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DE60322451D1 - 4-Tetrazolyl-4-Phenylpiperidinderivate zur Schmerzbehandlung - Google Patents

4-Tetrazolyl-4-Phenylpiperidinderivate zur Schmerzbehandlung

Info

Publication number
DE60322451D1
DE60322451D1 DE60322451T DE60322451T DE60322451D1 DE 60322451 D1 DE60322451 D1 DE 60322451D1 DE 60322451 T DE60322451 T DE 60322451T DE 60322451 T DE60322451 T DE 60322451T DE 60322451 D1 DE60322451 D1 DE 60322451D1
Authority
DE
Germany
Prior art keywords
tetrazolyl
pain
treatment
phenylpiperidine derivatives
phenylpiperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60322451T
Other languages
English (en)
Inventor
Zhengming Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Application granted granted Critical
Publication of DE60322451D1 publication Critical patent/DE60322451D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60322451T 2002-11-18 2003-11-17 4-Tetrazolyl-4-Phenylpiperidinderivate zur Schmerzbehandlung Expired - Lifetime DE60322451D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42738102P 2002-11-18 2002-11-18
US46027803P 2003-04-03 2003-04-03
US48848803P 2003-07-17 2003-07-17
US10/714,066 US7202259B2 (en) 2002-11-18 2003-11-13 Therapeutic agents useful for treating pain

Publications (1)

Publication Number Publication Date
DE60322451D1 true DE60322451D1 (de) 2008-09-04

Family

ID=32777221

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60313021T Expired - Lifetime DE60313021T2 (de) 2002-11-18 2003-11-17 4-tetrazolyl-4-phenylpiperidindervate zur schmerzbehandlung
DE60322451T Expired - Lifetime DE60322451D1 (de) 2002-11-18 2003-11-17 4-Tetrazolyl-4-Phenylpiperidinderivate zur Schmerzbehandlung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60313021T Expired - Lifetime DE60313021T2 (de) 2002-11-18 2003-11-17 4-tetrazolyl-4-phenylpiperidindervate zur schmerzbehandlung

Country Status (37)

Country Link
US (3) US7202259B2 (de)
EP (2) EP1562932B9 (de)
JP (2) JP4601429B2 (de)
KR (1) KR20050115221A (de)
CN (2) CN100567288C (de)
AP (1) AP2210A (de)
AR (1) AR047008A1 (de)
AT (2) ATE402167T1 (de)
AU (2) AU2003294313B2 (de)
BR (1) BR0316305A (de)
CA (1) CA2506242C (de)
CO (1) CO5690588A2 (de)
CR (2) CR7877A (de)
CY (2) CY1107682T1 (de)
DE (2) DE60313021T2 (de)
DK (2) DK1562932T3 (de)
EA (1) EA008621B1 (de)
EC (1) ECSP055840A (de)
ES (2) ES2312150T3 (de)
GE (1) GEP20084539B (de)
HK (1) HK1086829A1 (de)
IL (1) IL209352A0 (de)
IS (2) IS2720B (de)
MA (1) MA27565A1 (de)
ME (1) MEP48108A (de)
MX (1) MXPA05004669A (de)
MY (1) MY135647A (de)
NI (1) NI200500087A (de)
NO (1) NO20052894D0 (de)
NZ (2) NZ572685A (de)
OA (1) OA13010A (de)
PT (2) PT1562932E (de)
RS (1) RS51047B (de)
SG (1) SG165998A1 (de)
SI (2) SI1803718T1 (de)
TW (2) TW200819436A (de)
WO (1) WO2004046132A1 (de)

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US9988392B2 (en) 2013-12-26 2018-06-05 Purdue Pharma L.P. 7-beta-alkyl analogs of orvinols
US9994571B2 (en) 2013-12-26 2018-06-12 Purdue Pharma L.P. 10-substituted morphinan hydantoins
US10550088B2 (en) 2013-12-27 2020-02-04 Purdue Pharma L.P. 6-substituted and 7-substituted morphinan analogs and the use thereof
CA2950567A1 (en) 2014-05-27 2015-12-03 Purdue Pharma L.P. Spirocyclic morphinans and use thereof
EP3154972A4 (de) 2014-06-13 2017-11-22 Purdue Pharma L.P. Azamophinanderivate und verwendung davon
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Also Published As

Publication number Publication date
CY1108422T1 (el) 2014-04-09
ATE402167T1 (de) 2008-08-15
CY1107682T1 (el) 2013-04-18
TW200418828A (en) 2004-10-01
CA2506242C (en) 2011-07-05
BR0316305A (pt) 2005-09-27
RS51047B (sr) 2010-10-31
DK1803718T3 (da) 2008-10-27
US20070179141A1 (en) 2007-08-02
AU2003294313B2 (en) 2010-08-26
EA200500726A1 (ru) 2005-10-27
CN101648941A (zh) 2010-02-17
US20040152689A1 (en) 2004-08-05
ECSP055840A (es) 2005-08-11
JP4601429B2 (ja) 2010-12-22
PT1803718E (pt) 2008-09-26
TW200819436A (en) 2008-05-01
NZ540068A (en) 2007-07-27
JP2006525944A (ja) 2006-11-16
GEP20084539B (en) 2008-11-25
TWI343917B (en) 2011-06-21
EP1562932B1 (de) 2007-04-04
AU2010246411A1 (en) 2010-12-16
MXPA05004669A (es) 2005-06-08
DK1562932T3 (da) 2007-08-13
AP2005003297A0 (en) 2005-06-30
SG165998A1 (en) 2010-11-29
NI200500087A (es) 2007-07-24
CO5690588A2 (es) 2006-10-31
EP1803718B1 (de) 2008-07-23
MA27565A1 (fr) 2005-10-03
AP2210A (en) 2011-02-25
EP1803718A1 (de) 2007-07-04
CR11037A (es) 2009-10-29
CA2506242A1 (en) 2004-06-03
RS20050375A (en) 2007-11-15
MEP48108A (en) 2011-02-10
OA13010A (en) 2006-11-10
US20100069437A1 (en) 2010-03-18
MY135647A (en) 2008-06-30
CN100567288C (zh) 2009-12-09
DE60313021D1 (de) 2007-05-16
DE60313021T2 (de) 2007-12-13
CR7877A (es) 2005-11-30
HK1086829A1 (en) 2006-09-29
EP1562932B9 (de) 2007-09-12
EP1562932A1 (de) 2005-08-17
US7202259B2 (en) 2007-04-10
SI1803718T1 (sl) 2008-12-31
ATE358674T1 (de) 2007-04-15
IL209352A0 (en) 2011-01-31
IS8913A (is) 2010-07-21
ES2285235T3 (es) 2007-11-16
WO2004046132A1 (en) 2004-06-03
US8026254B2 (en) 2011-09-27
AR047008A1 (es) 2006-01-04
AU2003294313A1 (en) 2004-06-15
IS7812A (is) 2005-04-19
PT1562932E (pt) 2007-07-02
ES2312150T3 (es) 2009-02-16
US7687518B2 (en) 2010-03-30
CN1711256A (zh) 2005-12-21
NO20052894L (no) 2005-06-14
IS2720B (is) 2011-02-15
NO20052894D0 (no) 2005-06-14
JP2010163452A (ja) 2010-07-29
SI1562932T1 (sl) 2007-08-31
NZ572685A (en) 2010-06-25
EA008621B1 (ru) 2007-06-29
KR20050115221A (ko) 2005-12-07

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