DE60206923D1 - Kardiovaskulares sicherheitstestverfahren - Google Patents
Kardiovaskulares sicherheitstestverfahrenInfo
- Publication number
- DE60206923D1 DE60206923D1 DE60206923T DE60206923T DE60206923D1 DE 60206923 D1 DE60206923 D1 DE 60206923D1 DE 60206923 T DE60206923 T DE 60206923T DE 60206923 T DE60206923 T DE 60206923T DE 60206923 D1 DE60206923 D1 DE 60206923D1
- Authority
- DE
- Germany
- Prior art keywords
- testing procedure
- safety testing
- cardiovascular safety
- kits
- cardiotoxicity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002526 effect on cardiovascular system Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000009781 safety test method Methods 0.000 title 1
- 206010048610 Cardiotoxicity Diseases 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 2
- 231100000259 cardiotoxicity Toxicity 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101001047090 Homo sapiens Potassium voltage-gated channel subfamily H member 2 Proteins 0.000 abstract 1
- 102100022807 Potassium voltage-gated channel subfamily H member 2 Human genes 0.000 abstract 1
- GXDALQBWZGODGZ-UHFFFAOYSA-N astemizole Chemical compound C1=CC(OC)=CC=C1CCN1CCC(NC=2N(C3=CC=CC=C3N=2)CC=2C=CC(F)=CC=2)CC1 GXDALQBWZGODGZ-UHFFFAOYSA-N 0.000 abstract 1
- 229960004754 astemizole Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01202689 | 2001-07-13 | ||
| EP01202689 | 2001-07-13 | ||
| PCT/EP2002/007364 WO2003006988A1 (en) | 2001-07-13 | 2002-07-02 | Cardiovascular safety assay |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60206923D1 true DE60206923D1 (de) | 2005-12-01 |
| DE60206923T2 DE60206923T2 (de) | 2006-07-20 |
Family
ID=8180635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60206923T Expired - Lifetime DE60206923T2 (de) | 2001-07-13 | 2002-07-02 | Kardiovaskulares sicherheitstestverfahren |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20040161805A1 (de) |
| EP (1) | EP1410019B1 (de) |
| JP (1) | JP4570870B2 (de) |
| CN (1) | CN1276254C (de) |
| AT (1) | ATE308046T1 (de) |
| AU (1) | AU2002328312B8 (de) |
| CA (1) | CA2450581C (de) |
| DE (1) | DE60206923T2 (de) |
| DK (1) | DK1410019T3 (de) |
| ES (1) | ES2252505T3 (de) |
| HK (1) | HK1070693A1 (de) |
| IL (2) | IL159819A0 (de) |
| NZ (1) | NZ529496A (de) |
| WO (1) | WO2003006988A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0302775D0 (sv) * | 2003-10-20 | 2003-10-20 | Astrazeneca Ab | Chemical compound and assay |
| US7396524B2 (en) * | 2005-08-02 | 2008-07-08 | Main Line Health Heart Center | Methods for screening compounds for proarrhythmic risk and antiarrhythmic efficacy |
| US9820888B2 (en) | 2006-09-26 | 2017-11-21 | Smith & Nephew, Inc. | Wound dressing |
| GB0902368D0 (en) | 2009-02-13 | 2009-04-01 | Smith & Nephew | Wound packing |
| US9421132B2 (en) | 2011-02-04 | 2016-08-23 | University Of Massachusetts | Negative pressure wound closure device |
| RU2612529C2 (ru) | 2011-02-04 | 2017-03-09 | Юниверсити Оф Массачусетс | Устройство закрытия раны с созданием отрицательного давления |
| JP6336440B2 (ja) | 2012-05-22 | 2018-06-06 | スミス アンド ネフュー ピーエルシーＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ | 創傷閉鎖デバイス |
| US10070994B2 (en) | 2012-05-22 | 2018-09-11 | Smith & Nephew Plc | Apparatuses and methods for wound therapy |
| EP3954347A1 (de) | 2012-05-24 | 2022-02-16 | Smith & Nephew, Inc. | Vorrichtungen zur behandlung und zum schliessen von wunden mit unterdruck |
| US10130520B2 (en) | 2012-07-16 | 2018-11-20 | Smith & Nephew, Inc. | Negative pressure wound closure device |
| CN113730099A (zh) | 2013-03-13 | 2021-12-03 | 史密夫和内修有限公司 | 负压伤口封闭装置以及用于以负压处理伤口的系统和方法 |
| RU2015142877A (ru) | 2013-03-14 | 2017-04-18 | СМИТ ЭНД НЕФЬЮ ПиЭлСи | Сжимаемые наполнители раны и системы и способы их применения в лечении ран с применением отрицательного давления |
| EP3060181B1 (de) | 2013-10-21 | 2021-11-03 | Smith & Nephew, Inc. | Unterdruck-wundverschlussvorrichtung |
| EP4209201A1 (de) | 2015-04-29 | 2023-07-12 | Smith & Nephew, Inc. | Unterdruckwundverschlussvorrichtung |
| US10575991B2 (en) | 2015-12-15 | 2020-03-03 | University Of Massachusetts | Negative pressure wound closure devices and methods |
| US11471586B2 (en) | 2015-12-15 | 2022-10-18 | University Of Massachusetts | Negative pressure wound closure devices and methods |
| US10814049B2 (en) | 2015-12-15 | 2020-10-27 | University Of Massachusetts | Negative pressure wound closure devices and methods |
| CA3089957C (en) * | 2017-02-04 | 2024-01-23 | AnaBios Corporation | System and methods for predicting drug-induced inotropic and pro-arrhythmia risk |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4568649A (en) * | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
| WO2000070079A1 (en) * | 1999-05-13 | 2000-11-23 | Ortho-Mcneil Pharmaceutical, Inc. | High throughput assay for modulators of nuclear receptors |
| AU2002241555A1 (en) * | 2000-10-30 | 2002-06-03 | Vanderbuilt University | Human kcr1 regulation of herg potassium channel block |
-
2002
- 2002-07-02 AU AU2002328312A patent/AU2002328312B8/en not_active Ceased
- 2002-07-02 CN CNB02813995XA patent/CN1276254C/zh not_active Expired - Fee Related
- 2002-07-02 DE DE60206923T patent/DE60206923T2/de not_active Expired - Lifetime
- 2002-07-02 DK DK02762316T patent/DK1410019T3/da active
- 2002-07-02 US US10/483,617 patent/US20040161805A1/en not_active Abandoned
- 2002-07-02 JP JP2003512705A patent/JP4570870B2/ja not_active Expired - Fee Related
- 2002-07-02 EP EP02762316A patent/EP1410019B1/de not_active Expired - Lifetime
- 2002-07-02 AT AT02762316T patent/ATE308046T1/de not_active IP Right Cessation
- 2002-07-02 CA CA2450581A patent/CA2450581C/en not_active Expired - Lifetime
- 2002-07-02 NZ NZ529496A patent/NZ529496A/en not_active IP Right Cessation
- 2002-07-02 ES ES02762316T patent/ES2252505T3/es not_active Expired - Lifetime
- 2002-07-02 IL IL15981902A patent/IL159819A0/xx unknown
- 2002-07-02 WO PCT/EP2002/007364 patent/WO2003006988A1/en active IP Right Grant
-
2004
- 2004-01-12 IL IL159819A patent/IL159819A/en active IP Right Grant
-
2005
- 2005-04-19 HK HK05103346A patent/HK1070693A1/xx not_active IP Right Cessation
-
2006
- 2006-11-06 US US11/593,399 patent/US7820453B2/en not_active Expired - Fee Related
-
2010
- 2010-08-20 US US12/860,387 patent/US20110076696A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2450581A1 (en) | 2003-01-23 |
| NZ529496A (en) | 2005-09-30 |
| CN1541334A (zh) | 2004-10-27 |
| CA2450581C (en) | 2010-11-02 |
| ATE308046T1 (de) | 2005-11-15 |
| IL159819A0 (en) | 2004-06-20 |
| EP1410019B1 (de) | 2005-10-26 |
| US7820453B2 (en) | 2010-10-26 |
| US20080193924A1 (en) | 2008-08-14 |
| HK1070693A1 (en) | 2005-06-24 |
| IL159819A (en) | 2010-05-31 |
| WO2003006988A1 (en) | 2003-01-23 |
| AU2002328312B2 (en) | 2006-12-14 |
| US20110076696A1 (en) | 2011-03-31 |
| AU2002328312B8 (en) | 2007-02-15 |
| DE60206923T2 (de) | 2006-07-20 |
| EP1410019A1 (de) | 2004-04-21 |
| DK1410019T3 (da) | 2006-03-06 |
| CN1276254C (zh) | 2006-09-20 |
| US20040161805A1 (en) | 2004-08-19 |
| JP2005501037A (ja) | 2005-01-13 |
| ES2252505T3 (es) | 2006-05-16 |
| AU2002328312A1 (en) | 2003-01-29 |
| JP4570870B2 (ja) | 2010-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |