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DE60210612D1 - N-formylhydroxylamin verbindungen als inhibitoren von pdf - Google Patents

N-formylhydroxylamin verbindungen als inhibitoren von pdf

Info

Publication number
DE60210612D1
DE60210612D1 DE60210612T DE60210612T DE60210612D1 DE 60210612 D1 DE60210612 D1 DE 60210612D1 DE 60210612 T DE60210612 T DE 60210612T DE 60210612 T DE60210612 T DE 60210612T DE 60210612 D1 DE60210612 D1 DE 60210612D1
Authority
DE
Germany
Prior art keywords
pdf
inhibitors
formylhydroxylamine
compounds
formylhydroxylamine compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60210612T
Other languages
English (en)
Other versions
DE60210612T2 (de
Inventor
V Patel
Zhengyu Yuan
K Jain
Alvarez Salvador Garcia
Jeffrey Jacobs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vicuron Pharmaceuticals LLC
Original Assignee
Vicuron Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vicuron Pharmaceuticals LLC filed Critical Vicuron Pharmaceuticals LLC
Publication of DE60210612D1 publication Critical patent/DE60210612D1/de
Application granted granted Critical
Publication of DE60210612T2 publication Critical patent/DE60210612T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60210612T 2001-06-15 2002-06-14 N-formylhydroxylamin verbindungen als inhibitoren von pdf Expired - Lifetime DE60210612T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US29841901P 2001-06-15 2001-06-15
US298419P 2001-06-15
US36031302P 2002-02-27 2002-02-27
US360313P 2002-02-27
PCT/EP2002/006604 WO2002102790A1 (en) 2001-06-15 2002-06-14 N-formyl hydroxylamine compounds as inhibitors of pdf

Publications (2)

Publication Number Publication Date
DE60210612D1 true DE60210612D1 (de) 2006-05-24
DE60210612T2 DE60210612T2 (de) 2006-09-21

Family

ID=26970649

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60210612T Expired - Lifetime DE60210612T2 (de) 2001-06-15 2002-06-14 N-formylhydroxylamin verbindungen als inhibitoren von pdf

Country Status (31)

Country Link
US (1) US7148242B2 (de)
EP (1) EP1401828B1 (de)
JP (1) JP4361365B2 (de)
KR (2) KR100589544B1 (de)
CN (1) CN1511152A (de)
AR (1) AR036053A1 (de)
AT (1) ATE323081T1 (de)
AU (1) AU2002321062B2 (de)
BR (1) BR0210377A (de)
CA (1) CA2448526A1 (de)
CO (1) CO5640131A2 (de)
CY (1) CY1105085T1 (de)
CZ (1) CZ20033388A3 (de)
DE (1) DE60210612T2 (de)
DK (1) DK1401828T3 (de)
ES (1) ES2262824T3 (de)
HK (1) HK1064370A1 (de)
HU (1) HUP0400208A3 (de)
IL (1) IL158770A0 (de)
MX (1) MXPA03011628A (de)
MY (1) MY138619A (de)
NO (1) NO327420B1 (de)
NZ (1) NZ529489A (de)
PE (1) PE20030100A1 (de)
PL (1) PL364476A1 (de)
PT (1) PT1401828E (de)
RU (1) RU2325386C2 (de)
SI (1) SI1401828T1 (de)
SK (1) SK15242003A3 (de)
WO (1) WO2002102790A1 (de)
ZA (1) ZA200308379B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2446931A1 (en) * 2001-06-15 2002-12-27 Vicuron Pharmaceuticals Inc. Pyrrolidine bicyclic compounds
GB0208579D0 (en) * 2002-04-13 2002-05-22 British Biotech Pharm Antibacterial agents
CA2499426A1 (en) * 2002-09-19 2004-04-01 Novartis Ag Process for preparing n-hydroxylamine compounds
BRPI0407448A (pt) * 2003-02-21 2006-01-31 Novartis Ag Processo quìmico
TW200427458A (en) * 2003-04-02 2004-12-16 Novartis Ag Crystalline N-formyl hydroxylamine compounds
CN100410251C (zh) * 2003-06-26 2008-08-13 诺瓦提斯公司 可用于制备某些抗菌n-甲酰基羟胺的中间体的制备方法
KR100527624B1 (ko) * 2003-08-21 2005-11-22 한기종 질소에 포밀기를 갖는 아민유도체의 새로운 제조방법
CN1976703A (zh) * 2004-06-30 2007-06-06 诺瓦提斯公司 通过使用外排泵抑制剂增加肽脱甲酰基酶抑制剂敏感性的方法
US20080161249A1 (en) * 2004-11-17 2008-07-03 Smithkline Beecham Corporation Use of Novel Antibacterial Compounds
GT200600196A (es) 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
EP1893574A2 (de) * 2005-06-07 2008-03-05 Novartis AG Peptiddeformylase- (pdf-) inhibitoren 4
DE102005026231A1 (de) * 2005-06-07 2006-12-14 Origenis Ag Peptid-Deformylase (PDF) Inhibitoren 3
SG133452A1 (en) * 2005-12-30 2007-07-30 Novartis Ag Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases
KR20080095895A (ko) * 2006-03-03 2008-10-29 노파르티스 아게 Ｎ―포르밀 히드록실아민 화합물
CN101328155B (zh) * 2007-06-20 2010-11-03 上海医药工业研究院 噁唑烷衍生物及其制备方法和应用
CN101434570B (zh) * 2007-11-16 2011-02-02 上海医药工业研究院 吡咯烷衍生物及其制备方法和应用
CN101584694B (zh) * 2009-06-15 2011-01-12 华东师范大学 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法
CA2771568A1 (en) * 2009-09-04 2011-03-10 Novartis Ag Heteroaryl compounds as kinase inhibitors
KR20130016244A (ko) * 2010-03-10 2013-02-14 인게니움 파르마코이티칼스 게엠베하 단백질 키나아제의 억제제
JP5825086B2 (ja) 2011-12-19 2015-12-02 住友化学株式会社 α−置換−β−アミノ酸エステル誘導体不斉加水分解酵素
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
ES2876974T3 (es) 2015-04-07 2021-11-15 Novartis Ag Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina
WO2017193924A1 (zh) * 2016-05-11 2017-11-16 如东瑞恩医药科技有限公司 螺三元环、螺五元环类肽脱甲酰基酶抑制剂及其在抗菌和抗肿瘤中的应用

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Also Published As

Publication number Publication date
DK1401828T3 (da) 2006-07-31
CO5640131A2 (es) 2006-05-31
AU2002321062B2 (en) 2006-02-02
NO327420B1 (no) 2009-06-29
WO2002102790A1 (en) 2002-12-27
EP1401828B1 (de) 2006-04-12
CY1105085T1 (el) 2009-11-04
CN1511152A (zh) 2004-07-07
KR20040010721A (ko) 2004-01-31
PL364476A1 (en) 2004-12-13
CA2448526A1 (en) 2002-12-27
NZ529489A (en) 2005-10-28
ATE323081T1 (de) 2006-04-15
HUP0400208A2 (hu) 2004-06-28
IL158770A0 (en) 2004-05-12
NO20035571L (no) 2004-02-16
MY138619A (en) 2009-07-31
PE20030100A1 (es) 2003-03-28
CZ20033388A3 (en) 2004-03-17
PT1401828E (pt) 2006-08-31
RU2003137565A (ru) 2005-05-27
EP1401828A1 (de) 2004-03-31
AR036053A1 (es) 2004-08-04
BR0210377A (pt) 2004-08-10
RU2325386C2 (ru) 2008-05-27
US7148242B2 (en) 2006-12-12
KR100589544B1 (ko) 2006-06-15
DE60210612T2 (de) 2006-09-21
KR20060014083A (ko) 2006-02-14
NO20035571D0 (no) 2003-12-12
HUP0400208A3 (en) 2008-10-28
SK15242003A3 (sk) 2004-07-07
JP2005502606A (ja) 2005-01-27
MXPA03011628A (es) 2005-03-07
HK1064370A1 (en) 2005-01-28
ES2262824T3 (es) 2006-12-01
US20030045479A1 (en) 2003-03-06
ZA200308379B (en) 2004-05-21
SI1401828T1 (sl) 2006-10-31
JP4361365B2 (ja) 2009-11-11

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