DE69231495D1 - Neue cocain-derivate und protein- und polypeptid-cocain-derivate, konjugate und markierte verbindungen - Google Patents
Neue cocain-derivate und protein- und polypeptid-cocain-derivate, konjugate und markierte verbindungenInfo
- Publication number
- DE69231495D1 DE69231495D1 DE69231495T DE69231495T DE69231495D1 DE 69231495 D1 DE69231495 D1 DE 69231495D1 DE 69231495 T DE69231495 T DE 69231495T DE 69231495 T DE69231495 T DE 69231495T DE 69231495 D1 DE69231495 D1 DE 69231495D1
- Authority
- DE
- Germany
- Prior art keywords
- derivatives
- cocain
- polypeptid
- conjugates
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/946—CNS-stimulants, e.g. cocaine, amphetamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/808,515 US5233042A (en) | 1991-12-16 | 1991-12-16 | Cocaine derivatives |
PCT/US1992/010857 WO1993012111A1 (en) | 1991-12-16 | 1992-12-16 | Novel cocaine derivatives and protein and polypeptide cocaine derivative conjugates and labels |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69231495D1 true DE69231495D1 (de) | 2000-11-09 |
DE69231495T2 DE69231495T2 (de) | 2001-05-31 |
Family
ID=25199002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69231495T Expired - Lifetime DE69231495T2 (de) | 1991-12-16 | 1992-12-16 | Neue cocain-derivate und protein- und polypeptid-cocain-derivate, konjugate und markierte verbindungen |
Country Status (7)
Country | Link |
---|---|
US (1) | US5233042A (de) |
EP (1) | EP0575581B1 (de) |
AT (1) | ATE196767T1 (de) |
AU (1) | AU3322093A (de) |
CA (1) | CA2106563C (de) |
DE (1) | DE69231495T2 (de) |
WO (1) | WO1993012111A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6037455A (en) * | 1992-11-09 | 2000-03-14 | Biosite Diagnostics Incorporated | Propoxyphene derivatives and protein and polypeptide propoxyphene derivative conjugates and labels |
EP0613899B1 (de) * | 1993-03-04 | 2003-01-15 | Matsushita Electric Industrial Co., Ltd. | Kokainderivat,Proteinkonjugat,davon,einen monoklonalen Antikörper produzierende Hybridom-Zellinie, Verfahren zur Herstellung der Hybridom-Zellinie und des monoklonalen Antikörpers |
US5283344A (en) * | 1993-03-10 | 1994-02-01 | Abbott Laboratories | Coupling method using selective amination of maleimide |
DK0814843T3 (da) * | 1995-03-31 | 2004-03-29 | Xenova Res Ltd | Haptenbærerkonjugater til anvendelse i behandling af stofmisbrug |
US5773003A (en) * | 1995-03-31 | 1998-06-30 | Immulogic, Inc. | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
CA2239058A1 (en) | 1995-12-14 | 1997-06-19 | Peter Wirsching | Anti-cocaine vaccine |
US5808074A (en) * | 1996-02-02 | 1998-09-15 | Georgetown University | Benzoylecgonine conjugate diagnostic reagents |
US5817770A (en) * | 1997-03-21 | 1998-10-06 | Drug Abuse Sciences, Inc. | Cocaethylene immunogens and antibodies |
US7297554B2 (en) * | 1998-11-18 | 2007-11-20 | Microdiagnostics, Inc. | Immunoassay system |
US6232082B1 (en) | 1998-12-01 | 2001-05-15 | Nabi | Hapten-carrier conjugates for treating and preventing nicotine addiction |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4045420A (en) * | 1973-05-29 | 1977-08-30 | Syva Company | Non-oxo-carbonyl containing benzoyl ecgonine and cocaine compounds polypeptide and derivatives thereof |
US3888866A (en) * | 1973-06-01 | 1975-06-10 | Syva Co | Nitrogen derivatives of benzoyl ecgonine |
US3917582A (en) * | 1973-06-13 | 1975-11-04 | Syva Corp | Isothiocyanate and thiourea derivatives of benzoyl ecgonine conjugated to polypeptides |
US4102979A (en) * | 1976-09-22 | 1978-07-25 | Hoffmann-La Roche Inc. | Radioimmunoassay for benzoylecgonine |
US5155212A (en) * | 1986-05-21 | 1992-10-13 | Abbott Laboratories | Phencyclidine and phencyclidine metabolites assay, tracers, immunogens, antibodies and reagent kit |
US5238652A (en) * | 1990-06-20 | 1993-08-24 | Drug Screening Systems, Inc. | Analytical test devices for competition assay for drugs of non-protein antigens using immunochromatographic techniques |
DE69119312T2 (de) * | 1990-07-18 | 1997-01-16 | Abbott Lab | Analyt-Austauschreagenz zur Verwendung in spezifischen Bindungstests, -vorrichtungen und -sätzen |
US5143852A (en) * | 1990-09-14 | 1992-09-01 | Biosite Diagnostics, Inc. | Antibodies to ligand analogues and their utility in ligand-receptor assays |
-
1991
- 1991-12-16 US US07/808,515 patent/US5233042A/en not_active Expired - Lifetime
-
1992
- 1992-12-16 CA CA002106563A patent/CA2106563C/en not_active Expired - Fee Related
- 1992-12-16 DE DE69231495T patent/DE69231495T2/de not_active Expired - Lifetime
- 1992-12-16 EP EP93901270A patent/EP0575581B1/de not_active Expired - Lifetime
- 1992-12-16 AU AU33220/93A patent/AU3322093A/en not_active Abandoned
- 1992-12-16 AT AT93901270T patent/ATE196767T1/de not_active IP Right Cessation
- 1992-12-16 WO PCT/US1992/010857 patent/WO1993012111A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP0575581A1 (de) | 1993-12-29 |
AU3322093A (en) | 1993-07-19 |
CA2106563C (en) | 1997-11-25 |
WO1993012111A1 (en) | 1993-06-24 |
ATE196767T1 (de) | 2000-10-15 |
US5233042A (en) | 1993-08-03 |
EP0575581B1 (de) | 2000-10-04 |
DE69231495T2 (de) | 2001-05-31 |
CA2106563A1 (en) | 1993-06-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
R071 | Expiry of right |
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