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DE69118028D1 - Neue 2,6-Dialkyl-4-silyl-phenole als antiatherosclerotische Mittel und als Antioxidantien - Google Patents

Neue 2,6-Dialkyl-4-silyl-phenole als antiatherosclerotische Mittel und als Antioxidantien

Info

Publication number
DE69118028D1
DE69118028D1 DE69118028T DE69118028T DE69118028D1 DE 69118028 D1 DE69118028 D1 DE 69118028D1 DE 69118028 T DE69118028 T DE 69118028T DE 69118028 T DE69118028 T DE 69118028T DE 69118028 D1 DE69118028 D1 DE 69118028D1
Authority
DE
Germany
Prior art keywords
silyl
phenols
dialkyl
antioxidants
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69118028T
Other languages
English (en)
Other versions
DE69118028T2 (de
Inventor
Roger A Parker
Simon Jen Tan Mao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69118028D1 publication Critical patent/DE69118028D1/de
Publication of DE69118028T2 publication Critical patent/DE69118028T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/32—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing two or more of boron, silicon, phosphorus, selenium, tellurium or a metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
DE69118028T 1990-07-05 1991-07-05 Neue 2,6-Dialkyl-4-silyl-phenole als antiatherosclerotische Mittel und als Antioxidantien Expired - Fee Related DE69118028T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/548,052 US5155250A (en) 1990-07-05 1990-07-05 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents

Publications (2)

Publication Number Publication Date
DE69118028D1 true DE69118028D1 (de) 1996-04-25
DE69118028T2 DE69118028T2 (de) 1996-11-28

Family

ID=24187205

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69118028T Expired - Fee Related DE69118028T2 (de) 1990-07-05 1991-07-05 Neue 2,6-Dialkyl-4-silyl-phenole als antiatherosclerotische Mittel und als Antioxidantien

Country Status (20)

Country Link
US (2) US5155250A (de)
EP (1) EP0464852B1 (de)
JP (1) JP2963556B2 (de)
KR (1) KR0186005B1 (de)
CN (1) CN1029615C (de)
AT (1) ATE135705T1 (de)
AU (1) AU639576B2 (de)
CA (1) CA2046051C (de)
DE (1) DE69118028T2 (de)
DK (1) DK0464852T3 (de)
ES (1) ES2087180T3 (de)
FI (1) FI101703B (de)
GR (1) GR3019393T3 (de)
HU (1) HU211074B (de)
IE (1) IE912340A1 (de)
IL (1) IL98712A (de)
NO (1) NO180490C (de)
NZ (1) NZ238808A (de)
PT (1) PT98220B (de)
ZA (1) ZA915074B (de)

Families Citing this family (42)

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US5304668A (en) * 1990-07-05 1994-04-19 Merrell Dow Pharmaceuticals Bis-[4-(2,6-di-alkyl)phenolisilane derivatives as antiatherosclerotic agents
NZ238807A (en) * 1990-07-05 1994-03-25 Merrell Dow Pharma Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions
FR2707989B1 (fr) * 1993-07-22 1995-10-13 Pf Medicament Nouveaux dérivés de benzylamines silylées, leurs sels, leurs procédés de fabrication et les compositions pharmaceutiques les renfermant.
US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
DK0732928T3 (da) * 1993-12-10 2005-04-18 Merrell Pharma Inc Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler
JPH09506913A (ja) * 1993-12-15 1997-07-08 スミスクライン・ビーチャム・コーポレイション 化合物および方法
FR2722198B1 (fr) * 1994-07-08 1996-10-04 Pf Medicament 1derives de silylmethyl-anilines, le2fabrication, et leur utilisation co
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
EP0910384A1 (de) * 1996-04-30 1999-04-28 Hoechst Marion Roussel, Inc. Methoden zur hemmung von zell adhesion molekül-1 und behandlung von chronischen entzündungskrankheiten durch 2,6-dialkyl-4-sylilphenolen
WO1997044367A1 (en) * 1996-05-20 1997-11-27 Smithkline Beecham Corporation Silyl linker for solid phase organic synthesis of aryl-containing molecules
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
TR199902803T2 (xx) * 1997-05-14 2000-07-21 Atherogenics, Inc. VCAM-1' in te�hisinin daralt�lmas� i�in bile�ikler ve metodlar.
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
JP2002514226A (ja) * 1997-06-24 2002-05-14 アベンティス・ファーマスーティカルズ・インコーポレイテッド 抗酸化剤としてのアルキル−４−シリル複素環フェノール及びチオフェノール
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
CA2295232A1 (en) * 1997-06-25 1998-12-30 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[ (dimethyl-4-methoxyphenylsilyl) -methyloxy]phenol and 2,6-di-t-butyl-4-[ (dimethyl-2-methoxy-phenylsilyl) -methyloxy]phenol
KR20010020611A (ko) * 1997-07-01 2001-03-15 아테로제닉스, 인코포레이티드 항산화제에 의한 과증식질병 치료의 향상
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
EP1137948B1 (de) * 1998-11-09 2006-05-10 Atherogenics, Inc. Methode und zusammensetzungen zum vermindern des cholesterolspiegels im plasma
JP4408982B2 (ja) * 1999-03-31 2010-02-03 東レ・ダウコーニング株式会社 フェノール基含有有機ケイ素化合物およびその製造方法
AU2002248910A1 (en) 2000-11-17 2002-05-27 Idenix (Cayman) Limited Methods for inhibiting the transmission of HIV using topically applied substituted 6-benzyl-4-oxopyrmidines
JP2005514344A (ja) * 2001-10-25 2005-05-19 アセロジエニクス・インコーポレイテツド 移植拒絶治療のための化合物と方法
AU2002352826B2 (en) * 2001-11-09 2009-05-28 Atherogenics, Inc. Methods of reversing and preventing cardiovascular pathologies
AU2002360763A1 (en) * 2001-12-19 2003-07-09 Atherogenics, Inc. Chalcone derivatives and their use to treat diseases
CA2492433A1 (en) * 2002-07-12 2004-01-22 Artherogenics, Inc. Organic amine salts of poorly soluble probucol esters and ethers
US20040110803A1 (en) * 2002-09-13 2004-06-10 Hossein Dovlatabadi Methods and compositions for the use of D-malic acid to decrease serum triglyceride, cholesterol and lipoprotein levels
AU2003303239A1 (en) * 2002-12-19 2004-07-14 Atherogenics, Inc. Process of making chalcone derivatives
US7273948B2 (en) * 2003-01-13 2007-09-25 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
US7173129B2 (en) * 2003-06-06 2007-02-06 Athero Genics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005037251A1 (en) * 2003-10-17 2005-04-28 Amylin Pharmaceuticals, Inc. Self-emulsifying drug delivery systems for hydrophobic therapeutic compounds
EP1677804A1 (de) * 2003-10-17 2006-07-12 Amylin Pharmaceuticals, Inc. Silyl-phenole zur förderung der gefässgesundheit
WO2005037250A1 (en) * 2003-10-17 2005-04-28 Amylin Pharmaceuticals, Inc. Self emulsifying drug delivery systems for hydrophobic therapeutic compounds
US7294737B2 (en) 2004-04-20 2007-11-13 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
WO2006004903A2 (en) * 2004-06-28 2006-01-12 Atherogenics, Inc. 1,2-bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
US20060058268A1 (en) * 2004-07-01 2006-03-16 Sundell Cynthia L Compounds and methods for treating diabetic vascular diseases
CN101686676A (zh) * 2007-03-26 2010-03-31 沙路特里亚制药有限责任公司 用于治疗糖尿病的方法和普罗布考衍生物的组合物
WO2008118946A1 (en) * 2007-03-27 2008-10-02 Atherogenics, Inc. Methods and compositions using certain phenolic derivatives for the treatment of diabetes
DE102007015948A1 (de) * 2007-04-03 2008-10-09 Bayer Materialscience Ag Modifizierte Polycarbonate, Polyestercarbonate und Polyester mit verbessertem Dehnverhalten und Flammwidrigkeit
US20090254425A1 (en) * 2008-04-02 2009-10-08 Evan Horowitz Wiki-type collective intelligence mechanism for implementing a url redirect

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3328450A (en) * 1963-01-09 1967-06-27 Dow Corning Silylalkyl phenols
US3506674A (en) * 1967-07-03 1970-04-14 Gen Electric Certain pyridyl thio ether silanes
GB1232394A (de) * 1967-08-17 1971-05-19
US3853776A (en) * 1972-09-29 1974-12-10 Monsanto Co Low pour point fluids and blends containing same
US3801617A (en) * 1973-07-24 1974-04-02 Nasa Thiophenyl ether disiloxanes and trisiloxanes useful as lubricant fluids
DE2933206A1 (de) * 1978-08-18 1980-02-28 Ciba Geigy Ag Phenolhaltige silane und deren verwendung als schmiermittelzusaetze
US4624909A (en) * 1984-04-27 1986-11-25 Nec Corporation Silicon-containing novolak resin and resist material and pattern forming method using same
JPS61263988A (ja) * 1985-05-16 1986-11-21 Shionogi & Co Ltd シリル置換エ−テル類および殺虫・殺ダニ剤
US4636573A (en) * 1985-09-09 1987-01-13 Pastor Stephen D Hindered silicon ester stabilizers
DE3604781A1 (de) * 1986-02-13 1987-08-27 Schering Ag Neue silane, verfahren zu ihrer herstellung und diese verbindungen enthaltende einsektizide mittel
US4804653A (en) * 1986-05-02 1989-02-14 Uniroyal Chemical Company, Inc. Thiomethyl-substituted organosilane compounds and their use as pesticides
DE3638073A1 (de) * 1986-11-07 1988-05-11 Swf Auto Electric Gmbh Vorrichtung, insbesondere hubwischeranlage fuer kraftfahrzeuge
US4783495A (en) * 1987-11-20 1988-11-08 Ciba-Geigy Corporation (Hydroxyphenyl) silane stabilizers
US5138012A (en) * 1988-07-29 1992-08-11 General Electric Company Silicone release coating compositions
DE4031001A1 (de) * 1990-10-01 1992-04-02 Hoechst Ag Verfahren zur herstellung von 4-ethoxyphenyl-3-arylpropyl-(dimethyl)silanen

Also Published As

Publication number Publication date
JP2963556B2 (ja) 1999-10-18
US5532400A (en) 1996-07-02
AU8011691A (en) 1992-01-09
AU639576B2 (en) 1993-07-29
KR0186005B1 (ko) 1999-05-15
JPH04230393A (ja) 1992-08-19
KR920002617A (ko) 1992-02-28
ES2087180T3 (es) 1996-07-16
FI101703B1 (fi) 1998-08-14
NO912630D0 (no) 1991-07-04
EP0464852B1 (de) 1996-03-20
CN1057843A (zh) 1992-01-15
DE69118028T2 (de) 1996-11-28
FI913252L (fi) 1992-01-06
US5155250A (en) 1992-10-13
CA2046051A1 (en) 1992-01-06
ZA915074B (en) 1992-04-29
CA2046051C (en) 2001-06-05
PT98220B (pt) 1998-12-31
HUT58749A (en) 1992-03-30
GR3019393T3 (en) 1996-06-30
DK0464852T3 (da) 1996-04-15
IL98712A (en) 1995-11-27
NZ238808A (en) 1994-02-25
CN1029615C (zh) 1995-08-30
NO180490B (no) 1997-01-20
ATE135705T1 (de) 1996-04-15
IE912340A1 (en) 1992-01-15
FI913252A0 (fi) 1991-07-04
PT98220A (pt) 1992-05-29
HU912272D0 (en) 1991-12-30
IL98712A0 (en) 1992-07-15
HU211074B (en) 1995-10-30
EP0464852A1 (de) 1992-01-08
FI101703B (fi) 1998-08-14
NO180490C (no) 1997-04-30
NO912630L (no) 1992-01-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS INC. (N.D.GES.D. STAATES PENNSYLVANIA), GR

8339 Ceased/non-payment of the annual fee