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DE68919772D1 - Liposomen, an deren Oberfläche die Adsorption on Proteinen verhindert wird. - Google Patents

Liposomen, an deren Oberfläche die Adsorption on Proteinen verhindert wird.

Info

Publication number
DE68919772D1
DE68919772D1 DE68919772T DE68919772T DE68919772D1 DE 68919772 D1 DE68919772 D1 DE 68919772D1 DE 68919772 T DE68919772 T DE 68919772T DE 68919772 T DE68919772 T DE 68919772T DE 68919772 D1 DE68919772 D1 DE 68919772D1
Authority
DE
Germany
Prior art keywords
liposomes
adsorption
proteins
prevented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68919772T
Other languages
English (en)
Other versions
DE68919772T2 (de
Inventor
Hiroshi Yoshida
Hiroshi Goto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Publication of DE68919772D1 publication Critical patent/DE68919772D1/de
Application granted granted Critical
Publication of DE68919772T2 publication Critical patent/DE68919772T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE68919772T 1988-08-11 1989-08-11 Liposomen, an deren Oberfläche die Adsorption on Proteinen verhindert wird. Expired - Lifetime DE68919772T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19891588 1988-08-11
JP1063507A JPH0720857B2 (ja) 1988-08-11 1989-03-17 リポソームおよびその製法

Publications (2)

Publication Number Publication Date
DE68919772D1 true DE68919772D1 (de) 1995-01-19
DE68919772T2 DE68919772T2 (de) 1995-07-13

Family

ID=26404636

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68919772T Expired - Lifetime DE68919772T2 (de) 1988-08-11 1989-08-11 Liposomen, an deren Oberfläche die Adsorption on Proteinen verhindert wird.

Country Status (5)

Country Link
US (3) US5676971A (de)
EP (1) EP0354855B1 (de)
JP (1) JPH0720857B2 (de)
DE (1) DE68919772T2 (de)
ES (1) ES2064470T3 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0720857B2 (ja) * 1988-08-11 1995-03-08 テルモ株式会社 リポソームおよびその製法
US6132763A (en) * 1988-10-20 2000-10-17 Polymasc Pharmaceuticals Plc Liposomes
GB8824593D0 (en) * 1988-10-20 1988-11-23 Royal Free Hosp School Med Liposomes
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US20010051183A1 (en) * 1989-10-20 2001-12-13 Alza Corporation Liposomes with enhanced circulation time and method of treatment
US20020150539A1 (en) * 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5380536A (en) 1990-10-15 1995-01-10 The Board Of Regents, The University Of Texas System Biocompatible microcapsules
JP3220180B2 (ja) * 1991-05-23 2001-10-22 三菱化学株式会社 薬剤含有タンパク質結合リポソーム
EP0627911B1 (de) 1992-02-28 2000-10-25 Board Of Regents The University Of Texas System Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung
US5464696A (en) * 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
JP3351476B2 (ja) * 1993-01-22 2002-11-25 三菱化学株式会社 リン脂質誘導体及びそれを含有するリポソーム
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5885613A (en) * 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US5820873A (en) * 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
GB9509016D0 (en) * 1995-05-03 1995-06-21 Royal Free Hosp School Med Tissue entrapment
US6673364B1 (en) 1995-06-07 2004-01-06 The University Of British Columbia Liposome having an exchangeable component
US5910300A (en) * 1995-11-01 1999-06-08 Bracco Research S.A. Amphiphilic linkers for coupling administrable diagnostically or physiologically active agents and bioselective targeting compounds
JP3956402B2 (ja) * 1996-03-04 2007-08-08 日本油脂株式会社 アンホテリシンｂ運搬体
US5919480A (en) * 1996-06-24 1999-07-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal influenza vaccine composition and method
US6224903B1 (en) 1996-10-11 2001-05-01 Sequus Pharmaceuticals, Inc. Polymer-lipid conjugate for fusion of target membranes
TW520297B (en) * 1996-10-11 2003-02-11 Sequus Pharm Inc Fusogenic liposome composition and method
US6056973A (en) 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
US6103599A (en) * 1997-07-25 2000-08-15 Silicon Genesis Corporation Planarizing technique for multilayered substrates
US6734171B1 (en) 1997-10-10 2004-05-11 Inex Pharmaceuticals Corp. Methods for encapsulating nucleic acids in lipid bilayers
AU751434B2 (en) * 1997-12-23 2002-08-15 Inex Pharmaceuticals Corporation Polyamide oligomers
US6320017B1 (en) 1997-12-23 2001-11-20 Inex Pharmaceuticals Corp. Polyamide oligomers
CA2309373A1 (en) * 1999-05-27 2000-11-27 Johnson & Johnson Consumer Companies, Inc. Novel topical formulations
CA2393595A1 (en) * 1999-12-10 2001-06-14 Gigi Chiu Lipid carrier compositions with protected surface reactive functions
US20040057988A1 (en) * 2000-11-10 2004-03-25 Eishun Tsuchida Method for preparing microsome dispersion
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
JPWO2003015753A1 (ja) * 2001-08-20 2004-12-02 テルモ株式会社 リポソーム製剤
US20060099660A1 (en) * 2002-02-15 2006-05-11 Synovo Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US20040186063A1 (en) * 2002-02-15 2004-09-23 Hans-Jurgen Gutke Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US7271154B2 (en) * 2002-02-15 2007-09-18 Merckle Gmbh Antibiotic conjugates
WO2003070174A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
NZ534377A (en) * 2002-03-13 2008-04-30 Collagenex Pharm Inc Water-based topical delivery system consisting of cholesterol, fatty acids water and a phospholipid/ceramide portion.
AU2003245160B2 (en) 2002-06-28 2009-09-24 Arbutus Biopharma Corporation Method and apparatus for producing liposomes
ATE492295T1 (de) 2002-07-02 2011-01-15 Univ Texas Radioaktiv markierte verbindungen und liposome und ihre herstellungs- und anwendungsverfahren
CA2505918C (en) * 2002-11-15 2011-02-01 Nipro Corporation A liposome having bound albumin and peg
SG159387A1 (en) 2002-11-26 2010-03-30 Biocon Ltd In Modified natriuretic compounds, conjugates, and uses thereof
CA2511464C (en) 2002-12-31 2011-08-23 Bharat Serums & Vaccines Ltd. Non-pegylated long-circulating liposomes
US8980310B2 (en) * 2002-12-31 2015-03-17 Bharat Serums and Vaccines, Ltd. Non-pegylated long-circulating liposomes
JP2004307404A (ja) 2003-04-08 2004-11-04 Nipro Corp 人工酸素運搬体を含む医薬組成物
CN1867580B (zh) * 2003-09-03 2010-09-29 协和发酵麒麟株式会社 被甘油衍生物修饰的化合物
WO2005092388A1 (ja) * 2004-03-26 2005-10-06 Terumo Kabushiki Kaisha リポソーム製剤
RU2574926C9 (ru) 2004-05-03 2020-06-16 Ипсен Биофарм Лтд. Липосомные композиции, используемые для доставки лекарственных средств
ATE411006T1 (de) * 2004-06-03 2008-10-15 Bracco Research Sa Liposomale anordnung für die therapeutische und/oder diagnostische anwendung
JP4692983B2 (ja) 2004-07-12 2011-06-01 独立行政法人科学技術振興機構 リポソーム封入物質がエンドソームから脱出可能なリポソーム
CA2584279C (en) 2004-11-05 2015-01-27 Index Pharmaceuticals Corporation Compositions and methods for stabilizing liposomal drug formulations
JP5110880B2 (ja) * 2004-11-18 2012-12-26 テルモ株式会社 医薬組成物、製剤および組み合わせ製剤
WO2006080452A1 (ja) 2005-01-28 2006-08-03 Kyowa Hakko Kogyo Co., Ltd. 水溶性物質で表面修飾された微粒子の製造方法
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
WO2006101201A1 (ja) 2005-03-24 2006-09-28 National University Corporation Hokkaido University 目的物質を効率的に核内に送達可能なリポソーム
US20070014845A1 (en) * 2005-07-01 2007-01-18 Yuanpeng Zhang Liposomal delivery vehicle for hydrophobic drugs
EP1907392A1 (de) * 2005-07-26 2008-04-09 Merckle Gmbh Makrolidkonjugate von pyrrolizin- und indolizinverbindungen als inhibitoren von 5-lipooxygenase und cyclooxygenase
US8998881B2 (en) 2005-08-10 2015-04-07 Alza Corporation Method for delivering drugs to tissue under microjet propulsion
US20070154403A1 (en) * 2006-01-05 2007-07-05 Thomas Skold Oral, Pulmonary and Transmucosal Delivery Composition
JP5072275B2 (ja) * 2006-07-03 2012-11-14 テルモ株式会社 閉鎖小胞の分離方法、製剤の製造方法および評価方法
EP2127640A1 (de) * 2008-05-27 2009-12-02 Koninklijke Philips Electronics N.V. Modifizierte azid-enthaltende Proteine
JP5094696B2 (ja) * 2008-12-18 2012-12-12 テルモ株式会社 ヘモグロビン含有リポソーム懸濁液中のヘモグロビン及びヘモグロビン類縁物質の分離定量方法。
WO2010110471A1 (ja) * 2009-03-23 2010-09-30 国立大学法人北海道大学 脂質膜構造体
US8961929B2 (en) 2010-01-08 2015-02-24 Fujifilm Corporation Targeting agent for tumor site
WO2011132713A1 (ja) 2010-04-21 2011-10-27 国立大学法人北海道大学 核内移行性を有する脂質膜構造体
MX2013006430A (es) 2010-12-06 2014-07-09 Merrimack Pharmaceuticals Inc Dosis y administracion para prevenir cardiotoxicidad en el tratamiento con inmunoliposomas erbb2-focalizados comprendiendo agentes quimioterapeuticos de antraciclina.
US8993614B2 (en) 2012-03-15 2015-03-31 F. Hoffmann-La Roche Ag Substituted pyrrolidine-2-carboxamides
JP6057317B2 (ja) * 2012-04-05 2017-01-11 セイコーエプソン株式会社 分離装置
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
AU2013292636A1 (en) 2012-07-18 2015-02-05 Onyx Therapeutics, Inc. Liposomal compositions of epoxyketone-based proteasome inhibitors
CA2892859A1 (en) 2012-12-03 2014-06-12 Merrimack Pharmaceuticals, Inc. Combination therapy for treating her2-positive cancers
CA2974196C (en) 2015-01-20 2023-12-12 TetraDerm Group LLC Versatile topical drug delivery vehicle and multifactorial tissue moisturizer that provides mucosal and skin barrier restoration
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
TWI724018B (zh) 2015-08-20 2021-04-11 英商益普生生物製藥有限公司 用於癌症治療之組合療法
PT3337478T (pt) 2015-08-21 2020-10-19 Ipsen Biopharm Ltd Combinação de fármacos compreendendo irinotecano lipossómico, oxaliplatina, 5-fluorouracilo e leucovorina para o tratamento do cancro do pâncreas metastático
RU2732567C2 (ru) 2015-10-16 2020-09-21 Ипсен Биофарм Лтд. Стабилизированные фармацевтические композиции камптотецина
TWI754659B (zh) 2016-08-08 2022-02-11 台灣微脂體股份有限公司 用於製備含有弱酸性劑之微脂體組合物的傳輸載體、方法及套組
CA3040395A1 (en) 2016-11-02 2018-05-11 Ipsen Biopharm Ltd. Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin)
JP2020500020A (ja) 2016-11-14 2020-01-09 ノバルティス アーゲー 融合誘導性タンパク質ｍｉｎｉｏｎに関連する組成物、方法、および治療上の使用
EP3640237B1 (de) 2017-06-15 2024-02-28 National University Corporation Hokkaido University Lipidmembranstruktur zur verabreichung in sirna-zellen

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1578776A (en) * 1976-06-10 1980-11-12 Univ Illinois Hemoglobin liposome and method of making the same
US4217344A (en) * 1976-06-23 1980-08-12 L'oreal Compositions containing aqueous dispersions of lipid spheres
US4598051A (en) * 1980-03-12 1986-07-01 The Regents Of The University Of California Liposome conjugates and diagnostic methods therewith
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
DE3161962D1 (en) * 1980-07-01 1984-02-23 Oreal Process for obtaining stable dispersions in an aqueous phase of at least a water immiscible liquid phase, and corresponding dispersions
US4534899A (en) * 1981-07-20 1985-08-13 Lipid Specialties, Inc. Synthetic phospholipid compounds
US4426330A (en) * 1981-07-20 1984-01-17 Lipid Specialties, Inc. Synthetic phospholipid compounds
US4429008B1 (en) * 1981-12-10 1995-05-16 Univ California Thiol reactive liposomes
US4480041A (en) * 1982-07-09 1984-10-30 Collaborative Research, Inc. Use of phosphotriester intermediates for preparation of functionalized liposomes
JPS59137409A (ja) * 1983-01-27 1984-08-07 Green Cross Corp:The ベンゾジアゼピン系化合物脂肪小体製剤
JPS6058915A (ja) * 1983-09-12 1985-04-05 Fujisawa Pharmaceut Co Ltd 薬物含有脂質小胞体製剤
JPS6072830A (ja) * 1983-09-29 1985-04-24 Kao Corp ベシクル用組成物
US4971803A (en) * 1985-04-08 1990-11-20 California Institute Of Technology Lamellar vesicles formed of cholesterol derivatives
AT393169B (de) * 1985-06-05 1991-08-26 Staudinger Gernot Verfahren und vorrichtung zur korngroessenanalyse
US4885172A (en) * 1985-06-26 1989-12-05 The Liposome Company, Inc. Composition for targeting, storing and loading of liposomes
JPS6295134A (ja) * 1985-10-21 1987-05-01 Nippon Saafuakutanto Kogyo Kk リポソ−ムの製造法
US5122450A (en) * 1985-10-24 1992-06-16 Research Corporation Limited Biochemical reagent
GB8601100D0 (en) * 1986-01-17 1986-02-19 Cosmas Damian Ltd Drug delivery system
US4776991A (en) * 1986-08-29 1988-10-11 The United States Of America As Represented By The Secretary Of The Navy Scaled-up production of liposome-encapsulated hemoglobin
US4920016A (en) * 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
US4837028A (en) * 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4855090A (en) * 1987-03-13 1989-08-08 Micro-Pak, Inc. Method of producing high aqueous volume multilamellar vesicles
US4948590A (en) * 1987-06-09 1990-08-14 Yale University Avidin or streptavidin conjugated liposomes
US4921838A (en) * 1987-06-16 1990-05-01 Trustees Of Boston University Angiogenic and blood perfusion inducing properties of amphiphilic compounds
US4853228A (en) * 1987-07-28 1989-08-01 Micro-Pak, Inc. Method of manufacturing unilamellar lipid vesicles
US4915951A (en) * 1987-12-03 1990-04-10 California Institute Of Technology Cryoprotective reagent
JPH0720857B2 (ja) * 1988-08-11 1995-03-08 テルモ株式会社 リポソームおよびその製法
GB8824593D0 (en) * 1988-10-20 1988-11-23 Royal Free Hosp School Med Liposomes
US4931361A (en) * 1988-11-18 1990-06-05 California Institute Of Technology Cryoprotective reagents in freeze-drying membranes
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5225212A (en) * 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
ATE119034T1 (de) * 1990-04-18 1995-03-15 Takeda Chemical Industries Ltd Liposomenzusammensetzung.
JP3220180B2 (ja) * 1991-05-23 2001-10-22 三菱化学株式会社 薬剤含有タンパク質結合リポソーム

Also Published As

Publication number Publication date
JPH0720857B2 (ja) 1995-03-08
US5593622A (en) 1997-01-14
US5846458A (en) 1998-12-08
ES2064470T3 (es) 1995-02-01
US5676971A (en) 1997-10-14
DE68919772T2 (de) 1995-07-13
JPH02149512A (ja) 1990-06-08
EP0354855A3 (de) 1991-06-05
EP0354855A2 (de) 1990-02-14
EP0354855B1 (de) 1994-12-07

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