DE68912422D1 - 19-Fluor- oder Cyano-21-hydroxy-progesteron-Derivate als 19-Hydroxylase-Inhibitoren. - Google Patents

19-Fluor- oder Cyano-21-hydroxy-progesteron-Derivate als 19-Hydroxylase-Inhibitoren.

Info

Publication number: DE68912422D1
Authority: DE; Germany
Prior art keywords: cyano; fluorine; hydroxy; hydroxylase inhibitors; progesterone derivatives
Prior art date: 1988-06-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE89111699T

Other languages

English (en)

Other versions

DE68912422T2 (de

Inventor

Gene W Holbert

J O'neal Johnston

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharmaceuticals Inc

Original Assignee

Merrell Dow Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-28

Filing date

1989-06-27

Publication date

1994-03-03

1989-06-27 Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc

1994-03-03 Application granted granted Critical

1994-03-03 Publication of DE68912422D1 publication Critical patent/DE68912422D1/de

1994-08-18 Publication of DE68912422T2 publication Critical patent/DE68912422T2/de

2009-06-28 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Organic Insulating Materials (AREA)
Manufacture Of Macromolecular Shaped Articles (AREA)

DE68912422T 1988-06-28 1989-06-27 19-Fluor- oder Cyano-21-hydroxy-progesteron-Derivate als 19-Hydroxylase-Inhibitoren. Expired - Lifetime DE68912422T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/212,410 US4920114A (en)	1988-06-28	1988-06-28	19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as 19-hydroxylase inhibitors

Publications (2)

Publication Number	Publication Date
DE68912422D1 true DE68912422D1 (de)	1994-03-03
DE68912422T2 DE68912422T2 (de)	1994-08-18

Family

ID=22790899

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE68912422T Expired - Lifetime DE68912422T2 (de)	1988-06-28	1989-06-27	19-Fluor- oder Cyano-21-hydroxy-progesteron-Derivate als 19-Hydroxylase-Inhibitoren.

Country Status (19)

Country	Link
US (1)	US4920114A (de)
EP (1)	EP0348911B1 (de)
JP (1)	JP2727466B2 (de)
KR (1)	KR0140885B1 (de)
CN (1)	CN1039424A (de)
AT (1)	ATE100462T1 (de)
AU (1)	AU610413B2 (de)
CA (1)	CA1321579C (de)
DE (1)	DE68912422T2 (de)
DK (1)	DK318489A (de)
ES (1)	ES2061802T3 (de)
FI (1)	FI893162L (de)
HU (1)	HUT51289A (de)
IL (1)	IL90728A0 (de)
NO (1)	NO892679L (de)
NZ (1)	NZ229694A (de)
PH (1)	PH25771A (de)
PT (1)	PT90989B (de)
ZA (1)	ZA894753B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4433374A1 (de) *	1994-09-20	1996-03-21	Hoechst Ag	17-Desoxi-corticosteroid-21-/O/-Carbonsäure- ester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US6787530B1 (en)	1996-08-23	2004-09-07	Monash University	Use of pregnane-diones as analgesic agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3124574A (en) *		1964-03-10		Iz-halo pregnenes
IT1051705B (it) *	1962-05-12	1981-05-20	Vismara Spa F	Metodo per la preparazione di intermedi steroidali
US3154569A (en) *	1961-10-10	1964-10-27	Vismara Francesco Spa	19-nitrilosteroids and process for producing 19-norsteroids
GB984093A (en) *	1962-02-19	1965-02-24	Syntex Corp	Improvements in or relating to 19-halo-pregnane compounds
US3257435A (en) *	1962-09-21	1966-06-21	Syntex Corp	19-bisdifluoro pregnanes
US3257389A (en) *	1962-09-21	1966-06-21	Syntex Corp	19-bisdifluoro-pregnanes
US3205228A (en) *	1963-03-01	1965-09-07	Syntex Corp	19-substituted pregnenes
US3159620A (en) *	1963-05-22	1964-12-01	Vismara Francesco Spa	Process for the preparation of 17 alpha-ethynyl-19-norandrostene compounds
US3394128A (en) *	1964-09-26	1968-07-23	Syntex Corp	19-halo-androstane and pregnane derivatives and processes for the preparation thereof
FR2462445A1 (fr) *	1979-07-31	1981-02-13	Roussel Uclaf	Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
US4293548A (en) *	1980-09-02	1981-10-06	Merrell Dow Pharmaceuticals Inc.	18-Substituted pregn-4-ene-3,20-diones

1988
- 1988-06-28 US US07/212,410 patent/US4920114A/en not_active Expired - Lifetime
1989
- 1989-06-22 ZA ZA894753A patent/ZA894753B/xx unknown
- 1989-06-23 IL IL90728A patent/IL90728A0/xx not_active IP Right Cessation
- 1989-06-23 NZ NZ229694A patent/NZ229694A/en unknown
- 1989-06-26 KR KR1019890008781A patent/KR0140885B1/ko not_active Expired - Fee Related
- 1989-06-27 ES ES89111699T patent/ES2061802T3/es not_active Expired - Lifetime
- 1989-06-27 NO NO89892679A patent/NO892679L/no unknown
- 1989-06-27 HU HU893242A patent/HUT51289A/hu unknown
- 1989-06-27 DK DK318489A patent/DK318489A/da not_active Application Discontinuation
- 1989-06-27 AT AT89111699T patent/ATE100462T1/de not_active IP Right Cessation
- 1989-06-27 DE DE68912422T patent/DE68912422T2/de not_active Expired - Lifetime
- 1989-06-27 PT PT90989A patent/PT90989B/pt not_active IP Right Cessation
- 1989-06-27 CA CA000604022A patent/CA1321579C/en not_active Expired - Lifetime
- 1989-06-27 EP EP89111699A patent/EP0348911B1/de not_active Expired - Lifetime
- 1989-06-27 JP JP1162845A patent/JP2727466B2/ja not_active Expired - Lifetime
- 1989-06-27 PH PH38862A patent/PH25771A/en unknown
- 1989-06-27 CN CN89106339A patent/CN1039424A/zh active Pending
- 1989-06-28 AU AU37126/89A patent/AU610413B2/en not_active Ceased
- 1989-06-28 FI FI893162A patent/FI893162L/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2061802T3 (es)	1994-12-16
DE68912422T2 (de)	1994-08-18
NO892679D0 (no)	1989-06-27
CN1039424A (zh)	1990-02-07
KR900000321A (ko)	1990-01-30
FI893162A7 (fi)	1989-12-29
JP2727466B2 (ja)	1998-03-11
DK318489D0 (da)	1989-06-27
JPH0248597A (ja)	1990-02-19
EP0348911A3 (en)	1990-03-28
CA1321579C (en)	1993-08-24
IL90728A0 (en)	1990-01-18
AU3712689A (en)	1990-01-04
ATE100462T1 (de)	1994-02-15
ZA894753B (en)	1990-03-28
AU610413B2 (en)	1991-05-16
EP0348911A2 (de)	1990-01-03
FI893162A0 (fi)	1989-06-28
NZ229694A (en)	1992-03-26
EP0348911B1 (de)	1994-01-19
US4920114A (en)	1990-04-24
PH25771A (en)	1991-10-18
NO892679L (no)	1989-12-29
PT90989B (pt)	1994-11-30
FI893162L (fi)	1989-12-29
PT90989A (pt)	1989-12-29
DK318489A (da)	1989-12-29
KR0140885B1 (ko)	1998-06-15
HUT51289A (en)	1990-04-28

Publication	Publication Date	Title
NO881138D0 (no)	1988-03-15	Sammensetning til befrielse av fastsatte borestrenger.
MX9302932A (es)	1995-01-31	Nuevas 4-aza-5&-androstan-3-onas 7b-substituidas como inhibidores de la5&-reductasa.
FI890238A7 (fi)	1989-07-19	Aktiivista ainetta ohjelmoidusti vapauttavia galeenisia koostumuksia
BR8900004A (pt)	1989-08-15	Composicoes herbicidas de compostos de heterociclicos-alcoilenos de quinoxaliniloxifenoxipropanoato
ES2191659T3 (es)	2003-09-16	Derivados heterociclicos substituidos utiles como inhibidores de la agregacion plaquetaria.
ES2060818T3 (es)	1994-12-01	Derivados de indol, benzofurano y benzotiofeno sustituidos como inhibidores de la 5-lipooxigenasa.
FI895447A7 (fi)	1989-11-15	Substituoidut terapeuttisina aineina käytettävät adeniinijohdannaiset
DE68922660D1 (de)	1995-06-22	19-Substituierte Progesterone als 19-Hydroxylase-Inhibitoren.
NO894775L (no)	1990-05-31	Stabilisering av forpakket iodofor.
ES2179254T3 (es)	2003-01-16	1-poliarilpirazoles plaguicidas.
FI894491A7 (fi)	1990-03-24	Antihypertensiivisinä aineina käytettäviä uusia substituoituja tienopyraaneja
DE68912422D1 (de)	1994-03-03	19-Fluor- oder Cyano-21-hydroxy-progesteron-Derivate als 19-Hydroxylase-Inhibitoren.
ATE176233T1 (de)	1999-02-15	Imidazo(1,2-c)chinazolinderivate als antihypertensive und antidysurie
DE68912159D1 (de)	1994-02-24	Dioxoquinazolinderivat enthaltendes Antihypertensivum.
EP0297816A3 (en)	1990-09-05	Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents
ATE44144T1 (de)	1989-07-15	6h-dibenzo(b,e)(1,4)oxathiepin-verbindungen.
LV5522A3 (lv)	1994-03-10	Tieno-(3',4',:4,5)-imidazo-(2,1-b)-tiazola atvasinajumu iegusanas panemiens
KR900000009U (ko)	1990-01-07	경운기의 예취기 결합장치
LV5507A3 (lv)	1994-03-10	4,5.-Dihidrooksazolu atvasinajumu iegusanas panemiens

Legal Events

Date	Code	Title	Description
1995-02-23	8364	No opposition during term of opposition