DE60237388D1 - Verfahren zur herstellung von zusammensetzungen mit erhöhtem gehalt von salzen pharmazeutisch aktiver rotamere - Google Patents

Verfahren zur herstellung von zusammensetzungen mit erhöhtem gehalt von salzen pharmazeutisch aktiver rotamere

Info

Publication number: DE60237388D1
Authority: DE; Germany
Prior art keywords: rotamers; salts; pharmaceutically active; preparing compounds; increased content
Prior art date: 2001-11-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60237388T

Other languages

English (en)

Inventor

Dinesh Gala

Andrew J Goodman

Gary Lee

Hongbiao Liao

Martin L Schwartz

Suhan Tang

David J Tsai

Wenxue Wu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Sharp and Dohme LLC

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-29

Filing date

2002-11-26

Publication date

2010-09-30

2002-11-26 Application filed by Schering Corp filed Critical Schering Corp

2010-09-30 Application granted granted Critical

2010-09-30 Publication of DE60237388D1 publication Critical patent/DE60237388D1/de

2022-11-27 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Virology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Physical Education & Sports Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

DE60237388T 2001-11-29 2002-11-26 Verfahren zur herstellung von zusammensetzungen mit erhöhtem gehalt von salzen pharmazeutisch aktiver rotamere Expired - Lifetime DE60237388D1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US33433101P	2001-11-29	2001-11-29
US37391602P	2002-04-19	2002-04-19
PCT/US2002/038112 WO2003048153A1 (en)	2001-11-29	2002-11-26	Process for the preparation of compositions having an increased amount of pharmaceutically active salts of rotamers

Publications (1)

Publication Number	Publication Date
DE60237388D1 true DE60237388D1 (de)	2010-09-30

Family

ID=26989151

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60237388T Expired - Lifetime DE60237388D1 (de)	2001-11-29	2002-11-26	Verfahren zur herstellung von zusammensetzungen mit erhöhtem gehalt von salzen pharmazeutisch aktiver rotamere

Country Status (12)

Country	Link
US (2)	US6943251B2 (de)
EP (1)	EP1451174B1 (de)
JP (2)	JP2005511693A (de)
CN (1)	CN1596254A (de)
AR (1)	AR037679A1 (de)
AT (1)	ATE478065T1 (de)
AU (1)	AU2002346569A1 (de)
CA (1)	CA2468525A1 (de)
DE (1)	DE60237388D1 (de)
HK (1)	HK1063798A1 (de)
MX (1)	MXPA04005210A (de)
WO (1)	WO2003048153A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6689765B2 (en) *	1999-05-04	2004-02-10	Schering Corporation	Piperazine derivatives useful as CCR5 antagonists
JP2005511693A (ja) *	2001-11-29	2005-04-28	シェーリング　コーポレイション	回転異性体の薬学的に活性な塩の量が増加した組成物の調製のためのプロセス
CN101139343A (zh) *	2002-03-29	2008-03-12	先灵公司	作为ccr5拮抗药的哌啶和哌嗪化合物的合成
US7244765B2 (en) *	2004-06-25	2007-07-17	Cytokine Pharmasciences, Inc	Guanylhydrazone salts, compositions, processes of making and methods of using
WO2006074269A2 (en) *	2005-01-06	2006-07-13	Schering Corporation	Preparation of pharmaceutical salts of piperazine compounds
WO2007038496A2 (en) *	2005-09-27	2007-04-05	Chemic Laboratories, Inc.	Synthesis of fatty alcohol esters of hydroxy carboxylic acids, the use of the same as percutaneous permeation enhancers
US7561458B2 (en) *	2006-12-26	2009-07-14	Texas Instruments Incorporated	Ferroelectric memory array for implementing a zero cancellation scheme to reduce plateline voltage in ferroelectric memory
KR101982482B1 (ko)	2010-03-11	2019-05-27	와이어쓰 엘엘씨	메틸날트렉손의 경구 제형 및 친유성 염
US20170197980A1 (en) *	2014-06-25	2017-07-13	Abbvie Inc.	N-(4-phenyl)-n'-(3-fluorophenyl)urea docusate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3722700B2 (ja) *	1999-05-04	2005-11-30	シェーリングコーポレイション	Ｃｃｒ５アンタゴニストとして有用なピペラジン誘導体
US6391865B1 (en) *	1999-05-04	2002-05-21	Schering Corporation	Piperazine derivatives useful as CCR5 antagonists
JP3874229B2 (ja)	1999-07-02	2007-01-31	Ｔｄｋ株式会社	圧電セラミックスおよびこれを用いた圧電デバイス
JP2005511693A (ja) *	2001-11-29	2005-04-28	シェーリング　コーポレイション	回転異性体の薬学的に活性な塩の量が増加した組成物の調製のためのプロセス

2002
- 2002-11-26 JP JP2003549343A patent/JP2005511693A/ja active Pending
- 2002-11-26 US US10/304,674 patent/US6943251B2/en not_active Expired - Fee Related
- 2002-11-26 CA CA002468525A patent/CA2468525A1/en not_active Abandoned
- 2002-11-26 WO PCT/US2002/038112 patent/WO2003048153A1/en active Application Filing
- 2002-11-26 AU AU2002346569A patent/AU2002346569A1/en not_active Abandoned
- 2002-11-26 AT AT02784638T patent/ATE478065T1/de not_active IP Right Cessation
- 2002-11-26 EP EP02784638A patent/EP1451174B1/de not_active Expired - Lifetime
- 2002-11-26 MX MXPA04005210A patent/MXPA04005210A/es active IP Right Grant
- 2002-11-26 CN CNA028238079A patent/CN1596254A/zh active Pending
- 2002-11-26 DE DE60237388T patent/DE60237388D1/de not_active Expired - Lifetime
- 2002-11-27 AR ARP020104560A patent/AR037679A1/es unknown
2004
- 2004-09-03 HK HK04106661.1A patent/HK1063798A1/xx not_active IP Right Cessation
2005
- 2005-03-30 US US11/093,560 patent/US7534884B2/en not_active Expired - Fee Related
2010
- 2010-03-03 JP JP2010047148A patent/JP2010132705A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
US20030144510A1 (en)	2003-07-31
CA2468525A1 (en)	2003-06-12
HK1063798A1 (en)	2005-01-14
US7534884B2 (en)	2009-05-19
MXPA04005210A (es)	2004-08-19
EP1451174A2 (de)	2004-09-01
JP2010132705A (ja)	2010-06-17
EP1451174B1 (de)	2010-08-18
WO2003048153A8 (en)	2004-06-03
WO2003048153A1 (en)	2003-06-12
US6943251B2 (en)	2005-09-13
AU2002346569A8 (en)	2003-06-17
AR037679A1 (es)	2004-12-01
AU2002346569A1 (en)	2003-06-17
US20050171117A1 (en)	2005-08-04
CN1596254A (zh)	2005-03-16
ATE478065T1 (de)	2010-09-15
JP2005511693A (ja)	2005-04-28

Publication	Publication Date	Title
DE60119283D1 (de)	2006-06-08	Verfahren zur herstellung von 3-hydroxypicolinsäure-derivaten
DE122007000077I1 (de)	2008-02-14	Verfahren zur Herstellung von substituierten Octanoyl-Amiden
DE60124482D1 (de)	2006-12-28	Verfahren zur Herstellung von Xylylendiamin
DE60141788D1 (de)	2010-05-27	Verfahren zur Herstellung von epsilon-Caprolactam
DE60019747D1 (de)	2005-06-02	Verfahren zur herstellung von fluorolefinen
DE60104244D1 (de)	2004-08-19	Verfahren zur Herstellung von Amiden
DE60040720D1 (de)	2008-12-18	Verfahren zur Herstellung von Nitrilverbindungen
DE50103049D1 (de)	2004-09-09	Verfahren zur Herstellung von Aminodiphenylaminen
DE50205766D1 (de)	2006-04-13	Verfahren zur herstellung von 2-halogenpyridincarbonsäureamiden
DE60237388D1 (de)	2010-09-30	Verfahren zur herstellung von zusammensetzungen mit erhöhtem gehalt von salzen pharmazeutisch aktiver rotamere
DE60131954D1 (de)	2008-01-31	Verfahren zur herstellung von 2-hydroxy-4-methylthiobutansäure
DE60116874D1 (de)	2006-04-13	Verfahren zur herstellung von (r)-2-alkyl-3-phenyl-1-propanolen
DE60108668D1 (de)	2005-03-03	Verfahren zur herstellung von phenethylamin-derivaten
DE50207455D1 (de)	2006-08-17	Verfahren ZUR HERSTELLUNG VON CARBONSÄURESALZEN
DE60233589D1 (de)	2009-10-15	Verfahren zur herstellung von echinocandinderivaten
DE60024372D1 (de)	2006-01-05	Verfahren zur Herstellung von Tetraorganooxysilanen
DE60104691D1 (de)	2004-09-09	Verfahren zur herstellung von pyrazolopyrimidinonen
DE60128640D1 (de)	2007-07-12	Verfahren zur Herstellung von optisch aktivem 4-Halo-3-Hydroxybutanoat
DE60217414D1 (de)	2007-02-15	Verfahren zur Herstellung von Alpha-Hydroxycarbonsäure Amiden
DE60034843D1 (de)	2007-06-28	Verfahren zur Herstellung von L-arginin
DE60102763D1 (de)	2004-05-19	Verfahren zur Herstellung von Dihydroperimidin-Squarainverbindungen
DE60029847D1 (de)	2006-09-14	Verfahren zur Herstellung von erythro 3-Amino-2-hydroxybuttersäurederivaten
DE60031231D1 (de)	2006-11-23	Verfahren zur Herstellung von 2-Alkyl-4-Isothiazolin-3-onen
DE60043610D1 (de)	2010-02-11	Verfahren zur herstellung von l-lysin
DE60004119D1 (de)	2003-09-04	Verfahren zur Herstellung von Pentaacetyl-beta-D-Glucopyranose