DE682662C - Process for the extraction of therapeutically active substances from Lactuca virosa - Google Patents
Process for the extraction of therapeutically active substances from Lactuca virosaInfo
- Publication number
- DE682662C DE682662C DEK144456D DEK0144456D DE682662C DE 682662 C DE682662 C DE 682662C DE K144456 D DEK144456 D DE K144456D DE K0144456 D DEK0144456 D DE K0144456D DE 682662 C DE682662 C DE 682662C
- Authority
- DE
- Germany
- Prior art keywords
- extraction
- active substances
- therapeutically active
- lactuca virosa
- virosa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 241001293495 Lactuca virosa Species 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 3
- 239000013543 active substance Substances 0.000 title description 2
- 238000000605 extraction Methods 0.000 title description 2
- 239000000126 substance Substances 0.000 claims description 8
- 238000000502 dialysis Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Gewinnung von therapeutisch wirksamen Stoffen aus Lactuca virosa Es wurde gefunden, daß man die Bitterstoffe der Lactuca virosa in hochkonzentrierter Form dadurch gewinnt, daß man den Preßsaft der Pflanze, den Milchsaft oder eine ähnliche Zubereitung, wie z. B. das nach dem Patent 671 855 hergestellte wasserlösliche Pulver, der Dialyse unterwirft-und das Dialysat im Vakuum konzentriert.Process for the production of therapeutically active substances from Lactuca virosa It has been found that the bitter substances of Lactuca virosa are highly concentrated Form wins by using the pressed sap of the plant, the milky sap or a similar preparation, such as B. the water-soluble prepared according to the patent 671,855 Powder subjected to dialysis - and the dialysate concentrated in vacuo.
Bei der Konzentrierung des Dialysat scheidet sich das Bitterstoffgemisch freiwillig ab und kann durch Filtration gewonnen werden, ohne daß eine langwierige Extraktion mit organischen Lösungsmitteln notwendig ist. When the dialysate is concentrated, the bitter substance mixture separates voluntarily and can be recovered by filtration without the need for a tedious one Extraction with organic solvents is necessary.
Dieses Ergebnis konnte nicht erwartet werden, denn wenn man eine nicht dialysierte wäßrige Lösung eindampft, so findet keine Abscheidung der Bitterstoffe statt. Durch die Dialyse werden die Bitterstoffe überraschenderweise von solchen Stoffen getrennt, welche als Lösungsvermittler wirken. This result could not be expected because when you get one If the non-dialyzed aqueous solution is evaporated, the bitter substances are not deposited instead of. The dialysis surprisingly removes the bitter substances from them Separate substances that act as solubilizers.
Aus dem eingeengten Dialysat wird eine nahezu farblose kristalline Substanz vom Schmelzpunkt I90 bis 1930 erhalten, aus der durch Behandlung mit heißem Methanol oder Wasser vollkommen farblose Kristalle vom Schmelzpunkt 2120 gewonnen werden können; die Kristalle lösen sich leicht in der Wärme in Wasser, Methanol, Alkohol, Azeton und Essigester. The concentrated dialysate becomes an almost colorless crystalline one Substance obtained from melting point 190 to 1930, from which by treatment with hot Methanol or water obtained completely colorless crystals with a melting point of 2120 can be; the crystals dissolve easily in the warmth in water, methanol, Alcohol, acetone and ethyl acetate.
Beispiel I 500 g des Milchsaftes von Lactuca virosa werden je nach Beschaffenheit mit oder ohne Zusatz von Wasser der Dialyse unterworfen. Example I 500 g of the milk juice of Lactuca virosa are used according to Subjected to dialysis with or without the addition of water.
Das Dialysat wird eingeengt, wobei die Bitterstoffe sich abscheiden und auf üblichem Wege gewonnen werden können.The dialysate is concentrated, whereby the bitter substances are deposited and can be obtained in the usual way.
Beispiel 2 Der Preßsaft von Lactuca virosa wird der Dialyse unterworfen.-Die Weiterbehandlung geschieht wie nach Beispiel I. Example 2 The pressed juice of Lactuca virosa is subjected to dialysis Further treatment takes place as in Example I.
Beispiel 3 Zur Dialyse wird eine Lösung verwandt, die durch Auflösung des nach dem Patent 67I 855 gewonnenen trockenen Pulvers in Wasser erhalten wurde. Die weitere Aufarbeitung geschieht ebenfalls, wie in Beispiel I beschrieben, Example 3 A solution is used for dialysis which is obtained by dissolving of the dry powder obtained according to patent 67I855 in water. The further work-up is also carried out as described in Example I,
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEK144456D DE682662C (en) | 1936-11-18 | 1936-11-18 | Process for the extraction of therapeutically active substances from Lactuca virosa |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEK144456D DE682662C (en) | 1936-11-18 | 1936-11-18 | Process for the extraction of therapeutically active substances from Lactuca virosa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE682662C true DE682662C (en) | 1939-10-19 |
Family
ID=7250672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEK144456D Expired DE682662C (en) | 1936-11-18 | 1936-11-18 | Process for the extraction of therapeutically active substances from Lactuca virosa |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE682662C (en) |
-
1936
- 1936-11-18 DE DEK144456D patent/DE682662C/en not_active Expired
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