[go: up one dir, main page]

DE69202166D1 - Verwendung von Tetrahydrothienopyridinderivate als Angiogenese-Inhibitoren. - Google Patents

Verwendung von Tetrahydrothienopyridinderivate als Angiogenese-Inhibitoren.

Info

Publication number
DE69202166D1
DE69202166D1 DE69202166T DE69202166T DE69202166D1 DE 69202166 D1 DE69202166 D1 DE 69202166D1 DE 69202166 T DE69202166 T DE 69202166T DE 69202166 T DE69202166 T DE 69202166T DE 69202166 D1 DE69202166 D1 DE 69202166D1
Authority
DE
Germany
Prior art keywords
equals
optionally substituted
angiogenesis inhibitors
substituted alkyl
tetrahydrothienopyridine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69202166T
Other languages
English (en)
Other versions
DE69202166T2 (de
Inventor
Jean-Pierre Cazenave
Jean-Marc Herbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of DE69202166D1 publication Critical patent/DE69202166D1/de
Application granted granted Critical
Publication of DE69202166T2 publication Critical patent/DE69202166T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69202166T 1991-02-14 1992-02-13 Verwendung von Tetrahydrothienopyridinderivate als Angiogenese-Inhibitoren. Expired - Lifetime DE69202166T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9101783A FR2672801B1 (fr) 1991-02-14 1991-02-14 Utilisation de derives de tetrahydrothienopyridine comme inhibiteurs de l'angiogenese.

Publications (2)

Publication Number Publication Date
DE69202166D1 true DE69202166D1 (de) 1995-06-01
DE69202166T2 DE69202166T2 (de) 1995-11-09

Family

ID=9409732

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69202166T Expired - Lifetime DE69202166T2 (de) 1991-02-14 1992-02-13 Verwendung von Tetrahydrothienopyridinderivate als Angiogenese-Inhibitoren.

Country Status (8)

Country Link
US (1) US5225420A (de)
EP (1) EP0499544B1 (de)
JP (1) JPH072668A (de)
AT (1) ATE121621T1 (de)
CA (1) CA2061173A1 (de)
DE (1) DE69202166T2 (de)
DK (1) DK0499544T3 (de)
FR (1) FR2672801B1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
WO1998005293A2 (en) * 1996-08-02 1998-02-12 The Children's Medical Center Corporation Method of regulating the female reproductive system through angiogenesis inhibitors
WO1998014169A1 (en) * 1996-09-30 1998-04-09 Brigham & Women's Hospital Methods and compounds for treatment of abnormal uterine bleeding
DE69926750T2 (de) 1998-06-17 2006-06-29 Bristol-Myers Squibb Co. Vorbeugung des hirninfarkts durch kombinierte verabreichung von adp-rezeptor antiblutplättchen und antihypertensiven medikamenten
CA2457459A1 (en) * 2004-02-11 2005-08-11 Brantford Chemicals Inc. Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate
CN101591346B (zh) * 2009-07-03 2014-10-29 北京华禧联合科技发展有限公司 硫酸氢氯吡格雷有关物质b的合成方法
CN101585842B (zh) * 2009-07-13 2011-07-20 北京赛科药业有限责任公司 氯吡格雷中杂质b的研究及控制方法
CN101863901B (zh) * 2010-06-29 2012-12-05 天津药物研究院 2-(取代苯基)-2-(4,5,6,7-四氢噻吩并[3,2-c]吡啶-5(4H)-基)-N-取代-乙酰胺、其制备方法和用途
CN101967154B (zh) * 2010-10-11 2011-12-28 天津药物研究院 肟类化合物、其制备方法和用途
CN101974016A (zh) * 2010-10-14 2011-02-16 天津药物研究院 酰胺类化合物及其制备方法和用途
CN101962388B (zh) * 2010-10-14 2012-12-19 天津药物研究院 乙酰胺衍生物及其制备方法和用途
CN102329327B (zh) * 2011-10-20 2014-04-09 天津药物研究院 呋喃衍生物、其制备方法和用途
CN103694250B (zh) * 2012-09-28 2016-02-10 武汉启瑞药业有限公司 噻吩吡啶类衍生物及其制备方法和医药用途
CN103694252A (zh) * 2014-01-14 2014-04-02 中国药科大学 一种噻吩并吡啶类化合物及其抗血小板聚集活性

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant

Also Published As

Publication number Publication date
JPH072668A (ja) 1995-01-06
EP0499544B1 (de) 1995-04-26
FR2672801B1 (fr) 1995-03-03
EP0499544A2 (de) 1992-08-19
US5225420A (en) 1993-07-06
CA2061173A1 (en) 1992-08-15
FR2672801A1 (fr) 1992-08-21
ATE121621T1 (de) 1995-05-15
DK0499544T3 (da) 1995-08-28
DE69202166T2 (de) 1995-11-09
EP0499544A3 (en) 1993-03-03

Similar Documents

Publication Publication Date Title
NO922147L (no) Heterocykliske derivater
DK0513543T3 (da) Amidinophenylalaninderivater, fremgangsmåde til deres fremstilling, deres anvendelse og antikoagulationsmidler med indehold deraf
DE59203976D1 (de) Hydantoinderivate.
FI104172B1 (fi) Herbisidiset 4-bentsoyyli-isoksatsolijohdannaiset
DE69202166D1 (de) Verwendung von Tetrahydrothienopyridinderivate als Angiogenese-Inhibitoren.
ATE114670T1 (de) Phenylamidinderivate als plättchenaggregationsinhibitoren.
ES2190428T3 (es) Antagonistas biciclicos de fibrinogeno.
DK260588A (da) Heterocykliske ketoner
ATE269290T1 (de) Benzoylderivate
RU2088589C1 (en) Derivatives of 17 beta-substituted-4-aza-5-5 alpha-androstane-3-ones, methods of synthesis of compounds, pharmaceutical composition, compound 4
DE69008366D1 (de) 2-Aminopyrimidinon-Derivate.
SE9002206D0 (sv) New compounds
EA200000614A1 (ru) 2,3-замещенные соединения индола в качестве ингибиторов сох-2
NO923200D0 (no) Piperidin-derivater
DK0609289T3 (da) Imidazolderivater og farmaceutiske præparater med indhold deraf
HUT59124A (en) Process for producing 2-(aminoalkyl)-5-(arylalkyl)-1,3-dioxane derivatives and pharmaceutical compositions comprising such derivatives as active ingredient
ES2101059T3 (es) Derivados biciclicos nitrogenados, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ATE69611T1 (de) Piperazinylalkylpiperazindion-derivate, ihre verfahren zur herstellung und diese enthaltende pharmazeutische zusammenstellungen.
ATE24915T1 (de) Synergistin-derivate und ihre herstellung.
ES2062214T3 (es) Derivados de aminooligohidroxi inhibidores de renina.
DE69208384D1 (de) Fungizide Furanonderivate

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR