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DE60026737D1 - Verfahren zur herstellung von kristallin atorvastin kalcium - Google Patents

Verfahren zur herstellung von kristallin atorvastin kalcium

Info

Publication number
DE60026737D1
DE60026737D1 DE60026737T DE60026737T DE60026737D1 DE 60026737 D1 DE60026737 D1 DE 60026737D1 DE 60026737 T DE60026737 T DE 60026737T DE 60026737 T DE60026737 T DE 60026737T DE 60026737 D1 DE60026737 D1 DE 60026737D1
Authority
DE
Germany
Prior art keywords
kalcium
atorvastine
preparing crystalline
vacuum pan
pan dryer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60026737T
Other languages
English (en)
Other versions
DE60026737T2 (de
Inventor
John O'connell
William Tully
Evelyn Madigan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Science and Technology Ireland Ltd
Original Assignee
Pfizer Science and Technology Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Science and Technology Ireland Ltd filed Critical Pfizer Science and Technology Ireland Ltd
Application granted granted Critical
Publication of DE60026737D1 publication Critical patent/DE60026737D1/de
Publication of DE60026737T2 publication Critical patent/DE60026737T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60026737T 1999-12-17 2000-12-18 Verfahren zur herstellung von kristallin atorvastin kalcium Expired - Fee Related DE60026737T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
WOPCT/IE99/00133 1999-12-17
IE9900133 1999-12-17
PCT/IE2000/000151 WO2001044181A1 (en) 1999-12-17 2000-12-18 A process for producing crystalline atorvastatin calcium

Publications (2)

Publication Number Publication Date
DE60026737D1 true DE60026737D1 (de) 2006-05-11
DE60026737T2 DE60026737T2 (de) 2006-09-21

Family

ID=11042529

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60026737T Expired - Fee Related DE60026737T2 (de) 1999-12-17 2000-12-18 Verfahren zur herstellung von kristallin atorvastin kalcium

Country Status (13)

Country Link
US (2) US6605728B2 (de)
EP (1) EP1242373B1 (de)
JP (1) JP2003517039A (de)
AT (1) ATE320415T1 (de)
AU (1) AU780247B2 (de)
CA (1) CA2391357C (de)
DE (1) DE60026737T2 (de)
ES (1) ES2258030T3 (de)
HU (1) HUP0203798A3 (de)
IL (2) IL149088A0 (de)
MX (1) MXPA02004082A (de)
WO (1) WO2001044181A1 (de)
ZA (1) ZA200203649B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL128865A (en) 1995-07-17 2006-04-10 Warner Lambert Co Atorostatin IV form crystals and its hydrates, methods of preparation and pharmaceutical preparations containing it
US7411075B1 (en) 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
US7501450B2 (en) * 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
ATE420070T1 (de) * 2000-12-27 2009-01-15 Teva Pharma Kristalline formen von atorvastatin
GEP20053546B (en) * 2001-06-29 2005-06-10 Warner Lambert Co Crystalline Forms of 'R-(R*,R*)!-2-(4- Fluorophenyl)-Beta, Delta-Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-'Phenylamino) Carbonyl!-1H-Pyrrole-1-Heptanoic Acid Calcium Salt (2:1) (Atorvastatin)
US7074818B2 (en) * 2001-07-30 2006-07-11 Dr. Reddy's Laboratories Limited Crystalline forms VI and VII of Atorvastatin calcium
EP1572638A4 (de) * 2001-08-31 2010-05-05 Morepen Lab Ltd Verbessertes verfahren zur herstellung von amorphem atorvastatin-calciumsalz (2:1)
US20060020137A1 (en) * 2001-11-29 2006-01-26 Limor Tessler Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
CA2475864A1 (en) * 2002-02-15 2003-08-28 Teva Pharmaceutical Industries Ltd. Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation, as well as novel processes for preparing atorvastatin hemi-calcium forms i, viii and ix
MXPA04007995A (es) * 2002-02-19 2004-11-26 Teva Pharma Desolvatacion de solvatos de hemicalcio de atorvastatina.
IL150907A (en) * 2002-07-25 2007-07-04 Stephan Cherkez Process for the preparation of stable amorphous calcium pseudomonate
CA2508871C (en) * 2002-11-28 2008-09-09 Teva Pharmaceutical Industries Ltd. Crystalline form f of atorvastatin hemi-calcium salt
EP1424324A1 (de) * 2002-11-28 2004-06-02 Teva Pharmaceutical Industries Limited Kristalline Form F von Atorvastatin
DE102004007275B4 (de) 2004-02-14 2007-06-14 Stora Enso Maxau Gmbh & Co. Kg Verfahren zum Herstellen eines Glassinpapiers und Substratpapier als Halbzeug für ein Glassinpapier
AU2005263550C1 (en) * 2004-07-16 2013-01-17 Lek Pharmaceuticals D.D. Oxidative degradation products of atorvastatin calcium
WO2006048888A1 (en) * 2004-11-01 2006-05-11 Jubilant Organosys Limited Novel process for the preparation of amorphous atorvastatin calcium salt
EP1934195B1 (de) * 2005-09-10 2009-02-25 Ulkar Kimya Sanayii Ve Ticaret A.S. Verfahren zur herstellung von lactonen
CN102249978A (zh) * 2011-06-09 2011-11-23 浙江金立源药业有限公司 阿托伐他汀钙的ky晶型及制备方法
KR20230088761A (ko) 2020-10-13 2023-06-20 베링거 인겔하임 인터내셔날 게엠베하 재가공하는 방법

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US3288288A (en) * 1963-06-28 1966-11-29 Johns Manville Art of filtration
US3852480A (en) * 1972-04-11 1974-12-03 Beatrice Foods Co Bland soy protein
US3897307A (en) * 1974-10-23 1975-07-29 Hansens Lab Inc Stabilized dry cultures of lactic acid-producing bacteria
US4681893A (en) 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US5097045A (en) 1989-02-01 1992-03-17 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5149837A (en) 1988-02-22 1992-09-22 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5216174A (en) * 1988-02-22 1993-06-01 Warner-Lambert Co. Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5003080A (en) 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5245047A (en) 1988-02-22 1993-09-14 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5124482A (en) 1988-02-22 1992-06-23 Warner-Lambert Company Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis
NL8800801A (nl) 1988-03-30 1989-10-16 Philips Nv Data-verwerkend systeem met cyclische data-buffering, selektiemiddelen voor het selekteren van geheugenadressen, geschikt voor toepassing in een dergelijk systeem.
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5102648A (en) * 1990-03-02 1992-04-07 Olin Corporation Process for the production of lithium hypochloride
US5248793A (en) 1990-10-17 1993-09-28 Warner-Lambert Company Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5103024A (en) 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5155251A (en) 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5298627A (en) 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
HRP960313B1 (en) * 1995-07-17 2002-08-31 Warner Lambert Co Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)
IL128865A (en) * 1995-07-17 2006-04-10 Warner Lambert Co Atorostatin IV form crystals and its hydrates, methods of preparation and pharmaceutical preparations containing it
US6087511A (en) 1996-07-16 2000-07-11 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
JP2000515882A (ja) 1996-07-29 2000-11-28 ワーナー―ランバート・コンパニー （ｓ）―３，４―ジヒドロキシ酪酸の保護されたエステルを合成するための改善された方法
HUP0100252A3 (en) 1997-12-19 2002-12-28 Warner Lambert Exp Ltd Dun Lao Process for the synthesis of 1,3-diols

Also Published As

Publication number Publication date
US6605728B2 (en) 2003-08-12
DE60026737T2 (de) 2006-09-21
CA2391357C (en) 2009-01-06
US20040024226A1 (en) 2004-02-05
WO2001044181A1 (en) 2001-06-21
IL149088A (en) 2007-03-08
HUP0203798A2 (hu) 2003-03-28
US20020161239A1 (en) 2002-10-31
EP1242373B1 (de) 2006-03-15
HUP0203798A3 (en) 2008-10-28
ZA200203649B (en) 2002-12-20
IL149088A0 (en) 2002-11-10
AU2214301A (en) 2001-06-25
AU780247B2 (en) 2005-03-10
ATE320415T1 (de) 2006-04-15
MXPA02004082A (es) 2002-10-11
EP1242373A1 (de) 2002-09-25
JP2003517039A (ja) 2003-05-20
ES2258030T3 (es) 2006-08-16
CA2391357A1 (en) 2001-06-21
US6730797B2 (en) 2004-05-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee