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DE60220522D1 - Kombination von einem aldosterone rezeptor antagonisten und einem hmg coa reduktase hemmer - Google Patents

Kombination von einem aldosterone rezeptor antagonisten und einem hmg coa reduktase hemmer

Info

Publication number
DE60220522D1
DE60220522D1 DE60220522T DE60220522T DE60220522D1 DE 60220522 D1 DE60220522 D1 DE 60220522D1 DE 60220522 T DE60220522 T DE 60220522T DE 60220522 T DE60220522 T DE 60220522T DE 60220522 D1 DE60220522 D1 DE 60220522D1
Authority
DE
Germany
Prior art keywords
combination
receptor antagonist
coa reductase
reductase inhibitor
hmg coa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60220522T
Other languages
English (en)
Other versions
DE60220522T2 (de
Inventor
Bradley T Keller
Ellen G Mcmahon
Ricardo Rocha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia LLC
Original Assignee
Pharmacia LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia LLC filed Critical Pharmacia LLC
Publication of DE60220522D1 publication Critical patent/DE60220522D1/de
Application granted granted Critical
Publication of DE60220522T2 publication Critical patent/DE60220522T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Public Health (AREA)
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  • Veterinary Medicine (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Cardiology (AREA)
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  • Obesity (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
DE60220522T 2001-07-19 2002-07-18 Kombination von einem aldosterone rezeptor antagonisten und einem hmg coa reduktase hemmer Expired - Fee Related DE60220522T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30633601P 2001-07-19 2001-07-19
US306336P 2001-07-19
PCT/US2002/022896 WO2003007993A1 (en) 2001-07-19 2002-07-18 Combination of an aldosterone receptor antagonist and an hmg coa reductase inhibitor

Publications (2)

Publication Number Publication Date
DE60220522D1 true DE60220522D1 (de) 2007-07-19
DE60220522T2 DE60220522T2 (de) 2007-09-27

Family

ID=23184836

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60220522T Expired - Fee Related DE60220522T2 (de) 2001-07-19 2002-07-18 Kombination von einem aldosterone rezeptor antagonisten und einem hmg coa reduktase hemmer

Country Status (26)

Country Link
US (2) US20030149010A1 (de)
EP (1) EP1406660B1 (de)
JP (1) JP2004537553A (de)
KR (1) KR20040023660A (de)
CN (1) CN1537019A (de)
AP (1) AP2004002951A0 (de)
AT (1) ATE363917T1 (de)
BR (1) BR0211274A (de)
CA (1) CA2452678A1 (de)
CO (1) CO5550464A2 (de)
DE (1) DE60220522T2 (de)
EA (1) EA200400029A1 (de)
EC (1) ECSP044950A (de)
ES (1) ES2286270T3 (de)
GE (1) GEP20063811B (de)
IL (1) IL159588A0 (de)
IS (1) IS7093A (de)
MA (1) MA27050A1 (de)
MX (1) MXPA04000586A (de)
NO (1) NO20040211L (de)
OA (1) OA12983A (de)
PL (1) PL367417A1 (de)
TN (1) TNSN04001A1 (de)
UA (1) UA76475C2 (de)
WO (1) WO2003007993A1 (de)
ZA (1) ZA200400288B (de)

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CN1310941C (zh) * 2005-07-13 2007-04-18 南京大学 依普利酮的合成方法
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EP2051696A2 (de) * 2006-08-18 2009-04-29 Morton Grove Pharmaceuticals, Inc. Stabile flüssige levetiracetam-zusammensetzungen und verfahren
FR2917975B1 (fr) * 2007-06-26 2009-10-16 Ceva Sante Animale Sa Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
EP2135607A1 (de) 2008-06-18 2009-12-23 Pharnext Kombination aus Pilocarpin und Methimazol zur Behandlung der Charcot-Marie-Tooth Krankheit und verwandten Erkrankungen
WO2010062861A2 (en) 2008-11-26 2010-06-03 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of obesity and diabetes
US9387206B2 (en) 2009-11-03 2016-07-12 Pharnext Therapeutic approaches for treating Alzheimer's disease
EP2322163A1 (de) * 2009-11-03 2011-05-18 Pharnext Neue therapeutische Ansätze zur Behandlung von Alzheimer-Krankheit
ES2739888T3 (es) * 2009-11-30 2020-02-04 Adare Pharmaceuticals Inc Composiciones y comprimidos farmacéuticos con recubrimiento compresible y métodos de fabricación
WO2011150286A2 (en) 2010-05-26 2011-12-01 Satiogen Pharmaceuticals,Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
US8877221B2 (en) 2010-10-27 2014-11-04 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same
US9107983B2 (en) 2010-10-27 2015-08-18 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising statins
US9241933B2 (en) 2011-03-01 2016-01-26 Pharnext Compositions for treating amyotrophic lateral sclerosis
US10010515B2 (en) 2011-03-01 2018-07-03 Pharnext Therapeutic approaches for treating Parkinson's disease
DK2727588T3 (en) 2011-03-01 2018-12-10 Pharnext Baclofen- and acamprosate-based therapy for neurological disorders
US9248111B2 (en) 2011-03-01 2016-02-02 Pharnext Therapeutic approaches for treating parkinson's disease
DE102011015142A1 (de) * 2011-03-17 2012-09-20 Eberhard-Karls-Universität Tübingen Universitätsklinikum Agens zur Prophylaxe und Behandlung altersassoziierter Krankheiten und Störungen sowie zur Verlängerung der Lebensdauer
US9308190B2 (en) 2011-06-06 2016-04-12 Warsaw Orthopedic, Inc. Methods and compositions to enhance bone growth comprising a statin
BR112014010223B8 (pt) 2011-10-28 2021-02-23 Lumena Pharmaceuticals Llc uso de uma composição compreendendo inibidores de reciclagem de ácido de bílis e forma de dosagem pediátrica
EP3278796A1 (de) 2011-10-28 2018-02-07 Lumena Pharmaceuticals LLC Gallensäurerückflusshemmer zur behandlung von hypercholämie und cholestatischer lebererkrankung
RU2015139732A (ru) 2013-03-15 2017-04-24 ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи Ингибиторы рециркуляции желчных кислот для лечения пищевода барретта и гастроэзофагеальной рефлюксной болезни
CN105228607A (zh) 2013-03-15 2016-01-06 鲁美纳医药公司 用于治疗原发性硬化性胆管炎和炎性肠病的胆汁酸再循环抑制剂
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Also Published As

Publication number Publication date
NO20040211L (no) 2004-03-16
UA76475C2 (en) 2006-08-15
EP1406660B1 (de) 2007-06-06
CA2452678A1 (en) 2003-01-30
ATE363917T1 (de) 2007-06-15
WO2003007993A1 (en) 2003-01-30
TNSN04001A1 (fr) 2006-06-01
CN1537019A (zh) 2004-10-13
KR20040023660A (ko) 2004-03-18
JP2004537553A (ja) 2004-12-16
IL159588A0 (en) 2004-06-01
DE60220522T2 (de) 2007-09-27
GEP20063811B (en) 2006-05-10
ECSP044950A (es) 2004-02-26
BR0211274A (pt) 2004-08-03
AP2004002951A0 (en) 2004-03-31
IS7093A (is) 2003-12-23
PL367417A1 (en) 2005-02-21
OA12983A (en) 2006-10-13
US20060003975A1 (en) 2006-01-05
ES2286270T3 (es) 2007-12-01
MA27050A1 (fr) 2004-12-20
CO5550464A2 (es) 2005-08-31
EA200400029A1 (ru) 2004-08-26
EP1406660A1 (de) 2004-04-14
ZA200400288B (en) 2005-06-29
MXPA04000586A (es) 2004-04-20
US20030149010A1 (en) 2003-08-07

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