DE60203791D1 - Imidazolin-derivate, ihre herstellung und ihre verwendung als entzündungshemmende mittel - Google Patents

Imidazolin-derivate, ihre herstellung und ihre verwendung als entzündungshemmende mittel

Info

Publication number: DE60203791D1
Authority: DE; Germany
Prior art keywords: preparation; inflammatory agents; imidazolin; derivatives; imidazolin derivatives
Prior art date: 2001-03-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60203791T

Other languages

English (en)

Other versions

DE60203791T2 (de

Inventor

Volkmar Wehner

Horst Blum

Hartmut Ruetten

Ulrich Stilz

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis Deutschland GmbH

Original Assignee

Aventis Pharma Deutschland GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-10

Filing date

2002-02-23

Publication date

2005-05-25

2002-02-23 Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH

2002-02-23 Priority to DE60203791T priority Critical patent/DE60203791T2/de

2005-05-25 Application granted granted Critical

2005-05-25 Publication of DE60203791D1 publication Critical patent/DE60203791D1/de

2006-01-19 Publication of DE60203791T2 publication Critical patent/DE60203791T2/de

2022-02-24 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Tropical Medicine & Parasitology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE60203791T 2001-03-10 2002-02-23 Imidazolin-derivate, ihre herstellung und ihre verwendung als entzündungshemmende mittel Expired - Lifetime DE60203791T2 (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DE60203791T DE60203791T2 (de)	2001-03-10	2002-02-23	Imidazolin-derivate, ihre herstellung und ihre verwendung als entzündungshemmende mittel

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE10111877A DE10111877A1 (de)	2001-03-10	2001-03-10	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10111877		2001-03-10
PCT/EP2002/001917 WO2002072573A1 (en)	2001-03-10	2002-02-23	Imidazolidine derivatives, their preparation, and their use as antinflamatory agent.
DE60203791T DE60203791T2 (de)	2001-03-10	2002-02-23	Imidazolin-derivate, ihre herstellung und ihre verwendung als entzündungshemmende mittel

Publications (2)

Publication Number	Publication Date
DE60203791D1 true DE60203791D1 (de)	2005-05-25
DE60203791T2 DE60203791T2 (de)	2006-01-19

Family

ID=7677184

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE10111877A Withdrawn DE10111877A1 (de)	2001-03-10	2001-03-10	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE60203791T Expired - Lifetime DE60203791T2 (de)	2001-03-10	2002-02-23	Imidazolin-derivate, ihre herstellung und ihre verwendung als entzündungshemmende mittel

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE10111877A Withdrawn DE10111877A1 (de)	2001-03-10	2001-03-10	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate

Country Status (35)

Country	Link
US (1)	US6680333B2 (de)
EP (1)	EP1373249B1 (de)
JP (1)	JP4482277B2 (de)
KR (1)	KR100991678B1 (de)
CN (1)	CN1227248C (de)
AR (1)	AR035692A1 (de)
AT (1)	ATE293621T1 (de)
AU (1)	AU2002233358B2 (de)
BG (1)	BG108134A (de)
BR (1)	BR0207981A (de)
CA (1)	CA2440648C (de)
CZ (1)	CZ301893B6 (de)
DE (2)	DE10111877A1 (de)
DK (1)	DK1373249T3 (de)
EE (1)	EE05401B1 (de)
ES (1)	ES2240687T3 (de)
HK (1)	HK1062173A1 (de)
HR (1)	HRP20030713B1 (de)
HU (1)	HU228304B1 (de)
IL (2)	IL157830A0 (de)
ME (1)	MEP61108A (de)
MX (1)	MXPA03007634A (de)
MY (1)	MY129029A (de)
NO (1)	NO326001B1 (de)
NZ (1)	NZ528075A (de)
PE (1)	PE20020904A1 (de)
PL (1)	PL204622B1 (de)
PT (1)	PT1373249E (de)
RS (1)	RS51140B (de)
RU (1)	RU2303592C2 (de)
SI (1)	SI1373249T1 (de)
SK (1)	SK286652B6 (de)
TW (1)	TWI328587B (de)
WO (1)	WO2002072573A1 (de)
ZA (1)	ZA200306107B (de)

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US20070043078A1 (en) *	2003-10-10	2007-02-22	Kowa Co., Ltd.	Angiogenesis inhibitor
AU2009244863A1 (en) *	2008-05-05	2009-11-12	Winthrop University Hospital	Method for improving cardiovascular risk profile of COX inhibitors
SMT202000380T1 (it)	2010-10-25	2020-09-10	Biogen Ma Inc	Metodi per determinare le differenze nell'attivita' di integrina alfa-4 correlando le differenze dei livelli di svcam e/o smadcam
CN112707874A (zh) *	2020-12-29	2021-04-27	广东中科药物研究有限公司	一种抗病毒化合物及其制备方法

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DE19647380A1 (de)	1996-11-15	1998-05-20	Hoechst Ag	5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
WO1998042656A1 (en)	1997-03-21	1998-10-01	Cytel Corporation	Novel compounds
DE19741235A1 (de)	1997-09-18	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de)	1997-09-23	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
CN1327443A (zh)	1997-10-31	2001-12-19	艾文蒂斯药品有限公司	取代的酰苯胺化合物
GB9723789D0 (en) *	1997-11-12	1998-01-07	Zeneca Ltd	Chemical compounds
DE19751251A1 (de) *	1997-11-19	1999-05-20	Hoechst Marion Roussel De Gmbh	Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
AU3716499A (en)	1998-04-21	1999-11-08	Aventis Pharma Limited	Substituted diamines and their use as cell adhesion inhibitors
DE19821483A1 (de) *	1998-05-14	1999-11-18	Hoechst Marion Roussel De Gmbh	Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
YU77600A (sh) *	1998-06-30	2004-03-12	Pfizer Products Inc.	Nepeptidni inhibitori vla-4 zavisnog ćelijskog vezivanja koji su primenljivi u tretiranju inflamatornih, autoimunih i respiratornih oboljenja
WO2000002903A1 (en)	1998-07-10	2000-01-20	Cytel Corporation	Cs-1 peptidomimetics, compositions and methods of using the same
DE19922462A1 (de) *	1999-05-17	2000-11-23	Aventis Pharma Gmbh	Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate

2001
- 2001-03-10 DE DE10111877A patent/DE10111877A1/de not_active Withdrawn
2002
- 2002-02-23 RU RU2003129986/04A patent/RU2303592C2/ru not_active IP Right Cessation
- 2002-02-23 IL IL15783002A patent/IL157830A0/xx unknown
- 2002-02-23 RS YUP-708/03A patent/RS51140B/sr unknown
- 2002-02-23 ES ES02700268T patent/ES2240687T3/es not_active Expired - Lifetime
- 2002-02-23 NZ NZ528075A patent/NZ528075A/en not_active IP Right Cessation
- 2002-02-23 WO PCT/EP2002/001917 patent/WO2002072573A1/en active IP Right Grant
- 2002-02-23 DK DK02700268T patent/DK1373249T3/da active
- 2002-02-23 CN CNB028063147A patent/CN1227248C/zh not_active Expired - Fee Related
- 2002-02-23 PL PL362573A patent/PL204622B1/pl unknown
- 2002-02-23 PT PT02700268T patent/PT1373249E/pt unknown
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Also Published As

Publication number	Publication date
DK1373249T3 (da)	2005-08-22
DE10111877A1 (de)	2002-09-12
CN1227248C (zh)	2005-11-16
BG108134A (bg)	2004-09-30
HRP20030713A2 (en)	2005-02-28
RU2303592C2 (ru)	2007-07-27
SI1373249T1 (de)	2005-08-31
HRP20030713B1 (en)	2006-02-28
HK1062173A1 (en)	2004-10-21
IL157830A (en)	2009-05-04
EP1373249A1 (de)	2004-01-02
HUP0303455A3 (en)	2005-06-28
DE60203791T2 (de)	2006-01-19
HUP0303455A2 (hu)	2004-03-01
AU2002233358B2 (en)	2007-03-22
PE20020904A1 (es)	2002-12-10
EE05401B1 (et)	2011-04-15
PL362573A1 (en)	2004-11-02
CN1496360A (zh)	2004-05-12
MXPA03007634A (es)	2003-12-04
CZ20032429A3 (cs)	2003-12-17
SK11262003A3 (sk)	2004-01-08
HU228304B1 (en)	2013-03-28
NO326001B1 (no)	2008-09-01
BR0207981A (pt)	2004-06-15
JP2004523574A (ja)	2004-08-05
NO20033981L (no)	2003-09-09
PT1373249E (pt)	2005-07-29
SK286652B6 (sk)	2009-03-05
KR100991678B1 (ko)	2010-11-04
ZA200306107B (en)	2004-09-01
NZ528075A (en)	2005-02-25
MEP61108A (en)	2011-05-10
TWI328587B (en)	2010-08-11
ATE293621T1 (de)	2005-05-15
EP1373249B1 (de)	2005-04-20
RU2003129986A (ru)	2005-03-20
WO2002072573A1 (en)	2002-09-19
IL157830A0 (en)	2004-03-28
EE200300436A (et)	2003-12-15
KR20030082980A (ko)	2003-10-23
US20030073723A1 (en)	2003-04-17
RS51140B (sr)	2010-10-31
MY129029A (en)	2007-03-30
CZ301893B6 (cs)	2010-07-21
ES2240687T3 (es)	2005-10-16
JP4482277B2 (ja)	2010-06-16
US6680333B2 (en)	2004-01-20
CA2440648C (en)	2010-06-15
CA2440648A1 (en)	2002-09-19
AR035692A1 (es)	2004-06-23
YU70803A (sh)	2006-05-25
PL204622B1 (pl)	2010-01-29
NO20033981D0 (no)	2003-09-09

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Legal Events

Date	Code	Title	Description
2005-12-15	8327	Change in the person/name/address of the patent owner	Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, 65929 FRANKFURT,
2006-05-24	8364	No opposition during term of opposition