DE68929031D1 - Antimikrobielle wässerige Lösungen für die Kontaktlinsenpflege - Google Patents
Antimikrobielle wässerige Lösungen für die KontaktlinsenpflegeInfo
- Publication number
- DE68929031D1 DE68929031D1 DE68929031T DE68929031T DE68929031D1 DE 68929031 D1 DE68929031 D1 DE 68929031D1 DE 68929031 T DE68929031 T DE 68929031T DE 68929031 T DE68929031 T DE 68929031T DE 68929031 D1 DE68929031 D1 DE 68929031D1
- Authority
- DE
- Germany
- Prior art keywords
- contact lens
- aqueous solutions
- lens care
- antimicrobial aqueous
- antimicrobial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000845 anti-microbial effect Effects 0.000 title 1
- 239000007864 aqueous solution Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/143—Quaternary ammonium compounds
- A61L12/145—Polymeric quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2086—Hydroxy carboxylic acids-salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3723—Polyamines or polyalkyleneimines
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Eyeglasses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/244,974 US5037647A (en) | 1988-09-15 | 1988-09-15 | Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68929031D1 true DE68929031D1 (de) | 1999-08-19 |
DE68929031T2 DE68929031T2 (de) | 1999-11-11 |
Family
ID=22924837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68929031T Expired - Lifetime DE68929031T2 (de) | 1988-09-15 | 1989-09-15 | Antimikrobielle wässerige Lösungen für die Kontaktlinsenpflege |
Country Status (18)
Country | Link |
---|---|
US (1) | US5037647A (de) |
EP (1) | EP0359574B1 (de) |
JP (1) | JPH0649060B2 (de) |
AR (1) | AR247326A1 (de) |
AT (1) | ATE182081T1 (de) |
AU (1) | AU625099B2 (de) |
CA (1) | CA1334573C (de) |
DE (1) | DE68929031T2 (de) |
DK (1) | DK175224B1 (de) |
ES (1) | ES2136055T3 (de) |
FI (1) | FI105321B (de) |
GR (1) | GR3031328T3 (de) |
HK (1) | HK1011941A1 (de) |
MX (1) | MX168660B (de) |
NZ (1) | NZ230663A (de) |
PH (1) | PH26017A (de) |
WO (1) | WO1990002555A1 (de) |
ZA (1) | ZA897060B (de) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL90680A (en) * | 1988-06-28 | 1994-04-12 | Ciba Geigy Ag | Poor solutions containing dodecyl (dimethyl) 2-phenoxyethyl (ammonium brocide and ATDE and methods of use) |
US5547663A (en) * | 1991-11-08 | 1996-08-20 | Alcon Laboratories, Inc. | Absolute molecular weight polymers and methods for their use |
US5512597A (en) * | 1991-11-08 | 1996-04-30 | Alcon Laboratories, Inc. | Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobials |
US6051611A (en) * | 1991-11-08 | 2000-04-18 | Alcon Laboratories, Inc. | Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobias |
EP0542686A1 (de) * | 1991-11-13 | 1993-05-19 | Ciba-Geigy Ag | Verfahren und Behälter für die Sterilisation und Desinfektion |
US5256420A (en) * | 1991-12-23 | 1993-10-26 | Ciba-Geigy Corporation | Method of imparting antimicrobial acitivity to an ophthalmic composition |
US5356555A (en) * | 1992-09-14 | 1994-10-18 | Allergan, Inc. | Non-oxidative method and composition for simultaneously cleaning and disinfecting contact lenses using a protease with a disinfectant |
AU733386B2 (en) * | 1993-08-27 | 2001-05-10 | Alcon Laboratories, Inc. | Process for cleaning and disinfecting contact lenses |
US5370744B1 (en) * | 1993-08-27 | 1999-11-09 | Alcon Lab Inc | Process for cleaning and disinfecting contact lenses |
AU5417501A (en) * | 1993-08-27 | 2001-09-20 | Alcon Laboratories, Inc. | Process for cleaning and disinfecting contact lenses |
US5382599A (en) * | 1993-10-13 | 1995-01-17 | Allergan, Inc. | Method of inhibiting protozoan growth in eye care products using a polyvalent cation chelating agent |
US5536494A (en) * | 1994-10-04 | 1996-07-16 | Alcon Laboratories, Inc. | Polyethylene oxide-containing quaternary ammunium polymers and pharmaceutical compositions containing an antimicrobial amount of same |
US5603929A (en) * | 1994-11-16 | 1997-02-18 | Alcon Laboratories, Inc. | Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds |
WO2000028998A1 (fr) * | 1998-11-16 | 2000-05-25 | Rohto Pharmaceutical Co., Ltd. | Preparations ophtalmiques liquides |
US6790816B2 (en) | 1999-09-24 | 2004-09-14 | Bausch & Lomb Incorporated | High osmolyte cleaning and disinfection method and solution for contact lenses |
US6375973B2 (en) | 2000-01-25 | 2002-04-23 | Alcon Universal Ltd. | Ophthalmic anti-allergy compositions suitable for use with contact lenses |
US20020183233A1 (en) * | 2000-12-14 | 2002-12-05 | The Clorox Company, Delaware Corporation | Bactericidal cleaning wipe |
US7799751B2 (en) * | 2000-12-14 | 2010-09-21 | The Clorox Company | Cleaning composition |
US20030100465A1 (en) * | 2000-12-14 | 2003-05-29 | The Clorox Company, A Delaware Corporation | Cleaning composition |
DE10137978A1 (de) * | 2001-08-02 | 2003-02-13 | Creavis Tech & Innovation Gmbh | Antimikrobielle Reinigungsmittel |
JP4255656B2 (ja) | 2001-09-17 | 2009-04-15 | 株式会社メニコン | 眼科用液剤及びコンタクトレンズ用液剤 |
US20040028645A1 (en) * | 2001-12-13 | 2004-02-12 | Masood Chowhan | Artificial tear composition adapted to be used with contact lenses |
KR100976291B1 (ko) * | 2001-12-21 | 2010-08-16 | 알콘, 인코퍼레이티드 | 안과용 조성물중의 살생물제에 대한 담체로서 나노입자의용도 |
DK1474109T3 (da) * | 2001-12-21 | 2010-10-25 | Alcon Inc | Anvendelse af syntetiske uorganiske nanopartikler som bærere af ophthalmiske lægemidler |
KR20040073503A (ko) * | 2001-12-21 | 2004-08-19 | 알콘, 인코퍼레이티드 | 안과용 및 이과용 약제학적 조성물의 점도 및 기타물리학적 성질을 개질시키기 위한 무기 나노입자의 용도 |
US20060275173A1 (en) * | 2005-06-03 | 2006-12-07 | Bausch & Lomb Incorporated | Method for cleaning lipid deposits on silicone hydrogel contact lenses |
US7282178B2 (en) * | 2005-06-03 | 2007-10-16 | Bausch & Lomb Incorporated | Composition and method for cleaning lipid deposits on contact lenses |
US20060276359A1 (en) * | 2005-06-03 | 2006-12-07 | Bausch & Lomb Incorporated | Composition and method for cleaning lipid deposits on contact lenses |
JP5135526B2 (ja) * | 2005-06-27 | 2013-02-06 | 株式会社メニコンネクト | コンタクトレンズ用液剤 |
US20070053948A1 (en) * | 2005-09-08 | 2007-03-08 | Bausch & Lomb Incorporated | Lens care solution demonstration kit |
TWI434926B (zh) * | 2006-12-11 | 2014-04-21 | Alcon Res Ltd | 眼用組成物中聚氧化乙烯-聚氧化丁烯(peo-pbo)嵌段共聚物之使用 |
WO2009064890A2 (en) * | 2007-11-13 | 2009-05-22 | Quick-Med Technologies, Inc | System and method for enhancing the efficacy of antimicrobial contact lenses |
TWI544927B (zh) | 2008-03-17 | 2016-08-11 | 愛爾康研究有限公司 | 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物 |
WO2009117242A2 (en) | 2008-03-17 | 2009-09-24 | Alcon Research, Ltd. | Aqueous pharmaceutical compositions containing borate-polyol complexes |
WO2009142950A1 (en) * | 2008-05-19 | 2009-11-26 | Alcon Research, Ltd. | Pharmaceutical compositions having carboxyvinyl polymer and povidone polymer |
TW201023912A (en) * | 2008-12-05 | 2010-07-01 | Alcon Res Ltd | Pharmaceutical suspension |
US8431751B1 (en) | 2008-12-24 | 2013-04-30 | Alcon Research, Ltd. | Polymeric quaternary ammonium compounds with vicinal hydroxy groups |
US8912236B2 (en) * | 2009-03-03 | 2014-12-16 | Alcon Research, Ltd. | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye |
JP5583145B2 (ja) * | 2009-03-03 | 2014-09-03 | アルコン リサーチ, リミテッド | レセプターチロシンキナーゼ阻害(RTKi)化合物の眼への送達のための薬学的組成物 |
TW201038295A (en) * | 2009-04-17 | 2010-11-01 | Alcon Res Ltd | Aqueous ophthalmic compositions containing anionic therapeutic agents |
TWI489997B (zh) | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸-多元醇錯合物之水性藥學組成物 |
TWI547522B (zh) * | 2009-07-07 | 2016-09-01 | 愛爾康研究有限公司 | 環氧乙烷環氧丁烷嵌段共聚物組成物 |
TWI478730B (zh) * | 2009-12-03 | 2015-04-01 | Alcon Res Ltd | 眼科乳劑 |
WO2011153349A1 (en) | 2010-06-02 | 2011-12-08 | Alcon Research, Ltd. | Ophthalmic compositions comprising pbo-peo-pbo block copolymers |
JP2014525891A (ja) | 2011-04-22 | 2014-10-02 | アルコン リサーチ, リミテッド | 二つの異なる粘性増強剤を有する粘性増強システムを備えた眼科用組成物 |
RU2601115C2 (ru) | 2011-04-22 | 2016-10-27 | Алькон Рисерч, Лтд. | Офтальмологическая композиция с повышающей вязкость системой, содержащей два различных средства повышения вязкости |
TWI544922B (zh) | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠(olopatadine)眼用組成物 |
TW201336527A (zh) | 2012-02-10 | 2013-09-16 | Alcon Res Ltd | 具增強的穩定性之水性藥學組成物 |
WO2014058402A2 (en) * | 2012-10-12 | 2014-04-17 | Alke Saglik Urunleri Sanayi Ve Ticaret Anonim Sirketi | Liquid cip (clean-in-place) detergent combinations |
US10174006B2 (en) | 2013-06-06 | 2019-01-08 | Novartis Ag | Topical aqueous ophthalmic compositions containing a 1H-indole-1-carboxamide derivative and use thereof for treatment of ophthalmic disease |
CN105829081B (zh) | 2013-12-17 | 2017-12-19 | 诺华股份有限公司 | 具有交联的亲水性涂层的硅水凝胶镜片 |
WO2017022781A1 (ja) * | 2015-08-03 | 2017-02-09 | 花王株式会社 | 抗菌型衣料用液体洗浄剤組成物 |
KR102532825B1 (ko) | 2016-03-30 | 2023-05-17 | 아유비스 리서치, 인코포레이티드 | 신규한 조성물 및 치료 방법 |
TW201938141A (zh) | 2018-02-21 | 2019-10-01 | 瑞士商諾華公司 | 基於脂質的眼用乳劑 |
AU2019297321B2 (en) | 2018-07-02 | 2022-02-03 | Ayuvis Research, Inc. | Novel immunodulating small molecules |
JP6994061B2 (ja) | 2019-02-15 | 2022-01-14 | ノバルティス アーゲー | 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤 |
EP4431497A1 (de) | 2019-02-15 | 2024-09-18 | Bausch + Lomb Ireland Limited | Kristalline formen von 4-(7-hydroxy-2-isopropyl-4-oxo-4h-chinazolin-3-yl)-benzonitril und deren formulierungen |
EP4192466A1 (de) | 2020-08-06 | 2023-06-14 | Novartis AG | Kristalline formen von 4-(7-hydroxy-2-isopropyl-4-oxo-4h-chinazolin-3-yl)-benzonitril und formulierungen davon |
CN113088411A (zh) * | 2021-04-08 | 2021-07-09 | 山西利普达医药科技有限公司 | 一种含聚季铵盐-1的眼用清洗灭活病毒组合物及其应用 |
AU2023346366A1 (en) | 2022-09-21 | 2025-03-20 | Bausch + Lomb Ireland Limited | Crystalline polymorph forms of a trpv1 antagonist and formulations thereof |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US440771A (en) * | 1890-11-18 | Oil-cup | ||
DE2930865A1 (de) * | 1979-07-30 | 1981-02-12 | Schuelke & Mayr Gmbh | Desinfektions- und konservierungsmittel |
US4499077A (en) * | 1981-02-03 | 1985-02-12 | Stockel Richard F | Anti-microbial compositions and associated methods for preparing the same and for the disinfecting of various objects |
US4525346A (en) * | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
US4407791A (en) * | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
EP0145710A1 (de) * | 1983-05-25 | 1985-06-26 | Alcon Laboratories, Inc. | Ophthalmische lösung |
US4579960A (en) * | 1984-05-07 | 1986-04-01 | Schering Corporation | Stable solutions containing thimerosal |
CA1259542A (en) * | 1984-09-28 | 1989-09-19 | Francis X. Smith | Disinfecting and preserving solutions for contact lenses and methods of use |
US4599195A (en) * | 1984-12-28 | 1986-07-08 | Alcon Laboratories, Inc. | Solution and method for removing protein, lipid, and calcium deposits from contact lenses |
EP0232250B1 (de) * | 1985-07-22 | 1990-01-31 | BAUSCH & LOMB INCORPORATED | Verfahren und loesung zur desinfektion und konservierung von kontaktlinsen |
DE3782981T2 (de) * | 1986-01-06 | 1993-04-08 | Allergan Inc | Erhoehung von enzymatischer wirksamkeit bei der reinigung von kontaktlinsen durch verwendung von hypotonischen loesungen. |
US4734222A (en) * | 1986-04-03 | 1988-03-29 | Ciba-Geigy Corporation | Composition and method for cleaning soft and hard contact lenses |
GB8625103D0 (en) * | 1986-10-20 | 1986-11-26 | Unilever Plc | Disinfectant compositions |
EP0298105A4 (de) * | 1986-12-24 | 1989-03-29 | Alcon Lab Inc | Reinigungsmittel für kontaktlinsen und verfahren zur verwendung. |
DK0420798T3 (da) * | 1989-09-21 | 1994-04-11 | Ciba Geigy Ag | Antimikrobielle præparater |
-
1988
- 1988-09-15 US US07/244,974 patent/US5037647A/en not_active Expired - Lifetime
-
1989
- 1989-09-13 CA CA000611333A patent/CA1334573C/en not_active Expired - Lifetime
- 1989-09-14 NZ NZ230663A patent/NZ230663A/en unknown
- 1989-09-15 AU AU43113/89A patent/AU625099B2/en not_active Expired
- 1989-09-15 AR AR89314940A patent/AR247326A1/es active
- 1989-09-15 DE DE68929031T patent/DE68929031T2/de not_active Expired - Lifetime
- 1989-09-15 WO PCT/US1989/004002 patent/WO1990002555A1/en active IP Right Grant
- 1989-09-15 ES ES89309381T patent/ES2136055T3/es not_active Expired - Lifetime
- 1989-09-15 AT AT89309381T patent/ATE182081T1/de not_active IP Right Cessation
- 1989-09-15 EP EP89309381A patent/EP0359574B1/de not_active Expired - Lifetime
- 1989-09-15 PH PH39240A patent/PH26017A/en unknown
- 1989-09-15 MX MX017572A patent/MX168660B/es unknown
- 1989-09-15 ZA ZA897060A patent/ZA897060B/xx unknown
- 1989-09-15 JP JP1509897A patent/JPH0649060B2/ja not_active Expired - Lifetime
-
1990
- 1990-05-02 FI FI902194A patent/FI105321B/fi active IP Right Grant
- 1990-05-09 DK DK199001156A patent/DK175224B1/da not_active IP Right Cessation
-
1998
- 1998-12-11 HK HK98113204A patent/HK1011941A1/xx not_active IP Right Cessation
-
1999
- 1999-09-24 GR GR990402430T patent/GR3031328T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
PH26017A (en) | 1992-01-29 |
AU625099B2 (en) | 1992-07-02 |
AR247326A1 (es) | 1994-12-29 |
GR3031328T3 (en) | 1999-12-31 |
WO1990002555A1 (en) | 1990-03-22 |
DK115690A (da) | 1990-05-09 |
JPH02502733A (ja) | 1990-08-30 |
FI105321B (fi) | 2000-07-31 |
ATE182081T1 (de) | 1999-07-15 |
DK175224B1 (da) | 2004-07-12 |
MX168660B (es) | 1993-06-02 |
EP0359574A2 (de) | 1990-03-21 |
EP0359574B1 (de) | 1999-07-14 |
NZ230663A (en) | 1991-05-28 |
DE68929031T2 (de) | 1999-11-11 |
JPH0649060B2 (ja) | 1994-06-29 |
CA1334573C (en) | 1995-02-28 |
EP0359574A3 (de) | 1990-08-29 |
DK115690D0 (da) | 1990-05-09 |
FI902194A0 (fi) | 1990-05-02 |
HK1011941A1 (en) | 1999-07-23 |
US5037647A (en) | 1991-08-06 |
AU4311389A (en) | 1990-04-02 |
ZA897060B (en) | 1991-05-29 |
ES2136055T3 (es) | 1999-11-16 |
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