DE60236573D1 - Identifizierung der Virulenz-assoziierten Regionen RD1 und RD5, die die Entwicklung von verbesserten Impfstoffen mit M. bovis BCG und M. microti ermöglicht - Google Patents
Identifizierung der Virulenz-assoziierten Regionen RD1 und RD5, die die Entwicklung von verbesserten Impfstoffen mit M. bovis BCG und M. microti ermöglichtInfo
- Publication number
- DE60236573D1 DE60236573D1 DE60236573T DE60236573T DE60236573D1 DE 60236573 D1 DE60236573 D1 DE 60236573D1 DE 60236573 T DE60236573 T DE 60236573T DE 60236573 T DE60236573 T DE 60236573T DE 60236573 D1 DE60236573 D1 DE 60236573D1
- Authority
- DE
- Germany
- Prior art keywords
- microti
- bovis bcg
- strains
- virulence
- identification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241001467552 Mycobacterium bovis BCG Species 0.000 title abstract 3
- 241000187919 Mycobacterium microti Species 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 230000001018 virulence Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 101710166488 6 kDa early secretory antigenic target Proteins 0.000 abstract 1
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 101001057048 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) ESAT-6-like protein EsxB Proteins 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 201000008827 tuberculosis Diseases 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/5695—Mycobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02290864A EP1350839B1 (de) | 2002-04-05 | 2002-04-05 | Identifizierung der Virulenz-assoziierten Regionen RD1 und RD5, die die Entwicklung von verbesserten Impfstoffen mit M. bovis BCG und M. microti ermöglicht |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60236573D1 true DE60236573D1 (de) | 2010-07-15 |
Family
ID=27838170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60236573T Expired - Lifetime DE60236573D1 (de) | 2002-04-05 | 2002-04-05 | Identifizierung der Virulenz-assoziierten Regionen RD1 und RD5, die die Entwicklung von verbesserten Impfstoffen mit M. bovis BCG und M. microti ermöglicht |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7883712B2 (de) |
| EP (4) | EP1350839B1 (de) |
| AT (2) | ATE535600T1 (de) |
| AU (1) | AU2003223039A1 (de) |
| CA (1) | CA2481318C (de) |
| CY (1) | CY1110764T1 (de) |
| DE (1) | DE60236573D1 (de) |
| DK (1) | DK1350839T3 (de) |
| ES (1) | ES2346043T3 (de) |
| PT (1) | PT1350839E (de) |
| WO (1) | WO2003085098A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20040091A1 (it) | 2004-02-19 | 2004-05-19 | Istituto Naz Per Le Malattie | Test immunologico rapido per la diagnosi ed il monitoraggio dell'infezione tubercolare. |
| GB0406271D0 (en) * | 2004-03-19 | 2004-04-21 | Isis Innovation | Diagnostic test |
| US8475803B2 (en) * | 2005-04-29 | 2013-07-02 | Fusion Antibodies Limited | Assays for diagnosis of tuberculosis and uses thereof |
| US8398991B2 (en) * | 2005-06-22 | 2013-03-19 | Institut Pasteur | Modified ESAT-6 molecules and improved vaccine strains of Mycobacterium bovis BCG |
| GB0618127D0 (en) * | 2006-09-14 | 2006-10-25 | Isis Innovation | Biomarker |
| WO2008140598A2 (en) * | 2006-12-04 | 2008-11-20 | Bacilligen, Inc. | Novel immunotherapeutic mycobacteria, pharmaceutic formulations and uses thereof |
| US9074001B2 (en) * | 2009-04-24 | 2015-07-07 | Statens Serum Institut | Tuberculosis TB vaccine to prevent reactivation |
| US8367055B2 (en) | 2009-05-14 | 2013-02-05 | Wisconsin Alumni Research Foundation | Immunogenic compositions against tuberculosis |
| TR201101874A2 (tr) * | 2011-02-25 | 2011-08-22 | Leyla A�An Nac�Ye | Yüzeyel mesane tümorü tedavisinde kullanılabilecek mycobacterıum(mikobakteri) brumae hücre duvarı ekstreleri. |
| GR20120100415A (el) * | 2012-08-08 | 2014-03-17 | Νικολαος Χρηστου Πουλακης | Μεθοδος αμεσης ανιχνευσης του μυκοβακτηριδιου της φυματιωσης |
| IN2015DN03962A (de) * | 2012-10-23 | 2015-10-02 | Statens Seruminstitut | |
| US10010597B2 (en) | 2014-06-03 | 2018-07-03 | Institut Pasteur | Recombinant Mycobacterium bovis BCG expressing antigens of the Mycobacterium marinum ESX-1 secretion system |
| CN104628834B (zh) * | 2015-01-23 | 2016-03-23 | 中国疾病预防控制中心传染病预防控制所 | 一种结核感染t细胞免疫检测抗原及其应用 |
| CN104678097B (zh) * | 2015-03-10 | 2017-04-05 | 中国人民解放军军事医学科学院基础医学研究所 | 一种用于肺结核诊断的结核分枝杆菌组合抗原 |
| CN109406776B (zh) * | 2017-08-18 | 2022-02-11 | 中国科学院生物物理研究所 | 用于特异性检测结核分枝杆菌感染的蛋白Rv2818c |
| CN109406777B (zh) * | 2017-08-18 | 2022-02-18 | 中国科学院生物物理研究所 | 用于特异性检测结核分枝杆菌感染的蛋白Rv2824c |
| EP3643399B1 (de) | 2018-10-25 | 2022-04-27 | Heraeus Medical GmbH | Vorrichtung und verfahren zum bereitstellen von knochenzement |
| DE102018131266B4 (de) | 2018-12-07 | 2021-12-23 | Heraeus Medical Gmbh | Vorrichtung zum Mischen eines Knochenzements mit Hohlraum zum Monomertransfer und Verfahren zur Herstellung eines Knochenzementteigs |
| DE102018131268B4 (de) | 2018-12-07 | 2021-11-25 | Heraeus Medical Gmbh | Vorrichtung zum Mischen eines Knochenzements mit Hohlraum zum Monomertransfer |
| CN110763843B (zh) * | 2019-11-06 | 2020-09-15 | 华中农业大学 | 一种牛支原体双抗夹心elisa检测试剂盒及其应用 |
| CN116173213A (zh) * | 2023-01-16 | 2023-05-30 | 武汉大学 | Rv1977在制备抗结核分枝杆菌感染药物中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6096879A (en) | 1978-12-18 | 2000-08-01 | Institut Pasteur | Nucleotide sequence comprising the genome of hepatitis B virus, nucleotide sequence coding the surface antigen of the hepatitis B virus, vectors containing the nucleotide sequences, process for the preparation thereof, and antigen obtained thereby |
| EP0038765B1 (de) | 1980-04-22 | 1987-09-02 | Institut Pasteur | Impfstoff gegen Hepatitis B Virus, Verfahren und transformierte eukaryotische Zellen zur Herstellung dieses Impfstoffes |
| WO1986002383A1 (en) | 1984-10-18 | 1986-04-24 | Institut Pasteur | Envelope antigens of lymphadenopathy associated virus and their applications |
| FR2682122B1 (fr) | 1991-10-03 | 1995-06-09 | Pasteur Institut | Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori. |
| FR2735478B1 (fr) | 1995-06-13 | 1997-08-22 | Pasteur Institut | Molecules polypeptidiques de stade pre-erythrocytaire du paludisme |
| FR2744724B1 (fr) | 1996-02-14 | 2002-08-02 | Pasteur Institut | Proteine recombinante contenant un fragment c-terminal de la proteine msp-1 d'un plasmodium infectieux pour l'homme pour la production de vaccins anti-paludiques |
| AU8123898A (en) * | 1997-07-16 | 1999-02-10 | Institut Pasteur | A polynucleotide functionally coding for the lhp protein from mycobacterium tuberculosis, its biologically active derivative fragments, as well as metho ds usingthe same |
| JP2002505106A (ja) * | 1998-03-06 | 2002-02-19 | スタテンズ セーラム インスティテュート | 乳酸菌によるマイコバクテリアのポリペプチドの製造 |
| US6294328B1 (en) * | 1998-06-24 | 2001-09-25 | The Institute For Genomic Research | DNA sequences for strain analysis in Mycobacterium tuberculosis |
| DE60042078D1 (de) * | 1999-05-04 | 2009-06-04 | Univ New Jersey Med | Durch mycobacterium tuberculosis und nicht durch bcg exprimierte proteine und ihre verwendung als diagnostische reagenzien und impfstoffe |
| PT1338657E (pt) | 2002-02-25 | 2007-06-21 | Pasteur Institut | Sequências especificamente deletadas do genoma de mycobacterium tuberculosis e o seu uso em diagnóstico e como vacinas. |
-
2002
- 2002-04-05 EP EP02290864A patent/EP1350839B1/de not_active Expired - Lifetime
- 2002-04-05 DK DK02290864.4T patent/DK1350839T3/da active
- 2002-04-05 AT AT07122295T patent/ATE535600T1/de active
- 2002-04-05 ES ES02290864T patent/ES2346043T3/es not_active Expired - Lifetime
- 2002-04-05 DE DE60236573T patent/DE60236573D1/de not_active Expired - Lifetime
- 2002-04-05 AT AT02290864T patent/ATE469963T1/de active
- 2002-04-05 EP EP07122295A patent/EP1914299B9/de not_active Expired - Lifetime
- 2002-04-05 PT PT02290864T patent/PT1350839E/pt unknown
-
2003
- 2003-04-01 AU AU2003223039A patent/AU2003223039A1/en not_active Abandoned
- 2003-04-01 CA CA2481318A patent/CA2481318C/en not_active Expired - Fee Related
- 2003-04-01 WO PCT/IB2003/001789 patent/WO2003085098A2/en not_active Application Discontinuation
- 2003-04-01 US US10/510,021 patent/US7883712B2/en not_active Expired - Fee Related
- 2003-04-01 EP EP03719008A patent/EP1492867A2/de not_active Withdrawn
- 2003-04-01 EP EP10179423A patent/EP2302033A3/de not_active Withdrawn
-
2010
- 2010-09-01 CY CY20101100800T patent/CY1110764T1/el unknown
- 2010-09-21 US US12/923,432 patent/US8747866B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2346043T3 (es) | 2010-10-08 |
| ATE535600T1 (de) | 2011-12-15 |
| EP1492867A2 (de) | 2005-01-05 |
| DK1350839T3 (da) | 2010-07-12 |
| ATE469963T1 (de) | 2010-06-15 |
| WO2003085098A3 (en) | 2004-01-29 |
| AU2003223039A1 (en) | 2003-10-20 |
| US20120189662A1 (en) | 2012-07-26 |
| CA2481318A1 (en) | 2003-10-16 |
| PT1350839E (pt) | 2010-08-12 |
| EP2302033A2 (de) | 2011-03-30 |
| EP1914299B9 (de) | 2012-05-02 |
| HK1059803A1 (en) | 2004-07-16 |
| EP1350839B1 (de) | 2010-06-02 |
| EP1914299B1 (de) | 2011-11-30 |
| US7883712B2 (en) | 2011-02-08 |
| EP1914299A3 (de) | 2008-05-21 |
| CA2481318C (en) | 2014-06-10 |
| CY1110764T1 (el) | 2015-06-10 |
| WO2003085098A2 (en) | 2003-10-16 |
| AU2003223039A8 (en) | 2003-10-20 |
| EP1350839A1 (de) | 2003-10-08 |
| US8747866B2 (en) | 2014-06-10 |
| US20050220811A1 (en) | 2005-10-06 |
| EP1914299A2 (de) | 2008-04-23 |
| EP2302033A3 (de) | 2012-03-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60236573D1 (de) | Identifizierung der Virulenz-assoziierten Regionen RD1 und RD5, die die Entwicklung von verbesserten Impfstoffen mit M. bovis BCG und M. microti ermöglicht | |
| Ballester et al. | Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis | |
| EP4523756A3 (de) | Immunotherapeutischer impfstoff und antikörperkombinationstherapie | |
| WO2003059381A3 (en) | Immunogenic preparations and vaccines on the basis of mrna | |
| WO2019033043A3 (en) | ANTI-CD8 ANTIBODIES AND USES THEREOF | |
| MY149604A (en) | C.perfringens alpha toxoid vaccine | |
| WO2008112344A3 (en) | Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins | |
| EP2385059A3 (de) | Verfahren und Zusammensetzungen zum Auslösen von multivalenten Immunreaktionen gegen auf Krebszellen und Tumor-Stroma exprimierte dominante und subdominante Epitope | |
| JP2012041355A5 (de) | ||
| TW200722101A (en) | Novel composition | |
| NZ760783A (en) | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof | |
| MX2007003402A (es) | Composicion inmunogena para su uso en vacunacion contra estafilococos. | |
| MY173004A (en) | Mycobacterial antigen vaccine | |
| Kaufmann et al. | Exploiting immunology and molecular genetics for rational vaccine design against tuberculosis [State of the Art] | |
| WO2023049636A3 (en) | Cancer therapy compositions and uses thereof | |
| MX2019005423A (es) | Conjugado proteico de polisacarido inmunogenico que comprende un polisacarido derivado de estreptococo grupo b (gbs). | |
| WO2006071983A3 (en) | Use of compositions comprising various tumor-associated antigens as anti-cancer vaccines | |
| Lu et al. | Novel recombinant BCG coexpressing Ag85B, ESAT‐6 and Rv2608 elicits significantly enhanced cellular immune and antibody responses in C57BL/6 mice | |
| WO2003090687A3 (en) | Using heat shock proteins to increase immune response | |
| WO2006117538A3 (en) | Assays for diagnosis of tuberculosis and uses thereof | |
| TN2012000592A1 (en) | Vaccine compositions based on sticholysin encapsulated in liposomes | |
| WO2010080188A3 (en) | Epitope targeted anthrax vaccine | |
| DE60325586D1 (de) | Mycobakterielle Proteinantigene für Krebstherapie und Impfung | |
| UA132124U (uk) | Вакцина проти лептоспірозу м'ясоїдних бівалентна | |
| Bhaskar et al. | Immunotherapeutic Potential of Mycobacterium indicus pranii Against Tuberculosis |