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DE60336226D1 - Verfahren zur herstellung von olanzapin form i - Google Patents

Verfahren zur herstellung von olanzapin form i

Info

Publication number
DE60336226D1
DE60336226D1 DE60336226T DE60336226T DE60336226D1 DE 60336226 D1 DE60336226 D1 DE 60336226D1 DE 60336226 T DE60336226 T DE 60336226T DE 60336226 T DE60336226 T DE 60336226T DE 60336226 D1 DE60336226 D1 DE 60336226D1
Authority
DE
Germany
Prior art keywords
olanzapine form
producing olanzapine
producing
methyl
olanzapine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60336226T
Other languages
English (en)
Inventor
Hiren V Patel
Anup K Ray
Pramod B Patel
Mahendra R Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of DE60336226D1 publication Critical patent/DE60336226D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60336226T 2002-05-31 2003-05-30 Verfahren zur herstellung von olanzapin form i Expired - Lifetime DE60336226D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16095802A 2002-05-31 2002-05-31
PCT/US2003/017186 WO2003101997A1 (en) 2002-05-31 2003-05-30 Process of preparation of olanzapine form i

Publications (1)

Publication Number Publication Date
DE60336226D1 true DE60336226D1 (de) 2011-04-14

Family

ID=29709737

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60336226T Expired - Lifetime DE60336226D1 (de) 2002-05-31 2003-05-30 Verfahren zur herstellung von olanzapin form i

Country Status (7)

Country Link
US (2) US7297789B2 (de)
EP (1) EP1513846B1 (de)
AT (1) ATE500258T1 (de)
AU (1) AU2003237305A1 (de)
DE (1) DE60336226D1 (de)
SI (1) SI1513846T1 (de)
WO (1) WO2003101997A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL202856B1 (pl) * 2002-12-20 2009-07-31 Adamed Spo & Lstrok Ka Z Ogran Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
WO2004058773A1 (en) * 2002-12-24 2004-07-15 Teva Pharmaceutical Industries Ltd. Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
WO2005063771A1 (en) * 2003-12-22 2005-07-14 Teva Pharmaceutical Industries Ltd Methods of preparing olanzapine
WO2005070937A1 (en) * 2004-01-27 2005-08-04 Synthon B.V. A process for making olanzapine in a polymorph form i
DE602005027308D1 (de) 2004-01-27 2011-05-19 Synthon Bv Stabile salze von olanzapin
AR048272A1 (es) * 2004-03-18 2006-04-12 Lek Pharmaceuticals Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales.
CA2576862C (en) * 2004-07-14 2012-09-11 Jubilant Organosys Limited A process for producing pure form of 2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno[2,3-b][1,5]benzodiazepine
ES2253091B1 (es) 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
SI21850A (sl) * 2004-07-28 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Soli olanzapina in njihova pretvorba v prosto bazo olanzapina
WO2006027800A1 (en) 2004-09-06 2006-03-16 Shasun Chemicals And Drugs Limited A novel process for preparation of a pharmaceutically pure polymorphic form 1 of olanzapine
WO2006102176A2 (en) * 2005-03-21 2006-09-28 Dr. Reddy's Laboratories Ltd. Process for preparing crystalline form i of olanzapine
EP1919923A1 (de) * 2005-08-17 2008-05-14 Synthon B.V. Verfahren zur herstellung von olanzapin form i
HUP0501046A2 (en) 2005-11-11 2007-08-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of olanzapine
ES2279715B1 (es) 2005-12-26 2008-06-01 Laboratorios Lesvi, S.L. Formulacion oral de olanzapina.
US7834176B2 (en) * 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
WO2007138376A1 (en) * 2006-06-01 2007-12-06 Aurobindo Pharma Limited An improved process for preparing olanzapine form i
WO2007144901A1 (en) * 2006-06-12 2007-12-21 Jubilant Organosys Limited Process for stabilization of olanzapine polymorphic form i
PL381564A1 (pl) * 2007-01-22 2008-08-04 Koźluk Tomasz Nobilus Ent Sposób wytwarzania zasadniczo czystej odmiany polimorficznej I olanzapiny
CA2593407A1 (en) * 2007-06-22 2008-12-22 Apotex Pharmachem Inc. Improved processes for the synthesis of olanzapine
EP2292624A1 (de) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Olanzapinreinigungsverfahren
CN102268010A (zh) * 2011-06-17 2011-12-07 大连美罗大药厂 一种奥氮平的制备方法和精制方法
KR101489062B1 (ko) * 2013-03-28 2015-02-02 동아에스티 주식회사 고순도의 올란자핀 및 이의 결정형 ii의 제조방법
CN109456336A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 奥氮平的精制方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH554362A (de) 1970-07-30 1974-09-30 Spofa Vereinigte Pharma Werke Verfahren zur herstellung von neuen estern tricyklischer piperazinoalkanole.
US4115568A (en) 1974-11-26 1978-09-19 Lilly Industries Limited Thieno[3,2-b]-[1,5]benzodiazepines
GB9009229D0 (en) 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
US5229382A (en) 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
US5627178A (en) 1991-04-23 1997-05-06 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
US5605897A (en) 1991-04-23 1997-02-25 Eli Lilly And Company 2-methyl-thieno-benzodiazepine
US5817656A (en) 1991-04-23 1998-10-06 Eli Lilly And Company Mental disorders
US5817655A (en) 1991-04-23 1998-10-06 Eli Lilly And Company Methods of treatment using a thieno-benzodiazepine
US5817657A (en) 1991-04-23 1998-10-06 Eli Lilly And Company Psychoactive substance disorders
CR5278A (es) 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
EG23659A (en) 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
EG24221A (en) 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
US5637584A (en) 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
US5631250A (en) 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
ZA978515B (en) 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
EA001881B1 (ru) 1996-09-23 2001-10-22 Эли Лилли Энд Компани Форма d дигидрата оланзапина
EP1155696B1 (de) 1997-04-15 2004-03-03 Eli Lilly And Company Verwendung von Olanzapin zur Herstellung eines Arzneimittels zur Neuroprotektion
WO1999016312A1 (en) 1997-09-30 1999-04-08 Eli Lilly And Company Method for treating sexual dysfunction
US7022698B2 (en) 1999-12-28 2006-04-04 U & I Pharmaceuticals, Ltd. Pharmaceutical compositions containing new polymorphic forms of olanzapine and uses thereof
US6348458B1 (en) 1999-12-28 2002-02-19 U & I Pharmaceuticals Ltd. Polymorphic forms of olanzapine
NZ519926A (en) 1999-12-28 2004-02-27 Cipla Ltd New polymorphic forms of olanzapine
JP2004507548A (ja) 2000-08-31 2004-03-11 ドクター・レディーズ・ラボラトリーズ・リミテッド オランザピン水和物の調製方法、及びこれを結晶形態のオランザピンに変換する方法
US6740753B2 (en) 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
US20030097650A1 (en) * 2001-10-04 2003-05-22 International Business Machines Corporation Method and apparatus for testing software
AU2002340328A1 (en) 2001-10-29 2003-05-12 Janet I. Cord Olanzapine dihydrate-ii a process for its preparation and use thereof
EP2108651A1 (de) 2001-12-24 2009-10-14 Sun Pharmaceuticals Industries Ltd. Kristalline Form I von 2-Methyl-4-(4-Methyl-1-Piperazinyl)-10H-thieno[2,3-B][1,5]-Benzodiazepin
PL196814B1 (pl) 2002-05-17 2008-02-29 Inst Farmaceutyczny Sposób wytwarzania odmiany polimorficznej I olanzapiny i jej solwaty
EP1919923A1 (de) 2005-08-17 2008-05-14 Synthon B.V. Verfahren zur herstellung von olanzapin form i

Also Published As

Publication number Publication date
WO2003101997A1 (en) 2003-12-11
EP1513846B1 (de) 2011-03-02
ATE500258T1 (de) 2011-03-15
US7297789B2 (en) 2007-11-20
EP1513846A1 (de) 2005-03-16
US20080188465A1 (en) 2008-08-07
SI1513846T1 (sl) 2011-11-30
AU2003237305A1 (en) 2003-12-19
US20040048854A1 (en) 2004-03-11

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