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DE68385T1 - Antithrombogenes elastomer - Google Patents

Antithrombogenes elastomer

Info

Publication number
DE68385T1
DE68385T1 DE198282105425T DE82105425T DE68385T1 DE 68385 T1 DE68385 T1 DE 68385T1 DE 198282105425 T DE198282105425 T DE 198282105425T DE 82105425 T DE82105425 T DE 82105425T DE 68385 T1 DE68385 T1 DE 68385T1
Authority
DE
Germany
Prior art keywords
elastomer
value
silicone polymer
organic silicone
antithrombogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198282105425T
Other languages
English (en)
Inventor
Kazuaki Kobe-Shi Hyogo-Ken Kira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56097270A external-priority patent/JPS57211358A/ja
Priority claimed from JP57072298A external-priority patent/JPS58188458A/ja
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Publication of DE68385T1 publication Critical patent/DE68385T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/77—Polyisocyanates or polyisothiocyanates having heteroatoms in addition to the isocyanate or isothiocyanate nitrogen and oxygen or sulfur
    • C08G18/778—Polyisocyanates or polyisothiocyanates having heteroatoms in addition to the isocyanate or isothiocyanate nitrogen and oxygen or sulfur silicon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/068—Use of macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/50—Polyethers having heteroatoms other than oxygen
    • C08G18/5096—Polyethers having heteroatoms other than oxygen containing silicon
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/61—Polysiloxanes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/902—Method of implanting
    • Y10S623/903—Blood vessel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Materials For Medical Uses (AREA)

Claims (10)

VOSSIUS VOSSIUS TAUCHNER · HEUNEMANN- RAUH PAT E ImTA N WALTE SIE BERTSTRASS E 4- ■ 8OOO MÜNCHEN 8 6 · PHONE: (O89) 47 4O75 CABLE: BENZOLPATENT MÖNCHEN -TELEX 5-29 453 VOPAT D 1, 82 10 5425.1 Kanegafuchi Kagaku Kogyo K.K. u.Z.: R 900 EP (Vo/ko) Patentansprüche
1. Antithrombogenes Elastomer/ enthaltend ein Polyurethan oder einen Polyurethanharnstoff, die in der Hauptkette ein organisches Silikonpolymer enthalten.
2. Elastomer nach Anspruch 1, wobei das Elastomer thermoplastisch ist.
3. Elastomer nach Anspruch 1, wobei das Elastomer 1 bis 50 Gewichtsprozent des organischen Silikonpolymers enthält.
4. Elastomer nach Anspruch 1, wobei das Elastomer ein weiches Segmentverhältnis von 40 bis 80 Gewichtsprozent aufweist.
5. Elastomer nach Anspruch 1, wobei das organische Silikonpolymer ein Polysiloxan ist.
6. Elastomer nach Anspruch 1, wobei das organische SiIikonpolymer ein Polydimethylsiloxan ist.
7. Elastomer nach Anspruch 6, wobei das Polydimethylsiloxan die Formel
CH-, CH^
I3I3
CH3 CH3
hat, in der die Reste R1 bis Rg jeweils einen Alkylenrest mit mindestens einem Kohlenstoffatom bedeuten, a und e jeweils ganze Zahlen mit einem Wert von 0 bis 30 sind, b und d jeweils den Wert 0 oder 1 haben und c eine ganze Zahl mit einem Wert von mindestens 2 ist.
8. Antithrombogenes Formteil mit glatter Oberfläche aus einem antithrombogenen Elastomer auf der Basis eines Polyurethans oder eines Polyurethanharnstoffs, die ein organi^- sches Silikonpolymer in der Hauptkette enthalten, nach Anspruch 1 .
9. Verfahren zur Herstellung eines antithrombogenen Elastomers nach Anspruch 1, dadurch gekennzeichnet, daß man eine Isocyanatverbindung mit einer Verbindung mit aktiven Wasserstoff atomen, die weiche Segmente mit einem Molekulargewicht von 500 bis 6000 enthält, und eine synthetische Komponente mit aktiven Wasserstoffatomen und bzw. oder Isocyanafcgruppen, die in der Hauptkette ein organisches Silikonpolymer enthält,
zur Umsetzung bringt.
10. Verfahren nach Anspruch 9, dadurch gekennzeichnet, daß die synthetische Komponente die Formel
CH-. CH-.
Los
R1 OR? aVOR3O b Sx O^S^OR^r^O^RgX
CH3 CH3
hat, in der die Reste R1 bis Rß jeweils einen Alkylenrest mit mindestens einem Kohlenstoffatom bedeuten, X eine Gruppe mit aktivem Wasserstoff ist, a und e jeweils ganze Zahlen mit einem Wert von 0 bis 30 sind, b und d jeweils den Wert 0 oder 1 haben und c eine ganze Zahl mit einem Wert von mindestens 2 ist.
L J
DE198282105425T 1981-06-22 1982-06-21 Antithrombogenes elastomer Pending DE68385T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56097270A JPS57211358A (en) 1981-06-22 1981-06-22 Anti-thrombus elastomer and method
JP57072298A JPS58188458A (ja) 1982-04-27 1982-04-27 抗血栓性エラストマ−、その製造方法及び抗血栓性エラストマ−よりなる成形体

Publications (1)

Publication Number Publication Date
DE68385T1 true DE68385T1 (de) 1983-09-15

Family

ID=26413440

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8282105425T Expired DE3273433D1 (en) 1981-06-22 1982-06-21 Thermoplastic elastomers for medical use as moulded articles brought into direct contact with blood
DE198282105425T Pending DE68385T1 (de) 1981-06-22 1982-06-21 Antithrombogenes elastomer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8282105425T Expired DE3273433D1 (en) 1981-06-22 1982-06-21 Thermoplastic elastomers for medical use as moulded articles brought into direct contact with blood

Country Status (3)

Country Link
US (2) US4528343A (de)
EP (1) EP0068385B1 (de)
DE (2) DE3273433D1 (de)

Families Citing this family (48)

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US4861830A (en) * 1980-02-29 1989-08-29 Th. Goldschmidt Ag Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming
US4675361A (en) * 1980-02-29 1987-06-23 Thoratec Laboratories Corp. Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming
DE3273433D1 (en) * 1981-06-22 1986-10-30 Kanegafuchi Chemical Ind Thermoplastic elastomers for medical use as moulded articles brought into direct contact with blood
DE3478192D1 (en) * 1983-06-06 1989-06-22 Kanegafuchi Chemical Ind Artificial vessel and process for preparing the same
EP0157178B1 (de) * 1984-03-01 1988-11-30 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Künstliches Gefäss und Verfahren zu seiner Herstellung
US4600652A (en) * 1985-04-01 1986-07-15 Warner-Lambert Company Permanently bonded antithrombogenic polyurethane surface
US4642242A (en) * 1985-04-01 1987-02-10 Becton, Dickinson And Company Permanently bonded antithrombogenic polyurethane surface
DE3517612A1 (de) * 1985-05-15 1987-01-02 Titmus Eurocon Kontaktlinsen Modifizierter siliconkautschuk und seine verwendung als material fuer eine optische linse sowie optische linse aus diesem material
DE3541478A1 (de) * 1985-11-23 1987-05-27 Beiersdorf Ag Herzklappenprothese und verfahren zu deren herstellung
US4631329A (en) * 1985-11-29 1986-12-23 Dow Corning Corporation Moisture resistant polyurethanes derived from non-aromatic diisocyanates
US5512650A (en) 1986-06-20 1996-04-30 Minnesota Mining And Manufacturing Company Block copolymer, method of making the same, diamine precursors of the same, method of making such diamines and end products comprising the block copolymer
US5214119A (en) * 1986-06-20 1993-05-25 Minnesota Mining And Manufacturing Company Block copolymer, method of making the same, dimaine precursors of the same, method of making such diamines and end products comprising the block copolymer
JPH0763489B2 (ja) * 1986-10-31 1995-07-12 宇部興産株式会社 医療用チユ−ブ
US4839443A (en) * 1987-02-04 1989-06-13 Chisso Corporation Polysiloxane containing hydroxyl groups and a silicone-modified polyurethane using the same
JPS63209647A (ja) * 1987-02-26 1988-08-31 鐘淵化学工業株式会社 人工血管
DE3725728A1 (de) * 1987-08-04 1989-02-16 Freudenberg Carl Fa Medizinisches geraet und verfahren zu seiner herstellung
US5221724A (en) * 1987-08-12 1993-06-22 Wisconsin Alumni Research Foundation Polysiloxane polyurea urethanes
US5128408A (en) * 1987-11-16 1992-07-07 Toyo Boseki Kabushiki Kaisha Gas-permeable material with excellent compatibility with blood
DE3855365T2 (de) * 1988-03-14 1996-10-31 Corvita Corp Polyurethane
US4916199A (en) * 1988-07-14 1990-04-10 The B. F. Goodrich Company Polyurethanes made from blends of polypropyleneoxide polyol and organic-silicone block copolymer based polyol intermediates
JPH0245040A (ja) * 1988-08-03 1990-02-15 Terumo Corp 減圧採血管
DE4008259A1 (de) * 1990-03-15 1991-09-19 Bayer Ag Siloxanmodifizierte thermoplastische polyurethane
US6464713B2 (en) * 1990-06-28 2002-10-15 Peter M. Bonutti Body tissue fastening
US5533992A (en) * 1990-12-31 1996-07-09 Patel; Indrajit Material for medical grade products and products made therefrom
DE4217165C1 (de) * 1992-05-23 1993-08-19 Rehau Ag + Co, 8673 Rehau, De
US5500180A (en) 1992-09-30 1996-03-19 C. R. Bard, Inc. Method of making a distensible dilatation balloon using a block copolymer
DE4243799A1 (de) * 1992-12-23 1994-06-30 Bayer Ag Siloxanblockcopolymer-modifizierte thermoplastische Polyurethane
DE4414103A1 (de) * 1994-04-22 1995-10-26 Reinmueller Johannes Medizinische Implantate aus Formkörpern
US5670598A (en) * 1995-03-24 1997-09-23 Minnesota Mining And Manufacturing Company Diblock and triblock polydiorganosiloxane-polyurea block copolymers
US5609632A (en) * 1996-03-18 1997-03-11 Medtronic, Inc. Method of fabricating an artificial lung
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US6846893B1 (en) * 1996-10-23 2005-01-25 Minnesota Mining And Manufacturing Company Polymer mixtures containing polydiorganosiloxane urea-containing components
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US5863627A (en) * 1997-08-26 1999-01-26 Cardiotech International, Inc. Hydrolytically-and proteolytically-stable polycarbonate polyurethane silicone copolymers
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US7407709B2 (en) * 2003-12-22 2008-08-05 3M Innovative Properties Company Silicone pressure sensitive adhesive and articles
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US9474833B2 (en) 2006-12-18 2016-10-25 Cook Medical Technologies Llc Stent graft with releasable therapeutic agent and soluble coating
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CN106832184B (zh) * 2017-02-10 2020-09-01 美瑞新材料股份有限公司 一种热塑性有机硅聚氨酯弹性体及其制备方法
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CA1135140A (en) * 1978-03-07 1982-11-09 Kiyoshi Asai Catheter placement system
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DE3273433D1 (en) * 1981-06-22 1986-10-30 Kanegafuchi Chemical Ind Thermoplastic elastomers for medical use as moulded articles brought into direct contact with blood

Also Published As

Publication number Publication date
US4623347A (en) 1986-11-18
DE3273433D1 (en) 1986-10-30
EP0068385A1 (de) 1983-01-05
US4528343A (en) 1985-07-09
EP0068385B1 (de) 1986-09-24

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