DE60329323D1 - Substituierte heterozyklische verbindungen - Google Patents
Substituierte heterozyklische verbindungenInfo
- Publication number
- DE60329323D1 DE60329323D1 DE60329323T DE60329323T DE60329323D1 DE 60329323 D1 DE60329323 D1 DE 60329323D1 DE 60329323 T DE60329323 T DE 60329323T DE 60329323 T DE60329323 T DE 60329323T DE 60329323 D1 DE60329323 D1 DE 60329323D1
- Authority
- DE
- Germany
- Prior art keywords
- heterocyclic compounds
- angina
- substituted heterocyclic
- useful
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001420 substituted heterocyclic compounds Chemical class 0.000 title 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 2
- 206010002388 Angina unstable Diseases 0.000 abstract 1
- 206010003130 Arrhythmia supraventricular Diseases 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010022562 Intermittent claudication Diseases 0.000 abstract 1
- 208000007718 Stable Angina Diseases 0.000 abstract 1
- 208000007814 Unstable Angina Diseases 0.000 abstract 1
- 206010047281 Ventricular arrhythmia Diseases 0.000 abstract 1
- 230000001746 atrial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 abstract 1
- 208000021156 intermittent vascular claudication Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43786003P | 2003-01-03 | 2003-01-03 | |
| PCT/US2003/040607 WO2004063180A1 (en) | 2003-01-03 | 2003-12-19 | Substituted heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60329323D1 true DE60329323D1 (de) | 2009-10-29 |
Family
ID=32713240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60329323T Expired - Lifetime DE60329323D1 (de) | 2003-01-03 | 2003-12-19 | Substituierte heterozyklische verbindungen |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7205303B2 (de) |
| EP (1) | EP1578737B1 (de) |
| JP (1) | JP2006514066A (de) |
| KR (1) | KR20050086956A (de) |
| AT (1) | ATE443058T1 (de) |
| AU (1) | AU2003303676A1 (de) |
| CA (1) | CA2512261A1 (de) |
| DE (1) | DE60329323D1 (de) |
| ES (1) | ES2329997T3 (de) |
| HK (1) | HK1085467A1 (de) |
| NZ (1) | NZ541069A (de) |
| WO (1) | WO2004063180A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050086956A (ko) * | 2003-01-03 | 2005-08-30 | 씨브이 쎄러퓨틱스, 인코포레이티드 | 치환된 복소환 화합물 |
| SG174520A1 (en) * | 2009-04-02 | 2011-10-28 | Merck Patent Gmbh | Heterocyclic compounds as autotaxin inhibitors |
| CN102656151A (zh) * | 2009-09-04 | 2012-09-05 | 扎里卡斯药品有限公司 | 治疗疼痛和癫痫的取代的杂环衍生物 |
| WO2014134306A1 (en) | 2013-03-01 | 2014-09-04 | Zalicus Pharmaceuticals, Ltd. | Heterocyclic inhibitors of the sodium channel |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US181352A (en) * | 1876-08-22 | Improvement in cotton-cleaners | ||
| US729499A (en) * | 1901-08-12 | 1903-05-26 | John Machaffie | Igniter for gas-engines. |
| US4766125A (en) * | 1981-06-23 | 1988-08-23 | Janssen Pharmaceutica N.V. | N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia |
| JPS584774A (ja) * | 1981-06-23 | 1983-01-11 | ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ | Ｎ−アリ−ル−ピペラジンアルカンアミド類 |
| US4558129A (en) | 1983-05-18 | 1985-12-10 | Syntex (U.S.A.) Inc. | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade |
| US4567264A (en) * | 1983-05-18 | 1986-01-28 | Syntex (U.S.A.) Inc. | Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry |
| US4588129A (en) * | 1983-09-06 | 1986-05-13 | Hudson Oxygen Therapy Sales Company | Nebulizer |
| ES2091211T3 (es) * | 1989-06-23 | 1996-11-01 | Syntex Inc | Ranolazina y piperazinas relacionadas utilizadas en el tratamiento de tejidos que sufren una lesion fisica o quimica. |
| JPH03141258A (ja) * | 1989-10-25 | 1991-06-17 | Kowa Co | 新規なピペラジン誘導体 |
| HU209723B (en) | 1990-10-31 | 1994-10-28 | Richter Gedeon Vegyeszet | Process for producing of piperazine derivatives |
| US5455045A (en) * | 1993-05-13 | 1995-10-03 | Syntex (U.S.A.) Inc. | High dose formulations |
| AU2001238590A1 (en) * | 2000-02-22 | 2001-09-03 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
| US6638970B2 (en) * | 2000-02-22 | 2003-10-28 | Cv Therapeutics, Inc. | Substituted alkylene diamine compounds |
| US6552023B2 (en) * | 2000-02-22 | 2003-04-22 | Cv Therapeutics, Inc. | Aralkyl substituted piperazine compounds |
| JP3980885B2 (ja) | 2000-02-22 | 2007-09-26 | スィーヴィー セラピューティクス インコーポレイテッド | 置換ピペラジン化合物 |
| US6677336B2 (en) * | 2000-02-22 | 2004-01-13 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
| US6451798B2 (en) * | 2000-02-22 | 2002-09-17 | Cv Therapeutics, Inc. | Substituted alkyl piperazine derivatives |
| US6693099B2 (en) * | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| SE0003795D0 (sv) * | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Pharmaceutically useful compounds |
| US6573264B1 (en) * | 2000-10-23 | 2003-06-03 | Cv Therapeutics, Inc. | Heteroaryl alkyl piperazine derivatives |
| US6930111B2 (en) | 2001-07-19 | 2005-08-16 | Cv Therapeutics, Inc. | Substituted heterocyclic compounds |
| CN1181065C (zh) * | 2002-05-08 | 2004-12-22 | 上海医药工业研究院 | 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用 |
| ATE365737T1 (de) * | 2002-12-05 | 2007-07-15 | Cv Therapeutics Inc | Substituierte piperazinverbindungen undderen verwendung als fettsuureoxidationsinhibitoren |
| KR20050086956A (ko) * | 2003-01-03 | 2005-08-30 | 씨브이 쎄러퓨틱스, 인코포레이티드 | 치환된 복소환 화합물 |
-
2003
- 2003-12-19 KR KR1020057012518A patent/KR20050086956A/ko not_active Application Discontinuation
- 2003-12-19 US US10/745,224 patent/US7205303B2/en not_active Expired - Lifetime
- 2003-12-19 DE DE60329323T patent/DE60329323D1/de not_active Expired - Lifetime
- 2003-12-19 NZ NZ541069A patent/NZ541069A/en unknown
- 2003-12-19 ES ES03808498T patent/ES2329997T3/es not_active Expired - Lifetime
- 2003-12-19 EP EP03808498A patent/EP1578737B1/de not_active Expired - Lifetime
- 2003-12-19 JP JP2004566575A patent/JP2006514066A/ja active Pending
- 2003-12-19 AT AT03808498T patent/ATE443058T1/de not_active IP Right Cessation
- 2003-12-19 CA CA002512261A patent/CA2512261A1/en not_active Abandoned
- 2003-12-19 WO PCT/US2003/040607 patent/WO2004063180A1/en active Application Filing
- 2003-12-19 AU AU2003303676A patent/AU2003303676A1/en not_active Abandoned
-
2006
- 2006-03-20 HK HK06103540.3A patent/HK1085467A1/xx not_active IP Right Cessation
-
2007
- 2007-03-08 US US11/683,917 patent/US20070155728A1/en not_active Abandoned
-
2008
- 2008-07-09 US US12/170,199 patent/US7566717B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NZ541069A (en) | 2008-09-26 |
| KR20050086956A (ko) | 2005-08-30 |
| US20080275238A1 (en) | 2008-11-06 |
| US7566717B2 (en) | 2009-07-28 |
| US20040176356A1 (en) | 2004-09-09 |
| US20070155728A1 (en) | 2007-07-05 |
| CA2512261A1 (en) | 2004-07-29 |
| EP1578737A1 (de) | 2005-09-28 |
| ATE443058T1 (de) | 2009-10-15 |
| AU2003303676A1 (en) | 2004-08-10 |
| WO2004063180A1 (en) | 2004-07-29 |
| HK1085467A1 (en) | 2006-08-25 |
| JP2006514066A (ja) | 2006-04-27 |
| ES2329997T3 (es) | 2009-12-03 |
| EP1578737B1 (de) | 2009-09-16 |
| US7205303B2 (en) | 2007-04-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1406898E (pt) | Compostos de piperazina substituida e sua utilizacao como inibidores de oxidacao de acidos gordos | |
| NO20051965D0 (no) | Nye piperidinderivater for anvendelse ved behandling av kemokinmedierte sykdomstilstander. | |
| CU23210A3 (es) | NUEVOS COMPUESTOS DE OXABISPIDINE uTIL EN EL TRATAMIENTO DE ARRITMIAS CARDIACAS | |
| CY1109724T1 (el) | Θειαδιαζολιδινονες ως αναστολεις gsk-3 | |
| NO20054969L (no) | 2-cyanopropansyreamid- og esterderivater og deres anvendelse | |
| CY1106969T1 (el) | Αναστολεις dpp-iv | |
| ATE440087T1 (de) | 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen | |
| DE60207652D1 (de) | Durch Säuregruppen disubstitierte Heteroaryl-Derivate und ihre Verwendung als Matrix Metalloproteinas Inhibitoren | |
| SE0301368D0 (sv) | Chemical compounds | |
| CR7854A (es) | Dihidrofenantridinosulfonamidas sustituidas | |
| HK1085467A1 (en) | Substituted heterocyclic compounds | |
| SE0200844D0 (sv) | Chemical compounds | |
| NO20070148L (no) | Nye oksabispidinforbindelser og deres anvendelse ved behandling av forstyrrelser i hjerterytmen | |
| HK1111683A1 (en) | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors | |
| SE0200843D0 (sv) | Chemical compounds | |
| DE602004006118D1 (de) | 2,3,4,5-TETRAHYDROBENZOiFöi1,4öOXAZEPIN-5-CARBONSÄUREAMID DERIVATE ALS GAMMA-SECRETASE INHIBITOREN ZUR BEHANDLUNG VON ALZHEIMER | |
| MXPA02008213A (es) | Compuestos piperazina sustituidos. | |
| WO2004067506A3 (en) | Substituted heterocyclic compounds | |
| NO20070147L (no) | Nye oksabispidinforbindelser og deres anvendelse ved behandling av forstyrrelser i hjerterytmen | |
| JP2007514769A5 (de) | ||
| WO2006029179A3 (en) | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors | |
| NO20043925L (no) | Fremgangsmate for fremstilling av 1,2-dikloretan ved direkte klorering |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |