DE60132343D1 - Fgf-2 zur behandlung von erkrankungen der peripheralen arterien - Google Patents
Fgf-2 zur behandlung von erkrankungen der peripheralen arterienInfo
- Publication number
- DE60132343D1 DE60132343D1 DE60132343T DE60132343T DE60132343D1 DE 60132343 D1 DE60132343 D1 DE 60132343D1 DE 60132343 T DE60132343 T DE 60132343T DE 60132343 T DE60132343 T DE 60132343T DE 60132343 D1 DE60132343 D1 DE 60132343D1
- Authority
- DE
- Germany
- Prior art keywords
- fgf
- artery disease
- peripheral artery
- compositions
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21350400P | 2000-06-22 | 2000-06-22 | |
US213504P | 2000-06-22 | ||
US26457201P | 2001-01-26 | 2001-01-26 | |
US264572P | 2001-01-26 | ||
US27654901P | 2001-03-16 | 2001-03-16 | |
US276549P | 2001-03-16 | ||
US09/886,856 US20020115603A1 (en) | 2000-06-22 | 2001-06-21 | Methods and compositions for the treatment of peripheral artery disease |
US886856 | 2001-06-21 | ||
PCT/US2001/019978 WO2001098346A2 (en) | 2000-06-22 | 2001-06-22 | Methods and compositions for the treatment of peripheral artery disease |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60132343D1 true DE60132343D1 (de) | 2008-02-21 |
DE60132343T2 DE60132343T2 (de) | 2008-12-24 |
Family
ID=27498936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60132343T Expired - Fee Related DE60132343T2 (de) | 2000-06-22 | 2001-06-22 | Fgf-2 zur behandlung von erkrankungen der peripheralen arterien |
Country Status (8)
Country | Link |
---|---|
US (3) | US20020115603A1 (de) |
EP (1) | EP1324766B1 (de) |
JP (1) | JP2004501164A (de) |
AT (1) | ATE383168T1 (de) |
AU (1) | AU2001268680A1 (de) |
CA (1) | CA2414020A1 (de) |
DE (1) | DE60132343T2 (de) |
WO (1) | WO2001098346A2 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020072489A1 (en) * | 1998-10-13 | 2002-06-13 | Whitehouse Martha J. | Angiogenically effective unit dose of FGF-2 and method of use |
US20030166550A1 (en) | 1999-08-27 | 2003-09-04 | Chiron Corporation | Angiogenically effective unit dose of FGF-2 and method of use |
US20020115603A1 (en) * | 2000-06-22 | 2002-08-22 | Chiron Corporation | Methods and compositions for the treatment of peripheral artery disease |
US20030004753A1 (en) * | 2001-06-27 | 2003-01-02 | Blackshear William M. | Management method of persons at risk of complications of arterial occlusive disease |
CA2480423C (en) * | 2002-04-08 | 2012-01-03 | The Scripps Research Institute | Truncated 24 kda basic fibroblast growth factor |
JP4532092B2 (ja) * | 2003-09-30 | 2010-08-25 | 泰彦 田畑 | 血管新生剤 |
US7346382B2 (en) | 2004-07-07 | 2008-03-18 | The Cleveland Clinic Foundation | Brain stimulation models, systems, devices, and methods |
AU2006263669B9 (en) * | 2005-06-29 | 2012-12-13 | Mars, Incorporated | Inducing peripheral blood vessel vasodilation |
US20090062309A1 (en) * | 2007-08-28 | 2009-03-05 | Antonio Delgado-Almeida | Therapeutic compositions for the treatment of cardiovascular diseases and methods for use therefor |
US8812123B2 (en) * | 2007-10-17 | 2014-08-19 | Intelect Medical, Inc. | Patient programmer with input and sensing capabilities |
US9220889B2 (en) | 2008-02-11 | 2015-12-29 | Intelect Medical, Inc. | Directional electrode devices with locating features |
US8019440B2 (en) | 2008-02-12 | 2011-09-13 | Intelect Medical, Inc. | Directional lead assembly |
US9272153B2 (en) | 2008-05-15 | 2016-03-01 | Boston Scientific Neuromodulation Corporation | VOA generation system and method using a fiber specific analysis |
ES2646168T3 (es) | 2008-11-07 | 2017-12-12 | Galaxy Biotech, Llc | Anticuerpos monoclonales para el receptor del factor de crecimiento de fibroblastos 2 |
US8461111B2 (en) | 2009-05-20 | 2013-06-11 | Florida State University Research Foundation | Fibroblast growth factor mutants having improved functional half-life and methods of their use |
WO2011025865A1 (en) | 2009-08-27 | 2011-03-03 | The Cleveland Clinic Foundation | System and method to estimate region of tissue activation |
WO2011068997A1 (en) | 2009-12-02 | 2011-06-09 | The Cleveland Clinic Foundation | Reversing cognitive-motor impairments in patients having a neuro-degenerative disease using a computational modeling approach to deep brain stimulation programming |
US20130116171A1 (en) | 2010-04-16 | 2013-05-09 | Salk Institute For Biological Studies | Methods for treating metabolic disorders using fgf |
CA2802708A1 (en) | 2010-06-14 | 2011-12-22 | Boston Scientific Neuromodulation Corporation | Programming interface for spinal cord neuromodulation |
AU2012236737B2 (en) | 2011-03-29 | 2017-03-02 | Boston Scientific Neuromodulation Corporation | System and method for atlas registration |
US9592389B2 (en) | 2011-05-27 | 2017-03-14 | Boston Scientific Neuromodulation Corporation | Visualization of relevant stimulation leadwire electrodes relative to selected stimulation information |
US8751008B2 (en) | 2011-08-09 | 2014-06-10 | Boston Scientific Neuromodulation Corporation | Remote control data management with correlation of patient condition to stimulation settings and/or with clinical mode providing a mismatch between settings and interface data |
US9604067B2 (en) | 2012-08-04 | 2017-03-28 | Boston Scientific Neuromodulation Corporation | Techniques and methods for storing and transferring registration, atlas, and lead information between medical devices |
EP2890454B1 (de) | 2012-08-28 | 2017-11-08 | Boston Scientific Neuromodulation Corporation | Point-and-click-programmierung zur tiefen hirnstimulation unter verwendung monopolarer echtzeit-überprüfungstrendlinien |
US9792412B2 (en) | 2012-11-01 | 2017-10-17 | Boston Scientific Neuromodulation Corporation | Systems and methods for VOA model generation and use |
US9308000B2 (en) | 2013-07-12 | 2016-04-12 | Vasoinnovations, Inc. | Method of transradial catheterization, device for ulnar artery compression, and method of use |
US10888334B2 (en) | 2013-07-12 | 2021-01-12 | Vasoinnovations Inc. | Apparatus and method to stop bleeding |
US9949738B2 (en) * | 2013-07-12 | 2018-04-24 | Vasoinnovations, Inc. | Method to stop bleeding, with short hemostasis duration using a low dose of anticoagulant |
US10342551B2 (en) | 2013-07-12 | 2019-07-09 | Vasoinnovations Inc. | Method to stop bleeding, with short hemostasis duration using a low dose of anticoagulant |
US9332994B2 (en) | 2013-07-12 | 2016-05-10 | Vasoinnovations, Inc. | Apparatus and method to stop bleeding |
US11564697B2 (en) | 2013-07-12 | 2023-01-31 | Vasoinnovations Inc. | Apparatus and method to stop bleeding |
US9668744B2 (en) | 2015-08-05 | 2017-06-06 | Vasoinnovations, Inc. | Apparatus and method to stop bleeding |
US10213214B2 (en) | 2013-07-12 | 2019-02-26 | Vasoinnovations, Inc. | Method to stop bleeding, with short hemostasis duration using a low dose of anticoagulant |
WO2015061331A1 (en) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use |
US9959388B2 (en) | 2014-07-24 | 2018-05-01 | Boston Scientific Neuromodulation Corporation | Systems, devices, and methods for providing electrical stimulation therapy feedback |
US10265528B2 (en) | 2014-07-30 | 2019-04-23 | Boston Scientific Neuromodulation Corporation | Systems and methods for electrical stimulation-related patient population volume analysis and use |
US10272247B2 (en) | 2014-07-30 | 2019-04-30 | Boston Scientific Neuromodulation Corporation | Systems and methods for stimulation-related volume analysis, creation, and sharing with integrated surgical planning and stimulation programming |
US9974959B2 (en) | 2014-10-07 | 2018-05-22 | Boston Scientific Neuromodulation Corporation | Systems, devices, and methods for electrical stimulation using feedback to adjust stimulation parameters |
JP6481051B2 (ja) | 2015-05-26 | 2019-03-13 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 電気刺激を分析し活性化容積を選択又は操作するシステム及び方法 |
US10780283B2 (en) | 2015-05-26 | 2020-09-22 | Boston Scientific Neuromodulation Corporation | Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation |
ES2940303T3 (es) | 2015-06-29 | 2023-05-05 | Boston Scient Neuromodulation Corp | Sistemas de selección de parámetros de estimulación por uso de dianas y direccionamiento |
EP3280490B1 (de) | 2015-06-29 | 2021-09-01 | Boston Scientific Neuromodulation Corporation | Vorrichtungen zur auswahl von stimulationsparametern basierend auf der stimulationszielregion, effekten oder nebenwirkungen |
EP3359252B1 (de) | 2015-10-09 | 2020-09-09 | Boston Scientific Neuromodulation Corporation | System und verfahren zur kartierung klinischer wirkungen für direktionale stimulationselektroden |
WO2017127493A1 (en) * | 2016-01-22 | 2017-07-27 | Salk Institute For Biological Studies | Fgf2 truncations and mutants and uses thereof |
US10716942B2 (en) | 2016-04-25 | 2020-07-21 | Boston Scientific Neuromodulation Corporation | System and methods for directional steering of electrical stimulation |
JP6905541B2 (ja) | 2016-06-24 | 2021-07-21 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 臨床効果の視覚分析のためのシステム及び方法 |
WO2018044881A1 (en) | 2016-09-02 | 2018-03-08 | Boston Scientific Neuromodulation Corporation | Systems and methods for visualizing and directing stimulation of neural elements |
US10780282B2 (en) | 2016-09-20 | 2020-09-22 | Boston Scientific Neuromodulation Corporation | Systems and methods for steering electrical stimulation of patient tissue and determining stimulation parameters |
AU2017341910B2 (en) | 2016-10-14 | 2020-05-14 | Boston Scientific Neuromodulation Corporation | Systems and methods for closed-loop determination of stimulation parameter settings for an electrical simulation system |
US10792501B2 (en) | 2017-01-03 | 2020-10-06 | Boston Scientific Neuromodulation Corporation | Systems and methods for selecting MRI-compatible stimulation parameters |
ES2821752T3 (es) | 2017-01-10 | 2021-04-27 | Boston Scient Neuromodulation Corp | Sistemas y procedimientos para crear programas de estimulación en base a áreas o volúmenes definidos por el usuario |
US10625082B2 (en) | 2017-03-15 | 2020-04-21 | Boston Scientific Neuromodulation Corporation | Visualization of deep brain stimulation efficacy |
US11357986B2 (en) | 2017-04-03 | 2022-06-14 | Boston Scientific Neuromodulation Corporation | Systems and methods for estimating a volume of activation using a compressed database of threshold values |
WO2018200040A1 (en) * | 2017-04-26 | 2018-11-01 | University Of Cincinnati | Compositions of fibroblast growth factor ligands and methods of treating patients unergoing ischemia-reperfusion therapy |
AU2018301355B2 (en) | 2017-07-14 | 2020-10-01 | Boston Scientific Neuromodulation Corporation | Systems and methods for estimating clinical effects of electrical stimulation |
WO2019036180A1 (en) | 2017-08-15 | 2019-02-21 | Boston Scientific Neuromodulation Corporation | SYSTEMS AND METHODS FOR CONTROLLING ELECTRICAL STIMULATION USING MULTIPLE STIMULATION FIELDS |
CN112041022B (zh) | 2018-04-27 | 2024-07-02 | 波士顿科学神经调制公司 | 多模式电刺激系统及其制造和使用方法 |
WO2019210214A1 (en) | 2018-04-27 | 2019-10-31 | Boston Scientific Neuromodulation Corporation | Systems for visualizing and programming electrical stimulation |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5604293A (en) * | 1985-09-12 | 1997-02-18 | Scios Inc. | Recombinant human basic fibroblast growth factor |
US5852177A (en) * | 1987-02-24 | 1998-12-22 | Takeda Chemical Industries, Ltd. | Basic fibroblast growth factor (bFGF) muteins |
ATE198979T1 (de) * | 1994-10-12 | 2001-02-15 | Focal Inc | Zielgerichte verabreichung mittels biologisch abbaubarer polymere |
US5792453A (en) * | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
US5941868A (en) * | 1995-12-22 | 1999-08-24 | Localmed, Inc. | Localized intravascular delivery of growth factors for promotion of angiogenesis |
ATE434440T1 (de) * | 1998-09-03 | 2009-07-15 | Novartis Vaccines & Diagnostic | Fgf-2 angiogenische wirksame einheitdosis und verfahren zu ihrer verwendung |
SE9802974D0 (sv) * | 1998-09-03 | 1998-09-03 | Astra Ab | New crystalline forms |
US6440934B1 (en) | 1998-10-13 | 2002-08-27 | Chiron Corporation | Angiogenically effective unit dose of FGF-2 and method of use |
US20020072489A1 (en) * | 1998-10-13 | 2002-06-13 | Whitehouse Martha J. | Angiogenically effective unit dose of FGF-2 and method of use |
US20030166550A1 (en) * | 1999-08-27 | 2003-09-04 | Chiron Corporation | Angiogenically effective unit dose of FGF-2 and method of use |
EP1121141A2 (de) * | 1998-10-13 | 2001-08-08 | Chiron Corporation | Fgf angiogenische wirksäme einheitdosis und verfahren zür ihre verwendung |
US20020115603A1 (en) * | 2000-06-22 | 2002-08-22 | Chiron Corporation | Methods and compositions for the treatment of peripheral artery disease |
-
2001
- 2001-06-21 US US09/886,856 patent/US20020115603A1/en not_active Abandoned
- 2001-06-22 CA CA002414020A patent/CA2414020A1/en not_active Abandoned
- 2001-06-22 AT AT01946663T patent/ATE383168T1/de not_active IP Right Cessation
- 2001-06-22 JP JP2002504301A patent/JP2004501164A/ja not_active Withdrawn
- 2001-06-22 EP EP01946663A patent/EP1324766B1/de not_active Expired - Lifetime
- 2001-06-22 AU AU2001268680A patent/AU2001268680A1/en not_active Abandoned
- 2001-06-22 WO PCT/US2001/019978 patent/WO2001098346A2/en active IP Right Grant
- 2001-06-22 DE DE60132343T patent/DE60132343T2/de not_active Expired - Fee Related
-
2004
- 2004-05-14 US US10/845,911 patent/US7186407B2/en not_active Expired - Fee Related
-
2007
- 2007-02-05 US US11/671,382 patent/US7541337B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2001098346A3 (en) | 2003-05-01 |
AU2001268680A1 (en) | 2002-01-02 |
US20020115603A1 (en) | 2002-08-22 |
US20040209817A1 (en) | 2004-10-21 |
CA2414020A1 (en) | 2001-12-27 |
WO2001098346A2 (en) | 2001-12-27 |
US20070135348A1 (en) | 2007-06-14 |
EP1324766A2 (de) | 2003-07-09 |
DE60132343T2 (de) | 2008-12-24 |
JP2004501164A (ja) | 2004-01-15 |
US7186407B2 (en) | 2007-03-06 |
ATE383168T1 (de) | 2008-01-15 |
US7541337B2 (en) | 2009-06-02 |
EP1324766B1 (de) | 2008-01-09 |
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Legal Events
Date | Code | Title | Description |
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8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |