DE60320766D1 - Synthese von indolthiazolverbindungen als liganden des ah-rezeptors - Google Patents
Synthese von indolthiazolverbindungen als liganden des ah-rezeptorsInfo
- Publication number
- DE60320766D1 DE60320766D1 DE60320766T DE60320766T DE60320766D1 DE 60320766 D1 DE60320766 D1 DE 60320766D1 DE 60320766 T DE60320766 T DE 60320766T DE 60320766 T DE60320766 T DE 60320766T DE 60320766 D1 DE60320766 D1 DE 60320766D1
- Authority
- DE
- Germany
- Prior art keywords
- synthesis
- indolothiazole
- ligands
- receptor
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- YCDJABIMRVQSTA-UHFFFAOYSA-N 2h-[1,3]thiazolo[4,5-b]indole Chemical class C1=CC=CC2=NC3=NCSC3=C21 YCDJABIMRVQSTA-UHFFFAOYSA-N 0.000 title 1
- 102000003984 Aryl Hydrocarbon Receptors Human genes 0.000 title 1
- 108090000448 Aryl Hydrocarbon Receptors Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000008365 aromatic ketones Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000002194 synthesizing effect Effects 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35658502P | 2002-02-12 | 2002-02-12 | |
| US10/074,102 US6916834B2 (en) | 2001-02-14 | 2002-02-12 | Preparations and use of an Ah receptor ligand, 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester |
| PCT/US2003/004205 WO2003068742A1 (en) | 2002-02-12 | 2003-02-11 | Synthesis of indole thiazole compounds as ligands for the ah receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60320766D1 true DE60320766D1 (de) | 2008-06-19 |
Family
ID=27736819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60320766T Expired - Fee Related DE60320766D1 (de) | 2002-02-12 | 2003-02-11 | Synthese von indolthiazolverbindungen als liganden des ah-rezeptors |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7002019B2 (de) |
| EP (1) | EP1480951B1 (de) |
| JP (1) | JP4445266B2 (de) |
| CN (2) | CN1642910A (de) |
| AT (1) | ATE394373T1 (de) |
| AU (1) | AU2003209130B2 (de) |
| CA (1) | CA2475331C (de) |
| DE (1) | DE60320766D1 (de) |
| MX (1) | MXPA04007767A (de) |
| WO (1) | WO2003068742A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0207689A (pt) * | 2001-02-14 | 2004-03-09 | Wisconsin Alumni Res Found | Preparação, e, método de preparação de ligando de receptor de ah endógeno |
| WO2003000253A1 (en) | 2001-06-20 | 2003-01-03 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| DE60320766D1 (de) * | 2002-02-12 | 2008-06-19 | Wisconsin Alumni Res Found | Synthese von indolthiazolverbindungen als liganden des ah-rezeptors |
| DE60327550D1 (de) * | 2002-12-10 | 2009-06-18 | Wyeth Corp | Substituierte indoloxoacetylaminoessigsäurederivate als inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1) |
| WO2004052855A2 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| CA2509170A1 (en) | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| ES2314289T3 (es) | 2002-12-10 | 2009-03-16 | Wyeth | Derivados del acido 1h-indol-3-il glioxilico sustituidos con arilo, ariloxi y alquloxi como inhibidores del inhibidor del activador del plasminogeno-1(pai-1). |
| UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| US7230133B2 (en) | 2003-05-01 | 2007-06-12 | Bristol-Myers Squibb Company | Malonamides and malonamide derivatives as modulators of chemokine receptor activity |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7534894B2 (en) | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| BRPI0514544A (pt) | 2004-08-23 | 2008-06-17 | Wyeth Corp | ácidos de oxazol-naftila como moduladores de inibidor tipo-1 de ativador de plasminogênio (pai-1) |
| MX2007002177A (es) | 2004-08-23 | 2007-04-02 | Wyeth Corp | Acidos de pirrolo-naftilo como inhibidores de pai-1. |
| EP1794138A2 (de) | 2004-08-23 | 2007-06-13 | Wyeth | Thiazolo-naphthylsäuren als inhibitoren von plasminogen-aktivator-inhibitor-1 |
| MX2008002117A (es) | 2005-08-17 | 2008-09-26 | Wyeth Corp | Indoles sustituidos y metodos de uso de estos. |
| EP2082736A1 (de) * | 2008-01-23 | 2009-07-29 | Jean Hilaire Saurat | Pharmazeutische Zusammensetzung zur lokalen Anwendung |
| US8236849B2 (en) * | 2008-10-15 | 2012-08-07 | Ohio Northern University | Model for glutamate racemase inhibitors and glutamate racemase antibacterial agents |
| US10632106B2 (en) | 2009-11-02 | 2020-04-28 | Ariagen, Inc. | Methods of cancer treatment with 2-(1′H-Indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester |
| AU2010313622B2 (en) | 2009-11-02 | 2014-08-14 | Ahr Pharmaceuticals, Inc. | ITE for cancer intervention and eradication |
| CN102775399A (zh) * | 2011-12-27 | 2012-11-14 | 盛世泰科生物医药技术(苏州)有限公司 | arylhydrocarbon受体(AHR)的内源性配体,2-(1’H3’-吲哚羰基)噻唑-4-羧酸甲酯的合成新方法 |
| US10711106B2 (en) * | 2013-07-25 | 2020-07-14 | The University Of Chicago | High aspect ratio nanofibril materials |
| JP6665188B2 (ja) * | 2014-09-12 | 2020-03-13 | エイエイチアール ファーマシューティカルズ インコーポレイテッド | ２−（１’ｈ−インドール−３’−カルボニル）−チアゾール−４−カルボン酸メチルエステル及びその構造的類似体の効率的且つスケーラブルな合成 |
| CN108239083B (zh) | 2016-12-26 | 2021-08-17 | 阿里根公司 | 芳香烃受体调节剂 |
| CN111587249A (zh) | 2017-11-20 | 2020-08-25 | 阿里根公司 | 吲哚化合物及其用途 |
| EP3956327A1 (de) | 2019-04-15 | 2022-02-23 | Ariagen, Inc. | Chirale indolverbindungen und deren verwendung |
| US11136318B2 (en) | 2019-06-21 | 2021-10-05 | Noramco, Llc | Processes for the preparation of aryl hydrocarbon receptor ligands |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3265931A (en) * | 1964-09-21 | 1966-08-09 | Martin E Gerry | Magnetic ignition distributor |
| US3285931A (en) | 1964-12-21 | 1966-11-15 | Union Carbide Corp | Preparation of substituted pyrrole derivatives |
| US5366685A (en) | 1989-07-18 | 1994-11-22 | Idemitsu Petrochemical Co., Ltd. | Process of molding thermoplastic sheet by plug assist vacuum forming |
| US6323228B1 (en) | 2000-09-15 | 2001-11-27 | Abbott Laboratories | 3-substituted indole angiogenesis inhibitors |
| US6523228B1 (en) * | 2000-10-26 | 2003-02-25 | Avery Dennison Corporation | Tamper-proof tie |
| BR0207689A (pt) * | 2001-02-14 | 2004-03-09 | Wisconsin Alumni Res Found | Preparação, e, método de preparação de ligando de receptor de ah endógeno |
| EP1427413A2 (de) * | 2001-09-13 | 2004-06-16 | Synta Pharmaceuticals Corporation | 2-aroylimidazol-verbindungen zur behandlung von krebs |
| DE60320766D1 (de) * | 2002-02-12 | 2008-06-19 | Wisconsin Alumni Res Found | Synthese von indolthiazolverbindungen als liganden des ah-rezeptors |
-
2003
- 2003-02-11 DE DE60320766T patent/DE60320766D1/de not_active Expired - Fee Related
- 2003-02-11 CN CNA038063808A patent/CN1642910A/zh active Pending
- 2003-02-11 US US10/364,253 patent/US7002019B2/en not_active Expired - Lifetime
- 2003-02-11 MX MXPA04007767A patent/MXPA04007767A/es active IP Right Grant
- 2003-02-11 JP JP2003567873A patent/JP4445266B2/ja not_active Expired - Lifetime
- 2003-02-11 WO PCT/US2003/004205 patent/WO2003068742A1/en active Application Filing
- 2003-02-11 CA CA2475331A patent/CA2475331C/en not_active Expired - Lifetime
- 2003-02-11 AT AT03707863T patent/ATE394373T1/de not_active IP Right Cessation
- 2003-02-11 AU AU2003209130A patent/AU2003209130B2/en not_active Expired
- 2003-02-11 EP EP03707863A patent/EP1480951B1/de not_active Expired - Lifetime
- 2003-02-11 CN CN2006100915364A patent/CN1915991B/zh not_active Expired - Fee Related
-
2005
- 2005-11-23 US US11/286,537 patent/US7241900B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20060079692A1 (en) | 2006-04-13 |
| EP1480951A4 (de) | 2006-03-22 |
| CN1915991A (zh) | 2007-02-21 |
| US20040204588A1 (en) | 2004-10-14 |
| US7002019B2 (en) | 2006-02-21 |
| MXPA04007767A (es) | 2004-10-15 |
| US7241900B2 (en) | 2007-07-10 |
| JP4445266B2 (ja) | 2010-04-07 |
| ATE394373T1 (de) | 2008-05-15 |
| CN1915991B (zh) | 2010-05-26 |
| AU2003209130B2 (en) | 2008-06-05 |
| CN1642910A (zh) | 2005-07-20 |
| JP2005525340A (ja) | 2005-08-25 |
| EP1480951B1 (de) | 2008-05-07 |
| CA2475331A1 (en) | 2003-08-21 |
| AU2003209130A1 (en) | 2003-09-04 |
| EP1480951A1 (de) | 2004-12-01 |
| WO2003068742A1 (en) | 2003-08-21 |
| CA2475331C (en) | 2012-06-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60320766D1 (de) | Synthese von indolthiazolverbindungen als liganden des ah-rezeptors | |
| DE60041584D1 (de) | Substituierte oxoazaheterozyclische verbindungen | |
| EA200600925A1 (ru) | Производные триазола в качестве антагонистов вазопрессина | |
| NO20093402L (no) | Framgangsmate for syntetisering av camptothesin relaterte forbindelser | |
| RS20050380A (en) | 3-amino piperidine derivatives and methods of manufacture | |
| ATE452882T1 (de) | Herstellung von quetiapin | |
| NO20060219L (no) | Forbindelser | |
| DE50306845D1 (de) | Disubstituierte thiazolylcarboxanilide und ihre verwendung als mikrobizide | |
| GB0129476D0 (en) | Organic compounds | |
| NO982850L (no) | Ny syntese | |
| GB0031103D0 (en) | Chemical compounds | |
| HUP0102723A2 (hu) | Új difenilkarbamid-származékok, eljárás előállításukra és ezeket tartalmazó gyógyászati készítmények | |
| TR200100698T2 (tr) | 5-HT4 alıcı-Antagonistleri olarak Dihidrobenzodioksin Karboksamit ve Keton türevleri | |
| DE50010886D1 (de) | Neue cyclopropane als cgrp-antagonisten, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung | |
| MX2007004637A (es) | Sintesis asimetrica de derivados de dihidrobenzofurano. | |
| ATE429429T1 (de) | Pharmazeutisches verfahren und damit hergestellte verbindungen | |
| ATE453389T1 (de) | Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen | |
| BR0209901A (pt) | Processos para a sìntese de derivados de 2,3-dihidro-1,4-dioxino-[2,3-f] quinolina | |
| TR200302288T2 (tr) | Terapi için yeni bileşikler ve metotlar. | |
| EP1555261A4 (de) | Valerolactonverbindungen und parf mzusammensetzung | |
| DE60235365D1 (de) | Verfahren zur herstellung von 7-amino-syn-3,5-dihydroxyheptansäurederivaten und zwischenverbindungen diesesverfahrens und deren herestellung | |
| WO2005000804A3 (en) | Substituted indoles and a process for preparing substituted indoles | |
| ATE257831T1 (de) | Synthese von wasserlöslischem 9-dihydroplacitaxel derivate aus 9-dihydro-13-acetylbacchatin iii | |
| IS7181A (is) | Aralkýl-tetrahýdró-pýridín, framleiðsla þeirra oglyfjasamsetningar sem innihalda þau | |
| WO2004039776A3 (en) | A process for the preparation of benzyl 2-oxo-4- (heteroaryl) dithio-alpha-isoprenyl-1- azetidineazetate derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |