DE60210778D1 - Verfahren zur herstellung von 4-amino-2,5-bisheterocyclylchinazolinen - Google Patents
Verfahren zur herstellung von 4-amino-2,5-bisheterocyclylchinazolinenInfo
- Publication number
- DE60210778D1 DE60210778D1 DE60210778T DE60210778T DE60210778D1 DE 60210778 D1 DE60210778 D1 DE 60210778D1 DE 60210778 T DE60210778 T DE 60210778T DE 60210778 T DE60210778 T DE 60210778T DE 60210778 D1 DE60210778 D1 DE 60210778D1
- Authority
- DE
- Germany
- Prior art keywords
- bisheterocyclylchinazolines
- amino
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0118752 | 2001-08-01 | ||
GBGB0118752.5A GB0118752D0 (en) | 2001-08-01 | 2001-08-01 | Process for the production of quinazolines |
PCT/IB2002/002872 WO2003011829A1 (en) | 2001-08-01 | 2002-07-19 | Process for the production of quinazolines |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60210778D1 true DE60210778D1 (de) | 2006-05-24 |
DE60210778T2 DE60210778T2 (de) | 2007-01-04 |
Family
ID=9919612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60210778T Expired - Fee Related DE60210778T2 (de) | 2001-08-01 | 2002-07-19 | Verfahren zur herstellung von 4-amino-2,5-bisheterocyclylchinazolinen |
Country Status (27)
Country | Link |
---|---|
US (1) | US7026479B2 (de) |
EP (1) | EP1412331B1 (de) |
JP (1) | JP2005501054A (de) |
KR (1) | KR20040019097A (de) |
CN (1) | CN1533378A (de) |
AP (1) | AP1299A (de) |
AR (1) | AR036204A1 (de) |
AT (1) | ATE323677T1 (de) |
BR (1) | BR0211670A (de) |
CA (1) | CA2451075A1 (de) |
CZ (1) | CZ2004151A3 (de) |
DE (1) | DE60210778T2 (de) |
DO (1) | DOP2002000443A (de) |
EG (1) | EG23204A (de) |
ES (1) | ES2260457T3 (de) |
GB (1) | GB0118752D0 (de) |
HN (1) | HN2002000197A (de) |
HU (1) | HUP0401573A3 (de) |
IL (1) | IL158998A0 (de) |
MX (1) | MXPA04000978A (de) |
PA (1) | PA8550301A1 (de) |
PE (1) | PE20030346A1 (de) |
PL (1) | PL368520A1 (de) |
RU (1) | RU2261861C1 (de) |
UY (1) | UY27399A1 (de) |
WO (1) | WO2003011829A1 (de) |
ZA (1) | ZA200309043B (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4703183B2 (ja) | 2002-07-15 | 2011-06-15 | シンフォニー エボルーション, インク. | 受容体型キナーゼモジュレーターおよびその使用方法 |
PL2210607T3 (pl) * | 2003-09-26 | 2012-01-31 | Exelixis Inc | N-[3-fluoro-4-({6-(metyloksy)-7-[(3-morfolin-4-ylopropylo)oksy]chinolin-4-ylo} oxy)fenylo]-N'-(4-fluorofenylo)cyklopropano-1,1-dikarboksamid do leczenia raka |
RS52119B (en) * | 2004-05-06 | 2012-08-31 | Warner-Lambert Company Llc | 4-phenylamino-HINAZOLIN-6-IL-STARCHES |
BRPI0714766A2 (pt) * | 2006-08-04 | 2013-07-16 | Merz Pharma Gmbh & Co Kgaa | pirazolpirimidinas, processo para sua preparaÇço e seu uso como medicamento |
EP2387563B2 (de) | 2009-01-16 | 2022-04-27 | Exelixis, Inc. | Malatsalz von n-(4-{[6,7-bis(methyloxy)chinolin-4-yl]-oxy}phenyl-n'-(4-fluorphenyl)cyclo-propan-1,1-dicarbonsäureamid und kristalline formen davon zur behandlung von krebs |
CA2754509C (en) | 2009-03-18 | 2018-03-06 | Resverlogix Corp. | Novel anti-inflammatory agents |
IN2012DN00352A (de) * | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
BR112014012997A2 (pt) | 2011-11-30 | 2017-06-13 | Bikam Pharmaceuticals Inc | ligantes que se ligam à opsina, composições e métodos de uso |
ES2658221T3 (es) * | 2012-10-15 | 2018-03-08 | Resverlogix Corp. | Compuestos útiles en la síntesis de compuestos de benzamida |
CN107530356A (zh) | 2015-03-13 | 2018-01-02 | 雷斯韦洛吉克斯公司 | 用于治疗补体相关疾病之组合物及治疗方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8719378D0 (en) * | 1987-08-15 | 1987-09-23 | Pfizer Ltd | Antiarrythmic agents |
US6069149A (en) * | 1997-01-09 | 2000-05-30 | Terumo Kabushiki Kaisha | Amide derivatives and intermediates for the synthesis thereof |
-
2001
- 2001-08-01 GB GBGB0118752.5A patent/GB0118752D0/en not_active Ceased
-
2002
- 2002-07-11 PA PA20028550301A patent/PA8550301A1/es unknown
- 2002-07-19 EP EP02745749A patent/EP1412331B1/de not_active Expired - Lifetime
- 2002-07-19 KR KR10-2004-7001513A patent/KR20040019097A/ko not_active Application Discontinuation
- 2002-07-19 BR BR0211670-7A patent/BR0211670A/pt not_active IP Right Cessation
- 2002-07-19 MX MXPA04000978A patent/MXPA04000978A/es active IP Right Grant
- 2002-07-19 HU HU0401573A patent/HUP0401573A3/hu unknown
- 2002-07-19 US US10/199,755 patent/US7026479B2/en not_active Expired - Fee Related
- 2002-07-19 CN CNA028143256A patent/CN1533378A/zh active Pending
- 2002-07-19 RU RU2004102692/04A patent/RU2261861C1/ru not_active IP Right Cessation
- 2002-07-19 CA CA002451075A patent/CA2451075A1/en not_active Abandoned
- 2002-07-19 WO PCT/IB2002/002872 patent/WO2003011829A1/en active IP Right Grant
- 2002-07-19 CZ CZ2004151A patent/CZ2004151A3/cs unknown
- 2002-07-19 ES ES02745749T patent/ES2260457T3/es not_active Expired - Lifetime
- 2002-07-19 PL PL02368520A patent/PL368520A1/xx not_active Application Discontinuation
- 2002-07-19 AT AT02745749T patent/ATE323677T1/de not_active IP Right Cessation
- 2002-07-19 IL IL15899802A patent/IL158998A0/xx unknown
- 2002-07-19 JP JP2003517021A patent/JP2005501054A/ja active Pending
- 2002-07-19 DE DE60210778T patent/DE60210778T2/de not_active Expired - Fee Related
- 2002-07-23 DO DO2002000443A patent/DOP2002000443A/es unknown
- 2002-07-26 PE PE2002000678A patent/PE20030346A1/es not_active Application Discontinuation
- 2002-07-29 HN HN2002000197A patent/HN2002000197A/es unknown
- 2002-07-29 EG EG2002070853A patent/EG23204A/xx active
- 2002-07-29 UY UY27399A patent/UY27399A1/es not_active Application Discontinuation
- 2002-07-31 AR ARP020102914A patent/AR036204A1/es unknown
- 2002-08-01 AP APAP/P/2002/002602A patent/AP1299A/en active
-
2003
- 2003-11-20 ZA ZA200309043A patent/ZA200309043B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200309043B (en) | 2004-11-22 |
PE20030346A1 (es) | 2003-04-05 |
GB0118752D0 (en) | 2001-09-26 |
US7026479B2 (en) | 2006-04-11 |
AP2002002602A0 (en) | 2002-09-30 |
DE60210778T2 (de) | 2007-01-04 |
IL158998A0 (en) | 2004-05-12 |
EP1412331B1 (de) | 2006-04-19 |
DOP2002000443A (es) | 2003-02-15 |
CA2451075A1 (en) | 2003-02-13 |
CZ2004151A3 (cs) | 2005-01-12 |
RU2004102692A (ru) | 2005-07-10 |
PA8550301A1 (es) | 2003-09-05 |
EG23204A (en) | 2004-07-31 |
US20030100753A1 (en) | 2003-05-29 |
UY27399A1 (es) | 2003-02-28 |
RU2261861C1 (ru) | 2005-10-10 |
ES2260457T3 (es) | 2006-11-01 |
WO2003011829A1 (en) | 2003-02-13 |
MXPA04000978A (es) | 2004-04-20 |
HN2002000197A (es) | 2003-02-27 |
HUP0401573A2 (hu) | 2005-01-28 |
PL368520A1 (en) | 2005-04-04 |
AR036204A1 (es) | 2004-08-18 |
BR0211670A (pt) | 2004-07-13 |
CN1533378A (zh) | 2004-09-29 |
JP2005501054A (ja) | 2005-01-13 |
HUP0401573A3 (en) | 2005-06-28 |
AP1299A (en) | 2004-09-06 |
KR20040019097A (ko) | 2004-03-04 |
EP1412331A1 (de) | 2004-04-28 |
ATE323677T1 (de) | 2006-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |