DE60029091D1 - Verfahren zur herstellung von diphtheria toxin - Google Patents
Verfahren zur herstellung von diphtheria toxinInfo
- Publication number
- DE60029091D1 DE60029091D1 DE60029091T DE60029091T DE60029091D1 DE 60029091 D1 DE60029091 D1 DE 60029091D1 DE 60029091 T DE60029091 T DE 60029091T DE 60029091 T DE60029091 T DE 60029091T DE 60029091 D1 DE60029091 D1 DE 60029091D1
- Authority
- DE
- Germany
- Prior art keywords
- toxin
- diphtheria toxin
- glucose
- eluting
- purifying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000016607 Diphtheria Toxin Human genes 0.000 title abstract 5
- 108010053187 Diphtheria Toxin Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 3
- 239000008103 glucose Substances 0.000 abstract 3
- 239000003053 toxin Substances 0.000 abstract 3
- 231100000765 toxin Toxicity 0.000 abstract 3
- 239000011159 matrix material Substances 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 238000005342 ion exchange Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9904582.5A GB9904582D0 (en) | 1999-02-26 | 1999-02-26 | Process |
| GB9904582 | 1999-02-26 | ||
| PCT/GB2000/000680 WO2000050449A1 (en) | 1999-02-26 | 2000-02-25 | Process for production diphtheria toxin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60029091D1 true DE60029091D1 (de) | 2006-08-10 |
| DE60029091T2 DE60029091T2 (de) | 2007-05-31 |
Family
ID=10848658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60029091T Expired - Lifetime DE60029091T2 (de) | 1999-02-26 | 2000-02-25 | Verfahren zur herstellung von diphtheria toxin |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US6689871B1 (de) |
| EP (1) | EP1157034B1 (de) |
| AT (1) | ATE331731T1 (de) |
| AU (1) | AU2814600A (de) |
| DE (1) | DE60029091T2 (de) |
| ES (1) | ES2267499T3 (de) |
| GB (1) | GB9904582D0 (de) |
| WO (1) | WO2000050449A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9904582D0 (en) * | 1999-02-26 | 1999-04-21 | Nycomed Imaging As | Process |
| GB0505996D0 (en) * | 2005-03-23 | 2005-04-27 | Glaxosmithkline Biolog Sa | Fermentation process |
| EP1946397A4 (de) * | 2005-11-02 | 2009-12-02 | Univ St Louis | In hydrophob modifizierten polysacchariden immobilisierte enzyme |
| US7977283B2 (en) * | 2008-06-27 | 2011-07-12 | Baker Hughes Incorporated | Method of minimizing or reducing salt deposits by use of a fluid containing a fructan and derivatives thereof |
| IT1398927B1 (it) | 2009-06-25 | 2013-03-28 | Consorzio Interuniversitario Per Lo Sviluppo Dei Sistemi A Grande Interfase Csgi | Espressione batterica di un gene artificiale per la produzione di crm197 e derivati. |
| AU2010201410B2 (en) * | 2010-03-30 | 2015-04-30 | Pelican Technology Holdings, Inc. | High level expression of recombinant CRM197 |
| CA2793978C (en) | 2010-03-30 | 2021-08-03 | Pfenex Inc. | High level expression of recombinant toxin proteins |
| EP2764119A2 (de) | 2011-10-05 | 2014-08-13 | Genelux Corporation | Methoden zum nachweis der replikation oder kolonisierung eines biologischen therapiemittels |
| GB2495341B (en) * | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
| DE102011122891B4 (de) | 2011-11-11 | 2014-12-24 | Novartis Ag | Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen |
| DE102011118371B4 (de) | 2011-11-11 | 2014-02-13 | Novartis Ag | Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung |
| EP2592137A1 (de) | 2011-11-11 | 2013-05-15 | Novartis AG | Fermentierungsmedium ohne Bestandteile tierischen Ursprungs zur Herstellung von Diphtherie-Impfstoffen zur menschlichen Impfung |
| WO2013138522A2 (en) | 2012-03-16 | 2013-09-19 | Genelux Corporation | Methods for assessing effectiveness and monitoring oncolytic virus treatment |
| US20130280170A1 (en) | 2012-04-20 | 2013-10-24 | Aladar A. Szalay | Imaging methods for oncolytic virus therapy |
| US9169304B2 (en) | 2012-05-01 | 2015-10-27 | Pfenex Inc. | Process for purifying recombinant Plasmodium falciparum circumsporozoite protein |
| GB201209896D0 (en) | 2012-06-01 | 2012-07-18 | Fujifilm Diosynth Biotechnologies Uk Ltd | Process |
| WO2014055960A1 (en) | 2012-10-05 | 2014-04-10 | Genelux Corporation | Energy absorbing-based diagnostic and therapeutic methods employing nucleic acid molecules encoding chromophore-producing enzymes |
| US10238700B2 (en) | 2014-01-02 | 2019-03-26 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| US10329323B2 (en) | 2014-07-25 | 2019-06-25 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Method for purifying antibodies using PBS |
| BR112017007765B1 (pt) | 2014-10-14 | 2023-10-03 | Halozyme, Inc | Composições de adenosina deaminase-2 (ada2), variantes do mesmo e métodos de usar o mesmo |
| AU2017248830B2 (en) | 2016-04-15 | 2023-03-09 | Alpine Immune Sciences, Inc. | CD80 variant immunomodulatory proteins and uses thereof |
| BR112018070934A2 (pt) | 2016-04-15 | 2019-02-26 | Alpine Immune Sciences, Inc. | proteínas imunomoduladoras variantes ligantes de icos e usos das mesmas |
| US11834490B2 (en) | 2016-07-28 | 2023-12-05 | Alpine Immune Sciences, Inc. | CD112 variant immunomodulatory proteins and uses thereof |
| CN110088127A (zh) | 2016-07-28 | 2019-08-02 | 高山免疫科学股份有限公司 | Cd155变体免疫调节蛋白及其用途 |
| US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
| AU2017345764A1 (en) | 2016-10-20 | 2019-05-02 | Alpine Immune Sciences, Inc. | Secretable variant immunomodulatory proteins and engineered cell therapy |
| JP2020507349A (ja) | 2017-02-09 | 2020-03-12 | インダプタ セラピューティクス インコーポレイテッド | 操作されたナチュラルキラー（ｎｋ）細胞ならびにその組成物および方法 |
| US11732022B2 (en) | 2017-03-16 | 2023-08-22 | Alpine Immune Sciences, Inc. | PD-L2 variant immunomodulatory proteins and uses thereof |
| KR102692556B1 (ko) | 2017-03-16 | 2024-08-09 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Pd-l1 변이체 면역조절 단백질 및 그의 용도 |
| KR102813967B1 (ko) | 2017-03-16 | 2025-05-29 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Cd80 변이체 면역조절 단백질 및 그의 용도 |
| CU24668B1 (es) | 2017-04-22 | 2023-07-12 | Biological E Ltd | Método para la producción de alto nivel de crm197 a partir de una cepa genéticamente modificada de corynebacterium diphtheriae |
| EP3444269A1 (de) | 2017-08-17 | 2019-02-20 | National Research Council of Canada | Systeme und methoden für die produktion von diphteria-giftstoff-polypeptiden |
| AU2018351000B2 (en) | 2017-10-18 | 2023-11-30 | Alpine Immune Sciences, Inc. | Variant ICOS Ligand immunomodulatory proteins and related compositions and methods |
| WO2019136179A1 (en) | 2018-01-03 | 2019-07-11 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
| US11505782B2 (en) | 2018-06-04 | 2022-11-22 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
| EP3801584B1 (de) | 2018-06-04 | 2023-09-27 | Calidi Biotherapeutics, Inc. | Auf zellen basierende vehikel zur potenzierung einer virentherapie |
| US12065476B2 (en) | 2018-06-15 | 2024-08-20 | Alpine Immune Sciences, Inc. | PD-1 variant immunomodulatory proteins and uses thereof |
| WO2020047161A2 (en) | 2018-08-28 | 2020-03-05 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
| US11655455B2 (en) | 2018-11-06 | 2023-05-23 | Calidi Biotherapeutics, Inc. | Enhanced systems for cell-mediated oncolytic viral therapy |
| KR20210123289A (ko) | 2018-11-21 | 2021-10-13 | 인답타 세라뷰틱스 인코포레이티드 | 자연 살해 세포 서브세트의 증식을 위한 방법 및 관련 조성물 및 방법 |
| CN113727998A (zh) | 2018-11-30 | 2021-11-30 | 高山免疫科学股份有限公司 | Cd86变体免疫调节蛋白及其用途 |
| US12024709B2 (en) | 2019-02-27 | 2024-07-02 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| KR20220004959A (ko) | 2019-02-27 | 2022-01-12 | 액팀 테라퓨틱스, 인코퍼레이티드 | 종양, 종양-상주 면역 세포, 및 종양 미세환경을 콜로니화하기 위해 조작된 면역자극성 박테리아 |
| KR20230088306A (ko) | 2020-04-22 | 2023-06-19 | 인답타 세라뷰틱스 인코포레이티드 | 자연 살해(ｎｋ) 세포 조성물 및 이를 생성하는 방법 |
| TW202241479A (zh) | 2020-12-30 | 2022-11-01 | 美商安迅生物製藥公司 | 遞送外來抗原之溶瘤病毒及表現靶向外來抗原之嵌合受體之經工程化免疫細胞之組合療法 |
| CN113755380A (zh) * | 2021-09-23 | 2021-12-07 | 艾美卫信生物药业（浙江）有限公司 | 一种发酵生产白喉毒素crm197蛋白的菌种培养基、配制方法以及菌种复苏培养方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH660375A5 (it) * | 1983-02-08 | 1987-04-15 | Sclavo Spa | Procedimento per la produzione di proteine correlate alla tossina difterica. |
| US4711845A (en) * | 1984-08-31 | 1987-12-08 | Cetus Corporation | Portable temperature-sensitive control cassette |
| IN165717B (de) * | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US5728383A (en) * | 1987-10-05 | 1998-03-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Treatment of tumors of the central nervous system with immunotoxins |
| GB9904582D0 (en) * | 1999-02-26 | 1999-04-21 | Nycomed Imaging As | Process |
| US20060243666A1 (en) * | 2005-04-29 | 2006-11-02 | Jenkins Lauri L | Process for the preparation of protein separation solution |
-
1999
- 1999-02-26 GB GBGB9904582.5A patent/GB9904582D0/en not_active Ceased
-
2000
- 2000-02-25 AU AU28146/00A patent/AU2814600A/en not_active Abandoned
- 2000-02-25 EP EP00906484A patent/EP1157034B1/de not_active Expired - Lifetime
- 2000-02-25 DE DE60029091T patent/DE60029091T2/de not_active Expired - Lifetime
- 2000-02-25 ES ES00906484T patent/ES2267499T3/es not_active Expired - Lifetime
- 2000-02-25 WO PCT/GB2000/000680 patent/WO2000050449A1/en active IP Right Grant
- 2000-02-25 AT AT00906484T patent/ATE331731T1/de not_active IP Right Cessation
- 2000-02-25 US US09/914,162 patent/US6689871B1/en not_active Expired - Fee Related
-
2003
- 2003-10-22 US US10/690,855 patent/US6962803B2/en not_active Expired - Fee Related
-
2005
- 2005-08-15 US US11/204,193 patent/US7273728B2/en not_active Expired - Fee Related
-
2007
- 2007-09-13 US US11/854,683 patent/US7575891B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60029091T2 (de) | 2007-05-31 |
| EP1157034B1 (de) | 2006-06-28 |
| EP1157034A1 (de) | 2001-11-28 |
| ES2267499T3 (es) | 2007-03-16 |
| ATE331731T1 (de) | 2006-07-15 |
| US20040087775A1 (en) | 2004-05-06 |
| US7575891B2 (en) | 2009-08-18 |
| US7273728B2 (en) | 2007-09-25 |
| US20060035340A1 (en) | 2006-02-16 |
| AU2814600A (en) | 2000-09-14 |
| US20080153750A1 (en) | 2008-06-26 |
| US6962803B2 (en) | 2005-11-08 |
| GB9904582D0 (en) | 1999-04-21 |
| US6689871B1 (en) | 2004-02-10 |
| WO2000050449A1 (en) | 2000-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |