DE677982C - Process for the preparation of durable, saturated solutions of organic calcium salts - Google Patents
Process for the preparation of durable, saturated solutions of organic calcium saltsInfo
- Publication number
- DE677982C DE677982C DEW99878D DEW0099878D DE677982C DE 677982 C DE677982 C DE 677982C DE W99878 D DEW99878 D DE W99878D DE W0099878 D DEW0099878 D DE W0099878D DE 677982 C DE677982 C DE 677982C
- Authority
- DE
- Germany
- Prior art keywords
- durable
- calcium salts
- preparation
- solutions
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Verfahren zur Herstellung haltbarer übersättigter Lösungen organischer Calciumsalze Es ist bekannt, daß haltbare konzentrierte Calciuminjektionslösungen nur nach besonderen Arbeitsmethoden erhalten werden können und daß die Kalksalze nach parenteraler Verabreichung neben der Schmerzhaftigkeit mehr oder weniger ausgedehnte Nzekrosen verursachen.Process for making durable supersaturated solutions of organic Calcium salts It is known that stable concentrated calcium injection solutions can only be obtained by special working methods and that the calcium salts after parenteral administration more or less extensive in addition to the painfulness Cause necrosis.
Es wurde gefunden, daß es gelingt, haltbare und intramuskulär anwendbare Calciumsaizlösungen dadurch herzustellen, daß man zu den entsprechenden übersättigten Lösungen unter ErMnärmen Sulfhydrylgruppen enthaltende organische Säuren hinzufügt. It has been found that it is durable and can be used intramuscularly Calcium salt solutions to be prepared by adding to the corresponding supersaturated Add organic acids containing sulfhydryl groups to solutions with caution.
Beispiel r 10 Teile Calciumlactat werden unter Erwärmen in go Teilen Wasser gelöst. Diese Lösung kristallisiert nach kurzem Stehen. Example r 10 parts of calcium lactate are converted into 10 parts by heating Dissolved in water. This solution crystallizes after standing for a short time.
Versetzt man jedoch eine derartige Lösung vorher mit 1 0/0 Thioglykolsäure und erwärmt im Rundkolben am Rückflußkühler etwa 2 Stunden, so erhält man Lösungen, die sich nach Abkühlen als hinreichend haltbar erweisen, besonders wenn sie in Ampullen steril aufbewahrt werden.However, 1% thioglycolic acid is added to such a solution beforehand and heated in the round bottom flask on the reflux condenser for about 2 hours, solutions are obtained which prove to be sufficiently durable after cooling, especially when they are in ampoules be kept sterile.
Beispiel 2 12 Teile Calciumnatriumlactat werden in 88 Teilen Wasser gelöst. Derartige Lösungen beginnen selbst nach steriler Abfüllung in Ampullen nach spätestens 8 Tagen zu kristailisieren. Erhitzt man aber die Lösung mit 1 % Thiomilchsäure 2 Stunden am Rückflußkühler, so wird sie nach steriler Abfüllung in Ampullen haltbar. Example 2 12 parts of calcium sodium lactate are in 88 parts of water solved. Such solutions begin even after sterile filling in ampoules to crystallize no later than 8 days. But if the solution is heated with 1% thiolactic acid 2 hours in the reflux condenser, so it can be kept in ampoules after sterile filling.
Beispiel 3 Eine Lösung von 12 Teilen Calciumnatriumlactat in 88 Teilen Wasser wird, wie in Beispiel 2 angegeben, diesmal durch einen Zusatz von 2 0/0 Thioessigsäure stabilisiert. Example 3 A solution of 12 parts of calcium sodium lactate in 88 parts Water is, as indicated in Example 2, this time by adding 2% thioacetic acid stabilized.
Beispiel 4 Eine Lösung von Io Teilen Calciumlactat in 90 Teilen Wasser wird, wie in Beispiel 1 angegeben, diesmal durch einen Zusatz von 5% Sulfhydrylkeratinsäure stabilisiert. Example 4 A solution of 10 parts of calcium lactate in 90 parts of water is, as indicated in Example 1, this time by adding 5% sulfhydryl keratinic acid stabilized.
Beispiel 5 20 Teile Calciumglukonat werden unter Erwärmen in 100 Teilen Wasser gelöst. Die Lösung wird mit 2 Teilen Thioglykolsläure versetzt und 2 Stunden lang am Rückflußkühler erhitzt. Nach Abfüllen in Ampullen ist diese Lösung haltbar. Dagegen kristallisiert aus Lösungen von 20 Teilen Calciurnglukonat in 100 Teilen Wasser ohne Zusatz von Thioglykolsäure nach einiger Zeit Calciumglukonat wieder aus. Example 5 20 parts of calcium gluconate are heated to 100 Part of dissolved water. The solution is mixed with 2 parts of thioglycolic acid and Heated under the reflux condenser for 2 hours. This solution is after filling into ampoules durable. In contrast, solutions of 20 parts of calcium gluconate crystallize in 100 Share water without the addition of thioglycolic acid after some time calcium gluconate out again.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEW99878D DE677982C (en) | 1936-11-15 | 1936-11-15 | Process for the preparation of durable, saturated solutions of organic calcium salts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEW99878D DE677982C (en) | 1936-11-15 | 1936-11-15 | Process for the preparation of durable, saturated solutions of organic calcium salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE677982C true DE677982C (en) | 1939-07-06 |
Family
ID=7615250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEW99878D Expired DE677982C (en) | 1936-11-15 | 1936-11-15 | Process for the preparation of durable, saturated solutions of organic calcium salts |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE677982C (en) |
-
1936
- 1936-11-15 DE DEW99878D patent/DE677982C/en not_active Expired
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