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DE60235588D1 - Monoklonales Antikörper gegen das HCV Kernantigen - Google Patents

Monoklonales Antikörper gegen das HCV Kernantigen

Info

Publication number
DE60235588D1
DE60235588D1 DE60235588T DE60235588T DE60235588D1 DE 60235588 D1 DE60235588 D1 DE 60235588D1 DE 60235588 T DE60235588 T DE 60235588T DE 60235588 T DE60235588 T DE 60235588T DE 60235588 D1 DE60235588 D1 DE 60235588D1
Authority
DE
Germany
Prior art keywords
core antigen
hcv core
monoclonal antibody
antibody against
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60235588T
Other languages
English (en)
Inventor
Chander Bahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Clinical Diagnostics Inc
Original Assignee
Ortho Clinical Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Clinical Diagnostics Inc filed Critical Ortho Clinical Diagnostics Inc
Application granted granted Critical
Publication of DE60235588D1 publication Critical patent/DE60235588D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C07K16/109—Hepatitis C virus; Hepatitis G virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE60235588T 2001-11-05 2002-11-04 Monoklonales Antikörper gegen das HCV Kernantigen Expired - Lifetime DE60235588D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33745301P 2001-11-05 2001-11-05
US10/268,561 US7049060B2 (en) 2001-11-05 2002-10-10 HCV anti-core monoclonal antibodies

Publications (1)

Publication Number Publication Date
DE60235588D1 true DE60235588D1 (de) 2010-04-15

Family

ID=26953173

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60224346T Expired - Lifetime DE60224346T2 (de) 2001-11-05 2002-11-04 Monoklonales Antikörper gegen das HCV Kernantigen
DE60235588T Expired - Lifetime DE60235588D1 (de) 2001-11-05 2002-11-04 Monoklonales Antikörper gegen das HCV Kernantigen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60224346T Expired - Lifetime DE60224346T2 (de) 2001-11-05 2002-11-04 Monoklonales Antikörper gegen das HCV Kernantigen

Country Status (9)

Country Link
US (1) US7049060B2 (de)
EP (3) EP1308507B1 (de)
JP (1) JP2004035534A (de)
AT (2) ATE459706T1 (de)
CA (1) CA2406240C (de)
DE (2) DE60224346T2 (de)
DK (2) DK1308507T3 (de)
ES (2) ES2295292T3 (de)
PT (2) PT1308507E (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7902338B2 (en) 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
JP2009018990A (ja) * 2005-10-25 2009-01-29 Univ Kurume Ｃ型肝炎ウイルス由来ペプチド
US7858752B2 (en) 2006-12-05 2010-12-28 Abbott Laboratories Recombinant antibodies against hepatitis C virus and methods of obtaining and using same
US20160095939A1 (en) 2014-10-07 2016-04-07 Immunomedics, Inc. Neoadjuvant use of antibody-drug conjugates
ES3000111T3 (en) 2009-02-13 2025-02-27 Immunomedics Inc Intermediates for preparing conjugates with an intracellularly-cleavable linkage
CA2774260C (en) 2009-09-16 2018-10-09 Immunomedics, Inc. Class i anti-cea antibodies and uses thereof
EP2506881B1 (de) 2009-12-02 2024-03-06 Immunomedics, Inc. Kombination aus radioimmuntherapie und antikörper-arznei-konjugaten für verbesserte krebstherapie
WO2012006500A2 (en) * 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
CA2831572C (en) 2011-05-02 2019-11-26 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
FR2984328B1 (fr) 2011-12-20 2016-12-30 Bio-Rad Innovations Procede de detection d'une infection par le virus de l'hepatite c
EP2885002A4 (de) 2012-08-14 2016-04-20 Ibc Pharmaceuticals Inc Umleitung t-zell-bispezifischer antikörper zur behandlung von krankheiten
CA2884313C (en) 2012-12-13 2023-01-03 Immunomedics, Inc. Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity
CA2906417C (en) * 2013-03-14 2022-06-21 Robert Ziemann Hcv core lipid binding domain monoclonal antibodies
CA2906407A1 (en) 2013-03-14 2014-09-18 Abbott Laboratories Hcv ns3 recombinant antigens and mutants thereof for improved antibody detection
US9194873B2 (en) 2013-03-14 2015-11-24 Abbott Laboratories HCV antigen-antibody combination assay and methods and compositions for use therein
JP6447933B2 (ja) 2014-02-21 2019-01-09 アイビーシー ファーマスーティカルズ，インコーポレイテッド Ｔｒｏｐ−２発現細胞に対する免疫応答を誘発することによる疾患治療
US9139649B2 (en) 2014-02-25 2015-09-22 Immunomedics, Inc. Humanized anti-CD22 antibody
CA2953567C (en) 2014-06-24 2023-09-05 Immunomedics, Inc. Anti-histone therapy for vascular necrosis in severe glomerulonephritis
EP3286224A4 (de) 2015-04-22 2018-11-14 Immunomedics, Inc. Isolierung, detektion, diagnose und/oder charakterisierung von zirkulierenden trop-2-positiven krebszellen
AU2016281622C1 (en) 2015-06-25 2021-11-18 Immunomedics, Inc. Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, Bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer
EP3316885B1 (de) 2015-07-01 2021-06-23 Immunomedics, Inc. Antikörper-sn-38-immunkonjugate mit einem cl2a-linker
EP3465217A1 (de) 2016-05-31 2019-04-10 Roche Diagnostics GmbH Verfahren zum serologischen nachweis von virusantigenen
JP7044721B2 (ja) 2016-05-31 2022-03-30 エフ．ホフマン－ラ ロシュ アーゲー Ｈｃｖコア抗原の迅速な検出のための前処理法
JP7068323B2 (ja) 2017-02-02 2022-05-16 エフ．ホフマン－ラ ロシュ アーゲー 少なくとも２種のペグ化された分析物特異的結合剤を使用する免疫アッセイ
EP3658171B1 (de) 2017-07-27 2023-08-30 Roche Diagnostics GmbH Multi-epitop-fusionsprotein eines hcv-antigens und verwendungen davon
CN109738648B (zh) * 2018-12-29 2021-09-17 山东莱博生物科技有限公司 稳定高效表达丙型肝炎病毒核心抗原抗体的工程细胞株及其应用
WO2022239720A1 (ja) 2021-05-10 2022-11-17 公益財団法人川崎市産業振興財団 抗原への結合親和性を低減させた抗体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT54896A (en) 1989-03-17 1991-04-29 Chiron Corp Process for producing aquous diagnosticum and vaccine of nanbv
DE4209215A1 (de) * 1991-07-04 1993-01-07 Boehringer Mannheim Gmbh Hcv peptidantigene und verfahren zur bestimmung von hcv
ZA927837B (en) 1991-10-15 1994-03-11 Akzo Nv Monoclonal antibodiesto hepatitis C virus
JP3217600B2 (ja) * 1994-07-12 2001-10-09 株式会社先端生命科学研究所 非ａ非ｂ型肝炎ウイルス関連抗原のイムノアッセイ、それに使用するモノクローナル抗体、およびこの抗体を産生するハイブリドーマ
FR2775690B1 (fr) 1998-03-09 2001-12-14 Bio Merieux Anticorps monoclonal et utilisations pour detecter des antigenes de la proteine core de vhc
US20030022155A1 (en) * 1999-04-14 2003-01-30 Agata Budkowska Method for detecting hepatitis c virus with hybridomas
DK1350105T3 (da) * 2000-06-15 2007-11-12 Novartis Vaccines & Diagnostic Immunoanalyser for enti-HCV-antistoffer
JP4353793B2 (ja) * 2001-06-26 2009-10-28 アボット・ラボラトリーズ Ｈｃｖ抗原とｈｃｖ抗体との同時検出のための方法

Also Published As

Publication number Publication date
ATE382683T1 (de) 2008-01-15
EP1308507A2 (de) 2003-05-07
CA2406240C (en) 2011-01-04
ATE459706T1 (de) 2010-03-15
EP2186884A3 (de) 2010-09-08
US20030148333A1 (en) 2003-08-07
DK1881064T3 (da) 2010-06-07
EP1308507A3 (de) 2003-10-22
CA2406240A1 (en) 2003-05-05
DE60224346D1 (de) 2008-02-14
PT1881064E (pt) 2010-03-31
PT1308507E (pt) 2008-03-31
ES2295292T3 (es) 2008-04-16
EP1881064A2 (de) 2008-01-23
EP1881064A3 (de) 2008-04-09
ES2339709T3 (es) 2010-05-24
US7049060B2 (en) 2006-05-23
DE60224346T2 (de) 2008-12-24
EP2186884A2 (de) 2010-05-19
EP1308507B1 (de) 2008-01-02
DK1308507T3 (da) 2008-05-19
EP1881064B1 (de) 2010-03-03
JP2004035534A (ja) 2004-02-05

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