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DE60031682D1 - Antibakterielle verbindungen - Google Patents

Antibakterielle verbindungen

Info

Publication number
DE60031682D1
DE60031682D1 DE60031682T DE60031682T DE60031682D1 DE 60031682 D1 DE60031682 D1 DE 60031682D1 DE 60031682 T DE60031682 T DE 60031682T DE 60031682 T DE60031682 T DE 60031682T DE 60031682 D1 DE60031682 D1 DE 60031682D1
Authority
DE
Germany
Prior art keywords
antibacterial compounds
antibacterial
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60031682T
Other languages
English (en)
Other versions
DE60031682T2 (de
Inventor
Dirk Heerding
A Newlander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affinium Pharmaceuticals Inc
Original Assignee
Affinium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharmaceuticals Inc filed Critical Affinium Pharmaceuticals Inc
Publication of DE60031682D1 publication Critical patent/DE60031682D1/de
Application granted granted Critical
Publication of DE60031682T2 publication Critical patent/DE60031682T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60031682T 1999-05-25 2000-05-24 Antibakterielle verbindungen Expired - Lifetime DE60031682T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13594899P 1999-05-25 1999-05-25
US135948P 1999-05-25
PCT/US2000/014330 WO2000071120A1 (en) 1999-05-25 2000-05-24 Antibacterial compounds

Publications (2)

Publication Number Publication Date
DE60031682D1 true DE60031682D1 (de) 2006-12-14
DE60031682T2 DE60031682T2 (de) 2007-09-06

Family

ID=22470518

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60031682T Expired - Lifetime DE60031682T2 (de) 1999-05-25 2000-05-24 Antibakterielle verbindungen

Country Status (9)

Country Link
US (2) US6559172B1 (de)
EP (1) EP1194144B1 (de)
JP (1) JP4948708B2 (de)
AR (1) AR024077A1 (de)
AT (1) ATE344248T1 (de)
AU (1) AU5043500A (de)
CO (1) CO5170486A1 (de)
DE (1) DE60031682T2 (de)
WO (1) WO2000071120A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
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CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
CO5370679A1 (es) 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
US6730684B1 (en) * 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
AU773218B2 (en) 1999-10-08 2004-05-20 Debiopharm International Sa Fab I inhibitors
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
AU2002367773A1 (en) * 2001-04-06 2003-11-03 Affinium Pharmaceuticals, Inc. Fab i inhibitors
FR2825926A1 (fr) * 2001-06-14 2002-12-20 Sod Conseils Rech Applic Derives d'imidazoles modulant les canaux sodiques
US7297708B2 (en) * 2001-09-06 2007-11-20 Bristol-Myers Squibb Company Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands
SI1575951T1 (sl) * 2002-12-06 2014-10-30 Debiopharm International Sa Forum "Apres-Demain" Heterociklične spojine, postopki za njihovo izdelavo in njihova uporaba v terapiji
AU2004210711B2 (en) * 2003-02-12 2010-07-08 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
WO2004082586A2 (en) * 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
ZA200605526B (en) * 2004-02-12 2007-11-28 Transtech Pharma Inc Substituted azole derivatives, compositions and methods of use
US8450307B2 (en) * 2004-06-04 2013-05-28 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
CA2603534C (en) 2005-03-04 2014-02-04 Fan Wu Design and synthesis of novel antimicrobials
JP2009518399A (ja) * 2005-12-05 2009-05-07 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉ阻害剤および抗菌剤としてのヘテロ環アクリルアミド化合物
CN101374516A (zh) * 2006-01-27 2009-02-25 弗·哈夫曼-拉罗切有限公司 取代的咪唑啉的2-咪唑衍生物的用途
EP2687533B1 (de) 2006-07-20 2017-07-19 Debiopharm International SA Acrylamidderivate als FAB-I-Hemmer
CN101528730A (zh) * 2006-10-20 2009-09-09 默克公司 作为韩蛙皮素受体亚型-3调节剂的取代的咪唑
EP2083623A1 (de) * 2006-10-20 2009-08-05 Merck & Co., Inc. Substituierte imidazole als bombesin-rezeptor-3 modulatoren
CA2664794A1 (en) * 2006-10-20 2008-05-02 Merck & Co., Inc. Substituted imidazoles as bombesin receptor subtype-3 modulators
EP3255045A1 (de) * 2007-02-16 2017-12-13 Debiopharm International SA Salze, prodrugs und polymorphe von fab i-inhibitoren
JP5313044B2 (ja) * 2008-08-08 2013-10-09 四国化成工業株式会社 銅または銅合金の表面処理剤及びその利用
JP5301218B2 (ja) * 2008-08-25 2013-09-25 四国化成工業株式会社 銅または銅合金の表面処理剤及びその利用
JP5484795B2 (ja) * 2008-09-03 2014-05-07 四国化成工業株式会社 ２−ベンジル−４−（３，４−ジクロロフェニル）−５−メチルイミダゾール化合物
JP5260367B2 (ja) * 2008-09-26 2013-08-14 四国化成工業株式会社 ２−（クロロベンジル）−４−フェニルイミダゾール化合物
WO2010041614A1 (en) * 2008-10-06 2010-04-15 Shikoku Chemicals Corporation 2-benzyl-4-(2,4-dichlorophenyl)-5-methylimidazole compound
JP5368244B2 (ja) * 2009-10-14 2013-12-18 四国化成工業株式会社 ２−（２，４−ジクロロベンジル）−４−アリール−５−メチルイミダゾール化合物
JP5368263B2 (ja) * 2009-11-04 2013-12-18 四国化成工業株式会社 ４−（２，４−ジクロロフェニル）−５−メチルイミダゾール化合物
JP5368271B2 (ja) * 2009-11-20 2013-12-18 四国化成工業株式会社 ４−（４−ビフェニリル）−２−（２，４−ジクロロベンジル）イミダゾールおよび表面処理液
JP5398076B2 (ja) * 2009-12-10 2014-01-29 四国化成工業株式会社 ２−（ブロモベンジル）−４−（ブロモフェニル）−５−メチルイミダゾール化合物
JP5398075B2 (ja) * 2010-01-13 2014-01-29 四国化成工業株式会社 ４−（ジクロロフェニル）−２−（４−フルオロベンジル）−５−メチルイミダゾール化合物
JP5615227B2 (ja) 2011-05-23 2014-10-29 四国化成工業株式会社 銅または銅合金の表面処理剤及びその利用
JP5615233B2 (ja) * 2011-06-20 2014-10-29 四国化成工業株式会社 銅または銅合金の表面処理剤及びその利用
IN2014KN02915A (de) 2012-06-19 2015-05-08 Debiopharm Int Sa
JP5892605B2 (ja) * 2012-08-17 2016-03-23 四国化成工業株式会社 ４−（２−チエニル）イミダゾール化合物
WO2017144717A1 (en) 2016-02-26 2017-08-31 Debiopharm International S.A. Medicament for treatment of diabetic foot infections
US11236100B2 (en) 2017-08-09 2022-02-01 Denali Therapeutics Inc. Modulators of eukaryotic initiation factor 2B, compositions and methods
EP3676297B1 (de) 2017-09-01 2023-05-17 Denali Therapeutics Inc. Verbindungen, zusammensetzungen und verfahren
EP3749697A4 (de) 2018-02-05 2021-11-03 Bio-Rad Laboratories, Inc. Chromatografieharz mit einem liganden mit anionenaustausch-hydrophobem mischmodus
PE20212023A1 (es) 2019-02-13 2021-10-18 Denali Therapeutics Inc Compuestos, composiciones y metodos
MA54959A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
WO2020181247A1 (en) * 2019-03-06 2020-09-10 Denali Therapeutics Inc. Compounds, compositions and methods
JP7479686B2 (ja) 2020-10-16 2024-05-09 株式会社岩や 壁パネル

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3657441A (en) 1970-07-30 1972-04-18 Merck & Co Inc Method of inhibiting the formation of phenylethanolamine n-methyl transferase with imidazoles
FR2122395A1 (en) * 1971-01-19 1972-09-01 Berlin Chemie Veb Pharmacologically active imidazoles - by condensing alpha-aminoketones with formamide
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
FR2482859A1 (fr) * 1980-05-22 1981-11-27 Fabre Sa Pierre Fluorhydrates d'heterocycles azotes insatures utilisables en therapeutique dentaire
DE4015535A1 (de) * 1990-05-15 1991-11-21 Basf Ag Verfahren zur herstellung von n-substituierten imidazolen
CA2106337C (en) * 1992-09-26 1998-06-16 Hiroyuki Nakanishi Phenylimidazole derivatives, processes for production thereof, herbicides comprising said derivatives, and usages of said herbicides
JP3311858B2 (ja) * 1994-03-08 2002-08-05 四国化成工業株式会社 銅及び銅合金の表面処理剤
JPH10280162A (ja) * 1997-04-07 1998-10-20 Hideaki Yamaguchi プリント配線板の表面保護剤および表面保護膜の形成方法。
WO1999001128A1 (en) * 1997-07-03 1999-01-14 Neurogen Corporation Certain diarylimidazole derivatives; a new class of npy specific ligands

Also Published As

Publication number Publication date
US6673941B2 (en) 2004-01-06
JP2003500357A (ja) 2003-01-07
EP1194144A1 (de) 2002-04-10
WO2000071120A1 (en) 2000-11-30
EP1194144A4 (de) 2002-08-07
JP4948708B2 (ja) 2012-06-06
US20030149089A1 (en) 2003-08-07
CO5170486A1 (es) 2002-06-27
EP1194144B1 (de) 2006-11-02
AR024077A1 (es) 2002-09-04
US6559172B1 (en) 2003-05-06
DE60031682T2 (de) 2007-09-06
ATE344248T1 (de) 2006-11-15
AU5043500A (en) 2000-12-12

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Legal Events

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