ATE469963T1 - Identifizierung der virulenz-assoziierten regionen rd1 und rd5, die die entwicklung von verbesserten impfstoffen mit m. bovis bcg und m. microti ermöglicht - Google Patents
Identifizierung der virulenz-assoziierten regionen rd1 und rd5, die die entwicklung von verbesserten impfstoffen mit m. bovis bcg und m. microti ermöglichtInfo
- Publication number
- ATE469963T1 ATE469963T1 AT02290864T AT02290864T ATE469963T1 AT E469963 T1 ATE469963 T1 AT E469963T1 AT 02290864 T AT02290864 T AT 02290864T AT 02290864 T AT02290864 T AT 02290864T AT E469963 T1 ATE469963 T1 AT E469963T1
- Authority
- AT
- Austria
- Prior art keywords
- microti
- bovis bcg
- strains
- virulence
- identification
- Prior art date
Links
- 241001467552 Mycobacterium bovis BCG Species 0.000 title abstract 3
- 241000187919 Mycobacterium microti Species 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 101710166488 6 kDa early secretory antigenic target Proteins 0.000 abstract 1
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 101001057048 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) ESAT-6-like protein EsxB Proteins 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 201000008827 tuberculosis Diseases 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/5695—Mycobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02290864A EP1350839B1 (de) | 2002-04-05 | 2002-04-05 | Identifizierung der Virulenz-assoziierten Regionen RD1 und RD5, die die Entwicklung von verbesserten Impfstoffen mit M. bovis BCG und M. microti ermöglicht |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE469963T1 true ATE469963T1 (de) | 2010-06-15 |
Family
ID=27838170
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02290864T ATE469963T1 (de) | 2002-04-05 | 2002-04-05 | Identifizierung der virulenz-assoziierten regionen rd1 und rd5, die die entwicklung von verbesserten impfstoffen mit m. bovis bcg und m. microti ermöglicht |
| AT07122295T ATE535600T1 (de) | 2002-04-05 | 2002-04-05 | Identifizierung der virulenz-assoziierten region rd1, die die entwicklung von verbesserten impstoffen mit m. microti ermöglicht |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07122295T ATE535600T1 (de) | 2002-04-05 | 2002-04-05 | Identifizierung der virulenz-assoziierten region rd1, die die entwicklung von verbesserten impstoffen mit m. microti ermöglicht |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7883712B2 (de) |
| EP (4) | EP1914299B9 (de) |
| AT (2) | ATE469963T1 (de) |
| AU (1) | AU2003223039A1 (de) |
| CA (1) | CA2481318C (de) |
| CY (1) | CY1110764T1 (de) |
| DE (1) | DE60236573D1 (de) |
| DK (1) | DK1350839T3 (de) |
| ES (1) | ES2346043T3 (de) |
| HK (1) | HK1059803A1 (de) |
| PT (1) | PT1350839E (de) |
| WO (1) | WO2003085098A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20040091A1 (it) | 2004-02-19 | 2004-05-19 | Istituto Naz Per Le Malattie | Test immunologico rapido per la diagnosi ed il monitoraggio dell'infezione tubercolare. |
| GB0406271D0 (en) | 2004-03-19 | 2004-04-21 | Isis Innovation | Diagnostic test |
| US8475803B2 (en) * | 2005-04-29 | 2013-07-02 | Fusion Antibodies Limited | Assays for diagnosis of tuberculosis and uses thereof |
| US8398991B2 (en) * | 2005-06-22 | 2013-03-19 | Institut Pasteur | Modified ESAT-6 molecules and improved vaccine strains of Mycobacterium bovis BCG |
| GB0618127D0 (en) * | 2006-09-14 | 2006-10-25 | Isis Innovation | Biomarker |
| WO2008140598A2 (en) * | 2006-12-04 | 2008-11-20 | Bacilligen, Inc. | Novel immunotherapeutic mycobacteria, pharmaceutic formulations and uses thereof |
| MX2011011186A (es) * | 2009-04-24 | 2012-02-13 | Una vacuna antituberculosis tb para evitar la reactivacion. | |
| WO2010132112A2 (en) | 2009-05-14 | 2010-11-18 | Wisconsin Alumni Research Foundation | Immunogenic compositions against tuberculosis |
| TR201101874A2 (tr) * | 2011-02-25 | 2011-08-22 | Leyla A�An Nac�Ye | Yüzeyel mesane tümorü tedavisinde kullanılabilecek mycobacterıum(mikobakteri) brumae hücre duvarı ekstreleri. |
| GR20120100415A (el) * | 2012-08-08 | 2014-03-17 | Νικολαος Χρηστου Πουλακης | Μεθοδος αμεσης ανιχνευσης του μυκοβακτηριδιου της φυματιωσης |
| US9526773B2 (en) | 2012-10-23 | 2016-12-27 | Statens Serum Institut | M. tuberculosis vaccines |
| WO2015185669A1 (en) * | 2014-06-03 | 2015-12-10 | Institut Pasteur | Recombinant mycobacterium bovis bcg expressing antigens of the mycobacterium marinum esx-1 secretion system |
| CN104628834B (zh) * | 2015-01-23 | 2016-03-23 | 中国疾病预防控制中心传染病预防控制所 | 一种结核感染t细胞免疫检测抗原及其应用 |
| CN104678097B (zh) * | 2015-03-10 | 2017-04-05 | 中国人民解放军军事医学科学院基础医学研究所 | 一种用于肺结核诊断的结核分枝杆菌组合抗原 |
| CN109406777B (zh) * | 2017-08-18 | 2022-02-18 | 中国科学院生物物理研究所 | 用于特异性检测结核分枝杆菌感染的蛋白Rv2824c |
| CN109406776B (zh) * | 2017-08-18 | 2022-02-11 | 中国科学院生物物理研究所 | 用于特异性检测结核分枝杆菌感染的蛋白Rv2818c |
| EP3643398B1 (de) | 2018-10-25 | 2021-07-07 | Heraeus Medical GmbH | Vorrichtung und verfahren zum bereitstellen von knochenzement |
| DE102018131268B4 (de) | 2018-12-07 | 2021-11-25 | Heraeus Medical Gmbh | Vorrichtung zum Mischen eines Knochenzements mit Hohlraum zum Monomertransfer |
| DE102018131266B4 (de) | 2018-12-07 | 2021-12-23 | Heraeus Medical Gmbh | Vorrichtung zum Mischen eines Knochenzements mit Hohlraum zum Monomertransfer und Verfahren zur Herstellung eines Knochenzementteigs |
| CN110763843B (zh) * | 2019-11-06 | 2020-09-15 | 华中农业大学 | 一种牛支原体双抗夹心elisa检测试剂盒及其应用 |
| CN116173213A (zh) * | 2023-01-16 | 2023-05-30 | 武汉大学 | Rv1977在制备抗结核分枝杆菌感染药物中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6096879A (en) | 1978-12-18 | 2000-08-01 | Institut Pasteur | Nucleotide sequence comprising the genome of hepatitis B virus, nucleotide sequence coding the surface antigen of the hepatitis B virus, vectors containing the nucleotide sequences, process for the preparation thereof, and antigen obtained thereby |
| EP0038765B1 (de) | 1980-04-22 | 1987-09-02 | Institut Pasteur | Impfstoff gegen Hepatitis B Virus, Verfahren und transformierte eukaryotische Zellen zur Herstellung dieses Impfstoffes |
| PT81338B (pt) | 1984-10-18 | 1987-11-11 | Pasteur Institut | Antigenios, em especial antigenios do envolucro do virus de linfoadenopatias e do sindroma de imuno-deficiencia adquirido, e virus, processo para a producao de antigenios do envolucro do virus, utilizacao destes antigenios na preparacao de composicoes imunogenicas ou no diagnostico da presenca de anticorpos contra este virus |
| FR2682122B1 (fr) | 1991-10-03 | 1995-06-09 | Pasteur Institut | Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori. |
| FR2735478B1 (fr) | 1995-06-13 | 1997-08-22 | Pasteur Institut | Molecules polypeptidiques de stade pre-erythrocytaire du paludisme |
| FR2744724B1 (fr) | 1996-02-14 | 2002-08-02 | Pasteur Institut | Proteine recombinante contenant un fragment c-terminal de la proteine msp-1 d'un plasmodium infectieux pour l'homme pour la production de vaccins anti-paludiques |
| WO1999004005A1 (en) * | 1997-07-16 | 1999-01-28 | Institut Pasteur | A polynucleotide functionally coding for the lhp protein from mycobacterium tuberculosis, its biologically active derivative fragments, as well as methods using the same |
| EP1058731A2 (de) * | 1998-03-06 | 2000-12-13 | Statens Seruminstitut | Herstellung von mykobacterien-polypeptidens bei milchsaüre-bacterien |
| US6294328B1 (en) * | 1998-06-24 | 2001-09-25 | The Institute For Genomic Research | DNA sequences for strain analysis in Mycobacterium tuberculosis |
| WO2000066157A1 (en) * | 1999-05-04 | 2000-11-09 | The Public Health Research Institute Of The City Of New York, Inc. | Proteins expressed by mycobacterium tuberculosis and not by bcg and their use as diagnostic reagents and vaccines |
| ATE360097T1 (de) | 2002-02-25 | 2007-05-15 | Pasteur Institut | Spezifisch vom genom von mycobacterium tuberculosis deletierte sequenzen und deren verwendung in der diagnostik und als vakzine |
-
2002
- 2002-04-05 ES ES02290864T patent/ES2346043T3/es not_active Expired - Lifetime
- 2002-04-05 EP EP07122295A patent/EP1914299B9/de not_active Expired - Lifetime
- 2002-04-05 AT AT02290864T patent/ATE469963T1/de active
- 2002-04-05 DK DK02290864.4T patent/DK1350839T3/da active
- 2002-04-05 DE DE60236573T patent/DE60236573D1/de not_active Expired - Lifetime
- 2002-04-05 AT AT07122295T patent/ATE535600T1/de active
- 2002-04-05 PT PT02290864T patent/PT1350839E/pt unknown
- 2002-04-05 EP EP02290864A patent/EP1350839B1/de not_active Expired - Lifetime
-
2003
- 2003-04-01 EP EP10179423A patent/EP2302033A3/de not_active Withdrawn
- 2003-04-01 US US10/510,021 patent/US7883712B2/en not_active Expired - Fee Related
- 2003-04-01 CA CA2481318A patent/CA2481318C/en not_active Expired - Fee Related
- 2003-04-01 EP EP03719008A patent/EP1492867A2/de not_active Withdrawn
- 2003-04-01 WO PCT/IB2003/001789 patent/WO2003085098A2/en not_active Application Discontinuation
- 2003-04-01 AU AU2003223039A patent/AU2003223039A1/en not_active Abandoned
-
2004
- 2004-04-08 HK HK04102539.0A patent/HK1059803A1/xx not_active IP Right Cessation
-
2010
- 2010-09-01 CY CY20101100800T patent/CY1110764T1/el unknown
- 2010-09-21 US US12/923,432 patent/US8747866B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1914299A3 (de) | 2008-05-21 |
| WO2003085098A2 (en) | 2003-10-16 |
| EP1914299B9 (de) | 2012-05-02 |
| ES2346043T3 (es) | 2010-10-08 |
| HK1059803A1 (en) | 2004-07-16 |
| EP1914299B1 (de) | 2011-11-30 |
| EP1350839B1 (de) | 2010-06-02 |
| AU2003223039A1 (en) | 2003-10-20 |
| EP1350839A1 (de) | 2003-10-08 |
| CA2481318A1 (en) | 2003-10-16 |
| US20120189662A1 (en) | 2012-07-26 |
| ATE535600T1 (de) | 2011-12-15 |
| US20050220811A1 (en) | 2005-10-06 |
| CA2481318C (en) | 2014-06-10 |
| DK1350839T3 (da) | 2010-07-12 |
| EP1914299A2 (de) | 2008-04-23 |
| EP1492867A2 (de) | 2005-01-05 |
| DE60236573D1 (de) | 2010-07-15 |
| PT1350839E (pt) | 2010-08-12 |
| WO2003085098A3 (en) | 2004-01-29 |
| US7883712B2 (en) | 2011-02-08 |
| CY1110764T1 (el) | 2015-06-10 |
| EP2302033A2 (de) | 2011-03-30 |
| US8747866B2 (en) | 2014-06-10 |
| AU2003223039A8 (en) | 2003-10-20 |
| EP2302033A3 (de) | 2012-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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