[go: up one dir, main page]

DE60034370D1 - METHOD AND DEVICE FOR ANALYZING CELLS IN A FULL BLOOD TEST - Google Patents

METHOD AND DEVICE FOR ANALYZING CELLS IN A FULL BLOOD TEST

Info

Publication number
DE60034370D1
DE60034370D1 DE60034370T DE60034370T DE60034370D1 DE 60034370 D1 DE60034370 D1 DE 60034370D1 DE 60034370 T DE60034370 T DE 60034370T DE 60034370 T DE60034370 T DE 60034370T DE 60034370 D1 DE60034370 D1 DE 60034370D1
Authority
DE
Germany
Prior art keywords
blood test
full blood
analyzing cells
analyzing
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60034370T
Other languages
German (de)
Other versions
DE60034370T2 (en
Inventor
Carlos M Rodriguez
Jose M Cano
Barbara Carrillo
Kristie M Gordon
Allan F Horton
Ronald D Paul
Mark A Wells
James L Wyatt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Application granted granted Critical
Publication of DE60034370D1 publication Critical patent/DE60034370D1/en
Publication of DE60034370T2 publication Critical patent/DE60034370T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1019Associating Coulter-counter and optical flow cytometer [OFC]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/1031Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • G01N2015/139Measuring the ratio of AC/DC impedances
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/808Optical sensing apparatus
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/101666Particle count or volume standard or control [e.g., platelet count standards, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/107497Preparation composition [e.g., lysing or precipitation, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331Preservative, buffer, anticoagulant or diluent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
DE60034370T 1999-02-16 2000-02-03 METHOD AND DEVICE FOR ANALYZING CELLS IN A FULL BLOOD TEST Expired - Lifetime DE60034370T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US251019 1999-02-16
US09/251,019 US6228652B1 (en) 1999-02-16 1999-02-16 Method and apparatus for analyzing cells in a whole blood sample
PCT/US2000/002715 WO2000049385A2 (en) 1999-02-16 2000-02-03 Method and apparatus for analyzing cells in a whole blood sample

Publications (2)

Publication Number Publication Date
DE60034370D1 true DE60034370D1 (en) 2007-05-24
DE60034370T2 DE60034370T2 (en) 2007-12-20

Family

ID=22950141

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60034370T Expired - Lifetime DE60034370T2 (en) 1999-02-16 2000-02-03 METHOD AND DEVICE FOR ANALYZING CELLS IN A FULL BLOOD TEST

Country Status (5)

Country Link
US (1) US6228652B1 (en)
EP (1) EP1250585B1 (en)
JP (1) JP4468590B2 (en)
DE (1) DE60034370T2 (en)
WO (1) WO2000049385A2 (en)

Families Citing this family (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6618144B1 (en) * 1999-10-15 2003-09-09 The Administrators Of The Tulane Educational Fund Device and method of simultaneously measuring the light scattering from multiple liquid samples containing polymers and/or colloids
US6060322A (en) * 1998-10-20 2000-05-09 Coulter International Corp. Method for identification of reticulated cells
JP3817091B2 (en) * 1999-07-02 2006-08-30 テルモ株式会社 Cell number measuring device
US6587792B1 (en) 2000-01-11 2003-07-01 Richard A. Thomas Nuclear packing efficiency
US6646742B1 (en) * 2000-02-19 2003-11-11 Mwi, Inc. Optical device and method for multi-angle laser light scatter
US6624621B2 (en) * 2000-04-03 2003-09-23 Howard L. North, Jr. Particle counter volume sensor
US6890489B2 (en) * 2000-04-26 2005-05-10 Rheodyne, L.P. Mass rate attenuator
US7630063B2 (en) * 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
US6784981B1 (en) * 2000-06-02 2004-08-31 Idexx Laboratories, Inc. Flow cytometry-based hematology system
JP4494606B2 (en) * 2000-08-11 2010-06-30 浜松ホトニクス株式会社 Liquid-containing substance analysis apparatus and liquid-containing substance analysis method
US20020086431A1 (en) * 2000-08-21 2002-07-04 Markham Walter Bruce Sample preparation and slide plating apparatus and method
US20020028434A1 (en) * 2000-09-06 2002-03-07 Guava Technologies, Inc. Particle or cell analyzer and method
EP1189059B1 (en) * 2000-09-18 2009-06-24 Sysmex Corporation Blood cell detector, blood analyzer and blood analyzing method using the detector
JP4759188B2 (en) * 2000-09-18 2011-08-31 シスメックス株式会社 Blood cell detector and blood analyzer equipped with the same
WO2002059575A2 (en) * 2001-01-23 2002-08-01 The Trustees Of Princeton University, Princeton University Method and apparatus for analysis of biological solutions
US6793642B2 (en) * 2001-05-07 2004-09-21 Biomed Solutions, Llc Flow cytometer
US6743190B2 (en) * 2001-05-07 2004-06-01 Biomed Solutions L.L.C. Flow cytometer shunt
US20030027347A1 (en) * 2001-05-25 2003-02-06 Phyllis Shapiro Automated method for correcting blood analysis parameter results affected by interference from exogenous blood substitutes in whole blood, plasma, and serum
DE10128449B4 (en) * 2001-06-12 2004-07-15 Robert Bosch Gmbh Device and method for testing a material
US6472215B1 (en) * 2001-07-27 2002-10-29 Coulter International Corp. Method of analyzing nucleated red blood cells in a blood sample
WO2003012429A1 (en) * 2001-07-27 2003-02-13 Coulter International Corp. Method for measurement of nucleated red blood cells
US6410330B1 (en) * 2001-07-27 2002-06-25 Coulter International Corp. Method for measurement of nucleated red blood cells
US6803208B2 (en) * 2001-07-30 2004-10-12 The United States Of America As Represented By The Secretary Of The Navy Automated epifluorescence microscopy for detection of bacterial contamination in platelets
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US6723563B2 (en) 2001-12-03 2004-04-20 Streck Laboratories Inc. Hematology reference control
US6653137B2 (en) 2001-12-03 2003-11-25 Streck Laboratories Inc. Hematology reference control
ATE339687T1 (en) * 2002-05-22 2006-10-15 Sysmex Corp IMMUNOLOGICAL METHODS, DEVICES AND REAGENTS
US7569393B2 (en) 2002-06-28 2009-08-04 International Technidyne Corporation Analytical test cartridge; and, methods
JP4299597B2 (en) * 2002-07-29 2009-07-22 シスメックス株式会社 Hematology analyzer and method
US6794877B2 (en) * 2002-07-31 2004-09-21 International Technidyne Corporation Apparatus and method for analytical determinations
US6743634B2 (en) * 2002-08-23 2004-06-01 Coulter International Corp. Method and apparatus for differentiating blood cells using back-scatter
US20040166540A1 (en) * 2003-02-24 2004-08-26 Sysmex Corporation Methods of detecting CD34 positive and negative hematopoietic stem cells in human samples
US20040219612A1 (en) * 2003-05-02 2004-11-04 Beckman Coulter, Inc. Methods for detecting intracellular defensins in various leukocyte subpopulations
US20040228765A1 (en) * 2003-05-14 2004-11-18 Witty Thomas R. Point of care diagnostic platform
US20040228766A1 (en) * 2003-05-14 2004-11-18 Witty Thomas R. Point of care diagnostic platform
JP2005024472A (en) * 2003-07-04 2005-01-27 Sysmex Corp Immature platelet measuring apparatus
WO2005043113A2 (en) * 2003-10-12 2005-05-12 Beckman Coulter, Inc. Method of using a reference control composition for measurement of nucleated red blood cells
US7095492B2 (en) * 2003-12-19 2006-08-22 Beckman Coulter, Inc. Method and apparatus for measuring cell-by-cell hemoglobin
EP2341128A1 (en) * 2003-12-24 2011-07-06 GlycoFi, Inc. Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins
JP4435581B2 (en) * 2004-01-07 2010-03-17 シスメックス株式会社 Immunoassay apparatus and method
US7208319B2 (en) * 2004-02-10 2007-04-24 Beckman Coulter, Inc. Method of measurement of nucleated red blood cells
WO2005076995A2 (en) * 2004-02-10 2005-08-25 Beckman Coulter, Inc. Method of measurement of nucleated red blood cells
JP4417143B2 (en) * 2004-03-11 2010-02-17 シスメックス株式会社 SAMPLE ANALYZER, PROGRAM, AND RECORDING MEDIUM CONTAINING THE PROGRAM
US7674598B2 (en) * 2004-05-21 2010-03-09 Beckman Coulter, Inc. Method for a fully automated monoclonal antibody-based extended differential
US7625712B2 (en) * 2004-05-21 2009-12-01 Beckman Coulter, Inc. Method for a fully automated monoclonal antibody-based extended differential
US7075647B2 (en) * 2004-06-30 2006-07-11 Beckman Coulter, Inc. Back-scatter detection in flow cytometers
US7340957B2 (en) * 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
FR2873813B1 (en) * 2004-07-30 2006-11-17 Abx Sa METHOD AND DEVICE FOR CHARACTERIZING CELLULAR COMPONENTS OF A BIOLOGICAL LIQUID
WO2006013942A1 (en) * 2004-08-04 2006-02-09 Matsushita Electric Industrial Co., Ltd. Invasion detection device
US8685711B2 (en) * 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
US7392908B2 (en) * 2005-01-12 2008-07-01 Beckman Coulter, Inc. Methods and apparatus for sorting particles hydraulically
US7678578B2 (en) * 2005-02-07 2010-03-16 Beckman Coulter, Inc. Cell permeabilization and stabilization reagent and method of use
US20070077177A1 (en) * 2005-03-16 2007-04-05 Klaus Witt Stimulated detection of sample compounds
US7113266B1 (en) * 2005-03-30 2006-09-26 Beckman Coulter, Inc. Flow cytometer for differentiating small particles in suspension
FR2883973B1 (en) * 2005-03-31 2007-11-16 C2 Diagnostics Sa TANK FOR OPTICAL BLOOD ANALYSIS DEVICE, ANALYSIS APPARATUS EQUIPPED WITH SUCH A TANK
US7842247B2 (en) 2005-08-19 2010-11-30 Canadian Blood Services Sample holder for dynamic light scattering
US7609369B2 (en) * 2005-09-24 2009-10-27 Beckman Coulter, Inc. Methods of detection of iron deficiency and hemochromatosis
US7344890B2 (en) * 2005-11-09 2008-03-18 Beckman Coulter, Inc. Method for discriminating platelets from red blood cells
EP1966588B1 (en) * 2005-12-29 2018-12-12 Honeywell International Inc. Assay implementation in a microfluidic format
EP1976541B1 (en) * 2006-01-20 2011-07-13 Beckman Coulter, Inc. Low hemoglobin concentration cell percentage and method of use in detection of iron deficiency
WO2007131507A2 (en) * 2006-05-13 2007-11-22 Dako Denmark A/S Methods for flow cytometry analyses of cells without lysing subpopulations
WO2008008515A2 (en) * 2006-07-14 2008-01-17 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample
WO2008063758A2 (en) 2006-10-05 2008-05-29 Massachussetts Institute Of Technology Multifunctional encoded particles for high-throughput analysis
CN1945326A (en) * 2006-10-13 2007-04-11 江西特康科技有限公司 Five classifying full blood cell analysis method based on vision shape
US7835000B2 (en) 2006-11-03 2010-11-16 Los Alamos National Security, Llc System and method for measuring particles in a sample stream of a flow cytometer or the like
US8062609B2 (en) 2006-11-10 2011-11-22 Luminex Corporation Flow cytometer and fluidic line assembly with multiple injection needles
US20080121591A1 (en) * 2006-11-29 2008-05-29 Canon U.S. Life Sciences, Inc. Device for nucleic acid preparation
US7674622B2 (en) * 2006-12-22 2010-03-09 Abbott Laboratories, Inc. Method for determination of nucleated red blood cells and leukocytes in a whole blood sample in an automated hematology analyzer
EP1953526B1 (en) * 2007-02-01 2017-08-30 Sysmex Corporation Hematological analyzer, method for analyzing body fluid and computer program product
US7837040B2 (en) * 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
US8083068B2 (en) 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US7618821B2 (en) * 2007-04-13 2009-11-17 Streck, Inc. Simulated blood components and methods
JP5162177B2 (en) * 2007-07-31 2013-03-13 シスメックス株式会社 Particle analyzer and particle analysis method
US8263407B2 (en) 2007-10-24 2012-09-11 Los Alamos National Security, Llc Method for non-contact particle manipulation and control of particle spacing along an axis
US8528406B2 (en) * 2007-10-24 2013-09-10 Los Alamos National Security, LLP Method for non-contact particle manipulation and control of particle spacing along an axis
US8137975B2 (en) * 2007-10-29 2012-03-20 Beckman Coulter, Inc. Method for a rapid antibody-based analysis of platelet populations
US8266951B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, Llc Particle analysis in an acoustic cytometer
US9017610B2 (en) 2008-04-25 2015-04-28 Roche Diagnostics Hematology, Inc. Method of determining a complete blood count and a white blood cell differential count
US9602777B2 (en) 2008-04-25 2017-03-21 Roche Diagnostics Hematology, Inc. Systems and methods for analyzing body fluids
US8094299B2 (en) 2008-07-24 2012-01-10 Beckman Coulter, Inc. Transducer module
TW201017149A (en) 2008-08-06 2010-05-01 Invitrox Inc Use of focused light scattering techniques in biological applications
US8000940B2 (en) 2008-10-08 2011-08-16 Beckman Coulter, Inc. Shape parameter for hematology instruments
US20100086962A1 (en) 2008-10-08 2010-04-08 Streck, Inc. Hematology controls and methods
HU227875B1 (en) * 2008-10-13 2012-05-29 Diatron Medicinai Instr Laboratoriumi Diagnosztikai Fejlesztoe Gyarto Zartkoerueen Muekoedoe Reszven Optical circulation cytometer furthermore testing method
FR2939199B1 (en) * 2008-12-02 2011-02-11 C2 Diagnostics METHOD AND DEVICE FOR FLOW CYTOMETRY WITHOUT SAGING FLUID
US9464978B2 (en) 2009-03-04 2016-10-11 Beckman Coulter, Inc. Cross-instrument method and system for cell population discrimination
JP5670052B2 (en) * 2009-03-26 2015-02-18 シスメックス株式会社 Blood analyzer, blood analysis method and computer program
WO2010124202A1 (en) * 2009-04-24 2010-10-28 Beckman Coulter, Inc. Method of characterizing particles
WO2010138391A2 (en) * 2009-05-26 2010-12-02 Invitrox, Inc. Instrument and method for optical particle sensing
US20100329927A1 (en) 2009-06-26 2010-12-30 Perez Carlos A Pipelining Assembly For A Blood Analyzing Instrument
US9097704B2 (en) * 2010-05-05 2015-08-04 Abbott Laboratories Method for hematology analysis
EP2577300B1 (en) 2010-06-07 2016-09-28 Firefly Bioworks, Inc. Scanning multifunctional particles
JP5868982B2 (en) 2010-09-16 2016-02-24 ザ ジェネラル ホスピタル コーポレイション Red blood cell dynamics for diagnosis
CA2816014A1 (en) 2010-11-03 2012-05-10 Reametrix Inc. Method and device for fluorescent measurement of samples
US9111343B2 (en) 2011-01-18 2015-08-18 Roche Diagnostics Hematology, Inc. Microscope slide coordinate system registration
FR2971337B1 (en) * 2011-02-04 2013-03-01 Horiba Abx Sas DEVICE AND METHOD FOR MULTIPARAMETRIC MEASUREMENTS OF MICROPARTICLES IN A FLUID
EP3159692A1 (en) * 2011-04-28 2017-04-26 Sysmex Corporation Blood analyzer, blood analysis method, and computer program
ES2927316T3 (en) * 2011-05-04 2022-11-04 Abbott Lab White blood cell analysis system and method
WO2012151103A2 (en) 2011-05-04 2012-11-08 Abbott Laboratories Nucleated red blood cell analysis system and method
US9091625B2 (en) * 2011-05-04 2015-07-28 Abbott Laboratories Basophil analysis system and method
EP2520926B1 (en) * 2011-05-05 2022-06-15 Sysmex Corporation Blood analyzer, blood analysis method, and computer program product
CA2842681C (en) * 2011-07-21 2020-08-04 Invitrox, Inc. Instrument and method for optical particle sensing
WO2013101675A2 (en) 2011-12-29 2013-07-04 Abbott Laboratories Flow cytometry systems and methods for blocking diffraction patterns
WO2013134633A1 (en) * 2012-03-09 2013-09-12 Firefly Bioworks, Inc. Methods and apparatus for classification and quantification of multifunctional objects
KR101963477B1 (en) 2012-07-05 2019-03-28 베크만 컬터, 인코포레이티드 Method and apparatus for determining white blood cell counts
BR112015003000A2 (en) * 2012-08-13 2017-07-04 Beckman Coulter Inc leukemia classification using cpd data
WO2014084930A1 (en) 2012-11-30 2014-06-05 Beckman Coulter, Inc. Tuberculosis screening using cpd data
US9939453B2 (en) 2012-12-31 2018-04-10 Beckman Coulter, Inc. Immature platelet enumeration systems and methods
WO2014106270A1 (en) 2012-12-31 2014-07-03 Beckman Coulter, Inc. Systems and methods for platelet count with clump adjustment
EP2972550B1 (en) * 2013-03-11 2024-09-25 Roche Diagnostics Hematology, Inc. Method for classifying white blood cells
ES2770411T3 (en) * 2013-03-12 2020-07-01 Abbott Lab Optical analysis system of the mean corpuscular volume of red blood cells
BR112015022201B1 (en) 2013-03-15 2021-06-22 Beckman Coulter, Inc METHOD FOR DESIGNING A PROBE PANEL FOR A FLOW CYTOMETER
US9772274B2 (en) 2013-03-15 2017-09-26 Beckman Coulter, Inc. Compound optical flow cells and method of manufacture and use
WO2014186228A1 (en) * 2013-05-13 2014-11-20 Chiranjit Deka Apparatus and methods for cellular analysis
US10324020B2 (en) * 2013-12-23 2019-06-18 Palo Alto Research Center Incorporated Fluidic optical cartridge
CN107003224B (en) * 2014-08-20 2021-01-12 生物辐射实验室股份有限公司 Optical fluid sorter
US9581491B2 (en) 2014-09-30 2017-02-28 Perkinelmer Health Sciences, Inc. Flow cell modules and liquid sample analyzers and methods including same
US9500588B2 (en) 2014-09-30 2016-11-22 Perkinelmer Health Sciences, Inc. Flow cell modules and liquid sample analyzers and methods including same
US9612221B2 (en) 2014-10-14 2017-04-04 Chem-Aqua, Inc. + Pyxis Lab, Inc. Opto-electrochemical sensing system for monitoring and controlling industrial fluids
FR3034198B1 (en) 2015-03-26 2019-05-31 C2 Diagnostics HYDROFOCUS APPARATUS WITH SINGLE ANALYSIS SOLUTION
JP6729558B2 (en) * 2015-03-31 2020-07-22 ソニー株式会社 ELECTRICAL CHARACTERISTIC MEASURING DEVICE, ELECTRICAL CHARACTERISTIC MEASURING METHOD, BLOOD CONDITION ANALYSIS SYSTEM, AND ELECTRICAL CHARACTERISTIC MEASURING PROGRAM FOR IMPLEMENTING THE METHOD IN A COMPUTER
WO2017078672A1 (en) 2015-11-02 2017-05-11 Chiranjit Deka Light scatter based apparatus and methods for hematology analysis using only three detectors
US10955423B2 (en) 2015-12-15 2021-03-23 The General Hospital Corporation Methods of estimating blood glucose and related systems
WO2017132132A1 (en) 2016-01-28 2017-08-03 Beckman Coulter, Inc. Infection detection and differentiation systems and methods
US11293852B2 (en) 2016-04-07 2022-04-05 The General Hospital Corporation White blood cell population dynamics
EP3465142B1 (en) * 2016-05-27 2023-08-23 Martin Kuhn Flow cytometer assembly
WO2018148942A1 (en) 2017-02-17 2018-08-23 深圳迈瑞生物医疗电子股份有限公司 Blood cell analysis method, and blood cell analysis instrument
CN110494924A (en) 2017-02-28 2019-11-22 拜克门寇尔特公司 Cross discipline disease management program
US10648909B2 (en) * 2017-05-25 2020-05-12 Abbott Laboratories Methods and systems for assessing flow cell cleanliness
CN109211737B (en) * 2017-06-30 2024-07-16 深圳迈瑞生物医疗电子股份有限公司 Sample detection device, sample analyzer, and sample detection method
WO2019041270A1 (en) * 2017-08-31 2019-03-07 深圳迈瑞生物医疗电子股份有限公司 Sample testing device, sample analyzer, and sample testing method
US11852640B2 (en) 2017-10-27 2023-12-26 Beckman Coulter, Inc. Hematology analyzers and methods of operation
CN115901581A (en) 2018-03-30 2023-04-04 Idexx实验室公司 Laser optical assembly for flow cytometer
CN112041938A (en) 2018-04-20 2020-12-04 拜克门寇尔特公司 Sepsis infection determination system and method
US11521706B2 (en) 2018-04-20 2022-12-06 Beckman Coulter, Inc. Testing and representing suspicion of sepsis
US11538566B2 (en) 2018-05-23 2022-12-27 Beckman Coulter, Inc. Sample analysis with test determination based on identified condition
AU2019261360A1 (en) * 2018-04-23 2020-03-05 Anpac Bio-Medical Science Co., Ltd. New apparatus and methods for disease detection
CN111602046B (en) * 2018-04-28 2024-01-09 深圳迈瑞生物医疗电子股份有限公司 Blood analyzer and analysis method
US11022538B2 (en) * 2018-05-15 2021-06-01 Government Of The United States Of America, As Represented By The Secretary Of Commerce Quantum flow cytometer
CN111989032B (en) * 2018-06-15 2024-07-19 拜克门寇尔特公司 Methods for determining sepsis in the presence of blast markers
US12023178B2 (en) 2019-07-12 2024-07-02 Beckman Coulter, Inc. Method of detecting sepsis using vital signs, including systolic blood pressure, hematology parameters, and combinations thereof
WO2021011352A1 (en) 2019-07-12 2021-01-21 Beckman Coulter, Inc. Systems and methods for evaluating immune response to infection
EP3997461A1 (en) 2019-07-12 2022-05-18 Beckman Coulter, Inc. Systems and methods for evaluating immune response to infection
CN115769058A (en) 2020-04-21 2023-03-07 贝克曼库尔特有限公司 Detecting medical condition, severity, risk and sensitivity using parameters
CA3182847A1 (en) 2020-06-17 2021-12-23 Garland Christian Misener Flow cytometer and laser optics assembly thereof
EP3933376A1 (en) * 2020-07-02 2022-01-05 Deutsches Rheuma-Forschungszentrum Berlin Method and system for characterizing particles using an angular detection in a flow cytometer
KR20230033740A (en) * 2020-07-10 2023-03-08 베크만 컬터, 인코포레이티드 Automated Sample Preparation Platform for Cellular Analysis
CN116529586A (en) 2020-09-25 2023-08-01 贝克曼库尔特有限公司 Methods used to evaluate MIS-C related to COVID-19
CN112557281B (en) * 2020-11-23 2022-06-24 深圳市科曼医疗设备有限公司 PLT particle detection method and device of blood cell analyzer
WO2022119594A1 (en) 2020-12-02 2022-06-09 Beckman Coulter, Inc. Detection of medical condition, severity, risk, and acuity using parameters
EP4479744A1 (en) 2022-02-18 2024-12-25 Beckman Coulter, Inc. Detection of sepsis using hematology parameters
US11506587B1 (en) * 2022-06-29 2022-11-22 HLM Diagnostics Inc. Liquid droplet and solid particle sensing device
CN115524276A (en) * 2022-10-18 2022-12-27 四川成电医联科技咨询有限公司 Multi-frequency impedance blood cell classification counting chip and counting method
WO2024123776A1 (en) 2022-12-05 2024-06-13 Beckman Coulter, Inc. Multi-channel hematology flow system
WO2025076332A1 (en) 2023-10-05 2025-04-10 Beckman Coulter, Inc. Determining parameter values in a biological analyzer
WO2025145095A1 (en) 2023-12-29 2025-07-03 Beckman Coulter, Inc. Customized sample handling in biological analysis

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4673288A (en) * 1981-05-15 1987-06-16 Ratcom, Inc. Flow cytometry
US4507977A (en) 1981-10-19 1985-04-02 Coulter Electronics, Inc. Liquid metering and transfer valve assembly
US4445391A (en) 1981-10-19 1984-05-01 Coulter Electronics, Inc. Liquid metering and transfer valve assembly
US4510438A (en) * 1982-02-16 1985-04-09 Coulter Electronics, Inc. Coincidence correction in particle analysis system
GB2125181B (en) * 1982-08-11 1986-01-29 Coulter Electronics Flow cells for particle study
CH651930A5 (en) * 1983-03-24 1985-10-15 Coulter Corp Apparatus for analysis and sorting of particles
US4702889A (en) 1986-01-16 1987-10-27 Coulter Electronics Inc. Liquid sampling valve
KR970007077B1 (en) 1987-03-13 1997-05-02 코울터 일렉트로닉스 인커퍼레이티드 Multi-Partial Identification Method Using Light Scattering Technique
FR2621123B1 (en) * 1987-09-30 1989-12-01 Commissariat Energie Atomique METHOD FOR MANUFACTURING A DEVICE FOR OPTICAL ANALYSIS OF A MICROPARTICLE STREAM AND APPLICATION TO THE MANUFACTURE OF A CYTOFLUORIMETER
JPH0718785B2 (en) 1988-09-19 1995-03-06 株式会社日立製作所 Flow cell device
CA1324894C (en) * 1989-03-31 1993-12-07 Maritime Scientific Services Ltd. Method and apparatus for the identification of particles
US5255568A (en) 1990-12-13 1993-10-26 Coulter Corporation Liquid sample/reagent metering and delivery method
JP3048260B2 (en) * 1991-07-29 2000-06-05 シスメックス株式会社 Sample preparation method for leukocyte classification and counting
EP0698211B1 (en) * 1993-05-14 2003-04-02 Coulter International Corporation Reticulocyte analyzing method and apparatus utilizing light scatter techniques
JP3328032B2 (en) * 1993-11-04 2002-09-24 シスメックス株式会社 Particle analyzer
IL113805A0 (en) * 1994-05-23 1995-08-31 Coulter Corp Detection of reticulocytes
US5631165A (en) 1994-08-01 1997-05-20 Abbott Laboratories Method for performing automated hematology and cytometry analysis
WO1996004544A1 (en) * 1994-08-01 1996-02-15 Abbott Laboratories Method and apparatus for performing automated analysis
US5656499A (en) 1994-08-01 1997-08-12 Abbott Laboratories Method for performing automated hematology and cytometry analysis
US5798827A (en) * 1996-11-26 1998-08-25 Coulter International Corp. Apparatus and method for determination of individual red blood cell shape
US6060322A (en) * 1998-10-20 2000-05-09 Coulter International Corp. Method for identification of reticulated cells

Also Published As

Publication number Publication date
DE60034370T2 (en) 2007-12-20
WO2000049385A2 (en) 2000-08-24
EP1250585B1 (en) 2007-04-11
WO2000049385A3 (en) 2002-08-08
US6228652B1 (en) 2001-05-08
JP4468590B2 (en) 2010-05-26
EP1250585A2 (en) 2002-10-23
JP2003510557A (en) 2003-03-18

Similar Documents

Publication Publication Date Title
DE60034370D1 (en) METHOD AND DEVICE FOR ANALYZING CELLS IN A FULL BLOOD TEST
DE19983796T1 (en) Method and device for analyzing measurements
DE60037506D1 (en) METHOD AND DEVICE FOR ANALYZING ELECTRIC CARDIOGRAM SIGNALS
DE60020349D1 (en) METHOD AND DEVICE FOR ANALYZING ELECTRIC CARDIOGRAM SIGNALS
DE69805756D1 (en) METHOD AND DEVICE FOR ANALYSIS
DE69840330D1 (en) METHOD AND DEVICE FOR AUTOMATIC ANALYSIS
DE69719399D1 (en) Device and method for analyzing a sample
DE60132628D1 (en) METHOD AND DEVICE FOR COLLECTING AND STABILIZING A BIOLOGICAL SAMPLE
DE69822429D1 (en) Method and device for determining a substance coexisting with another substance
DE69740113D1 (en) DEVICE AND METHOD FOR INCUBATING CELLS
DE60000386D1 (en) ADAPTER FOR A PIPETTE, PIPETTE FOR ABSORPTION MEASUREMENT, METHOD AND DEVICE FOR ABSORPTION MEASUREMENT
DE60207148D1 (en) Device and method for obtaining cells
DE69733927D1 (en) METHOD AND DEVICE FOR PRE-TREATING SAMPLE IN A CHEMICAL ANALYZER
DE69732041D1 (en) METHOD AND DEVICE FOR ANALYZING BITSTRAMS
DE60014743D1 (en) Natural language analysis method and apparatus
EP0927880A4 (en) DEVICE AND METHOD FOR SAMPLE PREPARATION
DE69808352D1 (en) Device for cell culture and its application in a method for cell culture
DE69836558D1 (en) METHOD AND DEVICE FOR DETERMINING A CONCENTRATION
DE60018733D1 (en) DEVICE AND METHOD FOR SAMPLING
DE60021077D1 (en) DEVICE AND METHOD FOR SAMPLING
DE69830675D1 (en) Chromatographic apparatus and method for detecting an analyte in a whole blood sample
DE69839641D1 (en) METHOD AND DEVICE FOR BLOOD PRESSURE MEASUREMENT
DE69524732D1 (en) METHOD AND DEVICE FOR ANALYZING A LIQUID SAMPLE
DE60021564D1 (en) METHOD AND DEVICE FOR A SENSOR TEST
DE19580537D2 (en) Method and device for determining an analyte in a biological sample

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BECKMAN COULTER, INC., BREA, CALIF., US