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DE60238780D1 - Depot formulierungen von iloperidone und einem sternförmigen polymer - Google Patents

Depot formulierungen von iloperidone und einem sternförmigen polymer

Info

Publication number
DE60238780D1
DE60238780D1 DE60238780T DE60238780T DE60238780D1 DE 60238780 D1 DE60238780 D1 DE 60238780D1 DE 60238780 T DE60238780 T DE 60238780T DE 60238780 T DE60238780 T DE 60238780T DE 60238780 D1 DE60238780 D1 DE 60238780D1
Authority
DE
Germany
Prior art keywords
iloperidone
star
depot formulations
term polymer
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60238780T
Other languages
English (en)
Inventor
Markus Ahlheim
Rolf Loeffler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NOVARTIS PHARMA GmbH
Novartis AG
Original Assignee
NOVARTIS PHARMA GmbH
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NOVARTIS PHARMA GmbH, Novartis AG filed Critical NOVARTIS PHARMA GmbH
Application granted granted Critical
Publication of DE60238780D1 publication Critical patent/DE60238780D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
DE60238780T 2001-10-30 2002-10-29 Depot formulierungen von iloperidone und einem sternförmigen polymer Expired - Lifetime DE60238780D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33903601P 2001-10-30 2001-10-30
PCT/EP2002/012073 WO2003037337A1 (en) 2001-10-30 2002-10-29 Depot formulations of iloperidone and a star polymer

Publications (1)

Publication Number Publication Date
DE60238780D1 true DE60238780D1 (de) 2011-02-10

Family

ID=23327202

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60238780T Expired - Lifetime DE60238780D1 (de) 2001-10-30 2002-10-29 Depot formulierungen von iloperidone und einem sternförmigen polymer

Country Status (12)

Country Link
US (2) US7767230B2 (de)
EP (2) EP1441727B1 (de)
JP (1) JP5067998B2 (de)
CN (2) CN1578664A (de)
AT (1) ATE493129T1 (de)
BR (1) BRPI0213564B8 (de)
CA (1) CA2463158C (de)
CY (1) CY1111357T1 (de)
DE (1) DE60238780D1 (de)
ES (2) ES2436439T3 (de)
HK (2) HK1068263A1 (de)
WO (1) WO2003037337A1 (de)

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CZ2002850A3 (cs) * 1999-09-09 2003-04-16 The Regents Of The University Of California Kationtový liposom a použití kationtového liposomového prostředku
CN1578664A (zh) * 2001-10-30 2005-02-09 诺瓦提斯公司 伊潘立酮和星状聚合物的贮库制剂
GB0216416D0 (en) * 2002-07-15 2002-08-21 Novartis Ag Organic compounds
US20100063093A1 (en) * 2007-03-28 2010-03-11 Curt Wolfgang Methods for the administration of iloperidone
EP1799865B1 (de) 2004-09-30 2012-06-06 Vanda Pharmaceuticals Inc. Verfahren für die verabreichung von iloperidone
JP5264492B2 (ja) 2005-10-25 2013-08-14 エボニック デグサ ゲーエムベーハー 超分岐ポリマーを含有する調製物
DE102005051342A1 (de) * 2005-10-25 2007-04-26 Goldschmidt Gmbh Verkapselung und kontrollierte Freisetzung biologisch aktiver Wirkstoffe mit enzymatisch abbaubaren hyperverzweigten Trägerpolymeren
AU2007253684A1 (en) 2006-05-22 2007-11-29 Vanda Pharmaceuticals, Inc. Treatment for depressive disorders
CN100460441C (zh) * 2006-09-25 2009-02-11 南开大学 生物可降解星型结构聚乙丙交酯载药微球及其制备方法
DE602007008125D1 (de) 2006-10-31 2010-09-09 Surmodics Pharmaceuticals Inc Kugelförmige polymer-teilchen
EP2198048A2 (de) * 2007-09-10 2010-06-23 Vanda Pharmaceuticals Inc. Vorhersage der qt-verlängerung auf basis des snp-genotyps
CA2709103C (en) * 2007-12-13 2017-01-17 Vanda Pharmaceuticals Inc. Method and composition for treating an alpha adrenoceptor-mediated condition
PL2222300T3 (pl) 2007-12-13 2015-02-27 Vanda Pharmaceuticals Inc Sposób i skład preparatu do leczenia chorób z udziałem receptorów serotoniny
EP2453891A1 (de) 2009-07-16 2012-05-23 Vanda Pharmaceuticals Inc. Verwendung eines melatoninagonisten zur behandlung von schlafstörungen, u.a. primärer insomnie
EP2515863A2 (de) * 2009-12-23 2012-10-31 Lupin Limited Pharmazeutische iloperidonzusammensetzungen mit verzögerter freisetzung
CN102311430A (zh) * 2010-06-29 2012-01-11 大道隆达（北京）医药科技发展有限公司 伊潘立酮的新晶态及其制备方法
WO2012123963A2 (en) * 2011-02-24 2012-09-20 Megafine Pharma (P) Ltd. A process for preparation of iloperidone and amorphous co- precipitate of iloperidone with pharmaceutically acceptable excipient
KR102317399B1 (ko) 2012-01-26 2021-10-26 반다 파마슈티칼즈, 인코퍼레이티드. 일주기 리듬 장애의 치료
US11918557B2 (en) 2012-01-26 2024-03-05 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
ES2648987T3 (es) 2012-05-18 2018-01-09 Vanda Pharmaceuticals Inc. Metabolitos de (1R-trans)-N-[[2-(2,3-dihidro-4-benzofuranil)ciclopropil]metil]propanamida
AU2013361459A1 (en) 2012-12-18 2015-07-02 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
US10376487B2 (en) 2013-11-12 2019-08-13 Vanda Pharmaceuticals Inc. Method of treatment
US11090285B2 (en) 2013-11-12 2021-08-17 Vanda Pharmaceuticals Inc Treatment of circadian rhythm disorders
CN103599074A (zh) * 2013-11-26 2014-02-26 重庆医药工业研究院有限责任公司 一种伊潘立酮缓释微球及其制备方法
CN104352443A (zh) * 2014-10-21 2015-02-18 河北科技大学 伊潘立酮缓释微球及其制备方法
US10441580B2 (en) 2015-02-17 2019-10-15 Vanda Pharmaceuticals, Inc. Iloperidone for the treatment of schizophrenia
US11071728B2 (en) 2015-12-11 2021-07-27 Vanda Pharmaceuticals Inc. Treatment of schizophrenia
MX2021006601A (es) * 2018-12-04 2021-07-07 Vanda Pharmaceuticals Inc Administracion de iloperidona de liberacion lenta.
US11607408B2 (en) 2019-10-15 2023-03-21 Vanda Pharmaceuticals Inc. Method of treatment of schizophrenia
WO2024137439A1 (en) 2022-12-19 2024-06-27 Vanda Pharmaceuticals Inc. Dosage regime of iloperidone for treating bipolar i disorder and schizophrenia

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UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
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JP2003535106A (ja) 2000-06-02 2003-11-25 ノボ ノルディスク アクティーゼルスカブ グルコース検知性インスリン誘導体からの、インスリンのグルコース依存性放出
ATE518845T1 (de) 2001-08-31 2011-08-15 Novartis Pharma Gmbh Optische isomere eines iloperidon-metaboliten
CN1578664A (zh) * 2001-10-30 2005-02-09 诺瓦提斯公司 伊潘立酮和星状聚合物的贮库制剂
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
US20030091645A1 (en) 2003-05-15
CN101912367A (zh) 2010-12-15
JP5067998B2 (ja) 2012-11-07
CY1111357T1 (el) 2015-08-05
JP2005508975A (ja) 2005-04-07
BRPI0213564B1 (pt) 2016-08-02
BR0213564A (pt) 2004-08-31
ES2436439T3 (es) 2014-01-02
HK1068263A1 (en) 2005-04-29
HK1155381A1 (en) 2012-05-18
US8815293B2 (en) 2014-08-26
US7767230B2 (en) 2010-08-03
CA2463158A1 (en) 2003-05-08
US20100233217A1 (en) 2010-09-16
EP1441727A1 (de) 2004-08-04
WO2003037337A8 (en) 2004-05-13
CN1578664A (zh) 2005-02-09
EP2295058B1 (de) 2013-09-04
ES2358416T3 (es) 2011-05-10
EP2295058A1 (de) 2011-03-16
WO2003037337A1 (en) 2003-05-08
CA2463158C (en) 2013-07-30
BRPI0213564B8 (pt) 2021-05-25
ATE493129T1 (de) 2011-01-15
EP1441727B1 (de) 2010-12-29

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