DE69328540D1 - Diaryl 5,6-kondensierte heterozyklische Säuren als Leukotrienantagonisten - Google Patents

Diaryl 5,6-kondensierte heterozyklische Säuren als Leukotrienantagonisten

Info

Publication number: DE69328540D1
Authority: DE; Germany
Prior art keywords: diaryl; condensed heterocyclic; leukotriene antagonists; heterocyclic acids; compounds
Prior art date: 1992-12-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69328540T

Other languages

English (en)

Other versions

DE69328540T2 (de

Inventor

Robert N Young

Yi Bin Xiang

Marc Labelle

Cheuk K Lau

Yves Leblanc

Claude Dufresne

Yves Gareau

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Canada Inc

Original Assignee

Merck Frosst Canada and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-22

Filing date

1993-12-15

Publication date

2000-06-08

1993-12-15 Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co

2000-06-08 Publication of DE69328540D1 publication Critical patent/DE69328540D1/de

2001-01-04 Application granted granted Critical

2001-01-04 Publication of DE69328540T2 publication Critical patent/DE69328540T2/de

2013-12-16 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Pulmonology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE69328540T 1992-12-22 1993-12-15 Diaryl 5,6-kondensierte heterozyklische Säuren als Leukotrienantagonisten Expired - Fee Related DE69328540T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US99486992A	1992-12-22	1992-12-22

Publications (2)

Publication Number	Publication Date
DE69328540D1 true DE69328540D1 (de)	2000-06-08
DE69328540T2 DE69328540T2 (de)	2001-01-04

Family

ID=25541163

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69328540T Expired - Fee Related DE69328540T2 (de)	1992-12-22	1993-12-15	Diaryl 5,6-kondensierte heterozyklische Säuren als Leukotrienantagonisten

Country Status (23)

Country	Link
EP (1)	EP0604114B1 (de)
KR (1)	KR100310552B1 (de)
CN (1)	CN1040213C (de)
AT (1)	ATE192448T1 (de)
AU (1)	AU672837B2 (de)
CA (1)	CA2111372C (de)
CZ (1)	CZ290829B6 (de)
DE (1)	DE69328540T2 (de)
DK (1)	DK0604114T3 (de)
ES (1)	ES2145765T3 (de)
FI (1)	FI111368B (de)
GR (1)	GR3033985T3 (de)
HU (1)	HU222274B1 (de)
IL (1)	IL108050A (de)
MX (1)	MX9400022A (de)
NO (1)	NO313831B1 (de)
NZ (1)	NZ258835A (de)
PL (1)	PL177967B1 (de)
PT (1)	PT604114E (de)
RU (1)	RU2154065C2 (de)
SK (1)	SK282409B6 (de)
WO (1)	WO1994014815A1 (de)
ZA (1)	ZA939560B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5472964A (en) *	1992-12-22	1995-12-05	Merck Frosst Canada, Inc.	Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists
US5350760A (en) *	1993-08-04	1994-09-27	Merck Frosst Canada, Inc.	Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
TW416948B (en) *	1993-12-28	2001-01-01	Merck & Co Inc	Process for the preparation of leukotriene antagonists
US5491077A (en) *	1994-07-20	1996-02-13	Merck & Co., Inc.	Microbial method
US5427933A (en) *	1994-07-20	1995-06-27	Merck & Co., Inc.	Reduction of phenylalkyl ketones to the corresponding (S)-hydroxy derivatives using mucor hiemalis IFO 5834
US5523477A (en) *	1995-01-23	1996-06-04	Merck & Co., Inc.	Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
US5750539A (en) *	1995-06-07	1998-05-12	Merck Frosst Canada	Heteroaryl diol acids as leukotriene antagonists
RU2196772C1 (ru) *	2001-10-08	2003-01-20	Кубанский государственный технологический университет	6-МЕТИЛ-8-МЕТОКСИМЕТИЛ-3-ФЕНИЛИЗОКСАЗОЛО[3',4':4,5]ТИЕНО-[2,3-b]ПИРИДИН, ПРОЯВЛЯЮЩИЙ РОСТОРЕГУЛИРУЮЩУЮ И АНТИСТРЕССОВУЮ АКТИВНОСТЬ
BR0302902A (pt) *	2002-02-06	2004-07-06	Delmar Chemicals Inc	Processo para a preparação de ácido 1- (mercaptometil) - ciclopropanoacético
US7271268B1 (en)	2006-12-22	2007-09-18	Formosa Laboratories Inc.	Process for preparation of [1-(mercaptomethyl)cyclopropyl]acetic acid and related derivatives
RU2449807C2 (ru) *	2009-11-16	2012-05-10	Государственное образовательное учреждение высшего профессионального образования "Дагестанская государственная медицинская академия федерального агентства по здравоохранению и социальному развитию"	Способ лечения эндотоксикоза при хроническом пиелонефрите

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1984001576A1 (en) *	1982-10-07	1984-04-26	Takeda Chemical Industries Ltd	Fused pyrrolinone derivatives
US4957932A (en) *	1987-11-25	1990-09-18	Merck Frosst Canada, Inc.	Benzoheterazoles
EP0480716A1 (de) *	1990-10-12	1992-04-15	Merck Frosst Canada Inc.	Gesättigte Hydroxyalkylchinolinsäuren zur Verwendung als Leukotrien-Antagonisten
DE69129257T2 (de) *	1990-10-12	1998-11-05	Merck Frosst Canada Inc., Kirkland, Quebec	Ungesättigte Hydroxyalkylchinolinsäuren als Leukotrien-Antagonisten
US5308850A (en) *	1991-09-30	1994-05-03	Merck Frosst Canada, Inc.	(Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis

1993
- 1993-12-14 CA CA002111372A patent/CA2111372C/en not_active Expired - Fee Related
- 1993-12-15 DE DE69328540T patent/DE69328540T2/de not_active Expired - Fee Related
- 1993-12-15 WO PCT/CA1993/000541 patent/WO1994014815A1/en active IP Right Grant
- 1993-12-15 NZ NZ258835A patent/NZ258835A/en unknown
- 1993-12-15 DK DK93310127T patent/DK0604114T3/da active
- 1993-12-15 RU RU95113598/04A patent/RU2154065C2/ru not_active IP Right Cessation
- 1993-12-15 CZ CZ19951653A patent/CZ290829B6/cs not_active IP Right Cessation
- 1993-12-15 HU HU9501842A patent/HU222274B1/hu not_active IP Right Cessation
- 1993-12-15 SK SK822-95A patent/SK282409B6/sk unknown
- 1993-12-15 PT PT93310127T patent/PT604114E/pt unknown
- 1993-12-15 EP EP93310127A patent/EP0604114B1/de not_active Expired - Lifetime
- 1993-12-15 PL PL93309408A patent/PL177967B1/pl unknown
- 1993-12-15 KR KR1019950702546A patent/KR100310552B1/ko not_active Expired - Fee Related
- 1993-12-15 AT AT93310127T patent/ATE192448T1/de not_active IP Right Cessation
- 1993-12-15 ES ES93310127T patent/ES2145765T3/es not_active Expired - Lifetime
- 1993-12-16 IL IL108050A patent/IL108050A/en active IP Right Grant
- 1993-12-21 ZA ZA939560A patent/ZA939560B/xx unknown
- 1993-12-21 CN CN93119928A patent/CN1040213C/zh not_active Expired - Fee Related
- 1993-12-21 AU AU52579/93A patent/AU672837B2/en not_active Ceased
1994
- 1994-01-03 MX MX9400022A patent/MX9400022A/es not_active IP Right Cessation
1995
- 1995-06-21 NO NO19952495A patent/NO313831B1/no unknown
- 1995-06-21 FI FI953104A patent/FI111368B/fi active
2000
- 2000-07-19 GR GR20000401670T patent/GR3033985T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1994014815A1 (en)	1994-07-07
ES2145765T3 (es)	2000-07-16
NZ258835A (en)	1997-06-24
ATE192448T1 (de)	2000-05-15
CA2111372A1 (en)	1994-06-23
DK0604114T3 (da)	2000-08-07
HUT71810A (en)	1996-02-28
IL108050A (en)	1998-06-15
NO952495D0 (no)	1995-06-21
PL177967B1 (pl)	2000-02-29
FI953104L (fi)	1995-06-21
AU5257993A (en)	1994-07-07
RU95113598A (ru)	1997-06-10
CN1040213C (zh)	1998-10-14
SK82295A3 (en)	1995-12-06
HU222274B1 (hu)	2003-05-28
GR3033985T3 (en)	2000-11-30
CA2111372C (en)	2007-01-16
KR100310552B1 (ko)	2001-12-17
FI953104A0 (fi)	1995-06-21
PT604114E (pt)	2000-09-29
IL108050A0 (en)	1994-04-12
HU9501842D0 (en)	1995-08-28
FI111368B (fi)	2003-07-15
NO952495L (no)	1995-08-22
CZ290829B6 (cs)	2002-10-16
RU2154065C2 (ru)	2000-08-10
CN1094051A (zh)	1994-10-26
SK282409B6 (sk)	2002-01-07
ZA939560B (en)	1994-08-11
MX9400022A (es)	1995-01-31
AU672837B2 (en)	1996-10-17
EP0604114B1 (de)	2000-05-03
PL309408A1 (en)	1995-10-02
KR950704325A (ko)	1995-11-17
EP0604114A1 (de)	1994-06-29
CZ165395A3 (en)	1996-01-17
NO313831B1 (no)	2002-12-09
DE69328540T2 (de)	2001-01-04

Publication	Publication Date	Title
ATE165088T1 (de)	1998-05-15	Ungesättigte hydroxyalkylchinolinsäuren als leukotrien-antagonisten
DE69319482D1 (de)	1998-08-13	Chinolinderivate als Leukotrien-Antagoniste
FI920734A0 (fi)	1992-02-20	Ketosyror innehaollande kinoliner med leukotrienantagonisteffekt.
DE69328540D1 (de)	2000-06-08	Diaryl 5,6-kondensierte heterozyklische Säuren als Leukotrienantagonisten
NO914003D0 (no)	1991-10-11	Fremgangsmaate for fremstilling av hydroxyalkylkinolinethersyrer
DE69833429D1 (de)	2006-04-20	Chinolin-leukotrien-antagonisten

Legal Events

Date	Code	Title	Description
2001-05-31	8364	No opposition during term of opposition
2006-06-29	8327	Change in the person/name/address of the patent owner	Owner name: MERCK FROSST CANADA LTD., KIRKLAND, QUEBEC, CA
2008-10-16	8339	Ceased/non-payment of the annual fee