Family

ID=25388336

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE1993630949 Active DE122004000039I2 (de)	1992-05-20	1993-05-18	Gaba und L-Glutaminsa}re analoga zur Behandlung der Epilepsie
DE69330949T Expired - Lifetime DE69330949T2 (de)	1992-05-20	1993-05-18	Gaba und l-glutaminsaüre analoga zur behandlung der epilepsie

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE1993630949 Active DE122004000039I2 (de)	1992-05-20	1993-05-18	Gaba und L-Glutaminsa}re analoga zur Behandlung der Epilepsie

Country Status (22)

Country	Link
EP (1)	EP0641330B1 (de)
JP (2)	JP3856816B2 (de)
KR (1)	KR950701625A (de)
AT (1)	ATE207052T1 (de)
AU (1)	AU677008B2 (de)
CA (1)	CA2134674C (de)
CZ (1)	CZ286106B6 (de)
DE (2)	DE122004000039I2 (de)
DK (1)	DK0641330T3 (de)
ES (1)	ES2165857T3 (de)
FI (1)	FI945426A0 (de)
HK (1)	HK1011022A1 (de)
HU (2)	HU222776B1 (de)
LU (1)	LU91112I2 (de)
NL (1)	NL300164I2 (de)
NO (1)	NO944370L (de)
NZ (1)	NZ253459A (de)
PT (1)	PT641330E (de)
RU (2)	RU2140901C1 (de)
SG (1)	SG48288A1 (de)
SK (1)	SK283281B6 (de)
WO (1)	WO1993023383A1 (de)

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1993
- 1993-05-18 RU RU96124481A patent/RU2140901C1/ru active
- 1993-05-18 DK DK93925173T patent/DK0641330T3/da active
- 1993-05-18 SG SG1996008718A patent/SG48288A1/en unknown
- 1993-05-18 PT PT93925173T patent/PT641330E/pt unknown
- 1993-05-18 DE DE1993630949 patent/DE122004000039I2/de active Active
- 1993-05-18 WO PCT/US1993/004680 patent/WO1993023383A1/en active IP Right Grant
- 1993-05-18 AU AU43794/93A patent/AU677008B2/en not_active Ceased
- 1993-05-18 DE DE69330949T patent/DE69330949T2/de not_active Expired - Lifetime
- 1993-05-18 JP JP50380794A patent/JP3856816B2/ja not_active Expired - Lifetime
- 1993-05-18 ES ES93925173T patent/ES2165857T3/es not_active Expired - Lifetime
- 1993-05-18 NZ NZ253459A patent/NZ253459A/en not_active IP Right Cessation
- 1993-05-18 HU HU9702482A patent/HU222776B1/hu active IP Right Grant
- 1993-05-18 KR KR1019940704158A patent/KR950701625A/ko not_active Withdrawn
- 1993-05-18 HU HU9403310A patent/HU222339B1/hu active Protection Beyond IP Right Term
- 1993-05-18 RU RU94046105/04A patent/RU94046105A/ru unknown
- 1993-05-18 CZ CZ19942849A patent/CZ286106B6/cs not_active IP Right Cessation
- 1993-05-18 AT AT93925173T patent/ATE207052T1/de active
- 1993-05-18 EP EP93925173A patent/EP0641330B1/de not_active Expired - Lifetime
- 1993-05-18 CA CA002134674A patent/CA2134674C/en not_active Expired - Lifetime
- 1993-05-18 SK SK1395-94A patent/SK283281B6/sk not_active IP Right Cessation
1994
- 1994-11-16 NO NO944370A patent/NO944370L/no unknown
- 1994-11-18 FI FI945426A patent/FI945426A0/fi not_active Application Discontinuation
1998
- 1998-11-17 HK HK98112078A patent/HK1011022A1/xx not_active IP Right Cessation
2004
- 2004-03-16 JP JP2004075406A patent/JP4297814B2/ja not_active Expired - Lifetime
- 2004-10-06 LU LU91112C patent/LU91112I2/fr unknown
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Also Published As

Publication number	Publication date
HU222776B1 (hu)	2003-10-28
KR950701625A (ko)	1995-04-28
FI945426L (fi)	1994-11-18
AU4379493A (en)	1993-12-13
SK139594A3 (en)	1995-05-10
NL300164I2 (nl)	2005-02-01
DE69330949T2 (de)	2002-04-04
DE122004000039I1 (de)	2006-05-18
LU91112I2 (fr)	2004-12-06
NL300164I1 (nl)	2005-01-03
FI945426A0 (fi)	1994-11-18
AU677008B2 (en)	1997-04-10
NZ253459A (en)	1997-03-24
JP2004238398A (ja)	2004-08-26
ES2165857T3 (es)	2002-04-01
HU222339B1 (hu)	2003-06-28
RU94046105A (ru)	1997-06-20
CA2134674A1 (en)	1993-11-25
JPH07508288A (ja)	1995-09-14
JP4297814B2 (ja)	2009-07-15
CA2134674C (en)	2004-12-21
NO944370L (no)	1994-11-21
HU9702482D0 (en)	1998-03-02
SK283281B6 (sk)	2003-05-02
RU2140901C1 (ru)	1999-11-10
CZ286106B6 (cs)	2000-01-12
DE122004000039I2 (de)	2006-06-29
HUT71522A (en)	1995-12-28
NO944370D0 (no)	1994-11-16
WO1993023383A1 (en)	1993-11-25
HK1011022A1 (en)	1999-07-02
PT641330E (pt)	2002-03-28
JP3856816B2 (ja)	2006-12-13
HU9403310D0 (en)	1995-02-28
CZ284994A3 (en)	1995-03-15
EP0641330A1 (de)	1995-03-08
EP0641330B1 (de)	2001-10-17
ATE207052T1 (de)	2001-11-15
SG48288A1 (en)	1998-04-17
EP0641330A4 (de)	1997-05-28
DK0641330T3 (da)	2001-12-03

Publication	Publication Date	Title
DE69330949D1 (de)	2001-11-22	Gaba und l-glutaminsaüre analoga zur behandlung der epilepsie
ATE139783T1 (de)	1996-07-15	Azasteroide zur behandlung prostatischer hypertrophie, ihre herstellung und verwendung
IL110216A0 (en)	1994-10-21	Valproic acid amide and 2-valproenoic acid amide derivatives, their preparation and pharmaceutical compositions containing them
DE69711391D1 (de)	2002-05-02	Verbessertes verfahren zum herstellen von geschützten 3,4-dihydroxybuttersäure estern
PT91145A (pt)	1990-02-08	Processo para a sintese de amino-acidos opticamente activos
DE69327092D1 (de)	1999-12-30	Optisch aktives 1-phenylpyrrolidonderivat und dessen herstellung
MX9302970A (es)	1994-05-31	Analogos de acido l-glutamico y gaba para tratamiento anti-ataque.
MY101827A (en)	1992-01-31	2-[n-substitutedguanidino]-4-heteroarylthiazole antiulcer agents