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DE69219337D1 - Verbesserungen an kontrastmitteln - Google Patents

Verbesserungen an kontrastmitteln

Info

Publication number
DE69219337D1
DE69219337D1 DE69219337T DE69219337T DE69219337D1 DE 69219337 D1 DE69219337 D1 DE 69219337D1 DE 69219337 T DE69219337 T DE 69219337T DE 69219337 T DE69219337 T DE 69219337T DE 69219337 D1 DE69219337 D1 DE 69219337D1
Authority
DE
Germany
Prior art keywords
pct
contrast agents
sec
date
pub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69219337T
Other languages
English (en)
Other versions
DE69219337T2 (de
Inventor
Arne Berg
Jo Klaveness
Per Strande
Lars Stubberud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26299192&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69219337(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB919114565A external-priority patent/GB9114565D0/en
Priority claimed from GB929200386A external-priority patent/GB9200386D0/en
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Application granted granted Critical
Publication of DE69219337D1 publication Critical patent/DE69219337D1/de
Publication of DE69219337T2 publication Critical patent/DE69219337T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69219337T 1991-07-05 1992-07-03 Verbesserungen an kontrastmitteln Expired - Fee Related DE69219337T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919114565A GB9114565D0 (en) 1991-07-05 1991-07-05 Improvements in or relating to contrast agents
GB929200386A GB9200386D0 (en) 1992-01-09 1992-01-09 Improvements in or relating to contrast agents
PCT/EP1992/001477 WO1993000930A1 (en) 1991-07-05 1992-07-03 Improvements in or relating to contrast agents

Publications (2)

Publication Number Publication Date
DE69219337D1 true DE69219337D1 (de) 1997-05-28
DE69219337T2 DE69219337T2 (de) 1997-10-09

Family

ID=26299192

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69219337T Expired - Fee Related DE69219337T2 (de) 1991-07-05 1992-07-03 Verbesserungen an kontrastmitteln

Country Status (15)

Country Link
US (2) US5607661A (de)
EP (1) EP0593624B1 (de)
JP (1) JPH06510758A (de)
AT (1) ATE151993T1 (de)
AU (1) AU675050B2 (de)
CA (1) CA2112109A1 (de)
DE (1) DE69219337T2 (de)
DK (1) DK0593624T3 (de)
ES (1) ES2103376T3 (de)
FI (1) FI940027L (de)
GR (1) GR3023394T3 (de)
HK (1) HK1006945A1 (de)
IE (1) IE80926B1 (de)
NO (1) NO940015D0 (de)
WO (1) WO1993000930A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
ES2145011T5 (es) * 1991-09-17 2008-02-01 Ge Healthcare As Medios de contraste gaseoso para ecografias.
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
EP0680341B1 (de) * 1993-01-25 2001-05-09 Sonus Pharmaceuticals, Inc. Phase-Stift Kolloide zur Verwendung als Ultraschallkontrastmittel
DE69434119T3 (de) 1993-07-30 2011-05-05 Imcor Pharmaceutical Co., San Diego Stabilisierte mikrogasbläschen-zusammensetzungen für echographie
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US5897851A (en) * 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
DE19602930A1 (de) * 1996-01-18 1997-07-24 Schering Ag Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
AU721209B2 (en) * 1996-03-05 2000-06-29 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
GB9622711D0 (en) * 1996-10-31 1997-01-08 British Tech Group Instrument having enhanced ultrasound visibility
US6054118A (en) * 1997-01-22 2000-04-25 Nycomed Imaging As Contrast agents comprising two types of gas-containing microparticles
US20010003580A1 (en) * 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
AU2683899A (en) * 1998-02-19 1999-09-06 University Of Virginia Patent Foundation The use of bjerknes forces to manipulate contrast agents
JP5078212B2 (ja) 2000-06-02 2012-11-21 ブラッコ・スイス・ソシエテ・アノニム 内皮細胞を標的とするための化合物、それを含む組成物およびその使用方法
DE60223239T2 (de) * 2001-04-06 2008-08-14 Bracco Research S.A. Vorrichtung zur Messung lokaler physikalischer Parameter in einem flüssigkeitsgefüllten Hohlraum
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
CA2513044A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
AU2003213730A1 (en) 2002-03-01 2003-09-16 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
AU2004217894B2 (en) 2003-03-03 2010-07-15 Bracco International B.V. Peptides that specifically bind HGF receptor (cMet) and uses thereof
SE526838C2 (sv) * 2003-11-27 2005-11-08 Xcounter Ab Undersökningsmetod och anordning för detektion av joniserande strålning
US20050255175A1 (en) * 2004-05-17 2005-11-17 Burgess W P Method for protecting nephron against injury caused by disruption of a chemical environment in the kidneys
US7019035B2 (en) * 2004-05-17 2006-03-28 Md Scientific Llc Method for attenuating free radical formation resulting from bodily insult
US20050255176A1 (en) * 2004-05-17 2005-11-17 Burgess W P Method for attenuating free radical formation resulting from bodily insult
US7625586B2 (en) 2004-10-28 2009-12-01 Md Scientific, Llc Method for mitigating injury to a kidney resulting from an ischemic event
US7999134B2 (en) * 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using milling
US9827265B1 (en) 2012-04-06 2017-11-28 Md Scientific, Llc Method for attenuating free radical formation resulting from a bodily insult
AU2015308790B2 (en) 2014-08-28 2020-12-03 The General Hospital Corporation Compositions and methods for treatment of neurological disorders
US11504322B2 (en) 2014-08-28 2022-11-22 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
US11471401B2 (en) 2014-08-28 2022-10-18 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
WO2017147367A1 (en) 2016-02-26 2017-08-31 The General Hospital Corporation Medical ice slurry production and delivery systems and methods
JP7211699B2 (ja) * 2017-09-11 2023-01-24 バイエル ファーマ アクチエンゲゼルシャフト 超音波診断用造影剤
US11241330B1 (en) 2021-04-02 2022-02-08 Brixton Biosciences, Inc. Apparatus for creation of injectable slurry

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2680133A (en) * 1951-08-24 1954-06-01 Mallinckrodt Chemical Works Iodine-containing amino-benzoyl derivatives of amino acids
DE2629228C2 (de) * 1976-06-25 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
CA1170569A (en) * 1980-11-17 1984-07-10 Julia S. Rasor Microbubble precursors and methods for their production and use
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
DE3313946A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
DE3834705A1 (de) * 1988-10-07 1990-04-12 Schering Ag Ultraschallkontrastmittel aus gasblaeschen und fettsaeure enthaltenden mikropartikeln
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
US5354549A (en) * 1987-07-24 1994-10-11 Nycomed Imaging As Iodinated esters
DE3828905A1 (de) * 1988-08-23 1990-03-15 Schering Ag Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel
GB8900376D0 (en) * 1989-01-09 1989-03-08 Nycomed As Iodinated esters
US5215680A (en) * 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
US5205290A (en) * 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5233995A (en) * 1991-11-21 1993-08-10 Sterling Winthrop Inc. Encapsulated particles useful as contrast agents in ultrasound and x-ray imaging compositions and methods

Also Published As

Publication number Publication date
US5772984A (en) 1998-06-30
EP0593624A1 (de) 1994-04-27
DK0593624T3 (da) 1997-05-20
CA2112109A1 (en) 1993-01-21
IE922179A1 (en) 1993-01-13
GR3023394T3 (en) 1997-08-29
FI940027A0 (fi) 1994-01-04
DE69219337T2 (de) 1997-10-09
US5607661A (en) 1997-03-04
ATE151993T1 (de) 1997-05-15
AU675050B2 (en) 1997-01-23
FI940027L (fi) 1994-01-04
ES2103376T3 (es) 1997-09-16
EP0593624B1 (de) 1997-04-23
IE80926B1 (en) 1999-06-30
NO940015L (no) 1994-01-04
NO940015D0 (no) 1994-01-04
JPH06510758A (ja) 1994-12-01
AU2277292A (en) 1993-02-11
HK1006945A1 (en) 1999-03-26
WO1993000930A1 (en) 1993-01-21

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8339 Ceased/non-payment of the annual fee