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DE60215368D1 - Pyranderivate als inhibitoren von ace und nep - Google Patents

Pyranderivate als inhibitoren von ace und nep

Info

Publication number
DE60215368D1
DE60215368D1 DE60215368T DE60215368T DE60215368D1 DE 60215368 D1 DE60215368 D1 DE 60215368D1 DE 60215368 T DE60215368 T DE 60215368T DE 60215368 T DE60215368 T DE 60215368T DE 60215368 D1 DE60215368 D1 DE 60215368D1
Authority
DE
Germany
Prior art keywords
ace
nep
sub
pyranderivates
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60215368T
Other languages
English (en)
Other versions
DE60215368T2 (de
Inventor
Anne Fink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE60215368D1 publication Critical patent/DE60215368D1/de
Application granted granted Critical
Publication of DE60215368T2 publication Critical patent/DE60215368T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
DE60215368T 2001-09-21 2002-09-20 Pyranderivate als inhibitoren von ace und nep Expired - Lifetime DE60215368T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32382501P 2001-09-21 2001-09-21
US323825P 2001-09-21
PCT/EP2002/010608 WO2003027091A1 (en) 2001-09-21 2002-09-20 Pyrane derivatives as both ace- and nep- inhibitors

Publications (2)

Publication Number Publication Date
DE60215368D1 true DE60215368D1 (de) 2006-11-23
DE60215368T2 DE60215368T2 (de) 2007-08-16

Family

ID=23260883

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60215368T Expired - Lifetime DE60215368T2 (de) 2001-09-21 2002-09-20 Pyranderivate als inhibitoren von ace und nep

Country Status (12)

Country Link
US (2) US7071169B2 (de)
EP (1) EP1430045B1 (de)
JP (1) JP4263095B2 (de)
CN (1) CN1304415C (de)
AT (1) ATE342261T1 (de)
BR (1) BR0212899A (de)
CA (1) CA2456281A1 (de)
DE (1) DE60215368T2 (de)
ES (1) ES2274106T3 (de)
HK (1) HK1068332A1 (de)
PT (1) PT1430045E (de)
WO (1) WO2003027091A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1304415C (zh) 2001-09-21 2007-03-14 诺瓦提斯公司 作为ace和nep抑制剂的吡喃衍生物
TW200900399A (en) 2003-10-01 2009-01-01 Speedel Experimenta Ag Organic compounds
FI20040674A0 (fi) * 2004-05-12 2004-05-12 Orion Corp Menetelmä tromboembolisten sairauksien estoon
WO2006064016A1 (en) * 2004-12-15 2006-06-22 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising nep-inhibitors, inhibitors of the endogenous endothelin producing system and hmg coa reductase inhibitors
MX2007009977A (es) * 2005-02-18 2007-09-26 Solvay Pharm Gmbh Composiciones farmaceuticas que comprenden inhibidores de nep, inhibidores del sistema productor de endotelina endogena y diureticos.
US20060205625A1 (en) * 2005-02-18 2006-09-14 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
EP1897879A3 (de) 2005-03-31 2008-06-11 Speedel Experimenta AG 2,4,5-Substituierte Piperidine als Renin-Inhibitoren
TW200722424A (en) 2005-03-31 2007-06-16 Speedel Experimenta Ag Substituted piperidines
ATE509941T1 (de) * 2006-01-11 2011-06-15 Seikagaku Kogyo Co Ltd Cycloalkylcarbonylaminosäureester-derivat und herstellungsverfahren dafür
JP3975226B2 (ja) 2006-01-11 2007-09-12 生化学工業株式会社 シクロアルキルカルボニルアミノ酸誘導体及びその製造方法
JP4047365B2 (ja) 2006-01-11 2008-02-13 生化学工業株式会社 シクロアルカンカルボキサミド誘導体及びその製造方法
CA2697057A1 (en) * 2007-08-22 2009-02-26 Gilead Colorado, Inc. Therapy for complications of diabetes
WO2009127251A1 (en) * 2008-04-16 2009-10-22 Novartis Ag Combinations comprising a renin inhibitor
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04211648A (ja) * 1990-07-27 1992-08-03 Nippon Kayaku Co Ltd ケト酸アミド誘導体
EP0655461B1 (de) 1993-11-16 2000-06-07 Novartis AG Zyklische Aminosäure-Derivate mit ACE und NEP inhibierender Aktivität
US5432186A (en) 1993-11-16 1995-07-11 Ciba-Geigy Corporation Cyclic amino acid derivatives
EP1073674A1 (de) * 1998-04-23 2001-02-07 Novartis AG Thiol enthaltende inhibitore des endothelin konvertierenden enzyms
JP3646062B2 (ja) * 1998-04-23 2005-05-11 ノバルティス アクチエンゲゼルシャフト エンドセリン変換酵素のヘテロアリール置換チオール型阻害剤
AU2001254776A1 (en) 2000-04-06 2001-10-23 Novartis Ag Organic compounds
US6777443B2 (en) * 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
CN1304415C (zh) 2001-09-21 2007-03-14 诺瓦提斯公司 作为ace和nep抑制剂的吡喃衍生物

Also Published As

Publication number Publication date
ES2274106T3 (es) 2007-05-16
US20040266698A1 (en) 2004-12-30
ATE342261T1 (de) 2006-11-15
US7071169B2 (en) 2006-07-04
CN1555372A (zh) 2004-12-15
JP2005504099A (ja) 2005-02-10
EP1430045B1 (de) 2006-10-11
HK1068332A1 (en) 2005-04-29
JP4263095B2 (ja) 2009-05-13
CA2456281A1 (en) 2003-04-03
WO2003027091A1 (en) 2003-04-03
CN1304415C (zh) 2007-03-14
PT1430045E (pt) 2007-01-31
BR0212899A (pt) 2004-11-03
US20060194742A1 (en) 2006-08-31
EP1430045A1 (de) 2004-06-23
DE60215368T2 (de) 2007-08-16

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Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

R082 Change of representative

Ref document number: 1430045

Country of ref document: EP

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN, DE