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DE60210778D1 - Verfahren zur herstellung von 4-amino-2,5-bisheterocyclylchinazolinen - Google Patents

Verfahren zur herstellung von 4-amino-2,5-bisheterocyclylchinazolinen

Info

Publication number
DE60210778D1
DE60210778D1 DE60210778T DE60210778T DE60210778D1 DE 60210778 D1 DE60210778 D1 DE 60210778D1 DE 60210778 T DE60210778 T DE 60210778T DE 60210778 T DE60210778 T DE 60210778T DE 60210778 D1 DE60210778 D1 DE 60210778D1
Authority
DE
Germany
Prior art keywords
bisheterocyclylchinazolines
amino
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60210778T
Other languages
English (en)
Other versions
DE60210778T2 (de
Inventor
Lee Terence Boulton
Robert James Crook
Alan John Pettman
Robert Walton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Inc
Original Assignee
Pfizer Corp Belgium
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Inc filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of DE60210778D1 publication Critical patent/DE60210778D1/de
Publication of DE60210778T2 publication Critical patent/DE60210778T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60210778T 2001-08-01 2002-07-19 Verfahren zur herstellung von 4-amino-2,5-bisheterocyclylchinazolinen Expired - Fee Related DE60210778T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0118752 2001-08-01
GBGB0118752.5A GB0118752D0 (en) 2001-08-01 2001-08-01 Process for the production of quinazolines
PCT/IB2002/002872 WO2003011829A1 (en) 2001-08-01 2002-07-19 Process for the production of quinazolines

Publications (2)

Publication Number Publication Date
DE60210778D1 true DE60210778D1 (de) 2006-05-24
DE60210778T2 DE60210778T2 (de) 2007-01-04

Family

ID=9919612

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60210778T Expired - Fee Related DE60210778T2 (de) 2001-08-01 2002-07-19 Verfahren zur herstellung von 4-amino-2,5-bisheterocyclylchinazolinen

Country Status (27)

Country Link
US (1) US7026479B2 (de)
EP (1) EP1412331B1 (de)
JP (1) JP2005501054A (de)
KR (1) KR20040019097A (de)
CN (1) CN1533378A (de)
AP (1) AP1299A (de)
AR (1) AR036204A1 (de)
AT (1) ATE323677T1 (de)
BR (1) BR0211670A (de)
CA (1) CA2451075A1 (de)
CZ (1) CZ2004151A3 (de)
DE (1) DE60210778T2 (de)
DO (1) DOP2002000443A (de)
EG (1) EG23204A (de)
ES (1) ES2260457T3 (de)
GB (1) GB0118752D0 (de)
HN (1) HN2002000197A (de)
HU (1) HUP0401573A3 (de)
IL (1) IL158998A0 (de)
MX (1) MXPA04000978A (de)
PA (1) PA8550301A1 (de)
PE (1) PE20030346A1 (de)
PL (1) PL368520A1 (de)
RU (1) RU2261861C1 (de)
UY (1) UY27399A1 (de)
WO (1) WO2003011829A1 (de)
ZA (1) ZA200309043B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4703183B2 (ja) 2002-07-15 2011-06-15 シンフォニー エボルーション, インク. 受容体型キナーゼモジュレーターおよびその使用方法
PL2210607T3 (pl) * 2003-09-26 2012-01-31 Exelixis Inc N-[3-fluoro-4-({6-(metyloksy)-7-[(3-morfolin-4-ylopropylo)oksy]chinolin-4-ylo} oxy)fenylo]-N'-(4-fluorofenylo)cyklopropano-1,1-dikarboksamid do leczenia raka
RS52119B (en) * 2004-05-06 2012-08-31 Warner-Lambert Company Llc 4-phenylamino-HINAZOLIN-6-IL-STARCHES
BRPI0714766A2 (pt) * 2006-08-04 2013-07-16 Merz Pharma Gmbh & Co Kgaa pirazolpirimidinas, processo para sua preparaÇço e seu uso como medicamento
EP2387563B2 (de) 2009-01-16 2022-04-27 Exelixis, Inc. Malatsalz von n-(4-{[6,7-bis(methyloxy)chinolin-4-yl]-oxy}phenyl-n'-(4-fluorphenyl)cyclo-propan-1,1-dicarbonsäureamid und kristalline formen davon zur behandlung von krebs
CA2754509C (en) 2009-03-18 2018-03-06 Resverlogix Corp. Novel anti-inflammatory agents
IN2012DN00352A (de) * 2009-06-16 2015-08-21 Bikam Pharmaceuticals Inc
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
BR112014012997A2 (pt) 2011-11-30 2017-06-13 Bikam Pharmaceuticals Inc ligantes que se ligam à opsina, composições e métodos de uso
ES2658221T3 (es) * 2012-10-15 2018-03-08 Resverlogix Corp. Compuestos útiles en la síntesis de compuestos de benzamida
CN107530356A (zh) 2015-03-13 2018-01-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8719378D0 (en) * 1987-08-15 1987-09-23 Pfizer Ltd Antiarrythmic agents
US6069149A (en) * 1997-01-09 2000-05-30 Terumo Kabushiki Kaisha Amide derivatives and intermediates for the synthesis thereof

Also Published As

Publication number Publication date
ZA200309043B (en) 2004-11-22
PE20030346A1 (es) 2003-04-05
GB0118752D0 (en) 2001-09-26
US7026479B2 (en) 2006-04-11
AP2002002602A0 (en) 2002-09-30
DE60210778T2 (de) 2007-01-04
IL158998A0 (en) 2004-05-12
EP1412331B1 (de) 2006-04-19
DOP2002000443A (es) 2003-02-15
CA2451075A1 (en) 2003-02-13
CZ2004151A3 (cs) 2005-01-12
RU2004102692A (ru) 2005-07-10
PA8550301A1 (es) 2003-09-05
EG23204A (en) 2004-07-31
US20030100753A1 (en) 2003-05-29
UY27399A1 (es) 2003-02-28
RU2261861C1 (ru) 2005-10-10
ES2260457T3 (es) 2006-11-01
WO2003011829A1 (en) 2003-02-13
MXPA04000978A (es) 2004-04-20
HN2002000197A (es) 2003-02-27
HUP0401573A2 (hu) 2005-01-28
PL368520A1 (en) 2005-04-04
AR036204A1 (es) 2004-08-18
BR0211670A (pt) 2004-07-13
CN1533378A (zh) 2004-09-29
JP2005501054A (ja) 2005-01-13
HUP0401573A3 (en) 2005-06-28
AP1299A (en) 2004-09-06
KR20040019097A (ko) 2004-03-04
EP1412331A1 (de) 2004-04-28
ATE323677T1 (de) 2006-05-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee