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DE60237512D1 - N-(aryl)-2-arylethensulfonamide und ihre therapeutischen anwendungen - Google Patents

N-(aryl)-2-arylethensulfonamide und ihre therapeutischen anwendungen

Info

Publication number
DE60237512D1
DE60237512D1 DE60237512T DE60237512T DE60237512D1 DE 60237512 D1 DE60237512 D1 DE 60237512D1 DE 60237512 T DE60237512 T DE 60237512T DE 60237512 T DE60237512 T DE 60237512T DE 60237512 D1 DE60237512 D1 DE 60237512D1
Authority
DE
Germany
Prior art keywords
aryl
arylethesulfonamides
therapeutic applications
agents
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60237512T
Other languages
English (en)
Inventor
Premkumar E Reddy
M V Reddy
Stanley C Bell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Temple Univ School of Medicine
Traws Pharma Inc
Original Assignee
Onconova Therapeutics Inc
Temple Univ School of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Onconova Therapeutics Inc, Temple Univ School of Medicine filed Critical Onconova Therapeutics Inc
Application granted granted Critical
Publication of DE60237512D1 publication Critical patent/DE60237512D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
DE60237512T 2001-02-28 2002-02-28 N-(aryl)-2-arylethensulfonamide und ihre therapeutischen anwendungen Expired - Lifetime DE60237512D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27198501P 2001-02-28 2001-02-28
PCT/US2002/005979 WO2002067865A2 (en) 2001-02-28 2002-02-28 N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
DE60237512D1 true DE60237512D1 (de) 2010-10-14

Family

ID=23037924

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60237512T Expired - Lifetime DE60237512D1 (de) 2001-02-28 2002-02-28 N-(aryl)-2-arylethensulfonamide und ihre therapeutischen anwendungen

Country Status (11)

Country Link
US (1) US6646009B2 (de)
EP (1) EP1379508B9 (de)
JP (1) JP4171656B2 (de)
KR (1) KR100850330B1 (de)
AT (1) ATE479657T1 (de)
AU (1) AU2002306604B2 (de)
CA (1) CA2439255C (de)
DE (1) DE60237512D1 (de)
DK (1) DK1379508T3 (de)
IL (2) IL157540A0 (de)
WO (1) WO2002067865A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1370253B8 (de) * 2001-02-28 2008-11-26 Temple University of the Commonwealth System of Higher Education Verwendung von alpha, beta ungesättigten arylsulfonen zum schutz von zellen und geweben vor toxizität ionischer strahlung
JP4538233B2 (ja) * 2002-02-28 2010-09-08 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 増殖性障害治療用の、アミノ置換されたスルホンアニリド及びその誘導体
US7598232B2 (en) * 2002-02-28 2009-10-06 Temple University - Of The Commonwealth System Of Higher Education Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted-benzylsulfones for treating proliferative disorders
AU2004289281C1 (en) * 2003-11-14 2011-12-08 Onconova Therapeutics, Inc. Alpha, beta-Unsaturated sulfoxides for treating proliferative disorders
HUE030786T2 (en) 2004-03-16 2017-06-28 Temple Univ - Of The Commonwealth System Of Higher Education Substituted phenoxy and phenylthio derivatives for the treatment of proliferative disorders
WO2005090297A1 (en) * 2004-03-19 2005-09-29 Biotie Therapies Corporation Sulphonamide derivatives
PT2035369E (pt) 2006-07-05 2014-09-30 Fibrotech Therapeutics Pty Ltd Compostos terapêuticos
JP5278968B2 (ja) 2006-08-30 2013-09-04 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法
NZ584613A (en) * 2007-12-21 2011-07-29 Fibrotech Therapeutics Pty Ltd Halogenated cinnamoylbenzamide derivatives for anti-fibrotic drugs
WO2010144959A1 (en) * 2009-06-18 2010-12-23 Fibrotech Therapeutics Pty Ltd Analogues of anti-fibrotic agents
SG10201501272SA (en) 2009-10-22 2015-04-29 Fibrotech Therapeutics Pty Ltd Fused ring analogues of anti-fibrotic agents
US9371307B2 (en) 2011-09-12 2016-06-21 The Johns Hopkins University Serine protease inhibitors
US9730913B2 (en) 2011-10-13 2017-08-15 The Johns Hopkins University High affinity beta lactamase inhibitors
CN110776447A (zh) 2012-09-20 2020-02-11 坦普尔大学 取代的烷基二芳基衍生物、制备方法和用途
US10383831B2 (en) 2015-08-03 2019-08-20 Temple University—Of the Commonwealth System of Higher Education 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use
KR20190115451A (ko) 2017-02-03 2019-10-11 세르타 테라퓨틱스 피티와이 엘티디. 항-섬유성 화합물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2531367A (en) * 1947-07-15 1950-11-21 Sharp & Dohme Inc N-(substituted sulfonyl)-aminobenzoic acids
DE2118493C3 (de) 1971-04-16 1980-04-30 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Aminostilbenen
US4035421A (en) 1976-03-19 1977-07-12 Morton-Norwich Products, Inc. N-(3,4,-dichlorophenyl)-2-phenylethenesulfonamide
DE2809377A1 (de) * 1978-03-04 1979-09-13 Boehringer Mannheim Gmbh Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
NZ238911A (en) 1990-07-17 1993-10-26 Lilly Co Eli Furyl, pyrrolyl and thienyl sulphonyl urea derivatives, pharmaceutical compositions and intermediates therefor
JPH04202173A (ja) * 1990-11-30 1992-07-22 Zeria Pharmaceut Co Ltd スルホンアミド誘導体及びそれを含有する５―リポキシゲナーゼ阻害剤
AU2096895A (en) * 1994-03-07 1995-09-25 Sugen, Incorporated Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
EP0809492A4 (de) 1995-02-17 2007-01-24 Smithkline Beecham Corp Il-8 rezeptor antagonisten
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
PT896533E (pt) 1996-02-22 2004-02-27 Tularik Inc Pentafluorobenzenosulfonamidas e analogos
US6191170B1 (en) * 1998-01-13 2001-02-20 Tularik Inc. Benzenesulfonamides and benzamides as therapeutic agents
EP1115701B1 (de) 1998-09-23 2003-05-21 Tularik Inc. Arylsulfonanilid-harnstoffe
US6586617B1 (en) * 1999-04-28 2003-07-01 Sumitomo Chemical Takeda Agro Company, Limited Sulfonamide derivatives

Also Published As

Publication number Publication date
US20020165412A1 (en) 2002-11-07
CA2439255C (en) 2011-01-04
AU2002306604B2 (en) 2007-09-13
EP1379508A2 (de) 2004-01-14
EP1379508B1 (de) 2010-09-01
IL157540A (en) 2010-11-30
JP4171656B2 (ja) 2008-10-22
US6646009B2 (en) 2003-11-11
WO2002067865A3 (en) 2003-03-20
CA2439255A1 (en) 2002-09-06
IL157540A0 (en) 2004-03-28
DK1379508T3 (da) 2011-01-03
EP1379508B9 (de) 2011-02-09
WO2002067865A2 (en) 2002-09-06
KR100850330B1 (ko) 2008-08-04
JP2004530655A (ja) 2004-10-07
ATE479657T1 (de) 2010-09-15
KR20030086279A (ko) 2003-11-07
EP1379508A4 (de) 2005-12-28

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