DE60313982D1 - Dimere von thrombinpeptidderivaten - Google Patents

Dimere von thrombinpeptidderivaten

Info

Publication number: DE60313982D1
Authority: DE; Germany
Prior art keywords: gly; polypeptide; dimers; asp; seq
Prior art date: 2002-07-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60313982T

Other languages

English (en)

Other versions

DE60313982T2 (de

Inventor

Darrell H Carney

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Capstone Holding Corp

Original Assignee

Orthologic Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-02

Filing date

2003-07-01

Publication date

2007-07-05

2003-07-01 Application filed by Orthologic Corp filed Critical Orthologic Corp

2007-07-05 Publication of DE60313982D1 publication Critical patent/DE60313982D1/de

2008-01-17 Application granted granted Critical

2008-01-17 Publication of DE60313982T2 publication Critical patent/DE60313982T2/de

2023-07-02 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000539 dimer Substances 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 6
229920001184 polypeptide Polymers 0.000 abstract 4
102000004196 processed proteins & peptides Human genes 0.000 abstract 4
150000001413 amino acids Chemical group 0.000 abstract 3
108090000190 Thrombin Proteins 0.000 abstract 2
239000012634 fragment Substances 0.000 abstract 2
229960004072 thrombin Drugs 0.000 abstract 2
229940117028 Thrombin receptor agonist Drugs 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
OXHYRVSBKWIFES-WWSDOYNLSA-N trap-14 peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=CC=C1 OXHYRVSBKWIFES-WWSDOYNLSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Microbiology (AREA)
Cardiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DE60313982T 2002-07-02 2003-07-01 Dimere von thrombinpeptidderivaten Expired - Lifetime DE60313982T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US39357902P	2002-07-02	2002-07-02
US393579P		2002-07-02
PCT/US2003/020626 WO2004005317A2 (en)	2002-07-02	2003-07-01	Thrombin peptide derivative dimers

Publications (2)

Publication Number	Publication Date
DE60313982D1 true DE60313982D1 (de)	2007-07-05
DE60313982T2 DE60313982T2 (de)	2008-01-17

Family

ID=30115603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60313982T Expired - Lifetime DE60313982T2 (de)	2002-07-02	2003-07-01	Dimere von thrombinpeptidderivaten

Country Status (8)

Country	Link
US (2)	US7456250B2 (de)
EP (1)	EP1539800B1 (de)
JP (1)	JP4668612B2 (de)
AT (1)	ATE362939T1 (de)
AU (1)	AU2003247848B2 (de)
CA (1)	CA2491135A1 (de)
DE (1)	DE60313982T2 (de)
WO (1)	WO2004005317A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2287660T3 (es)	2003-12-31	2007-12-16	Orthologic Corp.	Composicion farmaceutica de los derivados peptidicos de trombina.
WO2008036387A2 (en) *	2006-09-22	2008-03-27	Orthologic Corp.	Method of treating endothelial dysfunction
WO2008100567A2 (en) *	2007-02-15	2008-08-21	Orthologic Corp.	Thrombin peptide derivatives for treating fractures in osteopenic patients
EP2155234A1 (de) *	2007-04-10	2010-02-24	The Board of Regents,The University of Texas System	Kombinationstherapie gegen chronische hautgeschwüre
EP2155236A1 (de) *	2007-04-10	2010-02-24	The Board of Regents,The University of Texas System	Kombinationstherapie zur herzrevaskularisation und herzreparatur
WO2009120304A1 (en) *	2008-03-26	2009-10-01	Orthologic Corp.	Thrombin derived peptides for smooth muscle relaxation
WO2009120300A2 (en) *	2008-03-26	2009-10-01	Orthologic Corp.	Method of treating degenerative diseases
WO2009142679A2 (en) *	2008-03-26	2009-11-26	Orthologic Corp.	Methods for treating acute myocardial infarction
AU2009229402A1 (en) *	2008-03-26	2009-10-01	Orthologic Corp.	Method of treating peripheral arterial disease
CU23716A1 (es) *	2008-09-30	2011-10-05	Ct Ingenieria Genetica Biotech	Péptido antagonista de la actividad de la interleucina-15
JP2013529600A (ja)	2010-06-11	2013-07-22	ザボードオブリージェンツ，ザユニバーシティオブテキサスシステム	放射の影響を軽減し、及び全身性感染症のリスクを減少させる方法
US10220078B2 (en)	2014-06-11	2019-03-05	The Board Of Regents Of The University Of Texas System	Methods of using thrombin derivatives to treat medulloblastoma
EP3952991A4 (de) *	2019-04-12	2023-08-09	Affirmed Pharma, LLC	Rusalatid-acetatzusammensetzungen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5352664A (en) *	1986-10-31	1994-10-04	Board Of Regents, The University Of Texas System	Thrombin derived polypeptides; compositions and methods for use
US6500934B1 (en) *	1996-07-24	2002-12-31	Michael Rush Lerner	Bivalent agonists for G-protein coupled receptors
TWI257307B (en) *	2000-07-12	2006-07-01	Orthologic Corp	Pharmaceutical composition for cardiac tissue repair
EP1301196B1 (de) *	2000-07-19	2003-11-26	The Board of Regents, The University of Texas System	Stimulierung des knochenwachstums mit peptidderivaten von thrombin
ES2232647T3 (es) *	2000-07-20	2005-06-01	The Board Of Regents, The University Of Texas System	Estimulacion del crecimiento del cartilago con agonistas (musculos no esenciales) del receptor de trombina no proteoliticamente activado.
CN100509055C (zh) *	2001-07-27	2009-07-08	奥索洛吉艾斯有限公司	使用凝血酶衍生的缩氨酸治疗慢性真皮溃疡
TW200407905A (en) *	2002-11-06	2004-05-16	Leadtek Research Inc	Data write-in and read-out method of flash memory and circuit thereof
ES2287660T3 (es) *	2003-12-31	2007-12-16	Orthologic Corp.	Composicion farmaceutica de los derivados peptidicos de trombina.

2003
- 2003-07-01 CA CA002491135A patent/CA2491135A1/en not_active Abandoned
- 2003-07-01 AT AT03763062T patent/ATE362939T1/de not_active IP Right Cessation
- 2003-07-01 WO PCT/US2003/020626 patent/WO2004005317A2/en active IP Right Grant
- 2003-07-01 EP EP03763062A patent/EP1539800B1/de not_active Expired - Lifetime
- 2003-07-01 JP JP2004519705A patent/JP4668612B2/ja not_active Expired - Fee Related
- 2003-07-01 AU AU2003247848A patent/AU2003247848B2/en not_active Ceased
- 2003-07-01 DE DE60313982T patent/DE60313982T2/de not_active Expired - Lifetime
2004
- 2004-12-30 US US11/027,795 patent/US7456250B2/en not_active Expired - Lifetime
2008
- 2008-10-10 US US12/287,703 patent/US7919457B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20050153893A1 (en)	2005-07-14
JP4668612B2 (ja)	2011-04-13
US20090124550A1 (en)	2009-05-14
WO2004005317A3 (en)	2004-09-30
EP1539800A4 (de)	2005-11-16
AU2003247848B2 (en)	2006-12-21
US7919457B2 (en)	2011-04-05
JP2006507229A (ja)	2006-03-02
WO2004005317A2 (en)	2004-01-15
EP1539800A2 (de)	2005-06-15
CA2491135A1 (en)	2004-01-15
AU2003247848C1 (en)	2004-01-23
DE60313982T2 (de)	2008-01-17
ATE362939T1 (de)	2007-06-15
AU2003247848A1 (en)	2004-01-23
EP1539800B1 (de)	2007-05-23
US7456250B2 (en)	2008-11-25

Publication	Publication Date	Title
ATE368053T1 (de)	2007-08-15	Antimikrobielle peptide
DK1265914T3 (da)	2008-03-10	WNT-1-relaterede polypeptider og nukleinsyrer, der koder for samme
DE60313982D1 (de)	2007-07-05	Dimere von thrombinpeptidderivaten
DE60030450D1 (de)	2006-10-12	Von MUC-1 abgeleitete Peptide
DK0662827T4 (da)	2009-04-20	Terapeutiske og diagnostiske fremgangsmåder og sammensætninger baseret på Notch-proteiner og nucleinsyrer
KR970702917A (ko)	1997-06-10	Lag-3의 가용성 폴리펩타이드 절편 및 생산 방법, 치료 조성물, 항-이디오타입 항체
NO20063026L (no)	2006-08-28	Antistoffer
DE69129865D1 (de)	1998-08-27	Osteogene peptide
WO2004014937A3 (en)	2005-02-17	Thrombin peptide derivatives
ATE299936T1 (de)	2005-08-15	Fas antigen-derivate
DE69840024D1 (de)	2008-10-30	Antimikrobielle Peptide, abstammend von Ubiquicidin
JP2006514822A5 (de)	2006-08-17
EP1132402A4 (de)	2005-12-21	Peptidfragmente mit den zelltod verhindernden aktivität
CY1109946T1 (el)	2014-09-10	Τροποποιημενα πεπτιδια και η χρηση τους για τη θεραπεια αυτοανοσων νοσων
ATE374246T1 (de)	2007-10-15	Polypeptidfragmente mit einem c-terminalen teil von katalase aus helicobacter
ATE290088T1 (de)	2005-03-15	Verfahren zur spaltung eines chimeren proteins mittels eines 'processing'-enzyms
ATE291033T1 (de)	2005-04-15	Therapeutische peptide
AU2676399A (en)	1999-08-30	Novel cystine knot protein and materials and methods for making it
DE60036676D1 (de)	2007-11-22	G-protein-gekoppelter rezeptor-ähnliche proteine
WO2003064446A3 (en)	2004-04-01	Plasma protein-binding peptides from bacterial curli
ATE432985T1 (de)	2009-06-15	Polypeptide mit aktivität der stimulierung von neutrophilen
WO2003044159A9 (en)	2013-10-31	Zinc finger proteins, polynucleotides encoding same and antibodies thereto
EP1225183A3 (de)	2002-12-11	Humaner G-Protein gekoppelter Rezeptor
DE69927524D1 (de)	2006-02-09	Topoisomerase-ii inhibitoren
WO2005019407A3 (en)	2008-07-31	Polynucleotides, polypeptides and antibodies and use thereof in treating tsg101-associated diseases

Legal Events

Date	Code	Title	Description
2008-06-12	8364	No opposition during term of opposition