DE69020548D1 - Blutplättchenspezifische immunokonjugate. - Google Patents
Blutplättchenspezifische immunokonjugate.Info
- Publication number
- DE69020548D1 DE69020548D1 DE69020548T DE69020548T DE69020548D1 DE 69020548 D1 DE69020548 D1 DE 69020548D1 DE 69020548 T DE69020548 T DE 69020548T DE 69020548 T DE69020548 T DE 69020548T DE 69020548 D1 DE69020548 D1 DE 69020548D1
- Authority
- DE
- Germany
- Prior art keywords
- immunoconjugates
- specific
- antibody
- blood plate
- thrombolytic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229940127121 immunoconjugate Drugs 0.000 title abstract 3
- 239000008280 blood Substances 0.000 title 1
- 210000004369 blood Anatomy 0.000 title 1
- 239000003527 fibrinolytic agent Substances 0.000 abstract 2
- 229960000103 thrombolytic agent Drugs 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000020764 fibrinolysis Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6815—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33287489A | 1989-04-03 | 1989-04-03 | |
| PCT/US1990/001773 WO1990011783A1 (en) | 1989-04-03 | 1990-04-03 | Platelet specific immunoconjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69020548D1 true DE69020548D1 (de) | 1995-08-03 |
| DE69020548T2 DE69020548T2 (de) | 1996-03-07 |
Family
ID=23300229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69020548T Expired - Fee Related DE69020548T2 (de) | 1989-04-03 | 1990-04-03 | Blutplättchenspezifische immunokonjugate. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0465556B1 (de) |
| JP (1) | JP3436270B2 (de) |
| AT (1) | ATE124267T1 (de) |
| CA (1) | CA2051436A1 (de) |
| DE (1) | DE69020548T2 (de) |
| WO (1) | WO1990011783A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770198A (en) * | 1988-05-18 | 1998-06-23 | The Research Foundation Of The State Of New York | Platelet-specific chimeric 7E3 immunoglobulin |
| US5196403A (en) * | 1989-01-27 | 1993-03-23 | Biogen, Inc. | Method of inhibiting platelet activation |
| US5242810A (en) * | 1990-12-07 | 1993-09-07 | Biogen, Inc. | Bifunctional inhibitors of thrombin and platelet activation |
| AU1873092A (en) * | 1991-04-09 | 1992-11-17 | Brigham And Women's Hospital | Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques |
| EP0557535B1 (de) * | 1991-09-17 | 1997-12-17 | Teijin Limited | Humaner monoklonaler antikörper gegen glycoprotein-iib/iiia |
| ZA937553B (en) * | 1992-10-12 | 1994-05-03 | Agen Ltd | Clot directed anticoagulant process for making same and methods of use |
| EP0602290B1 (de) * | 1992-12-04 | 1999-08-25 | ConjuChem, Inc. | Antikörper-konjugiertes-Hepatitis B-Oberflächenantigen und dessen Verwendung |
| ATE247980T1 (de) * | 1993-11-05 | 2003-09-15 | Centocor Inc | Verwendung von an glycoprotein gpiib/iiia bindenden substanzen zur vermeidung von stenosis und restenosis |
| US5840733A (en) * | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
| US5951981A (en) * | 1996-12-02 | 1999-09-14 | Diatide, Inc. | Thrombolytic agents with antithrombotic activity |
| ATE315410T1 (de) * | 1998-11-03 | 2006-02-15 | Centocor Inc | Modifizierte antikörper und antikörper-fragmente mit verlängerter aktivitätsdauer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU595173B2 (en) * | 1985-01-08 | 1990-03-29 | General Hospital Corporation, The | Method and use for site-specific activation of substances |
-
1990
- 1990-04-03 WO PCT/US1990/001773 patent/WO1990011783A1/en active IP Right Grant
- 1990-04-03 DE DE69020548T patent/DE69020548T2/de not_active Expired - Fee Related
- 1990-04-03 JP JP50558390A patent/JP3436270B2/ja not_active Expired - Fee Related
- 1990-04-03 EP EP90905802A patent/EP0465556B1/de not_active Expired - Lifetime
- 1990-04-03 CA CA002051436A patent/CA2051436A1/en not_active Abandoned
- 1990-04-03 AT AT90905802T patent/ATE124267T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP3436270B2 (ja) | 2003-08-11 |
| EP0465556B1 (de) | 1995-06-28 |
| CA2051436A1 (en) | 1990-10-04 |
| JPH07503450A (ja) | 1995-04-13 |
| EP0465556A1 (de) | 1992-01-15 |
| WO1990011783A1 (en) | 1990-10-18 |
| ATE124267T1 (de) | 1995-07-15 |
| DE69020548T2 (de) | 1996-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |