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DE68912819D1 - Gabapentinmonohydrat und Verfahren zu dessen Herstellung. - Google Patents

Gabapentinmonohydrat und Verfahren zu dessen Herstellung.

Info

Publication number
DE68912819D1
DE68912819D1 DE89107795T DE68912819T DE68912819D1 DE 68912819 D1 DE68912819 D1 DE 68912819D1 DE 89107795 T DE89107795 T DE 89107795T DE 68912819 T DE68912819 T DE 68912819T DE 68912819 D1 DE68912819 D1 DE 68912819D1
Authority
DE
Germany
Prior art keywords
preparation
novel
gabapentin
gabapentin monohydrate
monohydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE89107795T
Other languages
English (en)
Other versions
DE68912819T2 (de
Inventor
Donald Eugene Butler
Barbara Jean Greenman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22694659&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE68912819(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of DE68912819D1 publication Critical patent/DE68912819D1/de
Application granted granted Critical
Publication of DE68912819T2 publication Critical patent/DE68912819T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE68912819T 1988-05-02 1989-04-28 Gabapentinmonohydrat und Verfahren zu dessen Herstellung. Expired - Lifetime DE68912819T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/188,819 US4894476A (en) 1988-05-02 1988-05-02 Gabapentin monohydrate and a process for producing the same

Publications (2)

Publication Number Publication Date
DE68912819D1 true DE68912819D1 (de) 1994-03-17
DE68912819T2 DE68912819T2 (de) 1994-05-19

Family

ID=22694659

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68912819T Expired - Lifetime DE68912819T2 (de) 1988-05-02 1989-04-28 Gabapentinmonohydrat und Verfahren zu dessen Herstellung.

Country Status (12)

Country Link
US (1) US4894476A (de)
EP (1) EP0340677B1 (de)
JP (1) JP2619951B2 (de)
AT (1) ATE101116T1 (de)
AU (1) AU624130B2 (de)
CA (1) CA1306755C (de)
DE (1) DE68912819T2 (de)
DK (1) DK175400B1 (de)
ES (1) ES2061774T3 (de)
FI (1) FI892067L (de)
HK (1) HK1000798A1 (de)
IE (1) IE62958B1 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3928182A1 (de) * 1989-08-25 1991-02-28 Goedecke Ag Verfahren zur herstellung von gabapentin
PH27359A (en) * 1989-08-25 1993-06-21 Warner Lambert Co Process for cyclic amino acid anticonvulsant compounds
DE3928183A1 (de) * 1989-08-25 1991-02-28 Goedecke Ag Lactamfreie cyclische aminosaeuren
DE3928184A1 (de) * 1989-08-25 1991-02-28 Goedecke Ag Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte
EP0458751A1 (de) * 1990-05-25 1991-11-27 Warner-Lambert Company System zur Freisetzung von cyclischen Aminosäuren mit verbessertem Geschmack, Struktur und Komprimierbarkeit
IL125544A (en) * 1996-03-14 2002-03-10 Warner Lambert Co Transformed cyclic amino acids and pharmaceutical preparations containing them
US6372792B1 (en) 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
US6255526B1 (en) 1996-12-24 2001-07-03 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin
WO1999018063A2 (en) 1997-10-07 1999-04-15 Warner-Lambert Company Process for preparing a cyclic amino acid anticonvulsant compound
ES2137137B1 (es) 1998-05-25 2000-08-16 Medichem Sa Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica.
ITMI981535A1 (it) * 1998-07-03 2000-01-03 Zambon Spa Processo per la preparazione di gabapentina
HU225502B1 (en) * 1998-12-29 2007-01-29 Richter Gedeon Vegyeszet Process for producing 1-(amino-metyl)-cyclohexene-acetic-acid and intermediates
IT1311984B1 (it) 1999-03-26 2002-03-22 Bioindustria Lab Italiano Medi Procedimento per la preparzione di gabapentin.
DE60022333T2 (de) * 1999-04-09 2006-07-06 Euro-Celtique S.A. Natrium kanalblocker zusammensetzungen und deren verwendung
ES2164527B1 (es) * 1999-04-26 2003-04-01 Medichen S A Procedimiento de obtencion de gabapentina de calidad farmaceutica.
US6294198B1 (en) 1999-08-24 2001-09-25 Purepac Pharmaceutical Co. Pharmaceutical tablet formulation containing gabapentin with improved physical and chemical characteristics and method of making the same
US6333352B1 (en) 2000-04-05 2001-12-25 Mimicking Man Manually, Inc. Method of treating benign positional vertigo
CZ200339A3 (cs) * 2000-06-16 2003-06-18 Teva Pharmaceutical Industries Ltd. Stabilní gabapentin vykazující neutrální pH
DK1289364T3 (da) * 2000-06-16 2004-04-13 Teva Pharma Stabil gapapentin som indeholder mere end 20 ppm chlorioner
EP1384473A1 (de) * 2000-06-16 2004-01-28 Teva Pharmaceutical Industries Ltd. Stabiles Gabapentin das mehr als 20 ppm Chlor enthält
ITMI20011132A1 (it) 2001-05-29 2002-11-29 Procos Spa Procedimento per la preparazione dell'acido 1-amminometil-1-cicloesanacetico
RU2295337C2 (ru) * 2001-09-03 2007-03-20 Ньюрон Фармасьютикалс Спа Фармацевтическая композиция, содержащая габапентин или его аналог и альфа-аминоамид, и ее применение в качестве анальгетика
US6800782B2 (en) * 2001-10-09 2004-10-05 Warner-Lambert Co. Anhydrous crystalline forms of gabapentin
US20060159743A1 (en) * 2001-10-25 2006-07-20 Depomed, Inc. Methods of treating non-nociceptive pain states with gastric retentive gabapentin
TWI312285B (en) 2001-10-25 2009-07-21 Depomed Inc Methods of treatment using a gastric retained gabapentin dosage
US7612112B2 (en) 2001-10-25 2009-11-03 Depomed, Inc. Methods of treatment using a gastric retained gabapentin dosage
US20070184104A1 (en) * 2001-10-25 2007-08-09 Depomed, Inc. Gastric retentive gabapentin dosage forms and methods for using same
US20030119908A1 (en) * 2001-12-21 2003-06-26 Zambon Group S.P.A. Stable gabapentin compositions
US6682759B2 (en) 2002-02-01 2004-01-27 Depomed, Inc. Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs
US7217696B2 (en) 2002-02-28 2007-05-15 A & D Bioscience, Inc. Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof
WO2003079980A2 (en) * 2002-03-19 2003-10-02 A & D Bioscience, Inc. Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
WO2003086475A1 (en) * 2002-04-12 2003-10-23 A & D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof
EP1494996A1 (de) * 2002-04-16 2005-01-12 Taro Pharmaceutical Industries Limited Verfahren zur herstellung von gabapentin
US20050153928A1 (en) * 2002-05-07 2005-07-14 Holick Michael F. Conjugates comprising a central nervous system-active drug linked to glucuronic acid or glucosamine through an amide bond and uses thereof
US20050215487A1 (en) * 2002-06-27 2005-09-29 Holick Michael F Conjugates comprising an nsaid and a sugar and uses thereof
US7196216B2 (en) * 2002-11-18 2007-03-27 Nicholas Piramal India Limited Process for preparation of Gabapentin
US20040214893A1 (en) * 2003-04-11 2004-10-28 Matthew Peterson Gabapentin compositions
EP1615875A2 (de) * 2003-04-21 2006-01-18 Matrix Laboratories Limited Verfahren zur herstellung von gabapentin form-ii
US20070043236A1 (en) * 2003-05-19 2007-02-22 Chandiran Thakashina M Process for preparation of gabapentin
WO2004106281A1 (en) * 2003-05-30 2004-12-09 Ranbaxy Laboratories Limited Crystalline gabapentin
US20050013863A1 (en) 2003-07-18 2005-01-20 Depomed, Inc., A Corporation Of The State Of California Dual drug dosage forms with improved separation of drugs
US20050187295A1 (en) * 2004-02-19 2005-08-25 Surendra Kalyan Processes for the preparation of gabapentin
ITMI20040579A1 (it) * 2004-03-25 2004-06-25 Zambon Spa Processo di preparazione di gabapentina
GB0416228D0 (en) 2004-07-20 2004-08-25 Sandoz Ind Products S A Process for the preparation of gabapentin
PT1809271E (pt) * 2004-09-10 2010-08-30 Newron Pharm Spa Utilização de (halogenobenziloxi)benzilamino-propanamidas para o fabrico de medicamentos activos como moduladores selectivos dos canais de sódio e/ou de cálcio
ITMI20042418A1 (it) * 2004-12-17 2005-03-17 Zambon Spa Processo per la purificazione della gabapentina
US7071356B1 (en) * 2005-12-01 2006-07-04 Isp Investments Inc. Process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid
US20090176882A1 (en) 2008-12-09 2009-07-09 Depomed, Inc. Gastric retentive gabapentin dosage forms and methods for using same
RU2464023C2 (ru) * 2008-05-16 2012-10-20 АКСИС, Инс Лекарственное средство для лечения фибромиалгии
US8431739B2 (en) 2010-06-14 2013-04-30 Divi's Laboratories, Ltd. Process for the preparation of gabapentin
EP2923694B1 (de) 2014-03-27 2018-11-14 Sanovel Ilac Sanayi ve Ticaret A.S. Orale flüssige pharmazeutische lösung von gabapentin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4014175A (en) * 1975-05-05 1977-03-29 Brink Douglas F Cable and pipe laying machine
US4087594A (en) * 1977-03-21 1978-05-02 Gte Laboratories, Incorporated Reactivation of primary electrochemical cells
PH27359A (en) * 1989-08-25 1993-06-21 Warner Lambert Co Process for cyclic amino acid anticonvulsant compounds

Also Published As

Publication number Publication date
FI892067A0 (fi) 1989-04-28
US4894476A (en) 1990-01-16
AU3267889A (en) 1989-11-02
ES2061774T3 (es) 1994-12-16
ATE101116T1 (de) 1994-02-15
AU624130B2 (en) 1992-06-04
FI892067L (fi) 1989-11-03
JPH0211546A (ja) 1990-01-16
IE891142L (en) 1989-11-02
EP0340677A3 (en) 1990-12-27
CA1306755C (en) 1992-08-25
JP2619951B2 (ja) 1997-06-11
DK212689D0 (da) 1989-05-01
HK1000798A1 (en) 1998-05-01
IE62958B1 (en) 1995-03-08
DE68912819T2 (de) 1994-05-19
EP0340677B1 (de) 1994-02-02
DK212689A (da) 1989-11-03
DK175400B1 (da) 2004-09-27
EP0340677A2 (de) 1989-11-08

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